GLP-1 MaPachisi: Zvinoita Here?

GLP-1 maPachisi haana mushonga weGLP 1. Ndiyo yega mutsetse unonyanya kubatsira munyaya ino yose, uye zvose zviri pasi apa zvinozvitsigira.

Zvinhu zvinotengeswa paInternet se"GLP 1 maPachisi" itsvo dzakagadzikana dzine zvinhu zvemasayenzi zvinosanganisira berberine, green tea extract, uye cinnamon. Hazvina semaglutide. Hazvina tirzepatide. Hazvina mvumo yeFDA. Hazvipiwi nachiremba. Uye hapana humbowo hwesainzi hunoratidza kuti zvinogadzira kuderedza uremu kunokosha.

Kana wakatsvaga "GLP-1 maPachisi" uchitarisira kuwana shanduro isingadi jekiseni, isingadhure yeOzempic kana Wegovy, hausi wega. Vanhu mamiriyoni vakatsvaga izvi. Zvinhu izvi zviripo nekuda kwekuda kukuru. Asi sainzi hapo, uye kunzwisisa nei kunogona kukuponesa mari nekusashungurudzika. Iri gwara rinotsanangura kuti maPachisi aya ane chii chaizvo, nei mishonga chaiyo yeGLP 1 isingagoni kuunzwa kuburikidza nePachisi, uye chii chaizvo chinobatsira kana uchida kudzivisa majekiseni.

Anoshanda here GLP 1 maPachisi?

Kwete. Hapana humbowo hwekiriniki hunoratidza kuti maGLP 1 maPachisi anotengeswa pasina mushonga anogadzira kuderedza uremu kunofanana nemishonga yeGLP-1 inopiwa nachiremba.

Chikonzero chacho ndechebhizimisi, kwete kungonzi nezvemutemo chete. Vamiririri veGLP-1 receptor agonists vakadai sesemaglutide-subcutaneous-route" target="_blank" rel="noopener noreferrer">semaglutide netirzepatide-subcutaneous-route" target="_blank" rel="noopener noreferrer">tirzepatide mapetide makuru. Zvakakura, zvinonyanyobva mumvura, uye zvakanyanyogadzirwa necheji kuti zvipinde nepakati peganda rako rekunze (stratum corneum) uye zviise muropa rako. Dr. Sheldon Markowitz, mukuru wekuongorora marwadzo ekunze paEpiscopal Health Services muNew York, vakati kunyangwe Pachisi chaive nemushonga chaiwo weGLP 1, zvingadai zvisingakwanise kuunzwa nepakati peganda uchishandisa tekinoroji iripo.

Iyo hachisi chipingamupinyi chePachisi chete. Ndicho chikonzero nei mushonga wose weGLP-1 wakapiwa mvumo neFDA uri jekiseni (rinopfuura neganda chose chose) kana piritsi rakagadzirirwa zvakasiyana (rinoshandisa tekinoroji yekuvandudza kunyura mudumbu). Hapana nzira yechitatu yekuuunza inoshanda pari zvino.

Zvimwe zvezvinhu zviri mumapachisi aya, sekuziva berberine, zvine humbowo hushoma pamusoro pezvinokonzeresa shuga muropa kana zvakapfurwa nemumromo. Asi "zvakapfurwa nemumromo" ndiyo pfungwa yakakosha. Zvidzidzo zvakaratidza berberine kuderedza shuga muropa zvakabatanidza vanhu vanopfuura makamuri, kwete kunyatsa maPachisi paruoko rwavo. Kunyanya kana berberine kana green tea extract inobva yasvika neganda mumazingazi akakodzera hakusati kwadzidzwapo.

Chii chaizvo chiri mumapaPachisi eGLP 1?

Mishonga iri mumapaPachisi eGLP-1 mazhinji inosanganisira chimwe chezvinhu zvinotevera:

• Berberine (chimwe chezvinhu zvechirimwa chinogona kubata shuga muropa kana chapfurwa)

• Green tea extract (EGCG, chinokurudzira uye antioxidant)

• Cinnamon extract

• Garcinia cambogia

• Pomegranate extract

• Apple cider vinegar

• L glutamine (amino acid)

• B vitamins

• Ginger root extract

Hapana chimwe chezvinhu izvi chiri mushonga unopiwa nachiremba. Hapana chimwe chezvinhu izvi chiri GLP-1 receptor agonists. FDA yakasimbisa kuti hapana GLP-1 maPachisi akapiwa mvumo neFDA kana mishonga ine berberine yakapiwa mvumo neFDA.

Zvakakodzera kunzwisisa kuti zvinoitwa nechimwe chezvinhu zvakajairika, berberine, kana chapfurwa semishonga yekuwedzera. Zvidzidzo zvakaratidza kuti makamuri eBerberine anogona kuderedza shuga muropa uye cholesterol mudiki muvanhu vane chirwere cheshuga cherudzi rwechipiri. Zvinokanganisa chaizvo asi zvishoma, zvinenge zvakafanana nemushonga wechirwere cheshuga metformin pakukwirira. Asi izvo zvidzidzo zvakabatanidza vanhu vanopfuura 500 kusvika 1,500 mg zuva nezuva mumhando yemakamuri. Berberine inobva yasvika neganda? Izvi hazvisati zvadzidzwapo chero mumuyedzo wakabudiswa wevanhu. Hapana akaratidza kuti unowana dose rinobatsira kurapa kuburikidza nePachisi.

Green tea extract (EGCG) ine humbowo hwekufambira mberi kudiki kwekugadzirisa muviri kana yapfurwa sedoro kana kamakara. Zvinokanganisa zvinosvika pamakiro 1 kusvika 3 uremu mudiki munyaya yemwedzi yakati wandei. Zvekare, izvo kana chapfurwa. Kunyanya kana EGCG ichipinda neganda mumazingazi anobatsira kuburikidza nePachisi chakagadzika hakuzivikanwi.

Mamwe mabhurendi akatanga kunyorova zvakare zvigadzirwa zvavo. Kind Patches, chimwe chezvinhu zvakakurumbira paTikTok, chakagadzirisa zvakare "GLP 1 maPachisi" zvichiti "berberine maPachisi" mushure mekunge zvatsoropodzwa, kunyangwe chigadzirwa chacho chisina kuchinja. Iyo yekugadziriswa kwekugadzirisa inokudzosera kune nzira yekutanga yekushambadzira.

Nei GLP-1 maPachisi achinyanya kufarirwa kana asingashande?

Zvikonzero zvitatu, uye zvese zvinoita senzira kubva pakuona kwevatengi.

Chekutanga, mishonga yeGLP-1 inopiwa nachiremba inodhura. Kunyangwe nemapurogiramu evagadziri, mutengo wakaderera webhurendi unodhura $149 pamwedzi. GLP-1 maPachisi anotengwa pa $20 kusvika $40 pamwedzi. Kana uri kubviswa mushonga chaiwo, $30 Pachisi chinoti chiri kuita zvakafanana chinonakidza.

Chechipiri, vanhu vakawanda havadi majekiseni. Kutya kwemapfumo kwakajairika. Pachisi chaunonyatsisa paganda rako chinonzwa chiri nyore, chisinganyanyokurapa, chisinganyanyotyisa.

Chechitatu, kushambadzira kwacho kwakanaka. Zvishambadziro paSocial media zvezvinhu izvi zvakagadzirirwa kutaridzika sezvakabatana nemishonga yeGLP-1 inopiwa nachiremba. Zvinoshandisa mutauro wakawo ("kudzora kudya," "kutsigira pakugadzirisa muviri," "kutsigira GLP-1") uye maitiro akawo ezviratidzo. Kana usingaverenge zvinyorwa zvakadzika, unogona kungofunga kuti uri kutenga shanduro isingadhure chezvinhu zvakawo.

Dambudziko harisi rekuti vanhu vanoda sarudzo iri nyore. Ikodzero inonzwika. Dambudziko nderekuti zvigadzirwa izvi hazviiti sezvazvinogadzira. Sayenzi ye transdermal drug delivery haizvitsigiri zvemidziyo yakadai.

Kune here GLP-1 maPachisi chaiwo ari kugadzirwa?

Hongu. Vatsvagurudzi vezvemishonga vari kushanda pane tekinoroji yemichina-yekupfura Pachisi inogona kuunzwa nemishonga yeGLP-1 neganda. Iyi maPachisi achashandisa mapfumo madiki (asinganzwikwe) anopinda zvishoma zvakadzika kusvika kumukova uri pasi pechifukidziro chekunze cheganda, uko mushonga unogona kupinda muropa.

Kuongorora kwe 2024 muchinyorwa che Advanced Drug Delivery Reviews kwakadzvanya kufambira mberi pamisumo yekupfura michina yekutakura mishonga yepetide kusanganisira GLP-1 receptor agonists. Mapoka akati wandei ezvidzidzo akaratidza huchokwadi pakuona mumhando dzehupenyu, uye zvirongwa zviri pakunyorova zvinopa mukana (pazvinhu zve exenatide) zvakaedza michina-yekupfura Pachisi muvanhu zvichiratidza zvakanaka.

Asi hapana chimwe chezvinhu izvi chiri kutengeswa paInternet. Tekinoroji iri pachikamu chekiriniki, uye hapana mvumo yeFDA yeGLP-1 michina-yekupfura Pachisi yakapiwa kana kutarisirwa munguva pfupi yapfuura. Kana kambani yemishonga chaiyo ikapa imwe, ichava chigadzirwa chinopiwa nachiremba, kwete chinhu chaunotenga paTikTok nemadhora $30.

Chii chaizvo chinobatsira kana usingadi majekiseni?

Kana kupikisa kwako kukuru kumishonga yeGLP-1 kuri majekiseni, pane zvinhu zviviri zvakapiwa mvumo neFDA zvinotorwa nemumromo hazvidi majekiseni zvachose. Kune vanhu vane fivha vakatsvaga chimwe chinhu chiri nyore pane jekiseni revhiki nevhiki, izvi mapiritsi ndizvo zviri padyo nezvinovimbiswa neGLP-1 maPachisi, kunze kwazvo ane mushonga chaiwo uye ane data rekuzvisimbisa.

Piritsi reWegovy (oral semaglutide) igorosi rezuva nezuva rakapiwa mvumo yekuderedza uremu. Kuburikidza neNovoCare Pharmacy, mutengo wekuzvitsvaga unotanga pa $149 pamwedzi kune madhosi akaderera. Inoda dose rakaomarara: unoiisa mudumbu risina chinhu nekunwa mvura shoma uye kumirira maminitsi makumi matatu usati wadya kana kunwa chero chinhu tese.

Foundayo (orforglipron) igorosi rezuva nezuva rakapiwa mvumo yekuderedza uremu rakazara kutanga kwa2026. Inotanga pa $149 pamwedzi kuburikidza nezvirongwa zvakasarudzwa. Kusiyana nemapiritsi e semaglutide, Foundayo haidi mudumbu risina chinhu. Unogona kuiisa chero nguva uchidya kana usingadye, izvo zvinoita kuti ive sarudzo yeGLP-1 iri nyore kwazvo parizvino.

Zvose izvi zvakapiwa mvumo neFDA, mishonga inopiwa nachiremba ine data rekiriniki inoratidza kuderedza uremu hwemuviri hunosvika 10 kusvika 18%. Zvinodhura kupfuura Pachisi, asi zvinoshanda kuburikidza nemaitiro akaedzwa nevanhu zviuru gumi nezvitanhatu.

Kana mari iri chipingamupinyi kupfuura pajekiseni, semaglutide majekiseni akagadzirwa kuburikidza nezvipatara zvakapiwa mvumo zvinodhura madhora $129 kusvika $269 pamwedzi, zvichienderana nepuratifomu nedhosi. Ichiri kupfuura Pachisi, asi mushonga chaiwo weGLP 1 une zvinokanganisa chaiwo.

Chii chaunofanira kungwarira paunenge uchitenga zvigadzirwa zvekuwedzera uremu?

Musika weGLP-1 maPachisi uzere nezviratidzo zvengozi. Hezvino zvaunofanira kutsvaga usati watenga chero chinhu chakashambadzwazve chekuwedzera uremu paInternet.

Kana chigadzirwa chakanzi "GLP-1" pahwindo asi chisingadi mushonga, hachina mushonga weGLP 1. Mishonga yose chaiyo yeGLP 1 inoda mushonga kubva kumunhu akadzidza. Hapana zvimwe.

Kana hwindo rikati "chekuongorora chete" kana "kwete chekushandisa nevanhu," iko kugadzirisa kwezvirongwa. Zvinoreva kuti chigadzirwa chacho hachina kuongororwa kuti chakachengeteka here kana kuti chinopa dose rakarurama.

Kana kushambadzira kuchiita kuti chigadzirwa "chitsigire GLP-1 mazingazi" kana "chitsigire GLP 1 yechisikigo," iko mutauro wezvisungo, kwete mutauro wemishonga. Muviri wako unogadzira GLP 1 yechisikigo nguva dzose paunodya. Iyo hormone inogara masekondi kusvika maminitsi muropa rako. Mishonga yeGLP 1 yakagadzirirwa kugara kwesvondo rese. Chigadzirwa chekuwedzera chinokwidziridza GLP-1 yako yechisikigo nekufambira mberi kudiki hakusi kuita chinhu chakawo.

Kana chigadzirwa chine kuongorora kunoshamisa paTikTok kana Amazon asi hapana data rekiriniki rakabudiswa, zvabuda zvataurwa nevanhu zvingangove zviri placebo effect. Kupfeka Pachisi kunogona kuita kuti munhu ave nepfungwa nezvekudya kwake, uye iyoyo pfungwa inogona kukonzera shanduko shomanana emakiro. Izvi hazvireve kuti Pachisi chakaita chinhu chero zvacho chekune zvakawanda. Kana chigadzirwa chaive nezvinhu zvinokanganisa kuderedza uremu, chaizodzidzwa mune chidzidzo chakadzorwa uye chakabudiswa munyori wakadzorwa. Kusavapo kwe data iro hakusi mukana, ndiwo nyaya yose.

Kana mutengo uchitaridzika kunge uri wakanyanya kunaka kuti uve wechokwadi, ndizvo. Mishonga yeGLP 1 inodhura sezvavanodhura nekuti kugadzira, kuyedza, kugadzira, uye kuiongorora kunodhura. $30 Pachisi chinoti chiri kuita zvakawo nezve $149 kusvika $1,349 pamwedzi mushonga unopiwa nachiremba hausi chipo. Ichi chinhu chakafo chakafo chakafo.

Saka zviri sei kwaunenge uripo?

Anoshanda here GLP 1 maPachisi pakuderedza uremu? Kwete. Kwete nenzira ipi zvayo yakaratidzwa muongororo ye kiriniki. Mapetide mumishonga chaiyo yeGLP-1 akakura kwazvo kuti apinde nepakati peganda rako. Zvisungo zviri mumapaPachisi aya hazvina kuratidzwa kuti zvinogadzira kuderedza uremu kunokosha kana zvaunzwa neganda. Uye FDA yakasimbisa kuti hapana GLP 1 Pachisi chakapiwa mvumo chiripo.

GLP 1 maPachisi chikamu chezvinhu zviripo nekuda kwekuda, kwete nekuda kwesainzi. Vanhu vanoda kutsigirwa kwederedzero uremu kusingadhuri, kusingadi majekiseni, uye iyoyo kuda kwacho kwakakodzera chose. MaPachisi pachavo hazvisi mhinduro.

Kana uchida sarudzo yeGLP 1 isina jekiseni, piritsi reWegovy neFoundayo zviri zvechokwadi, mishonga yakapiwa mvumo neFDA iripo parizvino. Kana uchida nzira yakachipa yekutanga, zvese zvinotanga pa $149 pamwedzi. Kana uchida kunzwisisa kuti zvese zvesarudzo chaiyo yeGLP 1 dzinoyereka sei usati wasarudza, gwara rekuverengwa kwemishonga yeGLP-1 rinotsanangura mushonga wose wakapiwa mvumo wobva wauringanisa.

Chiremba wako anogona kukubatsira kunzwisisa kana mushonga weGLP 1 wakakodzera mamiriro ako ezvinhu uye kuti nzira yekuuunza yakakodzera sei muhupenyu hwako. Hurukuro iyoyo haina mari pahofisi dzakawanda dzevanachiremba vemuno kana mapuratifomu etelehealth, uye zvinokosha kupfuura $30 Pachisi.