Yini i-Abrocitinib: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Abrocitinib iyimithi kadokotela esiza ekuphatheni i-atopic dermatitis (eczema) ephakathi nendawo kuya kokukhulu ezinganeni nakubantu abadala abaneminyaka engu-12 nangaphezulu. Le mithi edliwayo isebenza ngokugxila ezindleleni ezithile zomzimba zokuzivikela ezibangela ukuvuvukala nokuluma okuhambisana ne-eczema, inikeze impumuzo lapho ukwelashwa okusebenzayo kunganele.

Uma ubhekene ne-eczema eqhubekayo ephazamisa impilo yakho yansuku zonke, i-abrocitinib ingaba yindlela udokotela wakho wesikhumba angayicabangela. Ingaphansi kwesigaba esisha semithi ebizwa ngokuthi ama-JAK inhibitors, okuye kwabonisa imiphumela ethembisayo ekusizeni abantu ukuthi babuyisele ukulawula isimo sesikhumba sabo.

Yini i-Abrocitinib?

I-Abrocitinib iyi-oral JAK1 inhibitor eyenzelwe ngqo ukwelapha i-atopic dermatitis ephakathi nendawo kuya kokukhulu. I-JAK imele i-Janus kinase, okuyizinhlobo zamaprotheni asiza ekulawuleni ukuvuvukala emzimbeni wakho.

Cabanga ngamaprotheni e-JAK njengezithunywa ezitshela amasosha akho omzimba ukuthi akhe ukuvuvukala. Uma une-eczema, lezi zithunywa ziba nomsebenzi omningi, okuholela esikhumbeni esibomvu, esilumayo, nesivuvukele ositholayo. I-Abrocitinib isebenza ngokuvimba lezi zithunywa ezithile, isiza ukuthulisa impendulo evuvukalayo ebangela izimpawu zakho ze-eczema.

Le mithi isanda kufika emakethe, ngemuva kokuthola imvume ye-FDA ngonyaka ka-2022. Yenzelwe abantu i-eczema yabo engaphendulanga kahle ngokwanele ekwelashweni okusebenzayo noma abadinga ukwelashwa okuhlelekile ukuze baphathe isimo sabo ngempumelelo.

Isetshenziselwani i-Abrocitinib?

I-Abrocitinib ikakhulukazi inikezwa ngemiyalelo ye-atopic dermatitis ephakathi nendawo kuya kokukhulu kubantu abadala nasebancane abaneminyaka engu-12 nangaphezulu abangaba ngabazokwelashwa okuhlelekile. Udokotela wakho angase acabangele le mithi lapho ukwelashwa okusebenzayo kungazange kunikeze impumuzo eyanele.

Umuthi usiza ukubhekana nezimpawu eziyinhloko ze-eczema ezingathinta kakhulu izinga lempilo yakho. Lokhu kufaka phakathi ukulunywa okuqhubekayo okuphazamisa ukulala, ukuvuvukala kwesikhumba okusabalalele, nezindawo zesikhumba esikhuhlwe noma esilimele ngenxa yokuzikloloba okungapheli.

Udermatologist wakho angase ancome i-abrocitinib uma uzamile imithi eminingi yendawo ngaphandle kwempumelelo, noma uma i-eczema yakho ihlanganisa ingxenye enkulu yomzimba wakho. Ilusizo ikakhulukazi kubantu abane-eczema ephazamisa imisebenzi yansuku zonke, umsebenzi, noma amaphethini okulala.

Isebenza Kanjani I-Abrocitinib?

I-Abrocitinib isebenza ngokuvimba ngokuqondile ama-enzyme e-JAK1, adlala indima ebalulekile enqubweni yokuvuvukala eqhuba izimpawu ze-eczema. Le ndlela eqondiwe isiza ukunciphisa ukusabela komzimba okusebenza ngokweqile okubangela ukuthi isikhumba sakho sivuvuke futhi silume.

Lapho ama-enzyme e-JAK1 evinjwa, uchungechunge lwezimpawu zokuvuvukala eziholela ezimpawini ze-eczema luphazamiseka. Lokhu kusho ukuvuvukala okuncane, ukulunywa okuncishisiwe, nokuthuthukiswa komsebenzi wesithiyo sesikhumba ngokuhamba kwesikhathi. Umuthi empeleni usiza ukusetha kabusha ukusabela komzimba wakho emazingeni avamile.

Njengokwelashwa kwesistimu, i-abrocitinib ithathwa njengomuthi onamandla aphakathi nendawo osebenza ngaphakathi emzimbeni wakho kunokuba nje ngaphezulu kwesikhumba. Le ndlela yangaphakathi ingasebenza ikakhulukazi nge-eczema esabalalele noma lapho ukwelashwa kwendawo kungafinyeleli zonke izindawo ezithintekile ngendlela efanele.

Kufanele Ngiyithathe Kanjani I-Abrocitinib?

Thatha i-abrocitinib ngendlela eqondile njengoba unqunyelwe udokotela wakho, ngokuvamile kanye ngosuku ngaphandle kokudla. Amathebhulethi kufanele agwinywe wonke ngamanzi futhi akufanele achotshozwe, ahlunywe, noma ahlukaniswe.

Ungathatha lo muthi ngokudla uma ubangela isisu esibuhlungu, nakuba ukudla kungadingeki ukuze kumuncwe. Abantu abaningi bathola ukuthi ukuyithatha ngesikhathi esifanayo nsuku zonke kusiza ukugcina amazinga aqhubekayo ohlelweni lwabo futhi kwenza kube lula ukukhumbula.

Udktela wakho uzoqala ngomthamo othile osuselwe eminyakeni yakho, isisindo, nobukhulu bezimpawu. Ungalungisi umthamo wakho ngaphandle kokubonisana nodokotela wakho kuqala, njengoba umthamo udinga ukuqashwa ngokucophelela kokubili ukusebenza kahle nokuphepha.

Ngingathatha isikhathi esingakanani i-Abrocitinib?

Ubude bokwelashwa nge-abrocitinib buyahluka ngokuya ngempendulo yakho emuthini kanye nezimo zakho. Abantu abaningi baqala ukubona ngcono phakathi kwamasonto angu-2-4, ngemiphumela ebaluleke kakhulu ngokuvamile evela ngemuva kwamasonto angu-12-16 okusetshenziswa njalo.

Udktela wakho uzoqapha inqubekela phambili yakho ngokuqokwa okulandelayo njalo futhi angase alungise uhlelo lwakho lokwelapha ngokusekelwe ekutheni uqhubeka kanjani kahle. Abanye abantu bangase badinge ukwelashwa kwesikhathi eside ukuze bagcine isikhumba esicacile, kanti abanye bangase bakwazi ukunciphisa umthamo wabo noma baphumule emuthini.

Kubalulekile ukuqhubeka nokuthatha i-abrocitinib njengoba kunqunyiwe ngisho noma uqala ukuzizwa ungcono. Ukuyeka kungazelelwe ngaphandle kwesiqondiso sezokwelapha kungaholela ekubuyeni kwezimpawu zakho ze-eczema, okungenzeka kube nzima kakhulu kunakuqala.

Yiziphi Imiphumela Eceleni ye-Abrocitinib?

Njengayo yonke imithi, i-abrocitinib ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Ukuqonda ukuthi yini okufanele uyibheke kukusiza ukuthi usebenze nodokotela wakho ukuze ulawule noma yiziphi izinkinga eziphakamayo.

Imiphumela emibi evame kakhulu ngokuvamile imnene futhi ithambekele ekuthuthukiseni njengoba umzimba wakho uzivumela emuthini:

• Isicanucanu nokungakhululeki kwesisu
• Ikhanda
• Izimpawu zomkhuhlane ovamile
• Isiyezi
• Ukukhathala
• Ama-acne noma ukuqubuka kwesikhumba
• Ukwanda kwengozi yokutheleleka okuncane

Le miphumela emibi evamile ngokuvamile ayidingi ukuyeka umuthi, kodwa yazisa udokotela wakho uma iba yisicefe noma iqhubeka.

Imiphumela emibi engathi sína ayivamile kodwa idinga ukunakekelwa kwezokwelapha ngokushesha. Lokhu kufaka phakathi izimpawu zokutheleleka okungathi sína, ukopha okungavamile noma ukulimala, ubuhlungu obukhulu besisu, noma yiziphi izimpawu ezikukhathazayo kakhulu.

Ngenxa yokuthi i-abrocitinib ithinta amasosha akho omzimba, kunengozi eyengeziwe yokutheleleka nezinhlobo ezithile zomdlavuza, yize lezi zingozi ziphansi uma ziqhathaniswa. Udokotela wakho uzokuhlola njalo ngezivivinyo zegazi nokuhlolwa ukuze abambe noma yiziphi izinkinga ezingaba khona ekuqaleni.

Ubani Ongafanele Athole I-Abrocitinib?

I-Abrocitinib ayifanele wonke umuntu, futhi izimo ezithile zezempilo noma izimo zenza kungafaneleki. Udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokukuyalela lo muthi.

Akufanele uthathe i-abrocitinib uma unokutheleleka okungathi sína okusebenzayo, okuhlanganisa i-tuberculosis noma ezinye izifo zamagciwane, amagciwane, noma ezingaveli emvelweni ezingalawulwa kahle. Umuthi ungenza kube nzima ngomzimba wakho ukulwa nezifo.

Abantu abanezinhlobo ezithile zomdlavuza, ikakhulukazi imidlavuza yegazi, kufanele bagweme i-abrocitinib. Uma unomlando womdlavuza, udokotela wakho uzodinga ukulinganisa izinzuzo ngokumelene nezingozi ezingaba khona ngokucophelela.

Ezinye izimo ezingakuvimbela ukuthatha i-abrocitinib zihlanganisa izinkinga ezinkulu zesibindi, izimo ezithile zenhliziyo, noma uma ukhulelwe noma uncelisa. Udokotela wakho uzoxoxa ngalezi zinto nawe ngesikhathi sokubonisana kwakho.

Igama Lomkhiqizo Le-Abrocitinib

I-Abrocitinib ithengiswa ngaphansi kwegama lomkhiqizo elithi Cibinqo e-United States nakwamanye amazwe amaningi. Leli igama lomkhiqizo elilodwa elitholakala njengamanje ngalo muthi.

Lapho uthola umuthi wakho, uzobona ukuthi “Cibinqo” emaphaketheni nasemabhodleleni amaphilisi. Umuthi uza ngamandla ahlukene, ngokuvamile amaphilisi angu-50mg, 100mg, kanye no-200mg, kuye ngokuthi udokotela wakho ukuyalela ini.

Izinhlobo ezivamile ze-abrocitinib azitholakali okwamanje, njengoba umuthi usavikelwe ngamalungelo obunikazi. Lokhu kusho ukuthi i-Cibinqo okwamanje iyona kuphela indlela yokuthola lokhu kwelashwa okuthile.

Ezinye izindlela zokwelapha i-Abrocitinib

Uma i-abrocitinib ingakulungele, ezinye izinketho zokwelapha ziyatholakala ze-eczema ephakathi nendawo kuya kokukhulu. Udokotela wakho wesikhumba angakusiza ukuthi uhlole lezi ezinye izindlela ngokusekelwe esimweni sakho esithile.

Eminye imithi yomlomo ihlanganisa ama-immunosuppressants esintu afana ne-methotrexate, cyclosporine, noma i-mycophenolate mofetil. Lezi zisetshenziswe isikhathi eside ekwelashweni kwe-eczema kodwa zingase zibe nemiphumela ehlukile.

Ama-biologics ajovwayo afana ne-dupilumab (Dupixent) anikeza enye inketho yokwelapha yesistimu. Le mithi iqondise izingxenye ezihlukene zesimiso somzimba sokuzivikela futhi ingase ilungele abanye abantu, ikakhulukazi labo abangakwazi ukuthatha imithi yomlomo.

Ukwelashwa okusebenzayo kusebalulekile ngisho nangokwelashwa kwesistimu. Imithi esetshenziswa ngemiyalelo, i-phototherapy, kanye nemikhuba yokunakekela isikhumba ebanzi ivame ukusebenza kanye nokwelashwa ngomlomo ukuze kutholakale imiphumela engcono kakhulu.

Ingabe i-Abrocitinib ingcono kune-Dupilumab?

I-Abrocitinib ne-dupilumab zombili ziyindlela yokwelapha ephumelelayo ye-eczema ephakathi nendawo kuya kokukhulu, kodwa zisebenza ngezindlela ezihlukene futhi zinezinzuzo ezihlukene. Ukukhetha okuthi "kungcono" kuncike ezimweni zakho, okuthandayo, nokuthi usabela kanjani ekwelashweni.

I-Abrocitinib ithathwa njengepilisi yansuku zonke, abanye abantu abakuthola kulula kune-dupilumab's injections njalo emavikini amabili. Umuthi womlomo ungase futhi usebenze ngokushesha, abanye abantu bebona ukuthuthuka phakathi kwamasonto angu-2-4 uma kuqhathaniswa nomugqa wesikhathi we-dupilumab ovamile wamasonto angu-8-16.

Nokho, i-dupilumab inerekhodi elide lokuphepha nokusebenza, selitholakala kusukela ngo-2017. Iphinde yamukelwa nangezinye izimo ezinjenge-asthma kanye nama-polyps ekhala, okungase kube usizo uma unezimo eziningi zokungezwani komzimba.

Udktela wakho uzocabangela izinto ezinjengomlando wakho wezokwelapha, ezinye izimo zempilo, izintandokazi zokuphila, kanye nomshwalense lapho ekusiza ukuthi ukhethe phakathi kwalezi zinketho. Yomibili imithi ikhombise izinzuzo ezinkulu ezivivinyweni zomtholampilo, ngakho isinqumo sivame ukwehla ezintweni zomuntu ngamunye.

Imibuzo Evame Ukubuzwa Mayelana ne-Abrocitinib

Ingabe i-Abrocitinib iphephile kubantu abanezifo zenhliziyo?

I-Abrocitinib idinga ukucatshangelwa ngokucophelela kubantu abanezifo zenhliziyo, ikakhulukazi labo abanomlando wokuhlaselwa yinhliziyo, unhlangothi, noma amahlule egazi. Ama-JAK inhibitors njengeklasi ahlobene nezingozi ezengeziwe zenhliziyo nemithambo yegazi kwezinye izifundo.

Udktela wakho uzohlola izici zakho eziyingozi zenhliziyo nemithambo yegazi ngaphambi kokukuyala i-abrocitinib. Lokhu kufaka phakathi ukubuyekeza umlando wakho wezinkinga zenhliziyo, ukuhlola umfutho wegazi lakho, futhi mhlawumbe uku-oda ezinye izivivinyo ezinjenge-EKG noma i-echocardiogram.

Uma unezifo zenhliziyo, udktela wakho angase ancome ukuqapha kaningi noma acabangele ezinye izindlela zokwelapha. Kodwa-ke, kubantu abaningi, izinzuzo zokwelapha i-eczema enzima zingase zidlule izingozi ezingaba khona uma ziqashwe kahle.

Ngingenzani uma ngiphuzile i-Abrocitinib eningi ngengozi?

Uma ngengozi uphuza i-abrocitinib eningi kunaleyo ebekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ungalindi ukubona ukuthi ngabe izimpawu ziyavela yini, njengoba ukuthola iseluleko sezokwelapha ngokushesha kuyindlela ephephe kunazo zonke ngaso sonke isikhathi.

Ngenkathi ukuthatha umthamo owengeziwe ngezikhathi ezithile kungenakwenzeka ukuthi kubangele ukulimala okukhulu, ukuthatha okuningi kakhulu kunalokho okubekiwe kungakhuphula ingozi yakho yemiphumela emibi. Udktela wakho angase afune ukukuqapha eduze noma alungise isimiso sakho semithi.

Ukuvimbela ukweqisa ngengozi, cabanga ukusebenzisa umhleli wamaphilisi noma ukusetha izikhumbuzi zansuku zonke ocingweni lwakho. Gcina imithi esitsheni sayo sokuqala futhi ungalokothi uthathe imithamo eyengeziwe ukuze

Uma uphuthelwa umthamo we-abrocitinib, yithathe ngokushesha nje lapho ukhumbula, ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo. Kuleso simo, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho ejwayelekile.

Ungathathi imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe, ngoba lokhu kungakhuphula ingozi yakho yemiphumela emibi. Kunalokho, qhubeka nje neshejuli yakho yokuthatha imithi ejwayelekile bese uzama ukuba nokuzimisela okwengeziwe phambili.

Uma uvame ukukhohlwa imithamo, khuluma nodokotela wakho ngamasu okukusiza ukuthi ukhumbule. Ukuthatha imithi nsuku zonke ngokuqhubekayo kubalulekile ekugcineni amazinga aqhubekayo omuthi emzimbeni wakho nasekutholeni imiphumela engcono kakhulu.

Ngingayeka nini ukuthatha i-Abrocitinib?

Kufanele uyeke kuphela ukuthatha i-abrocitinib ngaphansi kwesiqondiso sikadokotela wakho, ngisho noma izimpawu zakho ze-eczema zithuthuke kakhulu. Ukuyeka kungazelelwe kungaholela ekubuyeni kwezimpawu zakho, okungenzeka zibe zimbi kakhulu kunakuqala.

Udokotela wakho uzosebenza nawe ukunquma isikhathi esifanele sokuyeka ukwelashwa ngokusekelwe ekutheni usunesikhathi esingakanani ungenazo izimpawu kanye nokuphendula kwakho konke emuthini. Abanye abantu bangase bakwazi ukuyeka ngemva kokuthola ukuxolelwa okuqhubekayo, kanti abanye bangase badinge ukwelashwa isikhathi eside.

Uma sekuyisikhathi sokuyeka, udokotela wakho angase ancome ukunciphisa kancane kancane umthamo wakho kunokuyeka kungazelelwe. Lokhu kusiza ukunciphisa ingozi yokubuyela kwezimpawu futhi kuvumela ukuqapha ngokucophelela ukuthi isikhumba sakho siphendula kanjani.

Ngingakwazi yini ukuthola imigomo ngenkathi ngithatha i-Abrocitinib?

Imigomo eminingi ejwayelekile iphephile ngenkathi uthatha i-abrocitinib, kodwa kufanele ugweme imigomo ephilayo ngesikhathi sokwelashwa. Udokotela wakho uzobuyekeza umlando wakho wokugoma futhi ancome noma yikuphi ukugoma okudingekayo ngaphambi kokuqala umuthi.

Imigomo ephilayo efana nomgomo womkhuhlane ngamakhala, i-MMR, noma umgomo wamathumba kufanele igwenywe ngoba i-abrocitinib inganciphisa ikhono lomzimba wakho lokulwa nalezi zigciwane eziphilayo ezibuthakathaka. Kodwa-ke, imigomo engasebenzi njengomjovo womkhuhlane ngokuvamile iphephile futhi iyanconywa.

Uma udinga imigomo ngenkathi usebenzisa i-abrocitinib, xoxa ngesikhathi nodokotela wakho. Bangase bancomise ukuthola imigomo ethile ngaphambi kokuqala ukwelashwa noma ukulungisa isikhathi ngokuya ngesimo sakho ngasinye kanye nesimo sempilo yamanje.