Meloxicam na Naproxen: Ingufu, Ibyago ku Ndibye, Idosi, n'Uburyo bwo Guhitamo

Nta na rumwe rurenze ubundi. Mu bushakashatsi bagereranyije ibi bicuruzwa, meloxicam 7.5 mg rimwe ku munsi yakumiraga ububabare bwa artiritis kimwe na naproxen 750 mg ku munsi. Itandukaniro rya meloxicam na naproxen ni uko meloxicam igomba kwandikirwa na muganga, ifatwa rimwe ku munsi, kandi ikaba itoroheye inda ku dose nke; naproxen iboneka kuva ku isoko idasabye kwandikirwa na muganga kandi ikavura ububabare bwinshi.

TL;DR: Ibikubiye mu magambo ahinnye

• Ku dose zisanzwe, ibi bicuruzwa byombi bivura ububabare bwa artiritis kimwe. Ingano y'imiriyoni ntihwanye hagati y'ibicuruza bitandukanye.
• Meloxicam yagize ingaruka nke ku nda kuruta naproxen mu bushakashatsi bw'amezi atandatu (30.3% na 44.7%).
• Ibyiza byo kurinda inda byari bikomeye kuri 7.5 mg kandi bigabanuka kuri 15 mg.
• Bombi bifite iteka rya FDA ryo kuba byatera indwara z'umutima, stroke, no kuvugira mu nda.
• Ntuzigera ubifata icyarimwe. Gufata ibi bicuruzwa bibiri byongera ibyago bidakongeye kuzana ubufasha.

Meloxicam na naproxen: imikorere imwe, uburyo bwo kubona no gutanga iteka bitandukanye

Meloxicam na naproxen byose ni imiti yitwa nonsteroidal anti-inflammatory drugs (NSAIDs) ikinga ikorwa rya prostaglandins, ni nayo mpamvu ivura ububabare n'ububyimbirwa mu buryo busa. Meloxicam igomba kwandikirwa na muganga, ifatwa rimwe ku munsi, kandi yemewe by'umwihariko kuri artiritis. Naproxen iboneka ikandikirwa na muganga ndetse na yo isanzwe ku isoko, ifatwa kabiri cyangwa gatatu ku munsi, kandi ikavura ububabare bwinshi. Ku dose zisanzwe, uburyo bwo kwirinda ububabare burasa.

Ibyo byemewe bifite itandukaniro nyaryo. Meloxicam yemererwa guhangara osteoarthritis, rheumatoid arthritis, na juvenile idiopathic arthritis ku bana bafite imyaka 2 kuzamuka, kandi ntakindi. Naproxen ivura ibyo bikubiyeho bya artiritis, ndetse n'ububabare bw'imihango, ibihererekana, n'ububabare bw'imitsi, kandi uyigura nka Aleve udasabye kubona muganga.

Mu buryo bw'imikorere, kimwe gituma havuka itandukaniro. Ku dose nke, meloxicam irushijeho kwibanda ku guhagarika COX-2 kurusha COX-1, mu gihe naproxen ihagarika enzymes zombi mu buryo budahisemo. COX-1 ifasha guhagarara ku mukoba w'inda, kandi icyo kintu ni cyo cyonyine gitera meloxicam kwitwa ko itoroheye inda.

Izihe ni zo zikomeye, meloxicam cyangwa naproxen? Ubushakashatsi bwagaragaje ko zinganya

Abantu bagiye bakunda kubaza igikomeye, meloxicam cyangwa naproxen, baba bagereranya imibare y'ibinini. Hari igisubizo cy'ukuri. Mu bushakashatsi bwakorewe ku bantu 65 bafite rheumatoid arthritis mu gihe cy'amezi 6, meloxicam 7.5 mg ku munsi yari ingana n'iyobagoye ikoreshwa nka naproxen 750 mg ku munsi. Ibibazo by'igogora byari 30.3% mu itsinda rya meloxicam na 44.7% mu itsinda rya naproxen, kandi ibikomere byagaragaye kuri naproxen.

Bityo, 15 mg ya meloxicam ntabwo ari dose nke kuruta 500 mg ya naproxen. Imiyoni (milligrams) ibara uburemere bw'ikirungo, ntibwire ingano yacyo, kandi ntibihwanye ibicuruza bitandukanye kurushaho nk'uko santimita zitahwanya na kiro.

Ibyo byongera kwerekana ko utari guhitamo igicuruza gikomeye. Ahubwo, urimo guhitamo uburyo bw'ingaruka n'igihe gikwiye cyo kwirinda ububabare ushobora kubaho na cyo.

• Meloxicam irakwiriye niba ushaka ko ifatwa rimwe ku munsi kugira ngo ugire ububabare bwa artiritis burambye, niba waragize ibibazo by'igogora ku bicuruzwa bya NSAIDs bidahisemo, cyangwa niba kwibuka gufata imiti ari ikibazo gikomeye kuri wowe.
• Naproxen irakwiriye niba ukeneye kwirinda ububabare igihe cyose ushatse cyangwa ko wabona ku isoko, niba ububabare bwawe buruta artiritis bukagenda ku mihango, ibihererekana, cyangwa imitsi, cyangwa niba waramaze kugeramo neza.

Ku ngingo ya artiritis, ibikunze gufasha ni inda, umutima wawe, n'idose yawe

Ugereranyije naproxen na meloxicam ku ngingo ya artiritis, bombi bemewe na FDA mu kuvura osteoarthritis na rheumatoid arthritis, meloxicam ikongeraho juvenile idiopathic arthritis kuva ku myaka 2. Kwirinda ububabare bizakwigana. Amateka yawe mu nda, impyiko, n'umutima ni byo bizatuma uhitamo.

Dore ibyo abantu benshi batazakubwira: akamaro ka meloxicam ku nda kiterwa na dose. Inyandiko zo muri American Family Physician zagaragaje ko kwirinda ibibazo byo mu nda byari byiza cyane kuri dose ya 7.5 mg, kandi bigabanuka kuri 15 mg. Niba uwandikiye aguhaye 15 mg, ntugatekereze ko ufite akamaro ko kurinda inda kariho ku dose nke. Inyandiko zimwe zagaragaje ko ibyago byo guturika kw'amaraso byari bitari byiyongereye kuri meloxicam ugereranyije na naproxen, ibyo bikaba bidashyigikiye igitekerezo cy'uko naproxen ari yo myiza ku mutima.

Ibicuruza byombi bifite iteka rya FDA ridasanzwe: kwiyongera kw'ibyago byo gupfa kw'ibintu byo mu mutima nk'uguhagarara kw'amaraso mu bifu n'ububabare bukomeye mu gifu, kwiruka mu gifu, n'ibice bikomeye bikaba byabaho hatarimo ikimenyetso. Ibyago byiyongera ku bantu bafite imyaka myinshi, ubuzima bubi, umwotsi, n'inzoga nyinshi.

Gucika kw'amaraso mu gifu bishobora kuba bitagaragara. Rimwe na rimwe ikimenyetso cya mbere ni indwara yo kubura ij umuganga igaragazwa n' ibisubizo bya MCV mu bipimo by'amaraso ku bipimo bisanzwe, amezi mbere y'uko hari amaraso abonetse. Koresha dose ntoya ikora neza igihe gito cyane gikomeza ububabare bwa artiritis, kandi ubyiteho nk'ikintu ugomba gusubiramo kuruta kwiyongera bidashira.

Kwirinda gufata rimwe ku munsi ni akamaro kanini ka meloxicam

Itandukaniro ry'idose rya meloxicam na naproxen ni ikintu gikomeye cyane kibatandukanya. Meloxicam itangira ku 7.5 mg rimwe ku munsi kuri osteoarthritis na rheumatoid arthritis, hamwe n'icyagera cya 15 mg rimwe ku munsi idafite uko ihuzwa kandi hamwe n'icyagera cyo kwirinda cyane cya 7.5 mg ku munsi ku bantu bakoresha hemodialysis. Uyifata icyo gihe buri munsi, n'ibiryo cyangwa utabirimo.

Naproxen yandikiwe na muganga akenshi ifatwa kabiri ku munsi kuri artiritis, hamwe n'uburyo bwo kwirinda gutinda gufatwa rimwe ku munsi. Naproxen sodium isanzwe ku isoko ifite umurongo mukuru: ibinini 1 buri masaha 8 kugeza 12, ntibirenze 2 mu masaha 8 kugeza 12, kandi ntibirenze 3 mu masaha 24, hamwe n'idose ya mbere y'ibinini 2 yemererwa mu isaha ya mbere.

Kuki kugabanywa gutya? Ubushakashatsi bw'umubiri. Meloxicam imara mu mubiri amasaha 20, mu gihe naproxen imara amasaha 12 kugeza 17, bityo meloxicam ikaguma mu mubiri umunsi wose naproxen ikaba isabwa kongerwa.

Ibintu bibiri bishobora kwibeshya abantu. Kwirinda ububabare burambye bishobora gufata icyumweru kimwe cyangwa bibiri, bityo nta na kimwe muri ibi bicuruzwa gikwiye gufatwa ku munsi wa kabiri. Kandi kubona ku isoko ni inzira ya naproxen yo kwica ku ikosa: birashoboka cyane kurenga umurongo wa 24, cyangwa kwiyongera binyuze mu bicuruzwa by'ububabare bwinshi cyangwa ibihangara, utabigambiriye.

Kwihata byose byongera ibyago kandi ntibyongere ubufasha

Igisubizo gito ku kibazo cyo niba wafata meloxicam na naproxen icyarimwe ni oya. Guhurizanya ibi bicuruzwa bibiri NSAIDs byongera ibyago byo kugwa kw'amaraso mu gifu no kwangiza impyiko kandi ntibyongere ububabare, kuko bombi bahanganye ku enzyme imwe. Kwita kuri ibi bikubiye kandi kuri ibuprofen, diclofenac, aspirin, n'amaraso, keretse muganga yabibwiye.

Soma inyandiko kuri ibyo waba ugurira ububabare, ibihangara, cyangwa ibihangara byo mu mazuru. NSAIDs zihishwe mu bicuruzwa bifatanye ni uburyo busanzwe abantu bafata indose zirenga urugero batabigambiriye.

Niba muganga aguhinduriye imiti, ntakindi cyo kwitonderwa gikenewe, ariko kwirinda kuvanga ni byo by'ingenzi. Hagarika kimwe, utangire ikindi, kandi witege ko meloxicam imara iminsi myinshi mu mubiri kubera igihe kimara mu mubiri. Ntugakore ku muyoboro w'ububabare bwo ku isoko hejuru ya meloxicam mugihe utegereje ko imiti yawe igenda neza. Ibyo ni byo iteka ryavuze.

Rimwe na rimwe ibimenyetso bya NSAID bisaba kwita kuri uyu munsi, ntaho ugomba kwizigama ku gihe uzongera gufata imiti

Iteka ridafite akamaro. Ibi bibaho, kandi ibyihutirwa bikwiye kwibukwa.

Hamagara 911 cyangwa jya mu cyumba cy'ubutabazi ubu:

• Ufite ububabare mu gatuza, guhumeka bigorana, ubunebwe bw'uruhande rumwe cyangwa bw'uruhara rutunguranye, cyangwa kuvuga gusubira mu kanwa
• Weguruje amaraso cyangwa ibintu bisa n'ububaji bw'ikawa
• Inshira zawe zirimo umukara, zikajegajega, cyangwa zifite amaraso
• Ufite ububabare bukomeye mu gifu budashira
• Uruhu rwawe cyangwa ijosi ryawe birabyimba, ugorwa no guhumeka, cyangwa ugahinguka imvuvu zikomeye

Ikindi cyiciro ntikigatsindishirije ariko gikwiye gutegereza umwanya wo kwa muganga.

Fata gahunda yo kwivuza mu cyumweru gitaha niba:

• Uruhu rwawe cyangwa amaso bisa n'umuhondo, inkari zawe zirimo umwijima, cyangwa urwaye cyane
• Uraza kenshi, cyangwa amaguru n'ibirenge byawe birabyimba
• Ufite ububabare mu gifu budashira ku muti numwe mubiri
• Ububabare bwa artiritis bwawe ntirashira nyuma y'icyumweru kimwe cyangwa bibiri ku idose izewe

Kandi mbere yuko utangira gufata imiti, amateka amwe ahindura igitekerezo burundu.

Hagira muganga mbere yo gutangira niba:

• Waragize ikibazo cy'ububabare mu gifu cyangwa amaraso mu gifu, indwara z'impyiko cyangwa dialysis, kwanga gutera kw'umutima, indwara y'umutima cyangwa stroke, cyangwa umuvuduko udagenzuwe w'amaraso
• Witeguye gutwita cyangwa uri gutwita, cyangwa ufite imyaka 65 kuzamuka
• Ufata amaraso ahagarara, aspirin, SSRIs, diuretics, cyangwa ACE inhibitors

Niba uri guhitamo NSAID ikwiriye amateka yawe, ibyo ni byo byiza by' akazi ka $39 kuri online ka August, aho umuganga wemewe muri Amerika ashobora gusubiramo idose yawe, imiti yawe yose, n'ibyago byawe, kandi agafata icyemezo niba imiti yandikiwe ikwiriye. Gusura online ntishobora gusuzuma amaraso mu gifu, ububabare mu gatuza, cyangwa ibimenyetso bya stroke. Ibyo bisaba icyumba cy'ubutabazi. Ku bantu bakuru bakoresha NSAIDs igihe kirekire, ubusabane bw'imyaka yose kwa muganga ni ahantu heza ho gusubiramo niba imiti yandikiwe ikigana.

Ikibazo cyizewe buri gihe

Birashoboka gufata acetaminophen (Tylenol) hamwe na meloxicam cyangwa naproxen?

Bisanzwe. Acetaminophen ntabwo ari NSAID kandi ntikora ku gice cy'ibiryo kigenzura inda, bityo abaganga bakunze guhuza ibi bicuruzwa kugira ngo bibafashe kurushaho. Shinga mu bipimo bya buri munsi bya acetaminophen, kandi urebe buri gitangiriro, harimo ibinyobwa by'ibihangara n'imiti yandikiwe yihutirwa ikubiyemo.

Meloxicam na naproxen birasa nibishobora gufatwa mugihe utwite?

Oya. Nta na kimwe muri cyo gikwiye kugira igihe utwite, kandi NSAIDs zikunze kwirindwa mu gihe utwite kubera ingaruka ku maraso y'umwana no ku bifu by'amazi. Niba utwite, uri gutwita, cyangwa ufite umwana uri kunononsa, hagisha inama muganga wawe wo kwa njyanama mbere yo gufata ibi bicuruzwa, harimo na Aleve isanzwe ku isoko, kuruta kugira icyemezo ku rupapuro.

Ugomba kwirinda inzoga mugihe ufata meloxicam cyangwa naproxen?

Ntabwo burundu. Inzoga rimwe na rimwe ntibyemewe, ariko inzoga na NSAIDs zirakaza inda mu buryo butandukanye, bityo guhuza bikaba byongera ibyago. Kureka inzoga burundu niba waba waragize ikibazo cy'ububabare mu gifu cyangwa amaraso mu gifu, kandi ntukigere unywa inzoga ku gifu cy'umwanya mugihe ufata kimwe muri ibi bicuruzwa buri gihe.

Birashoboka gufata meloxicam cyangwa naproxen niba uri gufata imiti y'umuvuduko w'amaraso cyangwa diuretic?

Rimwe na rimwe, hamwe no kwitondera. NSAIDs ishobora kongera umuvuduko w'amaraso kandi ikagabanya ingaruka z'imiti y'umuvuduko, kandi ihuje na diuretic cyangwa ACE inhibitor igabanya amaraso ajya mu mpyiko. Bwira uwakwandikiye imiti imiti yose ufata y'umuvuduko kugira ngo imikorere y'impyiko n'umuvuduko bigenzurwe.

Uzakenera bipimo by'amaraso cyangwa impyiko niba uguma ku gukoresha kimwe muri ibi bicuruzwa igihe kirekire?

Yego, akenshi. Gukoresha NSAIDs igihe kirekire bisaba gusuzuma hemoglobin, imikorere y'impyiko, enzymes z'umwijima, n'umuvuduko w'amaraso, kuko amaraso n'ibibazo by'impyiko bikunze kugaragara bitari kare. Hagisha muganga wawe inama uburyo bukoreshwa, kandi ufashe kugabanyuka kw'umubare wa hemoglobin nk'ikimenyetso cyo gusuzuma kuruta kwitegerereza.

Igitekerezo gisigaye ku guhitamo hagati ya meloxicam na naproxen

Icyemezo cyo guhitamo meloxicam na naproxen kirebana n'uburyo bukugendekeye, ntabwo ari ingufu. Kwirinda ububabare burasa ku dose zisanzwe, bityo hitamo ku gihe bifatwa, ibyago by'inda n'impyiko, n'uburyo ububabare bwawe buri. Akamaro ka meloxicam ku nda kariho ku 7.5 mg kandi kari munsi kuri 15 mg. Bombi bifite iteka risanzwe, kandi nta n'imwe muri NSAIDs yakoreshwa igihe kirekire idasabwe. Intambwe yawe ikurikira ni imwe: zana idose yawe, urutonde rw'imiti yawe yose, n'amateka yawe mu nda, impyiko, n'umutima kuri muganga aho kwihindurira.

Inyandiko: Iyi nyandiko ni iy'amakuru gusa kandi ntabwo ikubiyemo inama z'ubuvuzi. Komeza ubagisha umukozi wo kwita ku buzima ufite uburenganzira kugira ngo ugire ibyo wisuzumira n'ibyemezo byo kuvura. Niba uri guhura n'ikibazo gikomeye cy'ubuzima, hamagara 911 cyangwa jya ku bitaro byegereye ubu.