Icyo Tepotinib ari cyo: Ibikoreshwa, Uburyo bwo gukoresha, Ingaruka ziterwa n'ibindi

Tepotinib ni umuti w'indwara ya kanseri ugamije guhagarika proteyine zihariye zifasha kanseri zimwe na zimwe zo mu muhogo gukura. Ni uburyo bushya bwo kuvura bwateguriwe abantu bafite kanseri yo mu muhogo idafite uturemangingo duto duto ifite ihinduka ryihariye ry'imikorere y'uturemangingo twitwa MET exon 14 skipping mutation.

Uyu muti ukora mu buryo butandukanye na shimi yo kuvura gakondo kuko yibanda ku kibazo nyacyo cy'imikorere y'uturemangingo gituma kanseri ikura. Tekereza nk'igikoresho cy'ubuhanga aho kuba uburyo rusange, akenshi bivuze ingaruka nke mu gihe zigikora neza ku ndwara ya kanseri.

Tepotinib ikoreshwa mu kuvura iki?

Tepotinib ivura ubwoko bwihariye bwa kanseri yo mu muhogo idafite uturemangingo duto duto. Muganga wawe azandika uyu muti gusa niba kanseri yawe ifite ihinduka ryihariye ry'imikorere y'uturemangingo twitwa MET exon 14 skipping.

Iri hinduka ry'imikorere y'uturemangingo ribaho kuri 3-4% bya kanseri zo mu muhogo idafite uturemangingo duto duto, bituma bitaba akenshi. Iri hinduka rituma uturemangingo twa kanseri dukura kandi tugakwira cyane binyuze mu kugira ingaruka ku buryo proteyine zimwe na zimwe zikora mu turemangingo twawe.

Itsinda ryawe ry'ubuzima rizasuzuma igituntu cyawe cya kanseri kugirango rishimangire ko ufite iri hinduka ryihariye mbere yo gutangira gukoresha tepotinib. Ubu buryo bwo gusuzuma, bwitwa biomarker testing, butuma wakira ubuvuzi bukwiye cyane kubwoko bwawe bwihariye bwa kanseri.

Tepotinib ikora ite?

Tepotinib ihagarika proteyine yitwa MET ifasha uturemangingo twa kanseri gukura no kubaho. Iyo iyi proteyine iba ikora cyane kubera impinduka z'imikorere y'uturemangingo, itanga ibimenyetso bibwira uturemangingo twa kanseri kwiyongera vuba.

Mugihe uhagaritse ibi bimenyetso, tepotinib mu byukuri ikata amabwiriza yo gukura ya kanseri. Ubu buryo bugamije bushobora gutinda cyangwa guhagarika kanseri kuva ikwira mu bindi bice by'umubiri wawe.

Nka uburyo bwo kuvura bwihariye, tepotinib ifatwa nk'umuti ukomeye kandi ufite akamaro ku bwoko bwihariye bwa kanseri y'ibihaha ivura. Ariko, ikora mu buryo butandukanye na chimiothérapie gakondo, akenshi itera ubwoko butandukanye bw'ingaruka ziterwa n'imiti, akenshi zicungwa neza.

Nkwiriye Gufata Gute Tepotinib?

Fata tepotinib uko muganga wawe abikwandikiye, akenshi rimwe ku munsi hamwe n'ibiryo. Kuyifata hamwe n'ibiryo bifasha umubiri wawe gukurura umuti neza kandi bishobora kugabanya ingaruka ziterwa n'umunda.

Mimina ibinini byose hamwe n'ikirahure cy'amazi - ntukabikoremo agahinda, ntukabumire, cyangwa ubimenagure. Niba ugira ingorane zo kumira ibinini, ganira n'ikipe yawe y'ubuzima ku bisubizo bishoboka.

Gerageza gufata tepotinib ku gihe kimwe buri munsi kugirango ugumane urwego ruzigama mu mubiri wawe. Urashobora kuyifata hamwe n'ifunguro iryo ariryo ryose, ariko abantu benshi babona ko byoroshye kwibuka iyo bafatiwe mu gitondo cyangwa nimugoroba.

Irinde pome n'umutobe wa pome mugihe ufata tepotinib, kuko ibi bishobora kubangamira uburyo umubiri wawe ukoresha umuti. Iyi mikoranire irashobora gutuma umuti udakora neza cyangwa ukongera ingaruka ziterwa n'imiti.

Nkwiriye Kumara Igihe Kingana Gite Ndafata Tepotinib?

Uzakomeza gufata tepotinib igihe cyose ikora neza kandi uyihanganira neza. Ubu buryo bwitwa

Kimwe n'imiti yose ivura kanseri, tepotinib ishobora gutera ingaruka zidakunzwe, nubwo atari buri wese uzazibona. Ingaruka nyinshi zishobora kugenzurwa neza hakoreshejwe ubufasha bukwiriye no gukurikiranwa n'ikipe yawe y'ubuzima.

Dore ingaruka zikunze kugaragara ushobora guhura nazo, zikaba zifata abantu barenga 20% bakoresha tepotinib:

• Kubyimba amaguru, ibibero, cyangwa ibirenge (edema)
• Kugira umunaniro no kumva unaniwe cyane
• Uburwayi bwo mu nda no kuruka rimwe na rimwe
• Impiswi cyangwa kwituma birimo amazi menshi
• Kugabanya ubushake bwo kurya
• Kugufiwa umwuka
• Urubavu cyangwa kubabara mu ngingo

Izi ngaruka zikunze kugaragara mubisanzwe ziba zoroshye cyangwa ziciriritse kandi akenshi zigenda zikira uko umubiri wawe ukimenyera umuti. Ikipe yawe y'ubuzima ishobora gutanga ingamba zo gufasha gukemura ibi bimenyetso neza.

Abantu bamwe bashobora guhura n'ingaruka zikomeye zisaba ubufasha bwihutirwa bw'abaganga, nubwo ibi bidakunze kugaragara:

• Ibibazo bikomeye by'ibihaha (pneumonitis) hamwe n'inkorora idahoraho cyangwa ingorane zo guhumeka
• Ibibazo by'umwijima hamwe no guhinduka uruhu cyangwa amaso umuhondo
• Kubyimba bikomeye bitagabanuka iyo byazamuriwe hejuru
• Ibimenyetso by'ubwandu hamwe n'umuriro, imbeho, cyangwa intege nke idasanzwe
• Impiswi zikomeye zikugeza ku kumuka amazi mu mubiri

Vugana n'ikipe yawe y'ubuzima ako kanya niba ubonye kimwe muri ibi bimenyetso bikomeye. Kujya mu buvuzi hakiri kare bishobora gufasha kwirinda ingorane no kugufasha kuguma mu mutekano mu gihe ukomeje kuvurwa.

Ninde utagomba gufata Tepotinib?

Tepotinib ntabwo ikwiriye kuri buri wese, kandi muganga wawe azasuzuma neza amateka yawe y'ubuzima mbere yo kuyandika. Abantu bafite ibibazo runaka cyangwa ibihe runaka bashobora gukenera kwirinda uyu muti cyangwa bakawukoresha bafite ubwitonzi bwinshi.

Ntabwo ugomba gufata tepotinib niba ufite allergie kuri wo cyangwa kuri kimwe mu bigize wo. Byongeye kandi, uyu muti ntusabwa niba utwite cyangwa wonka, kuko ushobora gukomeretsa abana bakiri bato.

Umuganga wawe azakoresha ubushishozi bwinshi mugihe akwandikira tepotinib niba ufite:

• Indwara ikomeye y'umwijima cyangwa ibibazo by'imikorere y'umwijima
• Indwara ikomeye y'impyiko
• Amateka y'ibibazo by'ibihaha cyangwa ingorane zo guhumeka
• Ibibazo by'umutima cyangwa ibibazo byo kubika amazi
• Infesiyo zikora cyangwa urwego rw'ubudahangarwa rwangiritse

Imiti imwe irashobora guhura na tepotinib, bishobora gutuma itagira akamaro cyangwa ikongera ingaruka ziterwa nayo. Buri gihe bwire abaganga bose, ibiyongera, nibicuruzwa by'ibyatsi ukoresha.

Izina ry'ubwoko bwa Tepotinib

Tepotinib igurishwa munsi y'izina ry'ubwoko bwa Tepmetko muri Amerika no mu Burayi. Iri zina ry'ubwoko rifasha gutandukanya n'indi miti ya kanseri kandi rituma wakira imiti ikwiye.

Mugihe ufata umuti wawe, genzura kabiri ko wakira Tepmetko (tepotinib) atari undi muti. Amavuriro rimwe na rimwe agira imiti ifite amazina asa, bityo gukora igenzura bifasha kurengera umutekano wawe.

Ubwishingizi bwawe n'ubuvuzi bishobora kugira ingaruka ku kuboneka n'ikiguzi. Niba ufite impungenge zo kubona Tepmetko, baza ikipe yawe y'ubuzima kubijyanye na gahunda zo gufasha abarwayi zishobora gufasha.

Andi mavuriro ya Tepotinib

Mugihe tepotinib yagenewe byumwihariko MET exon 14 skipping mutations, hariho ubundi buryo bwo kuvura kanseri y'ibihaha. Umuganga wawe ashobora gutekereza izindi nzira zishingiye ku miterere yawe yihariye n'uburyo tepotinib ikora neza.

Ubuvuzi bundi bwibanda kuri kanseri y'ibihaha burimo capmatinib (Tabrecta), nayo yibanda kuri MET mutations ariko ikora mu buryo butandukanye gato. Abantu bamwe bashobora gusubiza neza umuti umwe kuruta undi.

Ubuvuzi gakondo nka chemotherapy, immunotherapy, cyangwa radiation therapy birashobora kuba amahitamo niba ubuvuzi bwibanda butakwiriye. Umuganga wawe w'inzobere mu by'indwara ya kanseri azaganira ku buryo bwiza bushingiye ku miterere ya kanseri yawe n'ubuzima bwawe muri rusange.

Igerage ryo kwa muganga rishobora gutanga uburyo bwo kubona imiti mishya igeragezwa. Baza ikipe yawe y'ubuzima niba hari ubushakashatsi ubwo aribwo bwose bushobora kuba bukwiye kubera uko ubuzima bwawe bumeze.

Ese Tepotinib iruta Capmatinib?

Tepotinib na capmatinib byombi bigamije poroteyine imwe ya MET, ariko bikora mu buryo butandukanye gato kandi bishobora kugira ingaruka zitandukanye. Nta muti n'umwe ufite agaciro gakomeye kurusha undi - guhitamo biterwa n'uko ubuzima bwawe bumeze.

Abantu bamwe basubiza neza kuri tepotinib, mu gihe abandi bashobora kugira ibisubizo byiza na capmatinib. Muganga wawe azatekereza ibintu nk'ihinduka ryihariye ryawe, ubuzima muri rusange, indi miti urimo gufata, n'ingaruka zishobora kubaho mugihe uhitamo hagati yayo.

Niba umuti umwe uhagaze gukora cyangwa ugatera ingaruka zitihanganirwa, muganga wawe ashobora kuguherereza undi. Ibi biguha amahitamo menshi yo kuvura kandi bikaguha icyizere cyo gukomeza kurwanya kanseri.

Imiti yombi yerekanye imikorere isa mugihe cy'igeragezwa ryo kwa muganga, hamwe n'uburyo bwo gusubiza hafi 40-50% kubantu bafite MET exon 14 skipping mutations. Ikipe yawe y'ubuzima izakurikiza iterambere ryawe kandi ihindure uburyo bwo kuvura uko bikwiye.

Ibikunze Kubazwa Kuri Tepotinib

Ese Tepotinib irakwiriye abantu barwaye diyabete?

Tepotinib muri rusange irashobora gukoreshwa neza kubantu barwaye diyabete, ariko bisaba gukurikiranwa neza. Uyu muti ntugira ingaruka zigorora ku isukari yo mu maraso, ariko zimwe mu ngaruka nk'igabanuka ry'irari ryo kurya cyangwa isesemi bishobora kugira ingaruka ku buryo urya.

Ikipe yawe y'ubuzima izakorana nawe bya hafi kugirango ikurikirane uburyo bwo kuvura kanseri yawe n'imicungire ya diyabete. Bashobora gukenera guhindura imiti yawe ya diyabete cyangwa gahunda yo gukurikirana mugihe urimo gufata tepotinib.

Niba ugize umubyimbirwe (edema) uva kuri tepotinib, ibi rimwe na rimwe bishobora gutuma imicungire ya diyabete igorana cyane. Muganga wawe ashobora gutanga ingamba zo gucunga neza ibi byombi mugihe ukomeje kuvurwa kanseri yawe.

Ninkora iki niramuka nfashe tepotinib nyinshi bitunguranye?

Niba ufata tepotinib nyinshi bitunguranye kurusha uko byagutegetswe, vugana n'umuganga wawe cyangwa ikigo gishinzwe ubumara ako kanya. Ntukegere ngo urebe niba ibimenyetso bigaragara - gutabara hakiri kare buri gihe ni byiza.

Kunywa tepotinib nyinshi bishobora kongera ibyago byo kugira ingaruka zirimo isesemi ikabije, kuruka, cyangwa kubyimba. Itsinda ryawe ry'ubuzima rishobora kwifuza kugukurikiranira hafi cyangwa gutanga ubufasha kugirango bufashe gucunga ibimenyetso byose.

Bika tepotinib mu gikoresho cyayo cy'umwimerere hamwe n'inyandiko zisobanutse kugirango wirinde gufata doze nyinshi bitunguranye. Tekereza gukoresha umuteguro w'ibinini cyangwa gushyiraho ibyibutsa kuri terefone kugirango bigufashe gufata doze ikwiye ku gihe cyiza.

Ninkora iki ninsimbye doze ya tepotinib?

Niba usimbye doze ya tepotinib, yifate ako kanya wibuka, keretse igihe kigeze cyo gufata doze yawe itaha. Muri urwo rubanza, simba doze wasimbye ukomeze gahunda yawe isanzwe.

Ntuzigere ufata doze ebyiri icyarimwe kugirango wuzuze doze wasimbye - ibi bishobora kongera ibyago byo kugira ingaruka. Niba utazi neza igihe, vugana n'itsinda ryawe ry'ubuzima kugirango baguhe ubuyobozi.

Niba ukunda kwibagirwa doze, tekereza gushyiraho alarme ya buri munsi cyangwa gukoresha porogaramu yibutsa imiti. Gufata imiti buri gihe bifasha gukomeza urwego rwa medicament mu mubiri wawe kugirango bikore neza.

Nshobora guhagarika ryari gufata tepotinib?

Ugomba guhagarika gufata tepotinib gusa igihe muganga wawe yemeje ko bikwiye, akenshi iyo kanseri ikomeje nubwo ivurwa cyangwa ingaruka zikaba zitagishoboka. Ntuzigere uhagarika gufata tepotinib ku giti cyawe, kabone niyo wumva umeze neza.

Itsinda ryawe ry'ubuzima rizakoresha isesengura risanzwe n'ibizamini by'amaraso kugirango bagenzure uburyo tepotinib ikora neza. Niba umuti ucunga kanseri yawe neza kandi ukawihanganira neza, birashoboka ko uzakomeza kuwufata igihe cyose.

Niba ukeneye guhagarika tepotinib, muganga wawe azaganira ku ntambwe zikurikira n'uburyo bwo kuvura bushoboka. Ntabwo bisaba kugabanya urugero buhoro buhoro - urashobora guhagarika ako kanya igihe bikwiye mu by'ubuvuzi.

Nshobora kunywa inzoga nkanwa tepotinib?

Nubwo nta sano riri hagati ya tepotinib n'inzoga, akenshi ni byiza kugabanya kunywa inzoga mugihe cyo kuvurwa kanseri. Inzoga zirashobora gukomeza ingaruka zimwe nk'isuka, umunaniro, no guhangayika kw'umwijima.

Niba uhisemo kunywa inzoga rimwe na rimwe, banza uganire n'ikipe yawe y'ubuzima. Bashobora gutanga ubujyanama bwihariye bushingiye ku buzima bwawe muri rusange n'uburyo wihanganira tepotinib.

Wibuke ko inzoga zishobora no kwivanga n'ubudahangarwa bwawe n'uburyo uryama, byombi bikaba ari ngombwa kugirango umubiri wawe urwanye kanseri kandi ukire mu kuvurwa.