Norethindrone ku bicurane bwo mu miyoboro y'inkari bukora kuri benshi bagera ku rugero ruhagije. Urutonde rwa FDA rutangira kuri 5 mg ku munsi kandi rugakomeza kuzamuka kuri 2.5 mg buri cyumweru bibiri kugeza kuri 15 mg, bikagenda gutyo mu mezi atandatu kugeza icyenda. Buvura ububabare binyuze mu guhagarika imihango. Ntabwo buvura indwara.

  • Igihe cyanditse ku rutonde: 5 mg ku munsi, bizamuka kuri 2.5 mg buri cyumweru bibiri, kugeza kuri 15 mg ku munsi mu mezi 6 kugeza 9.
  • Akaramya ka miligiramu 5 za norethindrone acetate ntabwo ari ka ka miligiramu 0.35 ka gahagarika imbyaro. Ni umuryango umwe, ariko ufite urugero rutandukanye cyane.
  • Kunywa buri gihe nta cyumweru cyo kuruhuka ni cyo cyo kuvura, ntabwo ari inzira ngufi. Kutagira imihango bivuze kutagira ububabare bwo mu mihango.
  • Amav:[/u]ub[u]u[u]ryo mu gihe cyo kuvura ni impamvu ikunze gutuma abantu bava kuri ubu buryo, kandi mubisanzwe bigahagarara mu mezi atatu.
  • Norethindrone ku bicurane bwo mu miyoboro y'inkari ihagarika indwara. Ibimenyetso byombi bikunze kugaruka nyuma yo guhagarika.

Norethindrone ku Bicurane bwo mu Miyoboro y'Inkari Buvura Ububabare Kuri Benshi Babikoresha

Norethindrone acetate ifite urwandiko rwa FDA ku bicurane bwo mu miyoboro y'inkari, hamwe na amenoreya ya kabiri n'amaraso adasanzwe mu nyabubyaro aterwa no kubura kw'imisemburo. Ifatwa buri munsi ku 5 kugeza 15 mg, ihagarika imisemburo myiza y'igihembwe ku buryo ibice by'inyongerwa n'ibyo hanze by'inyongerwa bitongera kwishyuza no kwangizwa. Benshi mu bantu bagera no gukomeza kugira urugero ruhagije bavuga ko babonye ububabare buhumuriza bwo mu gihe cy'imihango n'ububabare bwo mu nda butari mu gihe cy'imihango.

Inama z'abanyamwuga zishyigikira aho bishyirwa. Ishyirahamwe ry'Abaganga b'Abagore n'Abaganga b'Abagore rivuga ko progestins, hamwe na NSAIDs, imiti ya nyabubyaro y'iminini y'ikubiye hamwe, danazol na GnRH agonists, ari uburyo bwiza bwo gutangira kuvura ububabare bwo mu nda mu gihe bikemanzwa ko ari ibicurane bwo mu miyoboro y'inkari. Bayikemure ku gihe gikwiye: tangira ku rugero ruhamye igihe cy'amezi atatu mbere yo gufata ko yananiwe, kandi wamenye ko urutonde rugenewe amezi atandatu kugeza icyenda.

Dore ibyo imbuga nyinshi zidasigaye zikubwira: imbuga za nyamwigendaho zihamya uko byagenze zihamya impuzandengo zingana na 5.3 kuri 10 z'ibitekerezo bya nyamwigendaho byerekeranye na endometriosis, bikerekerana nk'umuti unaniwe kugeza ubwo urebyeho imibabaro. Bateranira ku kuvugira mu cyumweru cya mbere, urugero rutigeze rwiyongera kurenza intambwe yo gutangira, no kwivanga na miligiramu 0.35 ya nyamwigendaho. Ibyo ni ikibazo cyo kwiyongera no gutunganywa, ntabwo ari ikigaragaza ko umuti wananiwe gukora.

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Oya. Imyanzuro ya 5 kugeza kuri 15 mg ikoreshwa ku bafite indwara ya endometriosis ntabwo yemejwe cyangwa ngo yigweho nk'uburyo bwo kwirinda inda, n’ubwo akenshi ibuza itegurwa ry'intanga ngore. Kuko iyo miti itajyana no gutwita, ukeneye gukoresha uburyo bwo kuboneza urubyaro bwizewe. Baza umuganga wawe uburyo bwiza wakoresha kuko igisubizo kigendera ku kuba ushobora gufata imiti irimo estrogen cyangwa utayishobora.

Akenshi bifata ibyumweru bicye cyangwa amezi make. Itangira ry'intanga ngore risubira mu buryo iyo uretse gufata imiti ya buri munsi, kandi abantu benshi bagira imihango yabo mu gihe cy'imwe kugeza kuri itatu. Ntabwo bitekerezwa ko imiti ubwayo igabanya ubushobozi bwo kubyara. Ikibazo gikomeye ni uko ibimenyetso bya endometriosis na byo akenshi bigaruka, bityo rero banza ugire inama n'umuganga ku cyo ukwiye gukora mbere y'uko urekera aho.

Uburenganzira bwo Gutanga Ubwa nyakuri: Norethindrone Ihagarika Ibicurane Byo Mu Miyoboro Y'Inkari, Ntabwo Buhukura

Kliniki ya Cleveland ivuga ko ikoreshwa ry'imisemburo: yagenzura ububabare n'amaraso binyuze mu guhagarika imihango ariko ntabwo ihura n'indwara, kandi ibimenyetso bikunze kugaruka iyo imiti ihagaritswe. Imiterere ntikura, ntikonde cyangwa ntikureba ibice. Bakuraho kwishyuza buri gihe gutera ibice kubabaza.

Ibyo bihindura icyemezo. Ntabwo uhitamo inzira yo kuvura ifite itariki yo kurangirira, uhitamo igenzura ry'igihe kirekire, rimwe na rimwe hamwe no gukurikirana cyangwa nyuma y'imitsi. Gusubira inyuma nyuma y'imitsi birakwiriye: ubushakashatsi bugaragaza kandi bugaragaza cyane bwo mu 2021 bw'ibihugu 17 n'abagore 2.137 babonye ko guhagarika imisemburo nyuma y'imitsi byagabanyije ibyago byo gusubiramo indwara kuri hafi 59% (RR 0.41, 95% CI 0.26 kugeza 0.65), numubare ugenwa kugirango uvurwe kuri hafi 8 kugeza 24. Mbere yuko utangira, soma ibibera iyo uhagaritse gukoresha norethindrone.

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Oya. Iri ni rimwe mu byiza byayo bitavugwa cyane. Norethindrone acetate 5 mg ku munsi yemerewe n'ikigo cya FDA nk'imiti yo gufasha abafata indi miti ya GnRH (GnRH agonist) kugira ngo itabangamira amagufa. Ibi bitandukanye n'ikibazo GnRH ishobora guteza, akaba ari yo mpamvu iyo miti ifasha ari ihame mu gihe ufashe imiti ya GnRH igihe kirekire.

Rimwe na rimwe. Kugira ibiro byiyongera biri mu ngaruka zikunze kugaragara, ariko si buri wese bibaho. Kugaragaza amazi mu mubiri no guhinduka kw'irari ryo kurya na byo biri mu bituma abantu bibwira ko ibiro byiyongereye. Gerageza kubikurikira mu gihe cy'amezi atatu aho kwihutira gufata umwanzuro mu byumweru bitatu gusa. Twagiye mu mizi y'ubushakashatsi bwerekana niba koko norethindrone itera kongera ibiro.

Urugero rw'Ibicurane Byo Mu Miyoboro Y'Inkari Ntabwo Rusana N'urw'Umuyoboro Mwiza

Urugero rwa norethindrone rwo kuvura ibicurane byo mu miyoboro y'inkari rwanditswe ku urutonde rwa FDA ni ugukomeza kuzamuka, ntabwo ari umubare umwe:

  • Tangira kuri 5 mg ku munsi mu cyumweru bibiri.
  • Zamura kuri 2.5 mg ku munsi buri cyumweru bibiri.
  • Komeza kuzamuka kugeza ugeze kuri 15 mg ku munsi.
  • Guma kuri 15 mg ku munsi mu mezi 6 kugeza 9, cyangwa kugeza amaraso agaragaye atumye uhagarara by'agateganyo.

Ibi ni byo bikomeye kuruta ibindi byose kuri page. Imiterere ya miligiramu 5 ya norethindrone acetate (izina ry'ubucuruzi Aygestin) ni itandukanye n'imiti ya miligiramu 0.35 ya norethindrone: havuyemo inshuro 14 mu gihe cyo gutangira kandi hejuru y'inshuro 40 kuri 15 mg. Norethindrone acetate 5 mg ku munsi nayo yemewe na FDA nko kwongera imiti hamwe na GnRH agonist kugirango igabanye igicuku gikomeye. Burimw'intambwe y'uyu murongo igenzura na muganga. Ntugafate cyangwa ntutere igipimo utabajijwe, kandi ntukivange na gahunda yo gukoresha norethindrone kugirango uhagarike cyangwa utindiwe igihembwe kimwe.

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Iyifate ugiye kuyibuka, keretse niba igihe cy'ikindi kinini cyawe cyegereje; icyo gihe usimbuka iyo wibagiwe. Ntuzigere ufata ibinini bibiri ngo wishyure ibyo wibagiwe. Ku miti ivura endometriosis, kubura iminsi bituma ujya umeneka amaraso kandi ukaribwa, bityo rero ujye usaba imiti mbere y'icyumweru ngo ishire, kandi ubwire umuganga wawe niba uhora ubigwamo.

Guhagarika Igihembwe Ni Kuvura, Ntabwo Ni Impanuka

Norethindrone ikomeje bisobanura imiterere imwe buri munsi nta cyumweru cyo kuruhuka kandi nta gihe cyo kuruhuka ku misemburo. Impamvu ntibishikirwa kenshi: kunywa buri gihe guhagarika ovulation, kugabanya estrogene kandi ugakoroga imyanya ndangagitsimbata, kandi ugatanga pseudo-amenorrhea. Kutagira imihango bivuze kutagira kwishyuza buri kwezi ku bice no kurangiza imihango yo gutera ububabare.

Ibyo ni ibinyuranye nibyo gukoresha progestin mu gihe cy'imihango cyangwa mu gihe cyo gutwika, aho intego ari ukurangiza imihango igenwe. Tegereza kuvugira igitaramo mbere. Benshi bagera kuri amenoreya mu mezi yumwe kugeza atatu. Guhagarika igihembwe ku miti ikomeje ni yo ntego, ntabwo ari ikimenyetso cy'akaga kandi ntabwo, ubwayo, ari ikimenyetso cy'ugusama.

Amav:[u]ub[u]u[u]ryo Mu Gihe Cy'Imiterere, Ntabwo Ni Akaga, Ni Impamvu Benshi Bava kuri Ubu Buryo

Imiti myinshi ya norethindrone irashobora kwihanganirwa. Uwuhagarika kuvura ni amaraso, ari kenshi kuri gahunda ikomeje kandi niwo muti ukomeye utuma abantu bava kuri ubu buryo. Mubisanzwe ni yo ikomeye mu mezi atatu ya mbere kandi ihagarara. NSAIDs zifasha bamwe, kandi urutonde ubwarwo rubaha ikiruhuko cy'agateganyo, bityo guhagarara gutegurwa na muganga ni ubundi buryo bukwiye aho kuba ibyago.

Hamagara muganga wawe aho kurinda kugeza igihe, niba ufite igikoresho cy'imashini gifata amaraso buri saha, uvugira iminsi 7 kugeza 10, cyangwa urimo kugorwa no guhumeka, kubabara umutwe cyangwa gucika intege bigaragaza ko ufite indwara ya anemia. Umutwe, kugangara, impinduka zo mu mutwe, acne, guhinda mu gituza no guhinduka ku bipimo ni ibindi bikorwa bisanzwe. Kubera ko norethindrone acetate ihagaritswe mu gihe ufite ikibazo cy'umwijima kandi ibyago by'umwijima byagaragaye kuri gahunda ya progestin, uzaze kuri ALT na AST isanzwe kandi ya buri gihe niba uzamara igihe kirekire.

Norethindrone Ni Ubundi Buryo Bukoreshwa Iyo Estrogene Itari Mu Murongo

Ikibazo nyacyo mu guhuza norethindrone na pilling za kontraseptike mu gihe cy'ibicurane byo mu miyoboro y'inkari ntabwo ari icyo kibaha ububabare kurushaho, ahubwo ni niba ushobora gukoresha estrogene mu buryo bwo kwirinda. Pilling z'ikubiye hamwe estrogene-progestin zishobora kandi gukoreshwa buri gihe, bityo gahunda ntabwo ari yo itandukanye. Igice cya estrogene ni cyo.

Norethindrone ya progestin gusa ikwiriye abantu bagomba kwirinda estrogene: amateka ya indwara z'imitsi cyangwa z'imitsi, migraine hamwe na aura, kunywa itabi hejuru y'imyaka 35, cyangwa ibindi bibazo by'estrogene bifitanye isano n'ubuzima. Ibyo ntabwo ari uruhushya rwo kwinjira. Urutonde rugihagarika, diyabete, ikoreshwa ry'itabi, kolesteroli nyinshi n'umubyibuho mwinshi, n'ikoreshwa ry'itabi hejuru y'imyaka 35 ku miti irimo progestin. Ubunini bwagutse bwo kuvura imisemburo ya endometriosis, harimo dienogest, IUD ya levonorgestrel, na GnRH agonists na antagonists, ni uguhagarika kwihariye. Nta muti w'umwe uruta abandi. Guhitamo gufite isano n'ibibazo by'estrogene, kwihanganira, n'amafaranga, bikorwa na muganga.

Ibindi Bimenyetso Ku Norethindrone Si Impanuka Zigomba Kurindwa

Hamagara 911 cyangwa ujye ku cyumba cy'ibitaro byihutirwa ubu niba:

  • Ufite impagarara yihuse cyangwa ububabare mu gukurura.
  • Ikirenge kimwe cyibagirwa, kibabaza cyangwa gikongoka.
  • Ufite umutwe ukabije wihuse, impinduka zo mu maso cyangwa kuvuga bidafatika.
  • Ufite ububabare bukomeye mu nda cyangwa mu nda butandukanye n'ubwoko bwawe busanzwe, bushobora kugaragaza endometrioma yakomeye.

Wiyandikishe gusura mu cyumweru gitaha niba:

  • Ubona amaraso mu mazi yawe cyangwa imyanda yawe, ishobora kwerekana ko uruhago cyangwa igifu bihamye.
  • Amav:[u]ub[u]u[u]ryo ntabwo bigarukira nyuma y'amezi atatu ku rugero ruhamye.
  • Umunwa wawe cyangwa amaso birabya, amazi yawe ararenga, cyangwa ufite ububabare mu gice cy'iburyo hejuru.

Vugana n'umuganga mbere yo gutangira niba:

  • Urasama, ushobora kuba urasama, cyangwa urashaka gutwita.
  • Ufite amaraso adasanzwe mu gitanda utarasobanukiwe, kanseri y'igituza cy'ubu cyangwa yahozeho, indwara y'imitsi cyangwa y'imitsi irimo cyangwa yahozeho, cyangwa indwara y'umwijima, byose bikaba bibujijwe ku rutonde.
  • Ufata imiti ya konvulsants, antibiotike zo mu bwoko bwa rifampin cyangwa imiti imwe ya HIV, ishobora kugabanya urugero rwa progestin.

Niba utazi niba ikimenyetso gishya gikomeje cyangwa gisaba kwitonderwa, urugero rw'ibitaro rwa virtual ku $39 ruguhuza numuganga wemewe na Leta Zunze Ubumwe za Amerika ushobora kukigenzura, kandi muganga yemeza niba gutanga imiti bikwiye. Urugero rwa telehealth ntirushobora kumenya ibicurane byo mu miyoboro y'inkari, bisaba igenzura, gukoresha ibishushanyo cyangwa laparoscopy, kandi ntabwo ari inzira yo kugira ikimenyetso cy'ikinyuranyo cyose cyavuzwe haruguru.

Bimwe Mu Bibazwa Cyane

Norethindrone ku Bicurane Byo Mu Miyoboro Y'Inkari Ibikora Nko Gutanga Ubuzima?

Oya. Urugero rwa 5 kugeza 15 mg rukoreshwa mu kuvura ibicurane byo mu miyoboro y'inkari ntirwemewe cyangwa ntirwagezweho nka kontraseptike, nubwo mubisanzwe guhagarika ovulation. Ubusambanyi ni ikibazo cy'urutonde, bityo ugomba kuguma ufite uburyo bwo kwiringirwa. Hamagara muganga wawe kugirango wamenye uburyo bwo kubihuza, kuko ibisubizo bitandukanye hashingiwe ku kuba ushobora gufata estrogene.

Ni Igihe Kinini Nyuma Yo Guhagarika Norethindrone Impinduka N'ubuzima Bugaruka?

Mubisanzwe mu cyumweru kugera mu mezi make. Ovulation yongera kugenda iyo igihagarara buri gihe cyahagaritswe, kandi benshi babona imihango igaruka mu gicyaro kimwe kugeza kuri bitatu. Ubuzima ntibukekwa ko bugabanywa numuti ubwawo. Ikintu gikomeye nuko ibimenyetso by'ibicurane byo mu miyoboro y'inkari bikunze kugaruka, bityo tegura intambwe ikurikira na muganga mbere yuko uhagarika.

Norethindrone Biteye Gusama Amagufwa Nk'uko GnRH Agonists Nibyo Bakora?

Oya. Ibi ni bimwe mu bikomeye byahagaritswe. Norethindrone acetate 5 mg ku munsi yemewe na FDA nk'uburyo bwo kongera imiti ikoreshwa hamwe na GnRH agonist kugirango igabanye gusama amagufwa iyo miti iterwa. Ibyo bifite isano n'ibinyuranye n'ikibazo cya GnRH agonist, ni cyo cyatumye kongera imiti bikoreshwa cyane mu gihe kirekire cy'iyo miti.

Norethindrone Izangirisha Ubuzima?

Rimwe na rimwe. Guhinduka kw'ibipimo biboneka mu bikorwa bisanzwe, ariko ntibikunda, kandi gutakaza amazi no guhindura ibyokurya bikugira ku birenze bice kuri bipimo. Biukurikirane mu mezi atatu aho kuba mu cyumweru mbere yo kubishinga ku miti. Tugaragaza ubushakashatsi mu buryo burambuye kuri niba norethindrone itera kwiyongera kw'ibipimo.

Nzagira Iki Niba Mbyitaye Ku Gusiba Imiterere Cyangwa Gusoza Imiterere?

Fata nk'uko wabibonye vuba uko wabishoboye, keretse ko igihe gikurikira kigeraho, mu gihe uhagaritse ikibabaje. Ntukore impuzandengo kugirango usubire inyuma. Mu rugero rw'ibicurane byo mu miyoboro y'inkari, iminsi yibagirijwe ni impamvu isanzwe yo kuvugira amaraso no kugaruka kw'ububabare, bityo gusaba gusubiramo imiti icyumweru mbere kandi ukayibwira muganga wawe niba ibigenda bibaho.

Iby'umwihariko

Norethindrone ku bicurane bwo mu miyoboro y'inkari ni urubanza, rutondekanye, rutanga ububabare, mugihe urugero rwakuriweho kuva 5 mg kugeza 15 mg kandi ukaba waruhaye igihe cy'amezi atatu ku rugero ruhamye. Fata buri gihe, utegereze amaraso mbere, kandi utegereze ko bihamya. Ibyo bizakora ntibyemere gutera indwara. Ikibazo gikwiye kubaza muganga wawe ntabwo ari niba gikora, ahubwo nuko gahunda izaba ingana mu myaka ibiri.

Uburenganzira: Ingingo iyi iragenewe gutanga amakuru gusa kandi ntibisobanura inama z'ubuvuzi. Horeye uhindure umuganga w'umwuga kugirango wifatire icyemezo kandi ufate imiti. Niba ufite ikibazo cy'ubuzima cyihutirwa, hamagara 911 cyangwa ujye ku cyumba cy'ibitaro byihutirwa cyane.