He aha te Amifostine: Ngā Whakamahinga, te Inenga, ngā Pānga taha me ētahi atu

He rongoā whakamarumaru te Amifostine e āwhina ana ki te tiaki i ngā pūtau hauora mai i te kino i te wā o te rongoā mate pukupuku. E mahi ana pērā i te kaitiaki pūtau, e uru ana ki te whakaiti i ngā pānga kino o te chemotherapy me te iraruke ki ngā kiko noa i te wā e tuku ana i ēnei rongoā kia haere tonu te whawhai i ngā pūtau mate pukupuku.

He taputapu whai hua tēnei rongoā i roto i te manaaki mate pukupuku mō ngā tekau tau, e tuku ana i te tūmanako ki ngā tūroro e hiahia ana ki ngā rongoā kaha engari e hiahia ana ki te tiaki i ō rātou okana hauora. Mā te māramatanga ki te mahi a te amifostine ka āwhina koe ki te whai i te māia ake mō ō whakatau rongoā.

He aha te Amifostine?

He rongoā cytoprotective te Amifostine, ko te tikanga e tiaki ana i ngā pūtau hauora mai i te kino paitini. Ka huri te rongoā ki tētahi āhua kaha i roto i tō tinana e mahi ana hei kaiwhakawā, e whakakore ana i ngā rauropi korekore kino i hangaia e ngā rongoā mate pukupuku.

Whakaarohia te amifostine hei whakangungu rakau e tiaki ana i ngā pūtau noa i te wā e waiho ana i ngā pūtau mate pukupuku kia tūpono ki te rongoā. Ka puta tēnei whakamarumaru whiriwhiri nā te mea he pai ake te rere toto o ngā pūtau hauora, ā, ka taea e rātou te ngongo i te rongoā i te pai ake i ngā pūtau mate pukupuku.

I te tuatahi i hangaia te rongoā e te Ope Taua o Amerika hei whakamarumaru i te pānga o te iraruke. I tēnei rā, e whakamahi ana ngā tohunga onkoloji i te reira hei āwhina i ngā tūroro ki te whakawhiti i ngā inenga teitei ake o ngā rongoā mate pukupuku whakaora-ora me te iti ake o ngā pānga taha.

He aha te Amifostine e whakamahia ana mō?

E mahi ana te Amifostine hei hoa whakamarumaru i te wā o ngā rongoā mate pukupuku motuhake. Ka tūtohu pea tō tākuta i te reira hei whakaiti i te kino o te tākihi mai i te chemotherapy cisplatin, hei aukati rānei i te waha maroke nui i te wā o te rongoā iraruke mō ngā mate pukupuku o te upoko me te kaki.

E āwhina ana te rongoā ki te aukati i ngā raruraru tākihi i whakauruhia e te cisplatin, he mea nui pea, ā, i ētahi wā ka pumau. Ki te whiwhi koe i te cisplatin mō ngā mate pukupuku pērā i te ovarian, te pūkahukahu, te mate pukupuku rānei o te pōro, ka taea e te amifostine te whakaiti nui i tō tūponotanga ki te kino o te tākihi.

Mō ngā tūroro mate pukupuku o te upoko me te kaki e whiwhi ana i te iraruke, ka āwhina te amifostine ki te tiaki i ngā repe huware. Mā tēnei whakamarumaru e ārai te waha maroke tonu, he mea uaua te kai, te kōrero, me te moe i muri i te maimoatanga iraruke.

E whakamahi ana ētahi tākuta i te amifostine hei whakamarumaru i ētahi atu pānga taha e pā ana ki te rongoā matū, ahakoa he iti noa iho ēnei whakamahinga, ā, kei runga i tō āhuatanga motuhake.

Me pēhea te mahi a te Amifostine?

Ka mahi te Amifostine mā te noho hei kaitiaki pūtau i te wā e uru ana ki tō tinana. Ka wāwāhia te rongoā e tētahi enzyme e kīia ana ko te alkaline phosphatase, he kaha ake tēnei i roto i ngā kiko hauora i ngā pūtau mate pukupuku.

Nā tēnei wāwāhi ka puta he puhui kaha e mahi ana pēnei i te hautai ngota, e mimiti ana i ngā momo iraruke kore utu paitini e hangaia ana e te rongoā matū me te iraruke. Ko ēnei iraruke kore utu te tino hē i muri i te kino o te okana e pā ana ki te maimoatanga.

Ko te ataahua o te amifostine kei roto i tōna kōwhiri. Ka taea e ngā pūtau hauora me te pai o te tuku toto te tango me te whakahohe i te rongoā, i te mea kāore e taea e ngā pūtau mate pukupuku me te ngoikore o te rere toto. Ko te tikanga ka whiwhi ō okana noa i te whakamarumaru i te wā e noho whakaraerae ana ngā pūtau mate pukupuku ki te maimoatanga.

Ka tere te mahi a te rongoā, me te tihi o te whakamarumaru ka puta i roto i te 15-30 meneti i muri i te whakahaerenga. Mā tēnei wā ka taea e tō rōpū hauora te whakatikatika i te rongoā ki tō hōtaka maimoatanga mate pukupuku.

Me pēhea taku tango i te Amifostine?

Ka tukuna tonu te Amifostine mā te uaua (mā te IV) i roto i te hōhipera, i te whare haumanu rānei. Kāore e taea e koe te tango i tēnei rongoā i te kāinga nā te mea e hiahia ana kia tūpato te tirotiro hauora me te wā motuhake me tō maimoatanga mate pukupuku.

Ka hoatu e tō rōpū hauora ki a koe te rongoā tata ki te 30 meneti i mua i tō maimoatanga rongoā matū, iraruke rānei. Mā tēnei wā e whakarite kia eke ngā pānga whakamarumaru ki tōna tihi i te wā e whiwhi ana koe i tō maimoatanga mate pukupuku.

I mua i te whiwhinga amifostine, me inu koe i te wai nui, ā, ka whiwhi pea koe i te rongoā anti-nausea. Ka aroturukihia tō pēhanga toto i te mea ka taea e te rongoā te whakaheke i te wā poto.

Ko te whakaurunga e pā ana ki te 15 meneti. Ka noho koe i te wāhi maimoatanga mō te mātakitaki kia mōhio ai koe kei te pai koe i mua i te haere tonu i tō maimoatanga mate pukupuku.

Kia Pēhea te Roa e Tango ai au i te Amifostine?

Ka whiwhi koe i te amifostine mō te wā e whiwhi ana koe i te maimoatanga mate pukupuku motuhake e tiakina ana koe. Mēnā kei te whiwhi koe i te cisplatin chemotherapy, ka whiwhi koe i te amifostine i mua i ia horopeta cisplatin puta noa i ō huringa maimoatanga.

Mō ngā tūroro rāpoi iraruke, ka hoatu te rongoā i ia rā i mua i ia wāhanga iraruke. Māu e whakatau te tūtohi tika i runga i tō mahere maimoatanga me te pai o tō whakawātea i te rongoā.

Ka whakawhirinaki te roa ki tō kawa maimoatanga mate pukupuku. Ka whiwhi ētahi tūroro i te rongoā mō ētahi wiki, i te mea ka hiahia ētahi atu mō ētahi marama. Ka arotake tonu tō rōpū hauora mēnā kei te nui tonu ngā painga i ngā pānga taha.

Ka whakamutu tō tākuta i te amifostine mēnā ka whanake koe i ngā pānga taha nui, mēnā rānei ka huri tō mahere maimoatanga mate pukupuku. Ka whakanui tonu rātou i tō haumaru me te whai hua o te maimoatanga i te wā e whakatau ana i ēnei whakatau.

He Aha ngā Pānga Taha o te Amifostine?

Pērā i te nuinga o ngā rongoā, ka taea e te amifostine te pānga taha, ahakoa he maha ngā tūroro e whakawātea ana i te rongoā. Ko ngā pānga taha tino noa he whakahaere me te wā poto, ka puta i te wā, i muri tata rānei i te whakaurunga.

Anei ngā pānga taha ka pā ki a koe, ka tīmata mai i ngā mea tino noa:

• Te whakapairuaki me te ruaki (e pā ana ki te 60% o ngā tūroro)
• Te pēhanga toto iti i te wā o te whakaurunga
• Te ngenge me te ngoikore
• Te whanoke, te āhua rānei e ngaro ana
• Te whero, te mahana rānei o tō mata me tō kaki
• Te reka rino i tō waha
• Te tihe, te hikoi rānei
• Te pōuri

Ko te nuinga o ēnei pānga he ngawari, ka ngaro i roto i ngā hāora ruarua. Ka mātakitaki tata tō rōpū hauora i a koe, ā, ka taea e rātou te whakarato rongoā hei āwhina i te whakahaere i te whakapairuaki me te tautoko i tō pēhanga toto ki te hiahiatia.

Ka pā te tahi tūroro i ngā pānga taha kāore i te pūnoa, engari he nui ake te māharahara, e hiahia ana kia aro mai te rongoā tonu:

• Ngā tauhohenga mate pāwera nui, me te uaua ki te hā, te pūhi rānei
• Te pēhanga toto iti rawa, kāore e aro ki te rongoā
• Ngā raruraru tākihi nui
• Te ngākau pōrearea
• Ngā pākia (he tino onge)

He onge ēnei pānga taha nui, engari kua whakangungua tō rōpū rongoā ki te mōhio me te rongoā tonu i a rātou. Ko te taiao rongoā whakahaere e whakarite ana ka whiwhi koe i te manaakitanga tere ki te puta mai ētahi tohumate e pā ana.

Ko wai kāore e tika kia tango Amifostine?

Kāore te Amifostine e tika ana mō te katoa, ā, ka āta arotake tō tākuta mō te haumaru mō koe. Ko ētahi āhuatanga rongoā me ngā tūāhuatanga e whakatūpono ana te rongoā ki te whakamahi.

Kāore koe e tika kia whiwhi amifostine mēnā he āhuatanga tō:

• Te mate pāwera mō te amifostine, ōna wāhanga rānei
• Te pēhanga toto tiketike kāore i te whakahaerehia
• Te mate ngākau nui, ngā raruraru ngākau rānei i tata nei
• Te mate tākihi nui
• Ētahi momo mate pukupuku ka taea te tiaki e te rongoā
• Te hapū, te whāngai ū rānei

Ka tūpato anō tō tākuta ki te whakahau amifostine mēnā he hītori tō te whiu, ngā raruraru manawataki ngākau, mēnā rānei kei te tango koe i ngā rongoā e pā ana ki te pēhanga toto. Kāore te pakeke anake i te arai, engari ka hiahia pea ngā pakeke ki te mātakitaki atu.

Ko ētahi momo mate pukupuku, inā koa ērā e pā ana ki te hāora wheua, ki ngā pūtau toto rānei, tērā pea kāore e tika mō te amifostine nā te mea ka raru pea te tiaki i ēnei wāhi i te whai huatanga o te rongoā.

Ngā Ingoa Waitohu o Amifostine

Kei te wātea te Amifostine i raro i te ingoa waitohu Ethyol i te United States. Koinei te momo e tino whakahauhia ana ka kitea e koe i ngā pokapū rongoā mate pukupuku.

Ko te momo whānui e kiia ana ko amifostine, ā, he rite tonu te mahi ki te ingoa waitohu. Tērā pea ka pai ake tō inihua ki tētahi momo i tētahi atu, engari kei roto i ngā mea e rua te whakauru kaha kotahi, ā, ka whai hua te tiaki kotahi.

Tērā pea he rerekē ngā ingoa waitohu i ētahi maakete o te ao, engari he rite tonu te rongoā. Mā tō rōpū hauora e whakarite kia whiwhi koe i te hanganga tika ahakoa te ingoa waitohu motuhake.

Ngā Kōwhiringa kē mō Amifostine

I tēnei wā, kāore he kōwhiringa kē tika mō te amifostine e mahi ana i te ara kotahi. Heoi anō, he rautaki anō tō tākuta ki te tiaki i ō rātou okana i te wā o te rongoā mate pukupuku.

Mō te tiaki tākihi i te wā o te rongoā cisplatin, ko ngā kōwhiringa kē ko te whakamahi i te carboplatin hei utu mō te cisplatin, ahakoa tērā pea kāore e whai hua mō ētahi mate pukupuku. Ka taea hoki e te wai nui me ngā rongoā pēnei i te mannitol te āwhina i te tiaki i te mahi tākihi.

Mō te waha maroke i puta mai i te iraruke, ko ngā kōwhiringa kē ko te rongoā iraruke i whakatikatikahia te kaha (IMRT) e pai ake ana te whāinga ki te mate pukupuku i te wā e tiaki ana i ngā repe huware, i ngā rongoā rānei pēnei i te pilocarpine e taea ai te whakahihiri i te hanga huware i muri i te rongoā.

Mā tō tākuta mate pukupuku e kōrero ēnei kōwhiringa kē mēnā kāore te amifostine e tika ana mōu, mēnā rānei ka pā mai ngā pānga taha e kore e taea te aro. Ka whakawhirinaki te kōwhiri ki tō momo mate pukupuku motuhake, te mahere rongoā, me te hauora whānui.

He Pai Ake Te Amifostine i Ētahi Atu Rongoā Tiaki?

Ko te Amifostine te rongoa anake kua whakaaetia e te FDA i hangaia hei tiaki i nga pūtau hauora i te wa o te maimoatanga mate pukupuku. Karekau he rongoa kotahi e tuku ana i nga painga tiaki whanui mo te chemotherapy me te kino o te radiation.

Ki te whakataurite ki etahi atu rautaki tiaki, he painga motuhake te amifostine. Ka mahi i te taumata pūtau ki te whakakore i te kino i mua i te puta, kaua ki te rongoa i nga tohu i muri mai. Ko tenei huarahi kaha ka nui ake te tiaki i nga maimoatanga urupare.

Heoi, "pai ake" kei runga i to ahuatanga takitahi. Ko etahi o nga turoro e pai ana ki te amifostine me te wheako i te tiaki nui, ko etahi atu ka kitea he wero nga paanga taha. Ka whakataurite to taakuta i nga painga ki nga tupono mo to keehi motuhake.

Kua whakamatauria te whai huatanga o te rongoa i roto i nga whakamatautau haumanu, e whakaatu ana i te whakahekenga nui o te kino o te whatukuhu me te waha maroke. Ko tenei taunakitanga i tautokona e te rangahau ka waiho hei whiringa pono ina he mea nui te tiaki okana mo te angitu o to maimoatanga.

Nga Pātai e Pātai pinepine ana mo Amifostine

He Haumaru te Amifostine mo nga Turoro Mate Ngakau?

Me ata arotake te Amifostine mo nga turoro e mate ngakau ana na te mea ka taea e ia te whakaheke i te toto mo te wa poto me te pa ki te manawataki o te ngakau. Ka mahi tahi to tohunga ngakau me te tohunga oncology ki te whakatau mena ka nui ake nga painga i nga tupono.

Mena he mate ngakau pumau koe, ka taea tonu e koe te whiwhi amifostine me te tirotiro atu. Heoi, ki te raru koe i te ngakau nui, i nga whakaeke ngakau tata nei, i nga take manawataki kore ranei, ka tohutohu pea to taakuta i etahi atu rautaki tiaki.

Ka aroturukihia e te roopu rongoa to manawataki ngakau me te toto i te wa o te maimoatanga. Kua rite ratou ki te whakarato tautoko tonu mena ka puta etahi take e pa ana ki te ngakau i te wa o te whakaurunga.

Me aha ahau ki te pa ana ahau ki nga paanga taha kino i te wa o te maimoatanga Amifostine?

Mēnā ka pā koe i ngā pānga taha kino, pērā i te uaua ki te hā, te mamae o te uma, te whanoke nui rānei i te wā o te whakauru amifostine, whakamōhio tonu ki tō rōpū hauora. Kaua e tatari, kaua rānei e ngana ki te manawanui.

Kua whakangungua tō rōpū hauora ki te whakahaere i ēnei āhuatanga i te tere. Ka taea e rātou te whakamutu i te whakauru, te whakarato rongoā tautoko, me te whakarite i tō haumaru. Ko te nuinga o ngā pānga kino ka ngaro wawe i te wā e whakamutua ana te whakauru.

I muri i te pānga kino, ka arotake anō tō tākuta mēnā e tika ana te amifostine mōu. Ka taea e rātou te whakatika i te horopeta, te huri i te reiti whakauru, te tūtohu rānei i ngā rautaki whakamarumaru kē atu mō ngā maimoatanga ā muri ake nei.

Ka taea e au te haere tonu ki te tango amifostine mēnā ka ngaro i au tētahi horopeta kua whakaritea?

I te mea ka hoatu te amifostine i roto i tētahi whare hauora i mua i te maimoatanga mate pukupuku, he onge te ngaro horopeta. Mēnā ka whakawhāitihia, ka whakarite anō rānei tō maimoatanga mate pukupuku, ka whakarite anō tō amifostine.

Kāore koe e hiahia ki te māharahara mō te whakatika i ngā horopeta kua ngaro, te pupuri rānei i tētahi hōtaka motuhake i waho o ō tūtohinga maimoatanga mate pukupuku. He whai hua anake te rongoā i te wā e hoatu ana i mua tata i te rongoā matū, te irahiko rānei.

Mēnā ka ngaro i a koe tētahi tūtohinga maimoatanga mate pukupuku, kōrerohia me tō rōpū hauora mēnā e hiahiatia ana ētahi whakatikatika ki tō mahere maimoatanga whānui. Ka whakarite rātou i te hōtaka rongoā whakamarumaru e rite ana ki tō hōtaka maimoatanga mate pukupuku.

Āhea ka taea e au te whakamutu i te tango amifostine?

Ka whakamutu koe i te tango amifostine i te wā e whakaoti ana koe i tō akoranga rongoā matū cisplatin, i te maimoatanga irahiko rānei. Kāore he take ki te whakaiti i te rongoā i te mea ehara i te mea ka whakawhirinaki tō tinana.

Ka taea hoki e tō tākuta te whakamutu i te amifostine mēnā ka pā koe i ngā pānga taha e kore e taea te manawanui, mēnā rānei ka huri tō mahere maimoatanga mate pukupuku. Ka whakatau rātou i tēnei whakatau i runga i ō whāinga maimoatanga whānui me te kounga o te oranga.

He maha ngā tūroro e māharahara ana mō te ngaro o te whakamarumaru ka mutu te amifostine, engari kia mahara me whai whakamarumaru anake koe i te wā e haere ana te rongoā mate pukupuku. Kia oti te rongoā matū, te iraruke rānei, ka taea e ō pūngao te tīmata i tō rātou hātepe whakaora tūturu.

He Whakawhitiwhiti te Amifostine i te Whaihua o te Rongoā Mate Pukupuku?

E whakaatu ana te rangahau nui e whakamarumaru ana te amifostine i ngā pūtau hauora me te kore e whakaiti i te whaihua o te rongoā mate pukupuku. Ko te mahi whiriwhiri o te rongoā te tikanga e noho whakaraerae ana ngā pūtau mate pukupuku i te wā e whiwhi whakamarumaru ana ō pūngao hauora.

Kua whakaatu ngā whakamātau haumanu he rite ngā hua o te rongoā mate pukupuku ki ngā tūroro e whiwhi ana i te amifostine ki te hunga kāore i whiwhi. E tautoko ana tēnei taunakitanga i tōna whakamahinga hei mehua whakamarumaru kāore e whakararu i tō manaakitanga mate pukupuku.

Ka tūtohu anake tō tākuta mate pukupuku i te amifostine mēnā e mōhio ana rātou kāore e whakawhitiwhiti i tō rongoā mate pukupuku. Mēnā he māharahara mō te whakaiti i te whaihua, ka whakanui rātou i tō rongoā mate pukupuku i runga i te whakamarumaru pūngao.