Icyo Dutasteride ari cyo: Ibyo ikoreshwa, urugero rwo gufata, ingaruka ziterwa n'iyo miti n'ibindi

Dutasteride ni umuti wandikirwa n'abaganga ukoreshwa cyane mu kuvura indwara ya benign prostatic hyperplasia (BPH), indwara umushongo ubyimba. Uyu muti ubarirwa mu cyiciro cy'imiti yitwa 5-alpha reductase inhibitors, ikora ibyo ikingira imisemburo ituma umushongo ukura. Nubwo dutasteride ikoreshwa cyane mu kuvura ibibazo by'umushongo, rimwe na rimwe ikoreshwa mu buryo butemewe n'amategeko mu kuvura ubwoya bwo ku mutwe bugenda bushira ku bagabo, nubwo atari yo ntego yayo y'ibanze yemewe.

Dutasteride ni iki?

Dutasteride ni umuti ukorwa mu buryo bwa gihanga ugamije kwibasira za enzymes zihariye mu mubiri wawe. Ikingira ubwoko bwombi bwa enzymes za 5-alpha reductase, zishinzwe guhindura testosterone muri dihydrotestosterone (DHT). DHT ni umusemburo ushobora gutuma umushongo wawe ukura cyane kandi ukagira uruhare mu gutuma umusatsi ugabanuka ku bagabo.

Uyu muti urakomeye kurusha imiti isa nawo kubera ko ukingira ubwoko bwombi bwa enzymes, bigatuma ukora neza mu kugabanya urugero rwa DHT. Ubusanzwe uzabona dutasteride igurishwa ku mazina y'ubucuruzi nka Avodart, kandi iza mu buryo bwa capsule yoroshye ya gelatin uyimira yose.

Dutasteride ikoreshwa mu kuvura iki?

Dutasteride ikoreshwa cyane mu kuvura benign prostatic hyperplasia (BPH) ku bagabo. BPH ni ukwiyongera kutari ukwa kanseri kw'umushongo ushobora gutera ibimenyetso bitari byiza byo kunyara nk'ukugorana gutangira kunyara, uruzi rutagira imbaraga, no kujya mu bwiherero kenshi nijoro.

Uyu muti ufasha kugabanya umushongo wabyimbye uko igihe kigenda gihita, ibyo bishobora kunoza ubushobozi bwawe bwo kunyara neza. Abaganga bamwe kandi bandikira dutasteride mu buryo butemewe n'amategeko mu kuvura ubwoya bwo ku mutwe bugenda bushira (androgenetic alopecia), nubwo iyi ntego itemewe ku mugaragaro na FDA. Inyungu zo kugabanya umusatsi ziterwa nuko DHT igira uruhare mu kugabanuka kw'imisatsi no gutuma umusatsi ugenda ushiraho.

Dutasteride ikora ite?

Dutasteride ikora ibi ikingira enzymes 5-alpha reductase mu mubiri wawe wose. Izi enzymes zisanzwe zihindura testosterone ikayihindura DHT, hormone ikomeye itera imikurire ya prostate no kugabanuka kw'imisatsi.

Mugukingira urugero rwa DHT kugeza kuri 90%, dutasteride ituma prostate yawe yagutse igabanuka buhoro buhoro igasubira ku busanzwe. Ibi bikorwa mubisanzwe bifata amezi menshi, kuko imitsi ya prostate ntihinduka mu ijoro rimwe. Uyu muti ufashwe nk'ukomeye cyane ugereranije n'indi miti isa kuko ukingira ubwoko bwombi bwa enzyme, bigatuma DHT igabanuka cyane.

Bitekereze nk'ugabanya ijwi rya hormone yateje ibibazo. Hamwe na DHT nkeya izunguruka mu mubiri wawe, umuvuduko kuri prostate yawe n'imisatsi igabanuka uko igihe kigenda.

Nkwiriye Gufata Dutasteride Nte?

Fata dutasteride nk'uko umuganga wawe abikwandikiye, mubisanzwe rimwe ku munsi ku gihe kimwe buri munsi. Urashobora kuyifata hamwe n'ibiryo cyangwa utabifashije, kuko ibiryo ntibigira ingaruka zigaragara ku buryo umubiri wawe wakira umuti.

Mimina ikinini cyose utagikuje, utagisekuye, cyangwa ngo ukigumure. Umuti uri imbere urashobora kwinjira mu ruhu rwawe, ibyo bishobora gutera ingaruka zitifuzwa. Niba ukoze ku birimo utabishaka, karaba intoki zawe neza n'isabune n'amazi.

Gerageza gushyiraho gahunda yo gufata urugero rwawe ku gihe kimwe buri munsi. Abantu benshi babona ko bifasha gufata dutasteride hamwe n'ibikorwa byabo bya mugitondo cyangwa ifunguro rya nimugoroba kugirango bibuke. Guhora bifasha gukomeza urugero rwawo rwawo mu mubiri wawe.

Nkwiriye Gufata Dutasteride Igihe Kingana Gite?

Dutasteride mubisanzwe ni uburyo bwo kuvura burambye uzakenera gukomeza igihe cyose ushaka gukomeza inyungu zayo. Abagabo benshi bafite BPH bayifata itagira iherezo, kuko guhagarika umuti bituma urugero rwa DHT rusubira ku busanzwe n'ibimenyetso bigaruka.

Ushobora gutangira kubona impinduka mu bimenyetso byo mu nkari mu mezi 3-6 umaze gutangira kuvurwa. Ariko, inyungu nyinshi zikunze gufata amezi 6-12 kugira ngo zigaragare neza. Ku bijyanye no kuvura umusatsi ucika, ibisubizo bishobora gutinda kugaragara, rimwe na rimwe bikaba bishobora gufata imyaka ibiri.

Muganga wawe azakurikiza uko urimo witwara binyuze mu gusuzumwa buri gihe kandi ashobora guhindura gahunda yawe yo kuvurwa bitewe n'uko urimo witwara neza. Ntukigere uhagarika gufata dutasteride mu buryo butunguranye utabanje kubiganiraho n'umuganga wawe, kuko ibi bishobora gutuma ibimenyetso byawe bya mbere bisubira.

Ni izihe ngaruka ziterwa na Dutasteride?

Kimwe n'imiti yose, dutasteride ishobora gutera ingaruka, nubwo atari buri wese uzibona. Ingaruka zisanzwe zifitanye isano n'imikorere y'imibonano mpuzabitsina kandi akenshi ziragenda zikemuka uko umubiri wawe wimenyereza umuti.

Dore ingaruka ushobora guhura nazo, zateguwe kuva ku zisanzwe kugeza ku zitari zisanzwe:

Ingaruka zisanzwe (zigira ingaruka ku kigera kuri 10% by'abazifata):

• Kugabanuka k'irari ry'imibonano mpuzabitsina (libido)
• Kugorana kugera ku gitsina cyangwa kugikomeza
• Kugabanuka kw'umubare w'intanga mu gihe cyo kurangiza
• Urubavu rwo mu gituza cyangwa kwaguka
• Kuribwa umutwe

Ingaruka zitari zisanzwe ariko zigaragara:

• Kugira agahinda gakabije cyangwa guhinduka kw'imitekerereze
• Uruhu ruruka cyangwa kuribwa
• Urubavu cyangwa kubyimba kw'imisemburo
• Kugorana kurangiza
• Umusatsi ukura ku mubiri

Ingaruka zitari zisanzwe ariko zikomeye zisaba ubufasha bwihutirwa bw'abaganga:

• Urugero rwo kwibasirwa n'umubiri (kugorana guhumeka, kubyimba mu maso, iminwa, ururimi, cyangwa umuhogo)
• Gutangira vuba kw'ibibyimba byo mu gituza cyangwa umwuka
• Kugira agahinda gakabije cyangwa gutekereza kwikomeretsa
• Ibimenyetso by'ibibazo by'umwijima (guhinduka kw'uruhu cyangwa amaso umuhondo, inkari z'umukara, kuribwa cyane mu nda)

Ingaruka nyinshi ziterwa n'imiti ziba nto kandi zikamaraho igihe gito, ariko ni ngombwa kuganira ku mpungenge zose ufite na muganga wawe. Ashobora kugufasha gupima inyungu ugereranije n'ibishobora guteza akaga kandi ashobora gutanga ibitekerezo byo guhangana n'ingaruka ziterwa n'imiti zirambye ziragutse.

Ninde utagomba gufata Dutasteride?

Dutasteride ntikwiriye kuri buri wese, kandi amatsinda amwe y'abantu agomba kwirinda rwose uyu muti. Abagore, cyane cyane abari batwite cyangwa bashobora kuzatwita, ntibagomba na rimwe gufata dutasteride cyangwa no gukora ku binini.

Aya ni amatsinda y'ingenzi atagomba gukoresha dutasteride:

Ibitemewe rwose (ntuzigere ufata dutasteride niba ufite ibi):

• Abagore b'imyaka iyo ari yo yose (umuti ushobora gutera ubumuga bwo kuvuka)
• Abana n'urubyiruko bari munsi y'imyaka 18
• Kumenya allergie kuri dutasteride cyangwa finasteride
• Indwara ikomeye y'umwijima

Koresha witonze cyane cyangwa wirinde (ganira neza na muganga wawe):

• Amateka yo kwiheba cyangwa ibibazo by'ubuzima bwo mu mutwe
• Ibibazo by'umwijima cyangwa imyunyu y'umwijima yazamutse
• Kanseri ya prostate cyangwa urwego rwo hejuru rwa PSA
• Amateka ya kanseri y'ibere
• Imigambi yo kubagwa prostate mu gihe kiri hafi

Muganga wawe azasuzuma amateka yawe y'ubuzima n'imiti urimo gufata mbere yo kugusabira dutasteride. Vuga ukuri ku bijyanye n'ubuzima bwawe n'ibindi byongerera imbaraga urimo gufata, kuko ibi bishobora kugira ingaruka ku niba dutasteride ikwiriye kuri wowe.

Amazina y'ubwoko bwa Dutasteride

Dutasteride iboneka mu mazina menshi y'ubwoko, Avodart ikaba ari yo izwi cyane kandi ikoreshwa cyane. Avodart ikorwa na GlaxoSmithKline kandi ni wo muti wa mbere wa dutasteride wemewe na FDA.

Ubundi bwoko bwa dutasteride buraboneka kandi burimo ibintu bikora kimwe n'ubwoko bw'izina ry'ubucuruzi. Ubu bwoko busanzwe buhendutse mugihe butanga inyungu zimwe zo kuvura. Umufarumasiti wawe ashobora kugufasha gusobanukirwa ubwoko bwawe bwishingirwa kandi niba gusimbuza rusange bikwiriye kuri wewe.

Ibicuruzwa bimwe bivanga birahari, nka Jalyn, irimo dutasteride na tamsulosin. Iyi miti ivanga yagenewe abagabo bakeneye kwiyongera kwa prostate no guhumuriza ibimenyetso byihuse.

Izindi nzira za Dutasteride

Hariho izindi nzira nyinshi za dutasteride zo kuvura BPH no gutakaza umusatsi ku bagabo. Guhitamo hagati y'uburyo butandukanye biterwa n'ibimenyetso byawe byihariye, amateka yawe y'ubuvuzi, n'intego zo kuvura.

Mugukoresha BPH, muganga wawe ashobora gutekereza izi nzira:

Izindi miti:

• Finasteride (Proscar) - isa ariko ntabwo ikomeye nka dutasteride
• Alpha-blockers nka tamsulosin (Flomax) - itanga guhumuriza ibimenyetso byihuse
• Ubuvuzi buvanga burimo ubwoko bwombi bwa imiti

Ubuvuzi butari imiti:

• Uburyo butavunanye cyane nka UroLift cyangwa Rezum
• Ubuvuzi bwa laser (GreenLight, HoLEP)
• Uburyo bwo kubaga gakondo nka TURP
• Guhindura imibereho harimo guhindura imirire no gukora imyitozo ngororamubiri

Mugutakaza umusatsi, izindi nzira zirimo minoxidil yo hejuru, uburyo bwo kwimura umusatsi, cyangwa ubuvuzi bwa laser yo hasi. Muganga wawe ashobora kugufasha gushakisha izi nzira zishingiye ku miterere yawe bwite n'ibyo ukunda.

Ese Dutasteride iruta Finasteride?

Dutasteride na finasteride byombi ni 5-alpha reductase inhibitors, ariko bikora mu buryo butandukanye gato mu mubiri wawe. Dutasteride ifunga ubwoko bwombi bwa enzyme (Ubwoko I n'Ubwoko II), mugihe finasteride ahanini ifunga Ubwoko II.

Iyo itandukanye ituma dutasteride ikora neza mu kugabanya urugero rwa DHT - irashobora kugabanya DHT ku kigereranyo cya 90% ugereranije no kugabanya finasteride kuri 70%. Mu kuvura BPH, ibi bikunze guhinduka mu kunoza ibimenyetso no kugabanya ubunini bwa prostate uko igihe kigenda.

Ariko, "neza" biterwa n'uko ubuzima bwawe bumeze. Finasteride imaze igihe kinini iboneka kandi ifite amakuru menshi yerekeye umutekano mu gihe kirekire. Irashobora kandi gutera ingaruka nke ku bagabo bamwe. Ingufu za dutasteride zishobora kugirira akamaro abagabo bafite prostate nini cyangwa ibimenyetso bikomeye, ariko kandi bishobora kongera ibyago byo kugira ingaruka.

Muganga wawe azatekereza ibintu nk'uburemere bw'ibimenyetso byawe, ubunini bwa prostate, uburyo wavuzwe mbere, n'ubushobozi bwo kwihanganira ibyago mugihe uhitamo hagati yiyi miti. Zombi ni uburyo bukora neza, kandi guhitamo neza bitandukanye ku muntu ku giti cye.

Ibibazo bikunze kubazwa kuri Dutasteride

Ese Dutasteride irakwiriye indwara y'umutima?

Dutasteride muri rusange ifatwa nk'umutekano ku bagabo bafite indwara y'umutima, kuko ntigira ingaruka zigororotse ku mikorere y'umutima cyangwa umuvuduko w'amaraso. Bitandukanye n'indi miti imwe ya BPH, dutasteride ntigira impinduka zigaragara ku muvuduko w'umutima cyangwa umuvuduko w'amaraso zishobora gutuma indwara z'umutima zirushaho kuba mbi.

Ariko, ugomba kubwira muganga wawe ibibazo byose by'umutima mbere yo gutangira dutasteride. Abagabo bamwe bafite indwara y'umutima bafata imiti myinshi, kandi muganga wawe agomba kumenya ko nta mikoranire ibaho. Byongeye kandi, niba ufata imiti igabanya amaraso cyangwa wakoze ibaganga ku mutima vuba aha, muganga wawe ashobora kwifuza kugukurikiranira hafi.

Ingaruka z'imibonano mpuzabitsina za dutasteride zishobora kugira ingaruka ku bagabo bamwe bafite indwara y'umutima, kuko imibonano mpuzabitsina ni uburyo bwo gukora imyitozo ngororamubiri. Niba ufite indwara y'umutima ikomeye kandi ufite impungenge z'imibonano mpuzabitsina, ganira kubyerekeye ibi na cardiologue wawe.

Nigute nzakora niba nifashishije dutasteride nyinshi mu buryo butunganye?

Niba wanyoye dutasteride nyinshi kurusha uko wategetswe, ntugahagarike umutima. Kunywa dutasteride nyinshi icyarimwe ntibishobora guteza ingaruka zikomeye ako kanya, ariko ugomba gufata ingamba vuba.

Vugana n'umuganga wawe cyangwa umufarimasi vuba na bwangu kugira ngo ubabwire uko byagenze kandi ubone ubujyanama bwihariye. Niba wanyoye dutasteride nyinshi cyane cyangwa urimo kugira ibimenyetso biteye inkeke nk'isazi ikabije, isesemi, cyangwa guhumeka bigoranye, hamagara serivisi zihutirwa cyangwa ujye mu cyumba cyihutirwa cyegereye.

Ntugerageze kwivuruguta keretse niba ubitegetswe n'umuganga. Andika neza umubare w'imiti y'inyongera wanyoye n'igihe, kuko aya makuru azagufasha abaganga kumenya uburyo bwiza bwo kubigenza. Mu gihe kizaza, tekereza gukoresha agasanduku k'imiti cyangwa gushyiraho ibyibutso kuri terefone yawe kugira ngo bifashe kwirinda amakosa yo kunywa imiti mu gihe kizaza.

Nkwiriye gukora iki niba nciweho urugero rwa dutasteride?

Niba waciweho urugero rwa dutasteride, yinywere vuba na bwangu uko wibuka, keretse igihe cyo kunywa urugero rukurikira kigeze. Muri urwo rubanza, reka urugero wibagiwe ukomeze gahunda yawe isanzwe yo kunywa imiti.

Ntunyweho urugero rwa kabiri icyarimwe kugira ngo usimbure urugero wibagiwe, kuko ibi bishobora kongera ibyago byo kugira ingaruka ziterwa n'imiti. Dutasteride ifite igihe kirekire cyo kuguma mu mubiri, bivuze ko iguma mu mubiri wawe iminsi myinshi, bityo rimwe na rimwe kwibagirwa urugero ntizagira ingaruka zikomeye ku kuvurwa kwawe.

Niba ukunda kwibagirwa kunywa imiti, gerageza gushyiraho alarme ya buri munsi kuri terefone yawe cyangwa ukoreshe agasanduku k'imiti gafite ibice by'iminsi y'icyumweru. Guhora ukora kimwe ni ingenzi kugira ngo ugumane urugero rwa hormone ruzigama kandi ubone ibisubizo byiza ku kuvurwa kwawe.

Nshobora guhagarika ryari kunywa dutasteride?

Ntugomba na rimwe guhagarika kunywa dutasteride utabanje kubiganiraho n'umuganga wawe. Uyu muti akenshi ugomba kunyobwa igihe kirekire kugira ngo ugumane akamaro kawo, kandi guhagarara mu buryo butunguranye bishobora gutuma ibimenyetso byawe bisubira mu mezi make.

Muganga wawe ashobora gutekereza kureka gufata dutasteride niba ubonye ingaruka zitihanganirwa, niba uburwayi bwawe butagenda neza nyuma y'igihe gihagije, cyangwa niba urwaye izindi ndwara zituma umuti utabereye. Bashobora kandi gutanga igitekerezo cyo guhagarika niba uteganya gukora ibikorwa by'ubuvuzi runaka.

Niba uhagaritse gufata dutasteride, tegera ko urugero rwawe rwa DHT ruzasubira buhoro buhoro mu buryo busanzwe mu mezi make. Ibi bivuze ko prostate yawe ishobora kongera kwaguka, kandi ibimenyetso byo kunyara bishobora kugaruka. Muganga wawe ashobora kugufasha gutegura iyi mpinduka no kuganira ku zindi nshuti zivura niba bibaye ngombwa.

Nshobora gutanga amaraso niba mfata Dutasteride?

Ibikorwa byinshi byo gutanga amaraso ntibizakira amaraso aturutse ku bagabo bafata dutasteride, kandi ugomba gutegereza byibuze amezi atandatu nyuma yo guhagarika umuti mbere yo gutanga. Iyi ngamba irahari kuko dutasteride ishobora kuguma mu maraso yawe mu mezi menshi kandi ishobora kwangiza uruhinja rukiri mu nda niba amaraso yatanzwe ku mugore utwite.

Iyi mbogamizi ikoreshwa nubwo urugero rwa dutasteride mu maraso yatanzwe rwari ruto cyane. Ibikorwa byo gutanga amaraso bikora ku ruhande rw'ubwitonzi iyo bigeze ku miti ishobora kugira ingaruka ku ngaruka zo gutwita.

Niba ubu ufata dutasteride kandi ushaka gutanga amaraso, uzakenera kuganira no guhagarika umuti na muganga wawe mbere na mbere. Bashobora kugufasha gupima inyungu zo gutanga amaraso ugereranije no kugaruka bishoboka kw'ibimenyetso byawe bya BPH mu gihe cyo gutegereza.