Tangira ufata methylfolate ku dawosi ntoya cyane iboneka, 400 kugeza 800 mcg rimwe ku munsi mu gitondo, kandi uyifate ibyumweru bibiri kugeza bitatu mbere yo guhindura ikintu icyo ari cyo cyose. Abantu benshi ntibayikeneye. Ikintu kirebana n\'ikimurika muntu cya MTHFR ntacyo gikora ngo uyifate, kandi niba ushobora gutwita, aside ya folic ikomeje kuba amahitamo meza.

  • CDC ivuga ko abantu bafite ikimurika muntu cya MTHFR bashobora gukoresha ubwoko bwose bwa folate, harimo na aside ya folic.
  • Ku rugero rumwe rwo kurya aside ya folic, ingimbi ya 677 TT yerekana folate mu maraso iri munsi ya 16% gusa kuruta CC.
  • Impamvu zemerwa zo kuyifata ziragufi: kongera umuti ukoreshwa ku bifata ku ndwara zo mu mutwe uhagombye kwita kuri muganga, imiti yanditse, cyangwa imiti yisekeje ikozwe na levomefolate.
  • Niba utwite cyangwa uteganya gutwita, komeza ufate 400 mcg ya aside ya folic. Ni uburyo bwagaragaye ko burinda ibibazo byo mu mutwe.
  • Ubuhanga bwo kwandika bwa 7.5 mg na 15 mg ni inyungu ya muganga, ntabwo ari intambwe yo kwigira yo kwishyira hejuru.

Ibyavuye mu gupimwa kwa MTHFR ntibyemeza ko ufata methylfolate

Uburyo bwo kwamamaza hafi buri bucuruzi bwa methylfolate ya MTHFR ni uko ikimurika cyawe cya varian gikoma aside ya folic, bityo ugomba gufata uburyo bumeze kimwe na methyl ya mbere. CDC ivuga neza ko abafite ikimurika muntu cya MTHFR bashobora gukoresha ubwoko bwose bwa folate, harimo na aside ya folic. Iryo jambo rimwe risubira inyuma mu kwamamaza menshi.

Imibare irabyemeza. Abantu bafite ingimbi ya 677 TT bafite folate mu maraso iri munsi ya 16% gusa kuruta abafite CC ku rugero rumwe rwo kurya aside ya folic, kandi kurya aside ya folic biragaragaza folate mu maraso kuruta ingimbi. 16% ni itandukaniro rito, ntabwo ari ibibazo byo mu mubiri.

Iyi varian kandi ntabwo ari ingenzi. Benshi mu bantu bo muri Amerika bafite kopi imwe cyangwa ebyiri za C677T kuruta abazifite, havuyemo hafi 25% b'abantu b'abanyamerika bavuga ko bifuza kandi 10 kugeza 15% b'abantu b'abazungu bo muri Amerika ya Ruguru bafite kopi ebyiri. Kopi ebyiri bivuga ko umuvuduko w'umusemburo ugabanuka, ntabwo umusemburo wabuze.

Dore ibyo imbazi nyinshi zizakubwira: metabolism ya folate ni uruziga rwo gusubiramo, ntabwo ari inzira imwe y'imodoka. Folate ihura ninzira ya MTHFR inshuro nyinshi nkuko homocysteine yongera gukoreshwa, bityo kunywa methylfolate yiteguye ntibishobora "kunesha" umusemburo nkuko ibiyikoresho bibivuga.

Methylfolate irusha aside ya folic mu bibazo bike cyane

Ku bijyanye na methylfolate na aside ya folic, igisubizo cy'ukuri ku bantu benshi ni aside ya folic, kuko ari uburyo bwiza bwagaragajwe. Methylfolate igomba kwibona mu rutonde ngufi rwibibazo: umuganga uyoboye L-methylfolate hamwe na antidepressant kubera igisubizo kidahagije, imiti yanditse, cyangwa uburyo bwo kurwanya inda hamwe na levomefolate.

Ntabwo ari impamvu zikomeye: ibisubizo bya MTHFR byiza, panel yo kwamamaza "methylation", cyangwa kumva utumva utandukanye ku miti ya vitamine isanzwe. Niba ushaka kumenya niba folate yawe nyuma ifite ikibazo, ibizamini bya folate na B12 mu maraso birakubwira byinshi kuruta ingimbi iyo ari yo yose.

Zirikana ibyo methylfolate yo kwandika ikoreye kandi ibyo itakoreye. Ibicuruzwa nka Deplin bigenzurwa na FDA nk'ibiribwa by'ubuvuzi, ntabwo ari imiti yemejwe na FDA, bivuze ko badafashe urugendo rw'umwanya wa mbere kugira ngo bamenye umutekano n'ubushobozi. FDA isobanura ibiribwa by'ubuvuzi nk'ibyo bikozwe kugira ngo bikoreshwe n'ubuyobozi bw'umuganga kugira ngo byite ku ndwara zifite ubushobozi bwo kugaburira bifite uburyo bwashyizweho n'igenzura ry'ubuvuzi.

Kwitwita ni ikibazo cyoroheje cyane. CDC isaba 400 mcg ya aside ya folic buri munsi ku bagore bose bashobora gutwita, yise aside ya folic uburyo bwagaragaye ko burinda ibibazo by'umutwe budafite MTHFR, kandi ko ikibazo gishobora kwigaragaza mbere yuko uziko utwite. Ntugahindure ibyo kugira ngo ufate methylfolate yo ku isoko.

Tangira methylfolate ku nsize nke, kandi uhindure ikintu kimwe icyarimwe

Fata methylfolate gusa nyuma yo kwemeza ko ufite impamvu nyayo yo kuyifata, hanyuma utangire ku dawosi ntoya cyane iboneka, rimwe ku munsi mu gitondo. Fata iyo dawosi ibyumweru bibiri kugeza bitatu kandi ntukore ikindi kintu mu gihe uhagaritse. Ongera gusa wifashishije inama ya muganga. Ntabwo hari inyungu zo gutangira hejuru kandi ntakubazo bwo gusobanura ibyavuyemo niba uhinduye ibintu bitatu icyarimwe.

Mbere yo kurenza dawosi isanzwe yo gufata ibiryo, banza wige dawosi yawe ya folate na B12. Kurya folate nyinshi bishobora guhisha ikibazo cya B12 ku bipimo bisanzwe by'amaraso, kandi ushaka ko iyo mibare yandikwa mbere yuko utangira, ntabwo ari nyuma.

Fata mu gitondo n\'ibiryo. Ibiryo ntibikenewe kugira ngo byinjire, ariko bigabanya isereri, kandi gufata mu gitondo bivuga ko niba dawosi yumva iryoherereye utari kubirwanya nijoro. Hanyuma uhagarare, kandi wandike imitekerereze, imbaraga, gusinzira n'ubwoba uko ugenda, kugira ngo ikintu cyose kibe gikwiriye dawosi kuruta kuvanga ibintu bishya.

Niba usohotse kuri aside ya folic, uzihuza aho kuzihuza. Kwihuriza hamwe ntacyo byongera. Uwo mwigisha ni uwamaze kubimenya: niba utwite cyangwa uteganya gutwita, komeza aside ya folic. Kandi ntutekereze ko dawosi zingana hagati yibicuruzwa, kuko NIH ODS ntabwo yashyizeho burundu uburyo bwo guhindura mcg DFE na mcg y'ubufasha bwa 5-MTHF.

Gukurikirana niho abantu benshi bagwa. Porogaramu imwe y'ibirebana n'ubuzima nka August AI irashobora kugufasha kwandika imitekerereze ya buri munsi, gusinzira n'ibyaha bifatika byatewe n'impinduka muri dawosi kandi ikaba ifite akamaro cyane muganga kuruta kwibuka.

Dawosi ya methylfolate: impinduka kuva 400 mcg kugeza 15 mg ntibyemeza ko wifata

Dawosi ya methylfolate ikubiyemo impinduka ebyiri zidafitanye isano: urwego rw'ibicuruzwa by'ubufasha bugaragazwa na mikrogramo, n'urwego rw'ibiribwa by'ubuvuzi bugaragazwa na miligramo. Nk'urugero, RDA ya folate ni 400 mcg DFE ku munsi ku bakuze na 600 mcg DFE mu gihe cyo gutwita.

Inzego z'ibicuruzwa by'ubufasha zirahari ku buryo bwazo. Tangira kuri 400 kugeza 800 mcg rimwe ku munsi, uhagarare ibyumweru bibiri kugeza bitatu, kandi uzamuke kugera kuri miliyoni 1 gusa niba hari impamvu yihariye kandi nta nyungu yariho. Ni urwo ruziga rwose.

Inzego z'ubuhanga ni 7.5 mg na 15 mg ya L-methylfolate, hafi 20 kugeza 40 inshuro za RDA. Izo nzego zakoreshejwe nk'inyunganizi mu kuvura kugaburirwa kugaburirwa kw'abafata ku ndwara zo mu mutwe, ntabwo ari nk'uburyo busanzwe bwo gufata ibiryo. Ubushakashatsi bwo mu 2025 bugaragaje impinduka ya 40.33% hamwe na L-methylfolate ku bantu badahagije kuruta 26.43% badahari. Ibyo ni impamvu yo kubaza umuganga, ntabwo ari impamvu yo kugura ibikoresho 15 mg.

Ikibazo: nta rwego rwo hejuru rwemejwe kuri 5-MTHF y'ubufasha nk'uko ibyo kuri aside ya folic bibaho. Icyo kibazo ni impamvu yo kwitonda, ntabwo ari uruhushya rwo gufata dawosi nyinshi. Inzira rusange ya CDC irahagije hano, ko byinshi ntibyaba byiza, mu gihe kandi ugaragaza ko aside ya folic yose isohoka mu nkari kandi nta kwangirika kwemejwe ku ruhande rw'aside ya folic yose kwagaragaye. Niba ufite indwara yo mu mizabibu cyangwa mu mpyiko, utwite, cyangwa ufata imiti yo gukumira indwara cyangwa methotrexate, dawosi ni inyungu ya muganga kuruta iy'ikiyiko.

"Folate" ku biyiko ntibisobanura ko ufata L-methylfolate

Ikiyiko cy'ubuyobozi cy'ibyiyiko gusa nticyakubwira niba waguze L-methylfolate. Soma mu bifu byo mu gice cya "Folate". Ushaka L-5-MTHF, levomefolate calcium (Metafolin), cyangwa (6S)-5-MTHF glucosamine salt (Quatrefolic). Ibyo (6S) cyangwa L isomer ni byo bifatika.

Ibigaragaza ibibazo ni uko panel ivuga gusa "folate" cyangwa "aside ya folic", ibintu bya D/L racemic, n'ibintu byahoza mu buryo bwo kwishyira hamwe na folinic acid (calcium folinate), bifitanye itandukaniro na methylfolate.

Reba kandi ibintu bikoreshwa. Ubwoko bwa mcg DFE buruta buri miliyoni nyayo za folate zifite akamaro, ni nayo mpamvu ibitaro bibiri bifuza umubare wa "folate" wa kimwe bashobora gutanga imibare itandukanye. Ibizamini by'impande z'umuryango n'umubare w'umuryango ushobora kwifashishwa biruta ibyo waba ufite ku bifata imiti, kuko ibyiyongeraho ntabwo byemejwe na FDA mbere yo kugurisha.

Ibyababazaga bimwe bivuga guhagarara kandi ugakoreshwa, ntuzamure gusa dawosi

Ibibazo byinshi bya methylfolate ni ibimenyetso bya dawosi, ariko bimwe ntibiba, kandi kubitandukanya ni ubuhanga bukomeye. Ubwoko bwa dawosi ni ubworoheje: ubwoba, guhangayika, kwiruka, gusinzira, kuribwa cyane cyangwa isereri bitangira mu minsi nyuma yo kuzamura dawosi kandi bikarangira mu minsi nyuma yo kugaruka ku dawosi y'inyuma. Ni ikibazo cya dawosi, ntabwo ari urugendo rwo kwanduza cyangwa "ihindurwa rya methylation."

Igisubizo ni cyoroshye. Garuka kuri dawosi yanyuma yari nziza, uhagarare ibyumweru bibiri kugeza bitatu, kandi ntuzongere kwongera kwiyongera utabimenyeshejwe na muganga.

Ibibazo by'imitsi byiharije. Kurya folate nyinshi bishobora guhisha ibikoresho by'B12 ku bipimo by'amaraso mu gihe kwangirika kw'imitsi bikomeje, bityo kuribwa cyangwa kwicwa bikaba bitigera bibaho ku kibazo cyo kwiyongera kwa dawosi. CDC ivuga ko guhana aside ya folic byagombye gutuma ibikoresho bya B12 bidakunda kwiyongera, ariko ayo ni amakuru y'abaturage, ntabwo ari ihumure ku bimenyetso byawe.

Hamagara 911 cyangwa ujye mu gikari cya kibumbiro vuba vuba niba:

  • Ufite kwishima mu maso cyangwa mu mazuru, guhumeka nabi, cyangwa ibisebe.
  • Ufite ibitekerezo by'ubwicanyi bishya cyangwa byiyongereye, impinduka zikomeye mu mitekerereze cyangwa ubwoba nyuma yo gutangira methylfolate cyangwa kongera umuti wa antidepressant.

Fata umwanya wo gusura mu cyumweru gitaha niba:

  • Ufite uburibwe, ubushishimwe, uburembe cyangwa ingorane zo kugenda.
  • Ufite igihe cy'ubutaro cyabuze cyangwa utwite kandi utaratangira aside ya folic cyangwa imiti ya mbere.
  • Ibibazo bikomeje nyuma yo kugaruka ku dawosi ntoya.

Vugana n'umuganga mbere yo gutangira niba:

  • Ufata methotrexate, umuti wo gukumira indwara cyangwa antidepressant.
  • Ufite indwara yo mu mizabibu cyangwa mu mpyiko, indwara yo kwihutira kwigobotora cyangwa B12 itavurwa neza.
  • Utwite, ufite amashereka cyangwa uteganya gutwita.

Niba utazi icyiciro ugiramo, August AI Symptom Checker y'ubuntu irashobora kugufasha gusobanura ibyihutirwa mbere yo gufata icyemezo cyo kujya he.

Kugira ngo wite ku kibazo gikomeye cy'ikiguzi cy'inyongeramusaruro gishya hamwe n'imiti yawe isanzwe, urugendo rwa muganga wa kibumbiro kuri macye cya August ($39) rishobora kuguha umuganga wemewe wo muri Amerika washobora kuganira ku gahunda no gutumiza ibizamini uko bikwiriye. Umuganga ni we ufata icyemezo ku buryo bwose bwo kwandika cyangwa kwipimisha. Uru rugendo rw'amashusho ntirushobora gukora igenzura ry'imitsi ry'umubiri ry'umubiri ryo kwibwa, uburembe cyangwa ingorane zo guhumeka.

Ikibazo gisubizwa kenshi

Ndateganya gutwita kandi imiti yanjye ya mbere irimo methylfolate aho kuba aside ya folic. Ni ikibazo?

Muri rusange ntacyo, ariko wabyibaza ku rugendo rwawe rukurikira aho guhagarika imiti ya mbere. Aside ya folic ni uburyo bufitwe na dane ya prevention by'ibibazo by'umutwe, bityo abaganga benshi bazongeramo ubwoko bwa 400 mcg ya aside ya folic cyangwa baguhindurira imiti ya mbere isanzwe. Uzane igikoresho nyacyo kugira ngo dawosi n'uburyo bishobore gusomwa ku biyiko.

Methylfolate ishobora gusimburana na antidepressant?

Oya. Ubushakashatsi bwashingiye ku buhanga bwo kwandika bwakoresheje nk'inyunganizi kuri antidepressant ku bantu batari bafite igisubizo cy'ibyo, ariko ntibyigeze bikoreshwa nk'isimbura. Guhagarika antidepressant bikaba byihuse bishobora gutera ibibazo byo guhagarika no gusubira inyuma. Niba ushaka guhindura gahunda yawe, icyo kiganiro gikwiriye kuba na muganga wayanditse.

Methylfolate ihura na imiti iyo ari yo yose?

Yego. Methotrexate ikora ku buryo bukabije mu guhagarika inzira za folate, bityo folate yiyongereye ishobora kubihangayikisha, kandi abakumira indwara bafitanye urugero rw'imitsi ibiri n'urwego rwa folate. Antidepressants bifite akamaro kuko kwiyongera guhindura ubuzima bw'ikigo. Wumvishe muganga wese ku byerekeye ko mu gihe uhuye n'ibyo uvuze, ntabwo ari ukubivuga nk'inyuma ya "vitamine gusa.".

Methylfolate ni bimwe na methylated B12 cyangwa B-complex methylated?

Oya. Methylcobalamin ni uburyo bwa vitamine B12, ikigamije cya kimwe. Ibyo bikoresho bya B-complex akenshi bifatanya bombi, ibyo bikaba bikomeye kumenya ibyo intungamubiri zakoresheje ikintu. Niba wemeza niba methylfolate igufitiye akamaro, uyifate nk'igishushanyo kimwe aho kuba mu gihe gikubiye.

"Overmethylation" ni ikintu kivugwa ku methylfolate?

Oya, ntabwo ari nk'uburwayi bumenyerewe bw'ubuvuzi. Ibyo abantu bavuga, ubwoba, gusinzira no kwiruka nyuma yo kwiyongera kwa dawosi, ni byo kandi bifite agaciro. Ariko ifasi igufasha ni dawosi yo hejuru cyane kuri wowe, ikarangira igarutse hasi, kuruta kuba mu miterere ya metabolic ikeneye inyongeramusaruro zidasanzwe.

Nshobora kubona folate ihagije mu biryo aho kuba methylfolate?

Yego, kuri 400 mcg DFE RDA y'abakuze. Imboga z'amababi, ibinyamiswa, imboga za citrus n'imyaka ifite imbaraga birimo ku bantu benshi. Ikigaragaza ni ko gutwita, aho CDC isaba 400 mcg ya aside ya folic ku munsi ku byo kurya, kuko folate yo mu biryo ubwayo idashobora gutanga ubwirinzi bumwe nk'ubw'ibibazo by'umutwe.

Icyo kuvuga

Methylfolate ni amahitamo meza ku bantu bake bafite impamvu yemejwe n'umuganga, kandi ni ibiciro byinshi ku bandi bose. Niba utangira, wigendere hasi, wigendere buhoro, uhindure ikintu kimwe icyarimwe, kandi komeza aside ya folic niba gutwita ari kure.

Kubona: Ingingo ni iy'amakuru gusa kandi ntabwo ifatwa nk'inama y'ubuvuzi. Hamwe buri gihe umuganga ufite ububasha kugira ngo ubashe gusobanura no kwirinda ibibazo. Niba ufite ikibazo gikomeye cy'ubuzima, hamagara 911 cyangwa ujye mu gikari cya kibumbiro cyegereye.