Kenza, Leukemia Myelogenous Yechigarire

Chronic myelogenous leukemia (CML) is a rare type of cancer that starts in the bone marrow. Bone marrow is the soft, inner part of your bones, where blood cells are created. CML causes the body to make too many white blood cells.

The word "chronic" means CML usually develops slowly, unlike some other, faster-growing types of leukemia. "Myelogenous" describes the specific type of blood cell affected by the cancer. This type of cancer is sometimes also called chronic myeloid leukemia or chronic granulocytic leukemia.

CML most often affects older adults, but can occur at any age, though it's less common in children.

Medical treatments for CML have greatly improved. Many people with CML can go into remission, meaning the cancer is under control, and live long, healthy lives after diagnosis.

Looking for treatment?

We are accepting new patients for CML treatment. Our team of experts is ready to schedule your appointment now.

Locations:

• Arizona: 520-667-2117
• Florida: 904-895-7709
• Minnesota: 507-792-8724

Chirwere chechitsitsinho chemarrow chinowanzoita kuti pasave nechirwere. Chinogona kuwanikwa pakuongororwa kweropa.

Kana zvikaitika, zviratidzo zvinogona kusanganisira:

• Kurwadziwa kwemwongo.
• Kubuda ropa nyore.
• Kunzwa wakazara mushure mekudya chikafu chidiki.
• Kushaya simba.
• Kupisa.
• Kurasikirwa nehuremu pasina kuedza.
• Kushaya chido chekudya.
• Kurwadziwa kana kuzara pasi pemabvi kurutivi rweruboshwe.
• Kupererwa neperspiration panguva yekurara.
• Kuona kusapfava kwakakonzerwa nekudira ropa kumashure kweziso.

Enda kunotarisa nachiremba wako kana uine zviratidzo zvinogara zvichikunetseka.

Vanhu vakawanda vane leukemia ye myelogenous yakasimba vane chromosome inonzi Philadelphia chromosome mukati memasero avo eropa. Masero akajairwa ese ane mapeya 23 emakromosomes anoitwa neDNA. DNA ine mirairo yemasero ese ari mumuviri. Philadelphia chromosome inoumbwa kana chromosome 9 ne chromosome 22 dzikapwanya dzikachinjana zvikamu. Izvi zvinoita kuti pave ne chromosome 22 pfupi uye musanganiswa mutsva wemirairo yemasero. Aya mirairo mitsva inogona kutungamira pakukura kwe leukemia ye myelogenous yakasimba.

Leukemia ye myelogenous yakasimba inoitika kana chimwe chinhu chikaita kuti kuchinja kuitike kumasero emoyo wemisumbu. Hazvina kujeka kuti chii chinotanga iyi nzira. Zvisinei, vanachiremba vakawana kuti inofambira sei kuita leukemia ye myelogenous yakasimba.

Masero emunhu kazhinji ane mapeya 23 emakromosomes. Aya makromosomes ane DNA ine mirairo inoudza masero kuti aite sei. Muvanhu vane leukemia ye myelogenous yakasimba, makromosomes ari muropa anochinjana zvikamu. Chikamu che chromosome 9 chinotsiva nzvimbo nechikamu che chromosome 22. Izvi zvinoita kuti pave ne chromosome 22 pfupi kwazvo uye chromosome 9 refu kwazvo.

Chromosome 22 pfupi kwazvo inonzi Philadelphia chromosome. Yakapihwa zita rekuti guta rakawanikwa mariri. Philadelphia chromosome iripo mumaselo eropa e 90% yevanhu vane leukemia ye myelogenous yakasimba.

Genes kubva ku chromosome 9 inosanganiswa ne genes kubva ku chromosome 22 kuita gene itsva inonzi BCR-ABL. BCR-ABL gene inoudza masero eropa kuti aite zvakawanda zve protein inonzi tyrosine kinase. Tyrosine kinase inokurudzira kenza nekubvumira masero eropa akati kuti kukura zvisina kudzora.

Masero eropa anotanga kukura mumoyo wemisumbu. Kana moyo wemisumbu uchishanda zvakanaka, unoita masero asina kukura, anonzi masero eropa stem, nenzira yakadzorwa. Aya masero anozokura uye kuita masero matsvuku, masero machena uye ma platelets anofamba muropa.

Mu leukemia ye myelogenous yakasimba, iyi nzira haishande zvakanaka. Tyrosine kinase inobvumira masero eropa machena mazhinji kukura. Kazhinji kana ese aya masero ane Philadelphia chromosome. Masero eropa machena ane chirwere haakuri uye afa sezvaanofanira. Masero eropa machena ane chirwere anoungana muhuwandu hukuru. Anodzvinyirira masero eropa ane hutano uye anokuvadza moyo wemisumbu.

Zvinhu zvinoita kuti munhu ave panjodzi yakakura yekurwara nechirwere chechomyelogenous leukemia chinoramba chichiitika zvinosanganisira:

• Kuwedzera kwezera. CML inowanzowanikwa muvanhu vakwegura kupfuura muvana nevakuru vechidiki.
• Kuva murume. Varume vane njodzi yakakura zvishoma yekuwana CML kupfuura vakadzi.
• Kuonekwa nekuzarirwa kwemwaranzi. Kurapwa kwemwaranzi kwemamwe marudzi ekenza kwakabatana neCML.

Hapana nzira yekudzivirira chirwere chechomyelogenous leukemia chinoramba chichiitika. Kana uchiwana, hapana chawaigona kuita kudzivirira.

Kuchinja kwegene kunotungamira kuchirwere chechomyelogenous leukemia chinoramba chichiitika hakusi kupfuudzwa kubva kuvabereki kuenda kuvana. Kuchinja uku kunofungidzirwa kuti kunokura mushure mekuberekwa.

Mukuvhima utachiona hwemiganda, mushandi wehutano anoshandisa tsono yakatetepa kubvisa huwandu hudiki hwemiganda yemiganda. Kazhinji inotorwa kubva panzvimbo iri kumashure kweguvhu, inonziwo pelvis. Biopsy yemiganda inowanzoitwa panguva imwe chete. Maitiro acho ekutanga anobvisa chidimbu chidiki che tishu yemiganda nemarrow yakavharirwa mukati.

Kuongororwa nekuita kwinoshandiswa kuona chirwere che leukemia che myelogenous chinoramba chichiitika kunosanganisira:

• Kuongororwa kweropa. Sampuli yeropa inotorwa uchishandisa tsono. Sampuli yacho inotumirwa ku laboratori kuti iongororwe nhamba yeropa, inonziwo CBC. CBC inotarisa nhamba ye marudzi akasiyana-siyana emasero ari muropa. Leukemia ye myelogenous inoramba ichitika kazhinji inoita kuti huwandu hwema cell machena huwedzere zvakanyanya. Kuongororwa kweropa kunogonawo kuyeresa basa renhengo kuti zviratidze kana chimwe chinhu chisingashande zvakanaka.
• Kuongororwa kwemiganda yemiganda. Biopsy yemiganda yemiganda nekuvhima utachiona hwemiganda zvinoshandiswa kuunganidza sampuli dzemiganda yemiganda kuti dziongororwe. Miganda yemiganda ine chikamu chakaoma nechikamu chemvura. Mukuvhima utachiona hwemiganda, tsono inoshandiswa kuunganidza huwandu hudiki hwetishu yakaoma. Mukuvhima utachiona hwemiganda, tsono inoshandiswa kubvisa sampuli yemvura. Sampuli dzacho kazhinji dzinotorwa kubva paguvhu. Sampuli dzacho dzinotumirwa ku laboratori kuti dziongororwe.
• Kuongororwa kwekutsvaga chromosome yePhiladelphia. Kuongororwa kwakakosha kunoshandiswa kuongorora sampuli dzeropa kana dzemiganda yemiganda kuti pave ne chromosome yePhiladelphia kana gene ye BCR-ABL. Kuongororwa uku kunogona kusanganisira kuongororwa kwe fluorescence in situ hybridization, kunonziwo FISH, nekuongororwa kwe polymerase chain reaction, kunonziwo PCR.

Danho re leukemia ye myelogenous inoramba ichitika rinoreva kuwanda kwechirwere ichi. Mupi wehutano hwako anoona danho racho nekukwana huwandu hwema cell ane chirwere nemasero ane hutano muropa rako kana miganda yemiganda. Huwandu hukuru hwema cell ane chirwere zvinoreva kuti leukemia ye myelogenous inoramba ichitika iri padanho rakakura.

Matanho e leukemia ye myelogenous inoramba ichitika anosanganisira:

• Inoramba ichitika. Danho rinoramba richitika ndiro danho rekutanga uye kazhinji rine mhinduro yakanaka pakurapa.
• Inokurumidza. Danho rinokurumidza ndiro danho rekushanduka apo chirwere chinova chakasimba.
• Blast. Danho re blast ndiro danho rakasimba, rakasimba rinouraya.

Chinangwa chekurapa chirwere che leukemia ye myelogenous yemazuva ese ndechekubvisa masero eropa ane jini reBCR-ABL. Kune vanhu vakawanda, kurapa kunotanga nekurapa kunangwa kunogona kubatsira kusvika pakurapa kwenguva refu kwechirwere ichi.

Kurapa kunangwa kunoshandisa mishonga inorwisa kemikari chaiyo mumaseli ekanser. Nekuvhara kemikari idzi, kurapa kunangwa kunogona kuita kuti masero ekanser afe. Mu leukemia ye myelogenous yemazuva ese, chinangwa chemishonga iyi ndiprotein ye tyrosine kinase inogadzirwa nejini reBCR-ABL. Mishonga iyi inonzi tyrosine kinase inhibitors, inozivikanwawo seTKIs.

TKIs ndiwo kurapa kwekutanga kwevanhu vanorwara ne leukemia ye myelogenous yemazuva ese. Zvinokonzerwa nemishonga iyi inangwa zvinosanganisira kuzvimba kana kuzvimba kwe ganda, kusvotwa, marwadzo emhasuru, kuneta, manyoka, uye kuzvimba kwe ganda.

Kuongororwa kweropa kunotarisa kuvapo kwejeni reBCR-ABL kunoshandiswa kutarisira kushanda kwe kurapa kunangwa. Kana chirwere chisina kupindura kana chikaita kuti kurapa kunangwa kusashande, vanachiremba vanogona kufunga nezvemimwe mishonga yekurapa inangwa kana kurapa kwakasiyana.

Vanachiremba havawanikwe nzvimbo yakachengeteka iyo vanhu vane leukemia ye myelogenous yemazuva ese vanogona kurega kutora mishonga inangwa. Nechikonzero ichi, vanhu vakawanda vanoramba vachitora mishonga inangwa kunyangwe kana bvunzo yeropa ikaratidza kuti chirwere chapera. Mumamiriro ezvinhu akati, iwe nemunyanzvi wako munogona kufunga nezvekumisa kurapa nemishonga inangwa mushure mekukurukura zvakanaka nezvakaipa.

Kusimudzirwa kwemapfupa, kunonziwo kusimudzirwa kwemasero estem, ndiwo kurapa chete kunogona kurapa leukemia ye myelogenous yemazuva ese. Zvisinei, kazhinji inosara kune vanhu vasina kubatsirwa nemamwe kurapa. Izvozvo ndizvo nekuti kusimudzirwa kwemapfupa kunongova ne ngozi uye kunouya nehuwandu hwakawanda hwezvinetso zvakakomba.

Panguva yekusimudzirwa kwemapfupa, mishonga yakasimba yechemotherapy inoshandiswa kuuraya masero anogadzira ropa mubone marrow yako. Zvadaro masero estem eropa kubva kumupi anozoshandiswa muropa rako. Masero matsva anogadzira masero eropa ane hutano kuti atsivisee masero ane chirwere.

Chemotherapy inoshandisa mishonga yakasimba kuuraya masero ekanser. Mishonga yechemotherapy dzimwe nguva inosanganiswa nekurapa kunangwa kurapa leukemia ye myelogenous inorwisa zvakanyanya. Zvinokonzerwa nemishonga yechemotherapy zvinoenderana nemishonga yaunotora.

Kuongororwa kwezvipatara ndizvidzidzo zve kurapa kwatsva. Zvidzidzo izvi zvinopa mukana wekuedza kurapa kwazvino. Ngozi yezvinokonzerwa ingave isingazivikanwe. Bvunza chiremba wako kana iwe ungakwanisa kuva mukuongororwa kwezvipatara.

Hapana mishonga imwe yakawanikwa yekurapa leukemia ye myelogenous yemazuva ese. Asi mishonga imwe inogona kukubatsira kukurira kuneta, izvo zvakajairika kune vanhu vane leukemia ye myelogenous yemazuva ese.

Unogona kuona kuneta sechikonzero chechirwere chako, chinokonzerwa nekurapa kana chikamu chekushushikana kunouya nekugara uchirwara kwemazuva ese. Chiremba wako anogona kurapa kuneta nekudzora zvinokonzera, asi dzimwe nguva mishonga chete haina kukwana.

Unogona kuwana zororo kuburikidza nekurapa kwakasiyana, sekunge:

• Kuita zvemuviri.
• Kunyora zvinyorwa.
• Kuve nechokwadi.
• Matekiniki ekusununguka.
• Yoga.

Taurira munyanzvi wako nezve sarudzo dzako. Pamwe chete munogona kuita hurongwa hwekukubatsira kukurira kuneta.

'Kune vanhu vakawanda, leukemia ye myelogenous yakasimba chirwere icho vachagara nacho kwemakore mazhinji. Vakawanda vachaenderera mberi kurapwa nekurapa kwakaringana kusvika pakusingaperi. Mazuva amwe, unogona kunzwa kurwara kunyangwe usati uchitaridzika kurwara. Uye mamwe mazuva, unongorwara nekukuvadzwa nekenza. Edza aya matanho ekutarisira kwako kuti akupe rubatsiro pakugadzirisa uye kubata nechirwere chisingaperi:\n\n- Taura nachiremba wako nezvemigumisiro yemishonga. Mishonga ine simba yekenza inogona kukonzera migumisiro yakawanda. Migumisiro iyoyo kazhinji inogona kutarisirwa nemimwe mishonga kana kurapwa. Haukwanise kuibata usina rubatsiro.\n- Usarega kurapwa wega. Kana ukawana migumisiro, senge kuzvimba kwe ganda kana kushaya simba, usarega mishonga yako usati wataura nachiremba wako. Saizvozvo, usarega kutora mishonga yako kana uchinzwa zvakanaka uye uchifunga kuti chirwere chako chingave chaenda. Kana ukarega kutora mishonga, chirwere chako chinogona kudzoka nekukurumidza, kunyangwe kana wanga uri mukuporeswa.\n- Kumbira rubatsiro kana uri kunetseka kubata. Kuva nechirwere chisingaperi kunogona kukuvadza mupfungwa. Udza mudzidzisi wako nezvemanzwiro ako. Kumbira kuti akutumire kukurukuri kana mumwe nyanzvi waunogona kutaura naye.\n\nKusangana nechirwere chakakomba kunogona kukupa hanya. Panguva yakati, uchawana nzira dzekubata nemanzwiro ako, asi unogona kuwana nyaradzo mune aya mazano:\n\n- Dzidza zvakakwana nezve leukemia ye myelogenous yakasimba kuti uite sarudzo nezvekuchengetedza kwako. Shoko rokuti "leukemia" rinogona kuva rakaoma kunzwisisa, nekuti rinoreva boka rekenza dzinotapukira mumapfupa ne ropa. Usapedze nguva uchitsvaga ruzivo rusina kukodzera rudzi rwe leukemia yako.\n\n Bvunza timu yako yekuchengetedza utano kuti inyore ruzivo nezvechirwere chako chaicho. Wobva waderedza kutsvaga kwako uye utsvage chete masosi akavimbika, ane mukurumbira, akadai seLeukemia & Lymphoma Society.\n- Ramba uine hukama neshamwari nemhuri. Kuongororwa kwenyu kwenzara kunogona kuva kunetsekawo kune shamwari nemhuri. Edza kuvaramba vakabatana muhupenyu hwako.\n\n Shamwari nemhuri yako vachakubvunza kana paine chimwe chinhu chavanogona kukubatsira nacho. Funga nezvemabasa aunoda kubatsirwa nawo, senge kutarisira imba yako kana uchifanira kuramba muchipatara kana kungoteerera kana uchida kutaura.\n\n Unogona kuwana nyaradzo mukubatana kweboka rinoshamwaridzana reshamwari nemhuri yako.\n- Tsvaga munhu wokutaura naye. Tsvaga munhu waunogona kutaura naye ane ruzivo rwekubatsira vanhu vanosangana nechirwere chinotyisa hupenyu. Kumbira mudzidzisi wako kuti akurudzire mukuru wekurapa kana mushandi wemagariro evanhu unogona kutaura naye. Kuti uwane mapoka ekutsigira, taura neAmerican Cancer Society kana kubvunza timu yako yekuchengetedza utano nezvemapoka emumagariro.\n\nDzidza zvakakwana nezve leukemia ye myelogenous yakasimba kuti uite sarudzo nezvekuchengetedza kwako. Shoko rokuti "leukemia" rinogona kuva rakaoma kunzwisisa, nekuti rinoreva boka rekenza dzinotapukira mumapfupa ne ropa. Usapedze nguva uchitsvaga ruzivo rusina kukodzera rudzi rwe leukemia yako.\n\nBvunza timu yako yekuchengetedza utano kuti inyore ruzivo nezvechirwere chako chaicho. Wobva waderedza kutsvaga kwako uye utsvage chete masosi akavimbika, ane mukurumbira, akadai seLeukemia & Lymphoma Society.\n\nRamba uine hukama neshamwari nemhuri. Kuongororwa kwenyu kwenzara kunogona kuva kunetsekawo kune shamwari nemhuri. Edza kuvaramba vakabatana muhupenyu hwako.\n\nShamwari nemhuri yako vachakubvunza kana paine chimwe chinhu chavanogona kukubatsira nacho. Funga nezvemabasa aunoda kubatsirwa nawo, senge kutarisira imba yako kana uchifanira kuramba muchipatara kana kungoteerera kana uchida kutaura.\n\nUnogona kuwana nyaradzo mukubatana kweboka rinoshamwaridzana reshamwari nemhuri yako.'