Chii chinonzi Adalimumab: Zvazvinoshandiswa, Mushonga, Matambudziko uye Zvimwe

Adalimumab mushonga unopiwa nachiremba unobatsira kudzikamisa immune system yako kana ichishanda zvakanyanya pamuviri wako. Ndizvo zvinodaidzwa nachiremba kuti mushonga we "biologic", zvinoreva kuti unogadzirwa kubva kumasero mhenyu panzvimbo pemakemikari semapiritsi echinyakare.

Mushonga uyu unoshanda nekudzivisa protein chaiyo mumuviri wako inonzi TNF-alpha inokonzera kuzvimba. Funga nezvazvo sekudzikisa vhoriyamu pane mhinduro ye immune system yako, ichibatsira kuderedza kurwadziwa, kuzvimba, uye zvimwe zviratidzo mumamiriro ezvinhu se rheumatoid arthritis uye chirwere cheCrohn's.

Chii chinonzi Adalimumab chinoshandiswa?

Adalimumab inorapa mamiriro akati wandei e autoimmune uko immune system yako inokanganisa zvikamu zvine hutano zvemuviri wako. Chiremba wako angakupa mushonga uyu kana mamwe marapirwo asina kupa rubatsiro rwakakwana kana paunoda mushonga wakasimba kuti utarise zviratidzo zvako.

Mushonga uyu unowanzo shandiswa kurapa rheumatoid arthritis, uko unobatsira kuderedza kurwadziwa kwemajoini uye kudzivirira kumwe kukuvadzwa kwemajoini. Inoshandawo kurapa psoriatic arthritis, iyo inokonzera zvese zviri zviviri zvikamu zve ganda uye kuzvimba kwemajoini.

Kune zvirwere zvinopisa ura zvakaita sechirwere cheCrohn's uye ulcerative colitis, adalimumab inogona kubatsira kuporesa ura uye kuderedza kurwadziwa. Inobatsira zvikuru kana mamiriro aya ari pakati nepakati kusvika akakomba.

Zvimwe zvirwere zvinopindura zvakanaka kuadalimumab zvinosanganisira ankylosing spondylitis (rudzi rwe spinal arthritis), pakati nepakati kusvika kune psoriasis yakakomba, uye mamwe maziso anopisa semu uveitis. Chiremba wako achasarudza kana zvakakunakira mamiriro ako chaiwo.

Adalimumab inoshanda sei?

Adalimumab inoonekwa semushonga wakasimba, wakatarwa unoshanda nekudzivisa TNF-alpha, protein inokonzera kuzvimba mumuviri wako wese. Kana protein iyi ikashanda zvakanyanya, inokonzera kuzvimba kunorwadza uye kukuvadzwa kwetishu kunoonekwa muzvirwere zve autoimmune.

Nokubatanidza ku TNF-alpha uye kudzivirira kuti isashande, adalimumab inokanganisa maitiro ekuputika kubva kwainobva. Izvi zvinobatsira kuderedza zviratidzo zvakaita sekurwadziwa kwemajoini, kuzvimba kweganda, uye kukuvadzwa kwematumbu nekukurumidza zvichienzaniswa nemamwe marapirwo.

Mishonga inowanzo kutanga kuratidza mhedzisiro mukati memavhiki 2-4, kunyangwe vamwe vanhu vachiona kuvandudzwa nekukurumidza. Nekuti mushonga webiologic, unoshanda zvakanyatsojeka kupfuura vanodzvinyirira immune, vachinanga zvikamu zvakatarwa zve immune response.

Zvisinei, nekuti adalimumab inokanganisa immune system yako, inoita kuti uve nyore kutapukirwa. Chiremba wako achakutarisa zvakanyatso kuti uenzanise mabhenefiti ekuderedzwa kwekuputika nekuda kwekuchengeta immune system yako yakasimba zvakakwana kurwisa utachiona.

Ndingatora sei Adalimumab?

Adalimumab inopiwa sejojo pasi peganda rako, kazhinji muzvitsitsinho zvako kana dumbu. Vanhu vazhinji vanozvijova ivo pachavo kumba mushure mekuwana hunyanzvi hwakakodzera kubva kumupi wavo wehutano.

Mishonga inouya mumapeni akazadzwa kana majekiseni anoita kuti kuzvijova kuve nyore. Chiremba wako kana mukoti vachakuratidza chaizvo kuti ungagadzirira sei nzvimbo yekujekiseni, kupa jojo, uye kurasa tsono zvakachengeteka.

Iwe unowanzo jekiseni adalimumab vhiki rega rega, kunyangwe mamwe mamiriro angangoda majekiseni ezuva nezuva pakutanga. Zvakakosha kutenderedza nzvimbo dzekujekiseni kudzivirira kutsamwa kweganda uye kuona kuti mushonga unonyatso kupinda.

Tora mushonga kubva mufiriji maminitsi gumi nemashanu kusvika makumi matatu usati wajekiseni kuti uregere kusvika pakupisa kwemumba, izvo zvinoita kuti jojo rive nyore. Usambofa wakazunza mushonga, uye tarisa kuti wakajeka uye usina ruvara usati wajekiseni.

Unogona kutora adalimumab uine kana usina chikafu sezvo ichijekiseni panzvimbo yekutorwa nemuromo. Zvisinei, dzivisa doro panguva dzekujekiseni, sezvo rinogona kuwedzera njodzi yako yematambudziko echiropa uye kukanganisa immune system yako.

Ndichatora Adalimumab Kwenguva Yakareba Sei?

Vanhu vazhinji vanotora adalimumab kwemwedzi kana makore, zvichienderana nemamiriro avo uye kuti vanopindura sei kurapwa. Kazhinji mushonga wenguva refu panzvimbo yemhinduro yenguva pfupi.

Kune mamiriro akaita se rheumatoid arthritis kana chirwere cheCrohn, unogona kuda kuenderera mberi neadalimumab kwenguva isingagumi kuti urambe uchidzora zviratidzo. Kumisa mushonga kazhinji kunotungamira kudzoka kwezviratidzo mukati memwedzi mishoma.

Chiremba wako achagara achiongorora kuti mushonga uri kushanda sei uye kana uri kusangana nemamwe mativi anokonzera. Vanogona kugadzirisa chirongwa chako chekurapa zvichienderana nekupindura kwako uye hutano hwese.

Vamwe vanhu vanogona pakupedzisira kuderedza kuwanda kwavo kana kumisa zvachose kana mamiriro avo achienda mukuregererwa kwenguva refu. Zvisinei, chisarudzo ichi chinofanira kugara chichiitwa nehutungamiri hwechiremba wako, sezvo kumisa nekukurumidza kunogona kutungamira kumoto.

Ndezvipi Zvinokonzera Adalimumab?

Zvinowanzoitika zveadalimumab zvinowanzoita zvinyoro uye zvinogoneka, kunyangwe zvakakosha kuziva zvekutarisa. Vanhu vazhinji vanowana imwe mhinduro panzvimbo yekujekesa, iyo yakajairika zvachose.

Zvinowanzoitika zvaungacherechedza zvinosanganisira kutsvuka, kuzvimba, kana kukwenya kwaunojekesa mushonga. Izvi zvinokonzeresa nzvimbo yekujekesa zvinowanzoita nani mukati memazuva mashoma uye zvinova zvishoma nezvishoma nekufamba kwenguva.

Vamwe vanhu vanokudziridza zviratidzo zvakaita sechando zvakadai semhino dzinoera, huro inorwadza, kana kutemwa nemusoro kudiki. Izvi zvinoitika nekuti adalimumab inokanganisa immune system yako, ichikuita kuti uve nyore kune zviduku zviduku.

Zvisingawanzoitiki asi zvakanyanya kukomba zvinokonzeresa zvinoda kutariswa kwekurapa nekukurumidza. Izvi zvinosanganisira zviratidzo zveutachiona hwakakomba senge fivha, kutonhora, kukosora kunoramba kuripo, kana kuneta kusinganzwisisike kusingavandudzi nekuzorora.

Heano mativi akakomba ekutarisa zvakanyanya:

• Zvirwere zvakakomba zvinosanganisira fivhiri yeTB, zvirwere zvefungi, kana zvirwere zvebhakitiriya
• Kubuda ropa kusinganzwisisike kana kupwanyika kusingapori zvakajairika
• Fivhiri inoramba iripo kana zviratidzo zvakaita sefuruwenza zvinowedzera nekufamba kwenguva
• Zviratidzo zvitsva kana kuwedzera kwekutadza kwemoyo zvakaita sekufema
• Zviratidzo zveuropi zvakaita sekuchinja kwekuona, kusava nesimba, kana kusanzwa
• Kuchinja kweganda kusanganisira kukura kutsva kana kuchinja mumavanga aripo
• Maitiro akakomba ekuita allergic ane matambudziko ekufema kana kuzvimba

Maitiro aya akakomba haawanzoitika, asi anoda kuongororwa nekukurumidza kwekurapa. Chiremba wako achakubatsira kunzwisisa kuti ndeapi zviratidzo zvinoda kutariswa nekukurumidza zvichienzaniswa neizvo zvaunogona kutarisa kumba.

Zvisingawanzoitiki asi zvinogona kuva nematambudziko akakomba zvinosanganisira kukura kwemamwe marudzi ekenza, kunyanya lymphoma, uye kumutsiridzwa kwehepatitis B muvanhu vakambove nehutachiona uhu. Chiremba wako achatarisa mamiriro aya asati atanga kurapwa.

Ndiani Asingafaniri Kutora Adalimumab?

Adalimumab haikodzeri munhu wese, uye chiremba wako achanyatsoongorora nhoroondo yako yekurapa asati akuraira. Mamwe mamiriro anoita kuti mushonga uyu uve nenjodzi zvekushandisa zvakachengeteka.

Haufaniri kutora adalimumab kana uine hutachiona hunoshanda, kusanganisira zvirwere zvidiki zvakaita sechando kana furuwenza. Mushonga uyu unogona kuita kuti muviri wako utadze kurwisa zvirwere, saka zvakakosha kuti usave nehutachiona usati watanga.

Vanhu vane nhoroondo yeTB, hepatitis B, kana zvimwe zvirwere zvisingaperi vangangoda matanho akakosha kana mamwe marapirwo. Chiremba wako achayedza mamiriro aya asati atanga adalimumab.

Kana uine kutadza kwemoyo kwepakati nepakati, adalimumab inogona kuwedzera mamiriro ako. Mushonga uyu unogona zvakare kuva nematambudziko kana uine nhoroondo yemamwe marudzi ekenza, kunyanya lymphoma kana kenza yeganda.

Heano mamiriro makuru anowanzo kudzivirira kushandiswa kweadalimumab:

• Zvirwere zvinoshanda zverudzi rupi zvarwo, kusanganisira zvirwere zvemazino
• Nhoroondo yeTB isina kurapwa zvakanaka
• Kukundikana kwemoyo kwepakati nepakati kana kwakanyanya
• Mishonga mitsva inoshanda kana zvirongwa zvekuiwana
• Kuzvitakura kana kuyamwisa (kunoda kufungwa kwakakosha)
• Nhoroondo ye lymphoma kana mamwe marudzi ekenza
• Chirwere chechiropa chakanyanya kana hepatitis inoshanda
• Mamwe mamiriro emutsipa akadai se multiple sclerosis

Chiremba wako achafungawo kana uri kutora mamwe mishonga inokanganisa immune system yako, sezvo kubatanidza kurapwa uku kunogona kuwedzera njodzi yekutapukirwa. Vachashanda newe kuti vawane nzira yekurapa yakachengeteka uye inoshanda.

Mazita eAdalimumab Brand

Zita rekutanga rebrand ye adalimumab ndiHumira, iyo yaive vhezheni yekutanga yakatenderwa neFDA. Uyu ndiwo mushonga unozivikanwa nevanhu vazhinji uye izvo zvirongwa zvakawanda zveinishuwarenzi zvinovhara.

Mavhezheni akati wandei e biosimilar e adalimumab aripo ikozvino, kusanganisira Amjevita, Cyltezo, Hyrimoz, uye Hadlima. Izvi zvakafanana zvikuru neHumira asi zvinogona kudhura zvishoma zvichienderana nekavharo yako yeinishuwarenzi.

Mavhezheni ese aya ane chinhu chimwe chete chinoshanda uye anoshanda nenzira imwechete mumuviri wako. Misiyano mikuru iri mumashoko ekugadzira uye pamwe mutengo kana kavharo yeinishuwarenzi.

Chiremba wako nemupharmacy vanogona kukubatsira kuona kuti ndeipi vhezheni yakanakira mamiriro ako zvichienderana nekushanda, mutengo, uye kavharo yeinishuwarenzi. Kuchinja pakati pemavhezheni kazhinji kunoda kutariswa kwekurapa.

Zvimwe zvingashandiswa panzvimbo peAdalimumab

Kana adalimumab isingashande zvakanaka kwauri kana kukonzera matambudziko, mishonga yakati wandei inogona kupa mabhenefiti akafanana. Chiremba wako achakubatsira kuwana sarudzo yakanakisa zvichienderana nemamiriro ako chaiwo uye mhinduro yekurapa.

Zvimwe zvinodzivirira TNF zvakaita se etanercept (Enbrel) uye infliximab (Remicade) zvinoshanda zvakafanana ne adalimumab asi zvine nguva dzakasiyana dzekushandisa uye mhedzisiro dzakasiyana. Etanercept inojekeswa kaviri pavhiki, nepo infliximab ichipiwa se IV infusion mumasvondo masere ega ega.

Mishonga mitsva yebiological inotarisa zvikamu zvakasiyana zve immune system. Izvi zvinosanganisira mishonga yakaita se rituximab, tocilizumab, uye abatacept, iyo inogona kushanda kana TNF inhibitors isingapi rubatsiro rwakakwana.

Kune mamwe mamiriro, mishonga yechinyakare yakaita se methotrexate kana sulfasalazine inogona kukwana yega kana pamwe chete nemishonga yebiological. Chiremba wako achafunga nezve kuoma kwezviratidzo zvako, mararamiro, uye nhoroondo yekurapa paanenge achikurudzira dzimwe nzira.

Ko Adalimumab Ari Nani Pane Methotrexate?

Adalimumab uye methotrexate zvinoshanda zvakasiyana uye zvinowanzo shandiswa pamwe chete panzvimbo pekurapa kunokwikwidzana. Methotrexate inowanzoedzwa kutanga nekuti yanga ichishandiswa kwenguva refu uye inodhura zvishoma pane adalimumab.

Adalimumab inowanzo shanda nekukurumidza uye inogona kushanda zvakanyanya kune zviratidzo zvakakomba, asi inodhurawo uye inotakura njodzi yakakwira yezvirwere zvakakomba. Methotrexate inoshanda zvishoma nezvishoma asi ine rekodhi yakareba yekuchengeteka uye kushanda.

Vanhu vazhinji vanotora mishonga yese miviri pamwe chete, sezvo ichiwedzerana zvakanaka. Methotrexate inogona kubatsira kudzivirira muviri wako kubva pakugadzira ma antibodies kurwisa adalimumab, zvichiita kuti mushonga we biological ushande zvakanyanya kwenguva refu.

Chiremba wako achafunga nezvezvinhu zvakaita sekuoma kwezviratidzo, mhinduro dzakapfuura dzekurapa, mutengo, uye hutano hwako hwese paunenge uchisarudza pakati pezvisarudzo izvi. Hapana kana imwe iri

Adalimumab inogona kushandiswa zvakachengeteka muvanhu vane chirwere cheshuga, asi inoda kuongororwa zvakanyanya. Mushonga wacho pachake hauna zvakananga zvaunokanganisa mazinga eshuga yeropa, asi zvirwere zvinogona kuita kuti chirwere cheshuga chinyanye kuoma kudzora.

Sezvo adalimumab inowedzera njodzi yezvirwere, vanhu vane chirwere cheshuga vanofanira kungwarira zvakanyanya pakuongorora zviratidzo zvechirwere. Shuga yeropa yakakwira inogonawo kuita kuti zvinyanye kuoma kurwisa zvirwere, zvichigadzira kunetseka kaviri.

Chiremba wako achashanda pedyo newe kuti aongorore mamiriro ako eautoimmune uye manejimendi ako echirwere cheshuga. Vanogona kukurudzira kuongororwa kakawanda uye kuongororwa kweshuga yeropa paunotanga adalimumab.

Ndoitei Kana Ndikashandisa Adalimumab Yakawandisa Netsaona?

Kana ukabaya adalimumab yakawanda netsaona kupfuura yakanyorwa, taura nachiremba wako kana wemishonga nekukasira kuti uwane gwara. Usamirira kuti uone kana zviratidzo zvichivapo, sezvo kupindira nekukurumidza kwakakosha.

Kupfuura muyero weadalimumab kunonyanya kuwedzera njodzi yako yezvirwere nedzimwe nyaya dze immune system. Chiremba wako anogona kuda kukutarisa zvakanyanya kana kugadzirisa muyero wako unotevera wakarongeka.

Chengeta kurongwa kwemishonga uye cherechedza chaizvo kuti wakatora yakawanda sei uye rini. Ruzivo urwu ruchabatsira mupi wako wehutano kuti aone nzira yakanakisisa yekutora.

Kana ukaona chero zviratidzo zvisinganzwisisike mushure mekutora adalimumab yakawanda, senge fivha, kuneta kusinganzwisisike, kana zviratidzo zvechirwere, tsvaga rubatsiro rwekurapa nekukurumidza.

Ndoitei Kana Ndikakanganwa Dose yeAdalimumab?

Kana ukakanganwa dose yeadalimumab, itore paunorangarira, wobva wadzokera kuchirongwa chako chetsika. Usawedzere madosi kana kutora mishonga yakawanda kuti "ubate".

Kana yasvika nguva yechikamu chako chinotevera chakarongeka, skip dose yakarasika uye uenderere mberi nenguva yako yenguva dzose. Kutora madosi pedyo pedyo kunogona kuwedzera mhedzisiro isina kupa mamwe mabhenefiti.

Kukanganwa mishonga dzimwe nguva kazhinji hakuzokonzeri matambudziko nekukasira, asi edza kuita zvakajairika sezvinobvira. Kushandisa mishonga nguva dzose kunobatsira kuchengetedza huwandu hwemishonga mumuviri mako.

Kana uchikanganwa mishonga kazhinji, funga kuisa zviyeuchidzo pafoni yako kana kushandisa app yekutevera mishonga. Kushandisa mishonga nguva dzose kwakakosha pakuchengetedza kutonga kwezviratidzo.

Ndingamira Rini Kutora Adalimumab?

Usambomira kutora adalimumab usati wataurirana nachiremba wako. Kumira kamwechete kunogona kukonzera kuti zviratidzo zvawedzere, izvo zvinogona kuipa kupfuura zviratidzo zvako zvepakutanga.

Chiremba wako angangofunga kumisa kana kuderedza adalimumab kana mamiriro ako akagadzikana kwenguva yakareba, kana ukaona mhedzisiro yakakomba, kana ukawana kukanganwa kwenguva refu.

Vamwe vanhu vanogona kumira adalimumab mushure memakore ekurapa kwakabudirira, asi sarudzo iyi inofanirwa kugara ichiitwa zvishoma nezvishoma uye nekutariswa kwechiremba. Chiremba wako anogona kuderedza dose zvishoma nezvishoma pane kumira kamwechete.

Kana uchifunga kumira nekuda kwemhedzisiro kana dzimwe nyaya, taura nyaya idzi nachiremba wako. Vanogona kugadzirisa chirongwa chako chekurapa kana kugadzirisa zvaunonetseka nazvo pasina kumisa mishonga zvachose.

Ndinganwa Doro Ndiri Kutora Adalimumab?

Unogona kuva nezvinwiwa zvedoro dzimwe nguva uchitora adalimumab, asi kuenzanisa kwakakosha. Doro neadalimumab zvinogona kukanganisa chiropa chako uye immune system, saka kuzvibatanidza nguva dzose hakukurudzirwi.

Doro rinogona kuwedzera njodzi yako yematambudziko echiropa uye rinogona kukanganisa kugona kweimmune system yako kurwisa zvirwere. Sezvo adalimumab yatove ichiwedzera njodzi yezvirwere, kuwedzera doro kunogona kuwedzera kunetsekana uku.

Kana ukasarudza kunwa, zvigumise kuzvinwiwa chimwe kana zviviri dzimwe nguva uye dzivisa kunwa zvakanyanya. Teerera kuti unonzwa sei uye tarisa chero zviratidzo zvematambudziko echiropa senge kuneta kusinganzwisisike kana kurwadziwa mudumbu.

Taura nachiremba wako nezve tsika dzako dzekunwa doro kuti vakwanise kukupa mazano akakodzera zvichienderana neutano hwako hwese nemimwe mishonga yaunotora.