Icyo Droxidopa ari cyo: Ibyo ikoreshwa, urugero rwo gufata, ingaruka zayo n'ibindi

Droxidopa ni umuti wandikirwa na muganga ufasha kuzamura umuvuduko w'amaraso ku bantu bagira ibibazo bikomeye iyo bahagurutse. Iyi ndwara, yitwa neurogenic orthostatic hypotension, ishobora gutera isereri, kugwa igihumure, no kugwa bikagira ingaruka zikomeye ku buzima bwawe bwa buri munsi.

Niba umaze igihe uhanganye n'isereri ry'ako kanya iyo uhagurutse cyangwa wumva ko ushobora kugwa igihumure mu bikorwa byoroheje, droxidopa ishobora kuba umuti muganga wawe agushakira. Uyu muti ukora uhinduka norepinephrine mu mubiri wawe, ifasha gukaza imitsi y'amaraso no gukomeza umuvuduko w'amaraso iyo uhinduye imyanya.

Droxidopa ni iki?

Droxidopa ni aside ya amino ikorwa mu buryo bwa gihanga umubiri wawe uhinduramo norepinephrine, imisemburo kamere ifasha kugenzura umuvuduko w'amaraso. Yagenewe by'umwihariko abantu sisitemu y'imitsi yabo idashobora kugenzura neza umuvuduko w'amaraso iyo bahagurutse.

Uyu muti ubarirwa mu cyiciro cyitwa norepinephrine precursors, bivuze ko itanga ibikoresho umubiri wawe ukeneye kugira ngo ukore imisemburo yayo igenzura umuvuduko w'amaraso. Tekereza nk'uko uha umubiri wawe ibikoresho bya ngombwa ukeneye kugira ngo ukore sisitemu igenzura umuvuduko w'amaraso.

FDA yemeje droxidopa mu 2014 by'umwihariko mu kuvura neurogenic orthostatic hypotension ku bantu bakuru. Ifatwa nk'umuti wihariye usaba gukurikiranwa neza n'umuganga wawe.

Droxidopa ikoreshwa mu kuvura iki?

Droxidopa ivura neurogenic orthostatic hypotension, indwara umuvuduko w'amaraso wawe ugabanukaho cyane iyo uhagurutse. Ibi bibaho kuko sisitemu yawe y'imitsi idashobora guhindura neza imitsi y'amaraso yawe n'umuvuduko w'umutima kugira ngo ukomeze amaraso ajye mu bwonko bwawe.

Iyi ndwara ikunze gufata abantu bafite indwara zimwe na zimwe z'imitsi. Aha hari indwara zikomeye droxidopa ifashamo:

• Indwara ya Parkinson n'izindi zifitanye isano
• Ibyiciro byinshi byangiza imikorere y'umubiri
• Kunanirwa kw'imikorere y'ubwonko
• Kubura kwa dopamine beta-hydroxylase
• Uburwayi bw'imitsi itunganya imikorere y'umubiri buterwa n'isukari

Izi ndwara zangiza igice cy'imitsi yawe itunganya imikorere y'umubiri, ituma umuvuduko w'amaraso ugabanuka mu buryo butunguranye, bigatuma uruka cyangwa ugahuka.

Muganga wawe ashobora no gutekereza guha umuti wa droxidopa niba urwaye indwara y'impyiko ukaba uri ku mashini ya dialysis kandi ukagira umuvuduko w'amaraso muke cyane mu gihe uvurwa. Ariko, ibi ntibisanzwe kandi bisaba kubitekerezaho byimbitse.

Droxidopa ikora ite?

Droxidopa ikora ihinduka norepinephrine igihe yinjiriye mu mubiri wawe. Norepinephrine ni umuti kamere ubwira imitsi yawe gufatana no gutuma umutima wawe utera neza, ibi bikagufasha kugira umuvuduko w'amaraso ukwiye.

Iyo ufite neurogenic orthostatic hypotension, umubiri wawe ntukora norepinephrine ihagije cyangwa ntushobora kuyikoresha neza. Droxidopa yirinda iki kibazo itanga inzira itaziguye yo gukora norepinephrine ukeneye.

Uyu muti ufatwa nk'ukomeye kandi akenshi utangira gukora mu masaha make nyuma yo kuwufata. Bitandukanye n'imiti imwe ifasha umuvuduko w'amaraso ikora ako kanya, droxidopa ikeneye igihe kugira ngo ihinduke mu buryo umubiri wawe ushobora gukoresha.

Ubu buryo bwo guhinduka bukorwa buhoro buhoro mu mubiri wawe, ibi bifasha gutanga uburyo buhamye bwo kugenzura umuvuduko w'amaraso ugereranije n'imiti ikora icyarimwe.

Nkwiriye gufata droxidopa nte?

Fata droxidopa nk'uko muganga wawe abikwandikiye, akenshi inshuro eshatu ku munsi hamwe n'ibiryo cyangwa utabifite. Ubusanzwe urugero rwo gutangiriraho ni 100mg inshuro eshatu ku munsi, ariko muganga wawe azabihindura bitewe n'uko ubisangamo.

Ushobora gufata droxidopa hamwe n'ibiryo cyangwa utabifite, ariko gerageza kubigenderaho. Niba uyifata hamwe n'ibiryo, komereza kuri uwo murongo, kandi niba uyifata igihe wicaye, komeza ubikore.

Uko wafata droxidopa mu buryo bwizewe:

1. Fata urugero rwa mbere mu gitondo, umaze gukanguka
2. Fata urugero rwa kabiri ku manywa y'ihangu
3. Fata urugero rwa gatatu nimugoroba, byibuze amasaha 3 mbere yo kuryama
4. Mimina ikinini cyose hamwe n'amazi
5. Ntugasenye, utafune, cyangwa ufungure ibinini

Irinde gufata urugero rwa nyuma hafi cyane yo kuryama kuko droxidopa ishobora kuzamura umuvuduko w'amaraso yawe iyo uryamye, ibyo bishobora guteza akaga mu gihe uryamye.

Niba ufata carbidopa kubera indwara ya Parkinson, komeza kuyifata nkuko byategetswe. Carbidopa ifasha droxidopa gukora neza irinda ko ihinduka norepinephrine hanze y'ubwonko bwawe.

Nzamara igihe kingana iki mfata Droxidopa?

Abantu benshi bakeneye gufata droxidopa igihe kirekire kugirango bacunge neza hypotension ya neurogenic orthostatic. Iyi ndwara ikunze kuba ihoraho, bivuze ko bisaba kuvurwa bihoraho aho kuba umuti w'igihe gito.

Muganga wawe azagenzura uko ubisangamo mu byumweru bike bya mbere kandi ashobora guhindura urugero ufata buri minsi mike kugeza ubona urugero rukwiriye. Urugero ntarengwa rwemewe ni 600mg inshuro eshatu ku munsi, ariko abantu benshi babona imbaraga n'urugero ruto.

Teganya gukorana bya hafi n'umuganga wawe mu gihe cy'ukwezi kwa mbere kw'imiti. Bazashaka kureba umuvuduko w'amaraso yawe wenda uryamye cyangwa uhagaze kugirango barebe ko umuti ukora neza utateje ingaruka ziteje akaga.

Abantu bamwe babona impinduka mu cyumweru cya mbere, mu gihe abandi bashobora gukenera ibyumweru byinshi kugirango babone inyungu zose. Ntukacike intege niba utiyumva neza ako kanya.

Ni izihe ngaruka ziterwa na Droxidopa?

Kimwe n'indi miti yose, droxidopa ishobora gutera ingaruka, nubwo abantu benshi bayihanganira neza. Ingaruka zisanzwe zikunze kuba zoroshye kandi akenshi zikagenda uko umubiri wawe wimenyereza umuti.

Dore ingaruka zikunze kuvugwa cyane:

• Umutwe
• Urugero
• Urugimbu
• Umubyazo mwinshi w'amaraso iyo uryamye
• Umunaniro
• Indwara z'inkari
• Gusitara (mu buryo butunguranye, nk'uko umubiri wawe wimenyereza kugenzura neza umuvuduko w'amaraso)

Izi ngaruka zikunda kugaragara mu byumweru bya mbere by'imiti kandi akenshi zigenda zigabanuka uko igihe kigenda.

Ingaruka zikomeye ntizikunda kugaragara ariko zisaba ubufasha bwihuse bw'abaganga. Vugana n'umuganga wawe ako kanya niba wumva umutwe ukabije, kubabara mu gituza, guhumeka bigoranye, cyangwa urujijo.

Abantu bamwe bagira icyo bita umuvuduko mwinshi w'amaraso iyo baryamye, aho umuvuduko w'amaraso uba mwinshi cyane iyo uryamye. Umuganga wawe azabikurikirana neza kandi ashobora kugusaba kuryama umutwe wawe uri hejuru cyangwa guhindura urugero rw'umuti wawe w'ijoro.

Gahoro, abantu bamwe bagira ibimenyetso byo kwivumbura ku miti, umutima utera nabi, cyangwa ibibazo by'impyiko. Izi ngaruka zikomeye ntizikunda kugaragara ariko zisaba ubufasha bwihuse bw'abaganga niba zigaragaye.

Ninde utagomba gufata Droxidopa?

Droxidopa ntiboneye kuri buri wese, kandi indwara zimwe na zimwe zituma bitabereye cyangwa biteje akaga kuyikoresha. Umuganga wawe azasuzuma neza amateka yawe mbere yo kugusaba uyu muti.

Ntabwo ugomba gufata droxidopa niba ufite kimwe muri ibi bikurikira:

• Umuvuduko mwinshi w'amaraso ukabije bigoye kugenzura
• Glaucoma ifunze
• Pheochromocytoma (igishyitsi gike gitera adrenaline nyinshi)
• Indwara ikomeye y'umutima cyangwa umutima wahagaze vuba
• Indwara ikomeye y'impyiko
• Kumenya ko ufite allergie kuri droxidopa cyangwa ibiyigize

Izi ndwara zishobora kuba mbi niba droxidopa yongera umuvuduko w'amaraso cyane cyangwa ikagirana imikoranire n'ibibazo byawe by'ubuzima bihari.

Muganga wawe azakoresha ubushishozi bwihariye niba urwaye diyabete, ibibazo byoroheje byo mu mpyiko, cyangwa ufata imiti imwe na rimwe yo kurwanya depression cyangwa indwara ya Parkinson. Ibi bibazo ntibisaba ko utabasha gufata droxidopa, ariko bisaba gukurikiranwa hafi.

Abagore batwite kandi bonsa bagomba kuganira ku byago n'inyungu na muganga wabo, kuko nta bushakashatsi buhagije bwo kwemeza umutekano wa droxidopa mugihe cyo gutwita cyangwa konsa.

Amazina ya Droxidopa

Droxidopa iboneka munsi y'izina ry'ubucuruzi rya Northera muri Leta Zunze Ubumwe z'Amerika. Ubu nicyo gicuruzwa cyonyine cya droxidopa cyemewe na FDA kiboneka kubarwayi.

Northera ikorwa na Lundbeck kandi iza mumashusho ya capsule ifite imbaraga za 100mg, 200mg, na 300mg. Muganga wawe azagena imbaraga zikwiriye kuri wewe bitewe n'uburyo wakiriyeho ubuvuzi.

Ubwoko bwa droxidopa ntiburaboneka muri Leta Zunze Ubumwe z'Amerika, bivuze ko Northera ishobora guhenda. Ariko, umukora afite gahunda zo gufasha abarwayi zishobora kugabanya ikiguzi niba wujuje ibisabwa.

Jya ukoresha izina ry'ubucuruzi rya Northera cyangwa ubaze umufarumasiti wawe by'umwihariko kuri droxidopa kugirango wemeze ko wakira umuti ukwiye, kuko amazina y'imiti asa ashobora gutera urujijo.

Uburyo bwo gusimbuza Droxidopa

Niba droxidopa itagukundiye cyangwa itera ingaruka zikomeye, uburyo bwo kuvura butandukanye bushobora gufasha gucunga hypotension ya neurogenic orthostatic. Muganga wawe ashobora kugusaba gukoresha izi nzira aho kubikora cyangwa hamwe na droxidopa.

Dore uburyo nyamukuru bwo gutekereza:

• Fludrocortisone (ifasha umubiri wawe kubika umunyu n'amazi)
• Midodrine (ihugura imitsi y'amaraso)
• Amashati yo gukanda (muburyo bugaragara abuza amaraso kwibumbira)
• Tableti zumunyu no kongera kunywa amazi
• Pyridostigmine (ifasha ibimenyetso by'imitsi gukora neza)

Uburyo butakoresha imiti akenshi bukora neza hamwe cyangwa mu mwanya wa droxidopa. Ibi birimo kuryama umutwe wawe uzamuye, guhaguruka buhoro uhagurutse wicaye cyangwa uryamye, no kurya amafunguro mato, akenshi.

Abantu bamwe basanga kongera umunyu bafata no kunywa amazi menshi bifasha kubungabunga umubare w'amaraso no gukumira igabanuka ry'umuvuduko w'amaraso. Muganga wawe ashobora kukuyobora ku buryo unywa umunyu n'amazi menshi bishobora gukwira mu bihe byawe.

Uburyo bwose bufite inyungu zabwo n'ingaruka zishobora kubaho, bityo korana na muganga wawe kugirango ubone uburyo bukora neza mu bihe byawe byihariye n'izindi ndwara.

Ese Droxidopa iruta Midodrine?

Droxidopa na midodrine zombi zivura neza neurogenic orthostatic hypotension, ariko zikora mu buryo butandukanye kandi zishobora gukwira abantu batandukanye. Guhitamo hagati yazo biterwa n'ibimenyetso byawe byihariye, izindi ndwara, n'uko witwara kuri buri muti.

Droxidopa ikunda gutanga ugenzurwa ry'umuvuduko w'amaraso uhamye umunsi wose kuko ikora yongera urwego rwa norepinephrine y'umubiri wawe. Ibi birashobora gutuma ibintu bikora neza, bishobora kumenyekana ugereranije n'ibikorwa bya midodrine byihuse ariko bimara igihe gito.

Midodrine ikora vuba kurusha droxidopa, akenshi bitwara isaha, mugihe droxidopa bishobora gutwara amasaha menshi kugirango yerekane inyungu zayo zose. Niba ukeneye ubufasha bwihuse ku bimenyetso, midodrine irashobora gukwira mbere na mbere.

Ariko, droxidopa irashobora gutera ibice bike by'umuvuduko w'amaraso mwinshi iyo uryamye ugereranije na midodrine. Ibi bituma bishobora kuba byiza kubantu bakeneye kuryama kenshi cyangwa bafite izindi ndwara zituma hypertension ya supine iba akaga.

Umuganga wawe azatekereza ku bintu nk'uko ubuzima bwawe bwa buri munsi buteye, imiti yindi ufata, imikorere y'impyiko, n'uko ukeneye gukira ibimenyetso vuba, mu gihe ahitamo hagati y'izi mpamvu. Abantu bamwe banakoresha imiti yombi icyarimwe bayobowe n'abaganga babigize umwuga.

Ibibazo bikunze kubazwa kuri Droxidopa

Ese Droxidopa irakwiriye abantu barwaye indwara z'umutima?

Droxidopa isaba ko ubitekerezaho neza niba urwaye indwara y'umutima, kuko ishobora kugira ingaruka ku mikorere y'imitsi yawe. Umuganga wawe azagomba gusuzuma uko umutima wawe umeze neza n'ubuzima bwawe muri rusange mbere yo kumenya niba droxidopa ikwiriye kuri wowe.

Abantu barwaye indwara y'umutima idakomeye, itajegajega, bashobora gukoresha droxidopa neza bakurikiranwa neza. Ariko, abafite indwara y'umutima ikomeye, abafite ibibazo by'umutima vuba aha, cyangwa umuvuduko w'amaraso udakontrolwa ntibagomba gufata uyu muti.

Umuvuzi w'umutima wawe n'umuganga wandika droxidopa bagomba gukorana kugira ngo bakurikirane ubuzima bw'umutima wawe mu gihe cyose uvurwa. Kugenzura buri gihe no gupima umuvuduko w'amaraso birushaho kuba by'ingenzi iyo ufite ibibazo byombi.

Nigira iki niba mfata droxidopa nyinshi bitunguranye?

Niba ufata droxidopa nyinshi bitunguranye kuruta uko byategetswe, vugana n'umuganga wawe cyangwa ikigo gishinzwe kurwanya ubumara ako kanya. Guhora ufata nyinshi bishobora gutera umuvuduko w'amaraso mwinshi cyane, kubabara umutwe bikabije, n'izindi ngorane zikomeye.

Mu gihe utegereje ubuyobozi bw'abaganga, ryama hasi ukurikirane ibimenyetso byawe neza. Urinde kubabara umutwe bikabije, kubabara mu gituza, kugorwa no guhumeka, cyangwa impinduka mu burebure, kuko ibi bishobora kwerekana umuvuduko w'amaraso mwinshi cyane.

Ntugerageze kwivuruguta keretse niba ubitegetswe n'abaganga. Bika urupapuro rw'umuti hamwe nawe igihe ushaka ubufasha bw'ubuvuzi kugira ngo abaganga bamenye neza icyo wafashe n'ingano yacyo.

Kugira ngo wirinde kunywa imiti irenze urugero, koresha agasanduku kabugenewe, shyiraho ibyibutsa kuri terefone yawe, cyangwa usabe abagize umuryango wawe kugufasha gukurikirana imiti yawe.

Nigira nte niba nirengagije urugero rwa Droxidopa?

Niba wirengagije urugero rwa droxidopa, yifate uko wibuka vuba, keretse igihe cyo gufata urugero rukurikira kigeze. Ntukigere ufata urugero rurenze rumwe icyarimwe kugira ngo wuzuze urugero wibagiwe, kuko ibyo bishobora gutera ingaruka mbi.

Niba wirengagije urugero rwawe rwa mu gitondo ukibuka mu masaha ya nyuma ya saa sita, komeza uyifate. Ariko, niba wirengagije urugero rwawe rwa nyuma ya saa sita kandi igihe cyo kuryama kigeze, uyirengagize rwose kugira ngo wirinde kugira umuvuduko mwinshi w'amaraso mu gihe uryamye.

Kwirengagiza urugero rimwe na rimwe ntibizatuma ugira ibibazo bikomeye, ariko gerageza kugira gahunda ihamye kugira ngo ugenzure ibimenyetso neza. Igenzurwa ry'umuvuduko w'amaraso yawe rishingiye ku rugero rwawo ruhamye mu mubiri wawe.

Shyiraho alarme kuri terefone yawe cyangwa ukoreshe porogaramu yibutsa imiti kugira ngo igufashe kwibuka urugero rwawe. Guhora ukora ni ingenzi mu gucunga neza neurogenic orthostatic hypotension yawe.

Nshobora guhagarika ryari gufata Droxidopa?

Ugomba guhagarika gufata droxidopa gusa uyobowe na muganga wawe, kuko neurogenic orthostatic hypotension akenshi ni indwara idakira isaba kuvurwa buri gihe. Guhagarara mu buryo butunguranye bishobora gutuma ibimenyetso byawe bisubira vuba kandi bishobora gutuma umuvuduko w'amaraso umanuka mu buryo buteye akaga.

Muganga wawe ashobora gutekereza kugabanya cyangwa guhagarika droxidopa niba indwara yawe yoroshye, niba ugize ingaruka mbi zikomeye, cyangwa niba izindi nshuti z'ubuvuzi ziba zikwiriye kurushaho kubera uko umubiri wawe umeze.

Abantu bamwe bashobora gukenera gufata droxidopa ubuzima bwabo bwose, mu gihe abandi bashobora gucunga indwara yabo binyuze mu mpinduka z'imibereho cyangwa imiti itandukanye uko igihe kigenda.

Ntuzahweme gufata droxidopa ku giti cyawe, n'iyo wumva urushijeho kumera neza. Ibimenyetso byawe bishobora kugaruka mu minsi mike, kandi impinduka zidakurikije gahunda zishobora guteza akaga. Banza uganire n'umuganga wawe ku byerekeye imiti yawe.

Nshobora kunywa inzoga nkanwa droxidopa?

Inzoga irashobora gutuma ibimenyetso droxidopa ivura birushaho kuba bibi bitewe no gutuma imitsi y'amaraso yaguka ndetse n'umuvuduko w'amaraso ukagabanuka. Ibi bivuze ko kunywa inzoga nkanwa droxidopa bishobora guhangana n'inyungu z'umuti kandi bishobora gutera impinduka ziteje akaga ku muvuduko w'amaraso.

Niba uhisemo kunywa inzoga rimwe na rimwe, bikore witonze cyane kandi mu bwinshi buto. Tangira n'ibitoya kuruta uko wasanzwe ukora kandi witondere uko wumva umeze iyo uhagaze cyangwa uhindura imiterere.

Irinde inzoga rwose niba ukiri kwimenyereza droxidopa cyangwa niba waragize ibibazo byo guta umutwe cyangwa kugwa. Guhuza inzoga n'impinduka z'umuvuduko w'amaraso bishobora kongera cyane ibyago by'impanuka.

Ganira na muganga wawe ku byerekeye imigenzo yawe yo kunywa inzoga kugira ngo batange ubujyanama bwihariye bushingiye ku buzima bwawe bwihariye n'uko droxidopa ikora neza kuri wowe.