Selinexor (oral route)
Available brands
Xpovio
About this medication
Selinexor is used together with bortezomib and dexamethasone to treat multiple myeloma in patients who have received at least 1 previous treatment that did not work well. It is also used together with dexamethasone to treat multiple myeloma that has come back (relapsed) or has not responded to treatment (refractory) in patients who have received at least 4 previous treatments that did not work well and cannot be treated with certain cancer medicines (eg, at least 2 proteosome inhibitors, at least 2 immunomodulatory agents, and an anti-CD38 monoclonal antibody). Selinexor is also used to treat certain types of diffuse large B-cell lymphoma (DLBCL) that has come back or has not responded to treatment (eg, DLBCL arising from follicular lymphoma) in patients who have received at least 2 previous treatments given by mouth or injection. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms:
Before using this medication
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Appropriate studies have not been performed on the relationship of age to the effects of selinexor in the pediatric population. Safety and efficacy have not been established. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of selinexor in the elderly. However, elderly patients are more likely to have serious unwanted effects, which may require caution in patients receiving this medicine. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
How to use this medication
Medicines used to treat cancer are very strong and can have many side effects. Before using this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment. Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. This medicine comes with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions. Take this medicine at the same time each day. Swallow the tablet whole with water. Do not break, chew, crush, or divide it. You may also receive medicines to help prevent nausea and vomiting. Drink plenty of fluids to help prevent dehydration and eat enough calories to help prevent weight loss during treatment with this medicine. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses. If you vomit after taking a dose, do not take an extra dose. Take the next dose at the regular time. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use.
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