Yini i-Baricitinib: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Baricitinib iyimithi kadokotela esiza ukuthulisa amasosha omzimba asebenza ngokweqile. Iyingxenye yeqembu elisha lemithi ebizwa ngokuthi ama-JAK inhibitors, asebenza ngokuvimba amaprotheni athile avusa ukuvuvukala emzimbeni wakho.

Le mithi isibe yindlela ebalulekile yokwelapha abantu ababhekene nezifo ezizenzakalelayo lapho amasosha omzimba ehlasela izicubu ezinempilo ngamaphutha. Cabanga ngayo njengendlela eqondiwe yokunciphisa ukuvuvukala esikhundleni sokucindezela wonke amasosha omzimba wakho.

Yini i-Baricitinib Esetshenziselwa Yona?

I-Baricitinib iphatha izifo eziningi ezizenzakalelayo lapho ukuvuvukala okungapheli kubangela izimpawu eziqhubekayo. Le mithi isiza ukunciphisa ubuhlungu emalungeni, ukuvuvukala, nezinye izimpawu zokuvuvukala ezingathinta kakhulu impilo yakho yansuku zonke.

Udokotela wakho angase akubhalele i-baricitinib uma une-rheumatoid arthritis ephakathi nendawo kuya kokubi kakhulu futhi ezinye izindlela zokwelapha azikunikezanga ukukhululeka okwanele. Iphinde isetshenziselwe i-alopecia areata ebucayi, isimo lapho amasosha omzimba akho ehlasela ama-follicles ezinwele, okubangela ukulahlekelwa izinwele.

Kwezinye izimo, odokotela babhala i-baricitinib ye-atopic dermatitis (eczema) ebucayi kubantu abadala lapho ezinye izindlela zokwelapha zingasebenzanga kahle ngokwanele. Le mithi ingasetshenziswa futhi ukwelapha izinhlobo ezithile ezinzima ze-COVID-19 ezigulini ezibhedlela, nakuba lokhu kusetshenziswa kungavamile.

Isebenza Kanjani i-Baricitinib?

I-Baricitinib ivimba ama-enzyme athile abizwa ngokuthi i-JAK1 ne-JAK2, afana nokushintsha kwamangqamuzana avula ukuvuvukala emzimbeni wakho. Uma lawa mashintshi ehlala “evuliwe,” abangela ukuvuvukala okuqhubekayo okubonakala ezifweni ezizenzakalelayo.

Ngokuvimba lezi zindlela, i-baricitinib isiza ukunciphisa izimpawu zokuvuvukala ezibangela ukulimala kwamalunga, izinkinga zesikhumba, nezinye izimpawu. Ithathwa njengemithi enamandla ngokulinganiselwe enikeza ukucindezelwa kwamasosha omzimba okuhloswe ngaso esikhundleni sokucindezela wonke amasosha omzimba wakho.

Umuthi ngokuvamile uqala ukusebenza emasontweni ambalwa, nakuba kungase kuthathe izinyanga ezintathu ukubona izinzuzo eziphelele. Ngokungafani neminye imithi, i-baricitinib ayidingi imijovo futhi ingathathwa njengamaphilisi omlomo alula.

Kufanele Ngiyithathe Kanjani I-Baricitinib?

Thatha i-baricitinib ngendlela eqondile udokotela wakho ayikunikeza ngayo, ngokuvamile kanye ngosuku ngaphandle kokudla. Ungayithatha nengilazi yamanzi nganoma yisiphi isikhathi sosuku, kodwa zama ukuyithatha ngesikhathi esifanayo nsuku zonke ukuze ugcine amazinga aqhubekayo emzimbeni wakho.

Gwinya ithebhulethi yonke ngaphandle kokuyichoboza, ukuyihlukanisa, noma ukuyihlafuna. Uma unenkinga yokugwinya amaphilisi, khuluma nodokotela wakho mayelana nezinketho ezingezinye noma izindlela ezingasiza.

Awudingi ukuthatha i-baricitinib nobisi noma ukugwema ukudla okuthile, kodwa ukuhlala unamanzi kahle kuhlale kunenzuzo. Uma uhlangabezana nesisu esibuhlungu, ukuyithatha nokudla kungasiza ukunciphisa noma yikuphi ukuphatheka kabi kokugaya ukudla.

Ukuhlolwa kwegazi okuvamile kubalulekile ngenkathi uthatha i-baricitinib ukuze uqaphele ukubalwa kwegazi lakho nomsebenzi wesibindi. Udokotela wakho uzohlela lezi zivivinyo ukuze aqinisekise ukuthi umuthi usebenza ngokuphepha kuwe.

Kufanele Ngiyithathe Isikhathi Eside Kangakanani I-Baricitinib?

Ubude bokwelashwa nge-baricitinib buyahluka ngokuya ngesimo sakho nokuthi usabela kanjani emuthini. Abantu abaningi abanomdlavuza wamathambo bawuthatha isikhathi eside njengengxenye yohlelo lwabo lokuqhubeka nokwelashwa.

Nge-alopecia areata, ubude bokwelashwa buxhomeke ekuqhubekeni kokukhula kabusha kwezinwele nokuthi uwuthatha kahle kangakanani umuthi. Abanye abantu bangase babone ukuthuthuka okukhulu ezinyangeni eziyisithu, kanti abanye bangase badinge ukwelashwa isikhathi eside.

Udokotela wakho uzohlola njalo ukuthi i-baricitinib iyaqhubeka yini ukuba yisinqumo esifanele kuwe. Bazocabangela izinto ezinjengokuthuthuka kwezimpawu, imiphumela emibi, nesimo sakho sempilo esiphelele lapho benquma ubude bokwelashwa.

Ungayeki ukuthatha i-baricitinib ngokuzumayo ngaphandle kokubonisana nodokotela wakho, ngoba lokhu kungaholela ekutheni isimo sakho sibe sibi. Uma udinga ukuyeka imithi, udokotela wakho uzokuqondisa ngenqubo ngokuphepha.

Yiziphi Izimo Ezingezinhle Ze-Baricitinib?

Njengayo yonke imithi ethinta amasosha omzimba, i-baricitinib ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Ukuqonda ukuthi yini okufanele uyibheke kukusiza wena nodokotela wakho ukuthi uphathe ukwelashwa kwakho ngempumelelo.

Imiphumela emibi evamile abantu abaningi abayitholayo ihlanganisa izifo eziphezulu zokuphefumula, isicanucanu, nezimpawu ezifana nomkhuhlane olula. Lokhu kuvame ukwenzeka ngoba i-baricitinib inciphisa umsebenzi wamasosha omzimba, okwenza ukuthi uthambekele kancane ezifweni ezincane.

Nawa amanye emiphumela emibi ebikwa njalo ongase uyibone:

• Izimpawu zomkhuhlane njengamakhala agobhozayo noma umphimbo obuhlungu
• Isicanucanu noma ukungakhululeki kwesisu okuncane
• Ukucindezeleka kwekhanda
• Ukwanda kwamazinga e-cholesterol (okutholwa ngezivivinyo zegazi)
• Ukwanda okuncane kwama-enzyme athile esibindi

Le miphumela evamile ivame ukulawuleka futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela imithi. Nokho, kubalulekile ukubika noma yiziphi izimpawu eziqhubekayo noma eziphazamisayo kumhlinzeki wakho wezempilo.

Imiphumela emibi engathi sína idinga ukunakekelwa kwezokwelapha ngokushesha, nakuba ingavamile. Lokhu kufaka phakathi izimpawu zezifo ezingathi sína, amahlule egazi, noma izinguquko ezinkulu ekubalweni kwegazi lakho.

Qaphela lezi zimpawu zokuxwayisa ezidinga ukuhlolwa kwezokwelapha ngokushesha:

• Umkhuhlane, ama-chills, noma izimpawu eziqhubekayo ezinjengomkhuhlane
• Ukukhathala okungavamile noma ubuthakathaka
• Ukuphefumula kanzima noma ubuhlungu besifuba
• Ukuvuvukala komlenze noma ubuhlungu obungase bubonise amahlule egazi
• Ukulimala kalula noma ukuphuma kwegazi okungavamile
• Ukuphuzi kwesikhumba noma amehlo

Izinkinga ezingavamile kodwa ezinzima zingabandakanya izifo ezinzima, amahlule egazi emaphashini noma emilenzeni, kanye nezinguquko ezinkulu ekubalweni kwamaseli egazi. Nakuba lezi zinto ezenzeka zingavamile, ukuqapha njalo kusiza ukubamba noma yiziphi izinkinga zisasekuqaleni.

Ubani Ongafanele Athathe I-Baricitinib?

Abantu abathile kufanele bagweme i-baricitinib ngenxa yengozi eyengeziwe yezinkinga ezinzima. Udokotela wakho uzohlola ngokucophelela ukuthi lo muthi uphephile yini esimweni sakho esithile.

Akufanele uthathe i-baricitinib uma unesifo esibucayi esisebenzayo, njengoba umuthi ungenza izifo zibe zimbi ngokucindezela amasosha akho omzimba. Lokhu kuhlanganisa izifo zamagciwane, amagciwane, isikhunta, noma ezinye izifo ezinethuba.

Abantu abanomlando wamahule egazi kufanele basebenzise ukuqapha okukhulu, njengoba i-baricitinib ingase ikhulise ingozi yokuthuthukisa amahlule amasha. Lokhu kuhlanganisa izimo ezinjengokujiya kwemithambo ejulile, i-pulmonary embolism, noma unhlangothi.

Ezinye izimo eziningana zidinga ukucatshangelwa ngokucophelela ngaphambi kokuqala i-baricitinib:

• Isifo sofuba esisebenzayo noma umlando we-TB ongaphathwanga ngokuphelele
• Isifo sesibindi esibi noma ama-enzyme esibindi aphakanyiswe kakhulu
• Ukubalwa kwamaseli egazi okuphansi kakhulu
• Imithi yokugoma esanda kuthathwa (kufanele ugweme imithi yokugoma esaphila ngenkathi uthatha i-baricitinib)
• Ukukhulelwa noma ukuncelisa ibele

Ubudala bungaba yisici futhi, njengoba abantu abaneminyaka engaphezu kwengama-65 bangase babe nezingozi eziphakeme zokutheleleka nezinye izinkinga. Udokotela wakho uzohlola izinzuzo ngokumelene nezingozi ezingaba khona ngokusekelwe kuphrofayili yakho yezempilo yomuntu ngamunye.

Amagama Omkhiqizo we-Baricitinib

I-Baricitinib ithengiswa ngaphansi kwegama lomkhiqizo elithi Olumiant emazweni amaningi, okuhlanganisa ne-United States. Le yindlela ejwayelekile kakhulu yokwelapha.

Izinhlobo ezivamile ze-baricitinib zingase zitholakale kwezinye izifunda, kodwa igama lomkhiqizo elithi Olumiant lihlala liyindlela eyinhloko edalulwa odokotela abaningi. Njalo sebenzisa uhlobo oluthile noma oluvamile oluchazwe udokotela wakho.

Uma uhamba noma uthuthela kwelinye izwe, xhumana nomhlinzeki wakho wezempilo mayelana nokutholakala kwendawo kanye nanoma yiziphi izinto ezingafani ngamagama emikhiqizo noma amafomula.

Ezinye izindlela zokwelapha ze-Baricitinib

Eminye imithi eminingi isebenza ngendlela efana ne-baricitinib ekwelapheni izimo ze-autoimmune. Lezi ezinye izindlela zokwelapha zingase zifaneleke kangcono esimweni sakho esithile noma emlandweni wakho wezokwelapha.

Ezinye izinto ezivimbela i-JAK zihlanganisa i-tofacitinib (Xeljanz) ne-upadacitinib (Rinvoq), ezisebenza ngezindlela ezifanayo kodwa zingase zibe nemiphumela ehlukene. Udokotela wakho angase acabangele lezi uma i-baricitinib ingakulungele.

Imithi yendabuko yokuguqula izifo ze-antirheumatic (DMARDs) njenge-methotrexate noma i-sulfasalazine isahlala iyizinketho ezibalulekile zokwelapha. Le mithi inemlando omude futhi ingase ithandwe njengokwelashwa komugqa wokuqala.

Imithi ye-Biologic efana nezinto ezivimbela i-TNF (njenge-adalimumab noma i-etanercept) inikeza enye indlela yokwelapha izimo ze-autoimmune. Lezi zidinga imijovo kodwa zingase zifaneleke kakhulu kubantu abathile.

Ingabe i-Baricitinib ingcono kune-Methotrexate?

I-Baricitinib ne-methotrexate zisebenza ngendlela ehlukile futhi ngasinye sinamathuba ahlukile ngokuya ngesimo sakho esithile. Akukho ngisho esisodwa esivamile "esingcono" kunenye, njengoba ukukhetha okungcono kuncike ezidingweni zakho zomuntu ngamunye kanye nomlando wezokwelapha.

I-Methotrexate isetshenziswe amashumi eminyaka futhi ineprofayili yokuphepha esungulwe kahle, okuyenza ivame ukuba yinto yokuqala yokwelapha i-rheumatoid arthritis. Ngokuvamile ibiza kancane futhi ingasebenza kahle kakhulu kubantu abaningi.

I-Baricitinib ingase isebenze ngokushesha kune-methotrexate futhi ingase ibe lula ukuyithatha njengoba iyiphilisi lansuku zonke kunomjovo wamasonto onke noma amaphilisi amaningi. Abanye abantu abangayiphenduli kahle i-methotrexate bathola imiphumela engcono nge-baricitinib.

Udktela wakho uzocabangela izinto ezifana nobukhulu besifo sakho, ezinye izimo zempilo, izimpendulo zokwelashwa zangaphambilini, nezintandokazi zakho siqu lapho ekhetha phakathi kwala makhambi. Ngezikhathi ezithile asetshenziswa ndawonye ukuze athuthukise ukusebenza kwawo.

Imibuzo Evame Ukubuzwa Mayelana ne-Baricitinib

Ingabe i-Baricitinib iphephile kubantu abanezifo zenhliziyo?

I-Baricitinib idinga ukucatshangelwa ngokucophelela kubantu abanezifo zenhliziyo, ikakhulukazi labo abasengozini yokuba namahlule egazi. Udktela wakho wenhliziyo kanye nodokotela wamathambo kufanele basebenzisane ukuze bahlole ukuthi izinzuzo zidlula yini izingozi.

Abantu abanomlando wokuhlaselwa yinhliziyo, unhlangothi, noma amahlule egazi bangase babe nezingozi ezengeziwe lapho bethatha i-baricitinib. Kodwa-ke, abanye abantu abanezimo zenhliziyo basengase bakwazi ukusebenzisa le mithi ngokuphepha ngokuqapha okufanele.

Udktela wakho uzohlola izici zakho eziyingozi yenhliziyo nemithambo yegazi futhi angase ancome ukuqapha okwengeziwe noma izinyathelo zokuvimbela uma unezifo zenhliziyo futhi udinga ukwelashwa nge-baricitinib.

Ngingenzani uma ngiphuzile i-Baricitinib eningi ngengozi?

Uma ngengozi uphuze i-baricitinib eningi kunaleyo ebekiwe, xhumana nodktela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ukuphuza okuningi kungakhuphula ingozi yakho yemiphumela emibi engathi sína, ikakhulukazi izifo nezinkinga ezihlobene negazi.

Ungazami ukuthi "ulungise" umthamo owengeziwe ngokususa imithamo yesikhathi esizayo, ngoba lokhu kungaphazamisa ukusebenza kokwelashwa kwakho. Kunalokho, landela isiqondiso sikadktela wakho sokuthi uqhubeke kanjani ngokuphepha.

Gcina i-baricitinib esitsheni sayo sokuqala futhi uyigcine ngokuphepha kude nezingane nezilwane ezifuywayo ukuze uvimbele ukweqisa ngengozi. Uma uvame ukukhohlwa ukuthi ngabe uyithathile yini umthamo wakho, cabangela ukusebenzisa umhleli wamaphilisi.

Ngingenzani uma ngiphuthelwa umthamo we-Baricitinib?

Uma uphuthelwa umthamo we-baricitinib, yithathe ngokushesha lapho ukhumbula, ngaphandle kokuthi sekuseduze isikhathi somthamo wakho olandelayo ohleliwe. Kuleso simo, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho ejwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ongekho, ngoba lokhu kungakhuphula ingozi yakho yemiphumela emibi. Kungcono ukugcina isimiso sakho esijwayelekile sokuthatha imithi.

Uma uvame ukukhohlwa imithamo, zama ukusetha i-alamu yansuku zonke noma usebenzise uhlelo lokusebenza lokukhumbuza imithi. Ukuthatha imithi ngokuqhubekayo kusiza ukugcina amazinga aqhubekayo omuthi emzimbeni wakho ukuze usebenze kahle.

Ngingayeka nini ukuthatha i-Baricitinib?

Kufanele uyeke kuphela ukuthatha i-baricitinib ngaphansi kwesiqondiso sikadokotela wakho, ngoba ukuyeka kungazelelwe kungaholela ekuqubukeni kwesimo sakho. Udokotela wakho uzokusiza ukuthi unqume isikhathi esifanele sokuyeka ngokusekelwe ezimpawini zakho nempilo yonke.

Abanye abantu bangase bakwazi ukuyeka i-baricitinib uma isimo sabo singena ekuxolelweni okuqhubekayo, kanti abanye bangase badinge ukwelashwa kwesikhathi eside ukuze balawule izimpawu. Lesi sinqumo sincike esimweni sakho esithile nokuthi usabela kahle kangakanani ekwelashweni.

Uma uhlangabezana nemiphumela emibi engathi sína noma izifo, udokotela wakho angase ayeke okwesikhashana i-baricitinib kuze kube yilapho inkinga ixazululwa. Bazosebenza nawe ukuze banqume ukuthi kuphephile yini ukuqala kabusha umuthi kamuva.

Ngingakwazi yini ukuthola imigomo ngenkathi ngithatha i-Baricitinib?

Imigomo eminingi ejwayelekile iphephile ngenkathi uthatha i-baricitinib, kodwa kufanele ugweme imigomo ephilayo ngesikhathi sokwelashwa. Udokotela wakho uzohlinzeka ngesiqondiso esiqondile mayelana nokuthi yimiphi imigomo enconyiwe nokuthi kufanele uyithole nini.

Imigomo engasebenzi njengomgomo womkhuhlane, umgomo wamaphaphu, kanye nemigomo ye-COVID-19 ngokuvamile iphephile futhi ibalulekile kubantu abathatha i-baricitinib. Kodwa-ke, ukusabela kwakho komzimba emithini yokugoma kungase kuncishiswe.

Zama ukuthola imigomo enconyiwe ngaphambi kokuqala i-baricitinib uma kungenzeka. Uma udinga ukugonywa ngokushesha ngenkathi uthatha umuthi, xoxa ngesikhathi nohlobo lomgomo nomhlinzeki wakho wezempilo.