Ni iki Acetylcysteine (Uburyo bwo gutera mu mitsi): Ibikoresho, Urutonde rw'imiti, Ingaruka ziterwa n'iyo miti n'ibindi

Acetylcysteine itangwa binyuze mu mutsi ni umuti wo kurokora ubuzima ukora nk'umuti wica uburozi bwa acetaminophen (Tylenol). Iyo umuntu afashe acetaminophen nyinshi cyane, uyu muti urashobora gukumira kwangirika gukomeye kw'umwijima mu gufasha umubiri wawe gutunganya neza ibintu byangiza.

Ubu buvuzi bukomeye bukora mu gusubiza ikintu cy'ingenzi mu mwijima wawe cyitwa glutathione, gisanzwe kirengera selile z'umwijima wawe kwangirika. Tekereza nk'uko uha umwijima wawe ibikoresho ukeneye kugirango urwanye ingaruka mbi zo kurenza urugero rwa acetaminophen.

Acetylcysteine ni iki?

Acetylcysteine ni umuti urimo N-acetylcysteine, uburyo buhindutse bw'aside ya amino cysteine. Bizwi cyane nk'ubuvuzi busanzwe bwo kurenza urugero rwa acetaminophen, aho bushobora kurokora ubuzima rwose iyo butanzwe vuba.

Uburyo bwo gutera mu mitsi bisobanura ko bitangwa mu maraso yawe binyuze mu muyoboro w'imitsi, bigatuma bikora vuba mu mubiri wawe wose. Ubu buryo bwo gutanga butaziguye butuma umuti ugera mu mwijima wawe vuba bishoboka, ibyo bikaba ari ngombwa mugihe uvura uburozi.

Abaganga bita kuri uyu muti ko ari ngombwa cyane kubijyanye no guhumeka acetaminophen ku buryo bigumana byoroshye mu mashami yihutirwa ku isi hose. Vuba bitanzwe nyuma yo kurenza urugero, nibyiza bikora kugirango birengere umwijima wawe.

Acetylcysteine ikoreshwa kubera iki?

Ikoreshwa ryambere rya IV acetylcysteine ni ukuvura uburozi bwa acetaminophen, haba kurenza urugero byabaye impanuka cyangwa nkana. Ni umuti wo gukoresha ushobora gukumira kwangirika gukomeye kw'umwijima kandi ushobora kurokora ubuzima bwawe.

Uyu muti rimwe na rimwe ukoreshwa kubindi bibazo aho umubiri wawe ukeneye inkunga yinyongera ya antioxidant. Abaganga bamwe barabikoresha kugirango bafashe kurengera impyiko mugihe cyimikorere imwe ya muganga ishobora gutera kwangirika kwimpyiko, nubwo iyi mikoreshereze idakunze.

Mu bice bikeya, abaganga bashobora gukoresha acetylcysteine kugira ngo bafashe mu bundi bwoko bw'uburozi cyangwa bafashe imikorere y'umwijima mu bihe by'ubuvuzi byihariye. Ariko, izi nshingano zikunze kubikwa mu bihe by'ubuvuzi byihariye kandi bisaba gukurikiranwa neza.

Acetylcysteine ikora ite?

Acetylcysteine ikora yongera urwego rw'umubiri rwo kwirinda ibintu byangiza umwijima. Iyo ufata acetaminophen nyinshi cyane, umwijima wawe ukora ikintu cyangiza cyitwa NAPQI gishobora kurimbura selile z'umwijima.

Uyu muti uha umwijima wawe ibikoresho ukeneye kugira ngo ukore glutathione, antioxidant ikomeye ikuraho NAPQI. Tekereza glutathione nk'ingabo y'umwijima wawe, na acetylcysteine nk'ibikoresho bikenewe kugira ngo bikore kandi bikomeze iyo ngabo.

Uyu muti ufatwa nk'ukora cyane kurusha uko ukora gake, cyane cyane iyo utanzwe mu masaha ya mbere ya 8-10 nyuma yo kunywa acetaminophen nyinshi. Nyuma y'iki gihe cy'ingenzi, birashoboka ko wagufasha, ariko uburinzi ntibuzuzuye, niyo mpamvu igihe ari ingenzi cyane.

Nkwiriye gufata Acetylcysteine nte?

Ntabwo uzifata uyu muti wenyine - buri gihe utangwa n'abakora mu buvuzi mu bitaro cyangwa ahantu hakorerwa ibizamini. Uburyo bwa IV buvanzwa n'umuti utagira mikorobe kandi butangwa binyuze mu rusinga rushyizwe mu muyoboro wawe w'amaraso.

Ubuvuzi busanzwe bukubiyemo doze nyinshi zitangwa mu masaha 20-21, ukurikiza gahunda yihariye itsinda ryawe ry'abaganga rizagenzura. Ntabwo ukeneye guhangayika kubijyanye n'ibiryo cyangwa ibinyobwa mu gihe cy'ubuvuzi, kuko umuti ujya mu maraso yawe.

Itsinda ryawe ry'ubuvuzi rizagukurikirana neza mu gihe cy'ubuvuzi, rigenzura urwego rw'amaraso yawe kandi rireba ibintu byose bishobora kubaho. Imikorere ya IV ibatuma guhindura doze cyangwa guhagarika ubuvuzi ako kanya niba bibaye ngombwa.

Mbwiriza gufata Acetylcysteine igihe kingana iki?

Uburyo busanzwe bwo kuvura uburozi bwa acetaminophen bumara amasaha agera kuri 20-21 yose hamwe, butangwa mu byiciro bitatu bifite imiti igabanuka. Uyu si umuti ufata iminsi cyangwa ibyumweru - ni uburyo bukomeye, bwagenewe igihe.

Muganga wawe azagenzura urwego rw'amaraso yawe mugihe cyose cyo kuvurwa kugirango amenye niba ukeneye uburyo bwuzuye cyangwa niba kuvurwa bishobora guhagarara kare. Abantu bamwe bafite urwego rwo kurenza urugero ruto bashobora kurangiza kuvurwa mbere, mugihe abandi bashobora gukenera kuvurwa igihe kirekire.

Icyemezo cyo gukomeza cyangwa guhagarika kuvurwa gishingiye ku bintu byinshi harimo urwego rw'amaraso ya acetaminophen, ibizamini by'imikorere y'umwijima, n'uburyo urimo gusubiza imiti. Itsinda ryawe ry'abaganga rizafata ibi byemezo hashingiwe ku miterere yawe yihariye.

Ni izihe ngaruka ziterwa na Acetylcysteine?

Abantu benshi bafata neza IV acetylcysteine, ariko ingaruka zimwe zirashobora kubaho mugihe cyo kuvurwa. Kumva icyo witegura birashobora kugufasha kumva witeguye kandi utagira impungenge mugihe cyo kuvurwa.

Ingaruka zisanzwe abantu benshi bahura nazo zirimo:

• Isesemi no kuruka, bishobora guhangana n'imiti irwanya isesemi
• Kwiruka cyangwa gutukura kw'uruhu, cyane cyane kumaso yawe no mumuhogo
• Uruhu ruto cyangwa kuribwa
• Umutwe ukunda gukira wenyine
• Umuzungero cyangwa kumva urimo gucika intege

Izi ngaruka zisanzwe zikunda kuba nto kandi zigihe gito. Itsinda ryawe ry'ubuvuzi rishobora gutanga imiti yo gufasha guhangana n'isesemi cyangwa izindi ngaruka zitari nziza mugihe ukomeje kuvurwa.

Ingaruka zikomeye ariko zitabaho cyane zirimo:

• Urugero rukomeye rwo kwanga imiti hamwe no guhumeka bigoye cyangwa kubyimba
• Impinduka zikomeye mumuvuduko w'amaraso cyangwa umuvuduko w'umutima
• Uruhu rukomeye cyangwa uruhu rwagutse
• Ingorane zo guhumeka cyangwa guhagarika igituza
• Isesemi ikomeye no kuruka bituma utabasha gukomeza kunywa amazi

Nubwo ibi bibazo bikomeye bidakunze kubaho, itsinda ry'abaganga bakurikirana imiterere yawe buri gihe kandi barashobora kubivura ako kanya nibiramuka bibaye. Inyungu zo kwirinda kwangirika kw'umwijima akenshi ziruta ibi byago.

Ninde utagomba gufata Acetylcysteine?

Abantu bake cyane ntibashobora guhabwa IV acetylcysteine iyo bikenewe kubera ubumara bwa acetaminophen. Uyu muti ufatwa nk'uvura by'ingenzi, kandi abaganga bazakora ibishoboka byose kugira ngo bakore ku bibazo byinshi by'ubuzima kugira ngo bakureho ko ushobora kuwuhabwa mu buryo butekanye.

Abantu bafite asima ikomeye bashobora gukenera gukurikiranwa by'umwihariko mugihe cy'ubuvuzi, kuko uyu muti rimwe na rimwe ushobora gutera ingorane zo guhumeka. Ariko, ibi ntibisanzwe bibuza ubuvuzi - bisobanura gusa ko hakenewe gukurikiranwa neza.

Niba ufite allergie ikomeye izwi kuri acetylcysteine, abaganga bawe bazagereranya neza ibyago n'inyungu. Barashobora guha uyu muti hamwe no gukurikiranwa by'inyongera ndetse n'imiti yo kwirinda allergie, kuko ubumara bwa acetaminophen butavuwe bushobora guteza akaga gakomeye.

Amazina y'ubwoko bwa Acetylcysteine

Izina risanzwe rya IV acetylcysteine ni Acetadote, ikoreshwa cyane mu bitaro byose muri Leta Zunze Ubumwe z'Amerika. Iyi ni formulation yagenewe gukoreshwa mu maraso mu kuvura ubumara bwa acetaminophen.

Ibitaro bimwe na bimwe bishobora gukoresha andi mazina y'ubwoko cyangwa verisiyo rusange y'uyu muti, ariko zose zikubiyemo ibikoresho bikora kimwe kandi bikora kimwe. Ikintu cy'ingenzi ni ukwakira ubuvuzi vuba, hatitawe ku izina ry'ubwoko.

Itsinda ryawe ry'ubuzima rizakoresha uburyo ubwo aribwo bwose buboneka mu kigo cyabo, kuko verisiyo zose zemewe zikora kimwe mu kuvura overdose ya acetaminophen.

Uburyo bwo gusimbuza Acetylcysteine

Nta bundi buryo bwo gusimbuza acetylcysteine ​​mu kuvura ubumara bwa acetaminophen. Uyu muti ni wo mwanya wa zahabu kandi niwo muti wenyine wemejwe wo kuvura overdose ya acetaminophen.

Nubwo hari imiti yageragerejwe yigishijwe, nta n'imwe yagaragaje ko ifite akamaro nk'aka acetylcysteine. Izindi miti ishyigikira nko kwimura umwijima ishobora gutekerezwa mu gihe gikomeye, ariko ibi ni uburyo bwa nyuma iyo imiti ya acetylcysteine itagize icyo igeraho.

Ikintu cy'ingenzi ni ukwakira acetylcysteine vuba bishoboka nyuma yo kunywa acetaminophen nyinshi, kuko nta yindi miti ishobora gutanga urwego rumwe rwo kurinda umwijima.

Ese Acetylcysteine iruta izindi miti?

Acetylcysteine ifatwa nk'umuti w'ukuri wo guhumanya acetaminophen, nta yindi miti yegera ubushobozi bwayo. Ntabwo ari ikibazo cyo kuba "byiza" kuruta izindi - ni umuti rukumbi ukora neza.

Ubushakashatsi bwakomeje kugaragaza ko acetylcysteine ishobora gukumira kwangirika kw'umwijima mu bihe byinshi iyo itanzwe mu masaha ya mbere 8-10 nyuma yo kunywa nyinshi. Niyo itanzwe nyuma, iracyatanga uburinzi bukomeye ugereranije no kutavurwa na rimwe.

Uyu muti umaze imyaka myinshi ukoreshwa neza, ufite umutekano mwiza ugereranije n'ubuzima buteye akaga bwo guhumanya acetaminophen. Iyi nyandiko irayigira amahitamo asobanutse ku baganga ku isi hose.

Ibikunze Kubazwa Kuri Acetylcysteine

Ese Acetylcysteine irakwiriye abantu barwaye indwara z'impyiko?

Yego, acetylcysteine muri rusange irakwiriye abantu barwaye indwara z'impyiko ndetse ishobora no gutanga uburinzi ku mpyiko. Uyu muti ukorwa mu buryo butandukanye n'imiti myinshi, bityo ibibazo by'impyiko ntibisanzwe bigira ingaruka ku buryo umubiri wawe uyikoresha.

Muri rusange, ubushakashatsi bumwe butanga icyerekezo ko acetylcysteine ishobora gufasha kurinda imikorere y'impyiko mu gihe cy'uburyo bumwe bwo kuvura. Itsinda ryawe ry'ubuvuzi rizakurikirana imikorere y'impyiko yawe mu gihe cy'imiti, ariko indwara y'impyiko ntisanzwe ikubuza kwakira uyu muti wo kurokora ubuzima.

Nigira iki niba mbonye Acetylcysteine nyinshi mu buryo butunganye?

Ntugomba guhangayika ku bijyanye no kwakira acetylcysteine nyinshi ku buryo butunguranye, kuko abaganga bita ku buzima babara kandi bagakurikirana buri doze. Uyu muti utangwa binyuze mu kuyobora IV, bituma bidasanzwe ko umuntu yanywa doze nyinshi ku buryo butunguranye.

Niba ufite impungenge ku bijyanye n'imiti yawe cyangwa ubonye ibimenyetso bidasanzwe, bimenyeshe ikipe yawe y'ubuvuzi ako kanya. Barashobora guhindura imiti yawe kandi bakagukurikirana neza niba bibaye ngombwa.

Bikunda gute niba nciwe doze ya Acetylcysteine?

Kucibwa doze si ikintu ugomba guhangayikaho, kuko abaganga bita ku buzima bagenzura gahunda yose y'imiti yawe. Uyu muti utangwa buri gihe binyuze muri IV yawe, bityo ntakibazo cyo gucibwa doze.

Niba hari ikintu cyahagarika imiti yawe ku mpamvu iyo ari yo yose, ikipe yawe y'ubuvuzi izahindura igihe n'imiti kugira ngo yemeze ko ukiri kubona inyungu zose zo kurinda ziva ku muti.

Ni ryari imiti ya Acetylcysteine ishobora guhagarikwa?

Ubusanzwe imiti ikomeza mu gihe cyose cy'amasaha 20-21, ariko muganga wawe ashobora kuyihagarika mbere y'igihe niba ibizamini byawe by'amaraso byerekana ko umubiri wawe wakuze acetaminophen kandi imikorere y'umwijima wawe isanzwe. Iyi myanzuro ifatwa buri gihe n'ikipe yawe y'ubuvuzi ishingiye ku ngaruka z'ibizamini.

Abantu bamwe na bamwe bakeneye imiti yongereweho igihe kirekire ugereranije n'igihe gisanzwe niba urwego rwa acetaminophen rukiri rwo hejuru cyangwa niba bagaragaza ibimenyetso byo kwangirika kw'umwijima. Ikipe yawe y'ubuvuzi izakomeza gukurikirana kandi ihindure imiti uko bikwiye.

Nshobora gutwara imodoka cyangwa gukora nyuma yo kuvurwa na Acetylcysteine?

Ugomba kwirinda gutwara imodoka cyangwa gukoresha imashini byibuze amasaha 24 nyuma yo kurangiza imiti ya acetylcysteine, kuko ushobora kumva uribwa umutwe cyangwa uruka. Uyu muti ushobora gutera ingaruka z'igihe gito zishobora kugira ingaruka ku bushobozi bwawe bwo kwibanda cyangwa gusubiza vuba.

Abantu benshi bumva bameze neza nyuma y'umunsi umwe cyangwa ibiri nyuma yo kuvurwa, ariko umva umubiri wawe kandi ntugahutire gusubira mu bikorwa bikomeye. Muganga wawe azaguha amabwiriza arambuye yerekeye igihe bizaba byemewe gusubira mu bikorwa bisanzwe bitewe n'uko wumva umeze.