Chii chinonzi Amifampridine: Zvinoshandiswa, Madosi, Migumisiro Yakaipa uye Zvimwe

Amifampridine mushonga unopiwa nachiremba unobatsira kuvandudza simba remhasuru nekufamba muvanhu vane mamwe mamiriro emuviri asingawanzoitiki. Inoshanda nekusimbisa kutaurirana pakati petsinga dzako nemhasuru, zvichiita kuti zviratidzo zvemagetsi zvifambe nyore uye zviite kuti mhasuru dzisungane.

Mushonga uyu unomiririra tariro yevanhu vanorarama nemamiriro anokonzera kusimba kwemhasuru nekuneta. Kunyange zvazvo ichionekwa semushonga wemhando yepamusoro wezvirwere zvisingawanzoitiki, kunzwisisa kuti inoshanda sei uye zvekutarisira zvinogona kukubatsira kuti unzwe wakavimbika nezvekufamba kwako kwekurapa.

Chii chinonzi Amifampridine?

Amifampridine imushonga unodzivisa potassium channel unowedzera hukama pakati petsinga dzako nemhasuru. Funga nezvazvo sekubatsira kuwedzera zviratidzo zvemagetsi zvinoudza mhasuru dzako kuti riini uye sei kusungana.

Mushonga uyu unouya muchimiro chepiritsi uye ndewemukirasi yemishonga yakagadzirirwa kurapa matambudziko emuviri netsinga. Inokosha zvikuru nokuti inogadzirisa dambudziko rekutaurirana pakati petsinga nemhasuru, panzvimbo pokungovanza zviratidzo.

Pakutanga yakagadzirwa muma1970s, amifampridine yakapfuura nekutsvakurudza kwakawanda uye kugadzirisa. Nhasi, inozivikanwa seimwe nzira yakakosha yekurapa vanhu vane kusimba kwemhasuru kunokanganisa zvakanyanya mabasa avo emazuva ese uye hupenyu hwavo.

Chii chinonzi Amifampridine chinoshandiswa?

Amifampridine inonyanya kupihwa Lambert-Eaton myasthenic syndrome (LEMS), mamiriro asingawanzoitiki eautoimmune anokonzera kusimba kwemhasuru nekuneta. Mamiriro aya anokanganisa nzira iyo magumo etsinga ako anosunungura mumiriri wemakemikari anonzi acetylcholine, iyo yakakosha pakusungana kwemhasuru.

Vanhu vane LEMS vanowanzoona kusimba kunotangira mumakumbo avo uye kunogona kupararira kune mamwe mapoka emhasuru. Kusimba kunowanzoita nani nekushandiswa kwemhasuru kakawanda, izvo zvakasiyana zvakanyanya kubva kune mamwe mamiriro emhasuru uko chiitiko chinoita kuti zvinhu zviwedzere kuipa.

Chiremba wako angangofungawo nezve amifampridine kune mamwe mamiriro asingawanzoitiki e neuromuscular uko kutaurirana pakati petsinga nemhasuru kunokanganiswa. Zvisinei, LEMS inoramba iri iyo inonyanya kuzivikanwa uye yakanyatsoongororwa kushandiswa kwemushonga uyu.

Mushonga uyu unonyanya kubatsira vanhu vanoona zvikuru zvinovhiringidza basa nekuda kwekushaya simba kwavo kwemhasuru. Izvi zvinogona kusanganisira kuoma kufamba, kukwira masitepisi, kana kuita mabasa ezuva nezuva anoda kushanda kwemhasuru kwenguva refu.

Amifampridine Inoshanda Sei?

Amifampridine inoshanda nekudzivisa nzira dzakatarwa mumagumo etsinga dzako ayo anowanzoita kuti potassium ibude mumasero. Nekudzivisa nzira idzi, mushonga unobatsira masero etsinga kuti arambe akashandiswa kwenguva refu, izvo zvinowedzera kuburitswa kwe acetylcholine.

Acetylcholine yakaita sekiyi inovhura kusangana kwemhasuru. Paunenge uine zvakawanda zvemakemikari aya anotumira mameseji aripo, mhasuru dzako dzinogona kupindura zvakanyanya kune zviratidzo zvevhavha. Izvi zvinoshandura kuita simba rakavandudzwa uye kuderedzwa kuneta panguva yemabasa ezuva nezuva.

Mushonga uyu unoonekwa seune simba zvine mwero mune zvaunoita. Vanhu vazhinji vanoona kumwe kuvandudzwa kwesimba remhasuru mukati memavhiki mashoma ekutanga ekurapa, kunyangwe zvingatora mwedzi yakati wandei kuti uwane rubatsiro rwakazara.

Chinoita kuti amifampridine ive yakakosha ndeyekuti inogadzirisa chikonzero chekusimba kwemhasuru muLEMS, panzvimbo yekungorapa zviratidzo. Iyi nzira yakatarwa inowanzoita kuti pave nekuvandudzwa kunoreva zvakawanda mubasa uye mhando yehupenyu.

Ndingatora Sei Amifampridine?

Torai amifampridine sezvinorayirwa nachiremba wenyu, kazhinji katatu kana kana kana pazuva nemadyiro. Kuitora nechikafu kunobatsira kuderedza kusagadzikana mudumbu uye kunovimbisa kunyudzwa kwakanyanya kwemishonga.

Momedza mahwendefa ese nemvura yakazara. Usapwanya, kutsenga, kana kuputsa mahwendefa, sezvo izvi zvinogona kukanganisa nzira iyo mushonga unoburitswa mumuviri wako. Kana uine dambudziko rekumedza mapiritsi, taura nachiremba wako nezve dzimwe sarudzo.

Edza kutora zvikamu zvako panguva dzakafanana zuva rese. Izvi zvinobatsira kuchengetedza mazinga akagadzikana emushonga mumuviri wako, izvo zvakakosha pakuvandudzwa kwesimba remhasuru.

Dzivisa kudya chikafu chikuru, chine mafuta usati watora amifampridine, sezvo izvi zvinogona kukanganisa kunyudzwa. Zvokudya zvakareruka kana zvekudya zvinoshanda zvakanaka. Ramba wakanyatsogadzirwa mvura zuva rese, sezvo izvi zvinotsigira kushanda kwemishonga.

Ndingatora Amifampridine Kwenguva Yakareba Sei?

Amifampridine inowanzoita kurapwa kwenguva refu kwaunoenderera mberi chero ichipa rubatsiro uye uchichigamuchira zvakanaka. Vanhu vazhinji vane LEMS vanoda kurapwa kuri kuenderera mberi kuti vachengetedze kuvandudzwa kwesimba remhasuru dzavo.

Chiremba wako achatarisa mhinduro yako kumushonga mumwedzi mishoma yekutanga uye achigadzirisa chiyero sezvinodiwa. Vamwe vanhu vanoona kuvandudzwa mukati memazuva, nepo vamwe vangada mavhiki akati wandei kuti vawane mhedzisiro yakazara.

Kugadzwa kunowanzoitika kwakakosha kuongorora kuti mushonga uri kushanda sei uye kutarisa chero mhedzisiro. Chiremba wako anogona kuraira bvunzo dzenguva nenguva kuti ave nechokwadi chekuti mushonga haukanganisi rhythm yemoyo wako kana mamwe mabasa emuviri.

Usambomira kutora amifampridine kamwechete usina kutanga wataura nachiremba wako. Zviratidzo zvako zvekusimba kwemhasuru zvinogona kudzoka kana ukamisa mushonga, uye kumira kamwechete kunogona kukonzera mamwe matambudziko.

Ndezvipi Zvipingamupinyi zveAmifampridine?

Vanhu vazhinji vanogona kushandisa amifampridine zvakanaka, asi semishonga yese, inogona kukonzera matambudziko. Kunzwisisa zvekutarisa kunokubatsira kuti unzwe wakagadzirira uye kuziva nguva yekubata chiremba wako.

Matambudziko anowanzoitika ayo vanhu vazhinji vanowana anosanganisira kunzwa kunzwa mumawoko ako netsoka, izvo zvinowanzoita zviri nani muviri wako uchigadzirisa kumushonga:

• Kunzwa kana kusanzwa munwe neminwe yetsoka
• Kunzwa kusvotwa kana dumbu kusagadzikana
• Kutemwa nemusoro
• Kutenderera musoro
• Kutadza kurara
• Zvirwere zvepamusoro zvekufema
• Kurwadziwa kwemuzongoza

Matambudziko aya anowanzoitika anowanzoita nyoro uye anowanzoita asinganyanyi kuoneka nekufamba kwenguva. Kutora mushonga uyu nekudya kunogona kubatsira kuderedza matambudziko ane chekuita nedumbu.

Matambudziko akakomba haawanzoitiki asi anoda kutariswa kwekurapa nekukurumidza. Izvi zvinogona kukanganisa rhythm yemoyo wako uye tsinga dzako:

• Kutapukirwa kana convulsions
• Kurova kwemoyo kusingaite kana moyo unonetsa
• Kutenderera musoro kwakanyanya kana kufenda
• Kurwadziwa muchipfuva kana kufema kwemhepo
• Kusagadzikana kwakanyanya kwemuviri nekutsvuka, kuzvimba, kana kutadza kufema

Kana iwe ukawana chero matambudziko aya akakomba, bata chiremba wako nekukurumidza kana kutsvaga rubatsiro rwekurapa rwekukurumidza. Kuchengeteka kwako ndiko kukosha kukuru, uye zviratidzo izvi zvinoda kuongororwa nekukurumidza.

Ndiani Asingafaniri Kutora Amifampridine?

Amifampridine haina kuchengeteka kune vese, uye mamwe mamiriro ekurapa kana mamiriro anoita kuti isakodzere. Chiremba wako achanyatsoongorora nhoroondo yako yekurapa asati akurudzira mushonga uyu.

Vanhu vane mamwe mamiriro emoyo vanofanira kudzivisa amifampridine nekuti inogona kukanganisa rhythm yemoyo. Izvi zvinosanganisira avo vane nhoroondo yekurova kwemoyo kusingaite kana matambudziko chaiwo e rhythm yemoyo.

Haufaniri kutora amifampridine kana uine nhoroondo yekubatwa kana chirwere chepfari, sezvo mushonga uyu unogona kuderedza chikumbaridzo chekubatwa. Izvi zvinonyanya kukosha kuti ukurukure nachiremba wako kana wakambove nechero rudzi rwechirwere chekubatwa.

Kana uri nepamuviri kana kuyamwisa, amifampridine ingasava yakakodzera. Mushonga uyu unogona kuyambuka placenta uye kupinda mumukaka wemazamu, zvichikwanisa kukanganisa mwana wako. Chiremba wako achayerera zvakanakira nenjodzi zvakanyatso chenjerera mumamiriro ezvinhu aya.

Vanhu vane matambudziko akakomba eitsvo kana chiropa vangangoda kugadziridzwa kwemadosi kana mamwe marapirwo. Nhengo idzi dzinobatsira kugadzirisa nekubvisa mushonga kubva mumuviri wako, saka kushanda kwakakanganiswa kunogona kukanganisa mazinga emishonga.

Mazita eAmifampridine Brand

Amifampridine inowanikwa pasi pemazita akati wandei emhando, neRuzurgi naFirdapse ndiyo mhando dzinonyanya kunyorerwa muUnited States. Ose ari maviri ane chinhu chimwe chete chinoshanda asi anogona kunge aine mafomula akasiyana zvishoma.

Ruzurgi inonyanya kubvumidzwa yeLambert-Eaton myasthenic syndrome muvanhu vakuru nevana. Inowanikwa mumhando dzakawanda dzemahwendefa kuti ibvumire kugadzirisa kwakaringana kwemadosi zvichienderana nezvido zvako.

Firdapse rimwe zita remhando yeamifampridine rinoshandiswa zvakanyanya kurapa LEMS. Chiremba wako achasarudza mhando yakakodzera zvichienderana nemamiriro ako chaiwo uye inishuwarenzi.

Mhando dzakajairika dzeamifampridine dzinogonawo kuwanikwa, zvichienderana nenzvimbo yako uye pharmacy. Murapi wako wemishonga anogona kukubatsira kunzwisisa kuti ndeipi vhezheni yaunogamuchira uye kuona kuenderana mukurapa kwako.

Zvimwe Zvinhu zveAmifampridine

Nepo amifampridine ichiwanzova yekutanga-mutsara kurapwa kweLEMS, dzimwe nzira dziripo kana usingakwanise kuitsungirira kana kusapindura zvakanaka. Sarudzo imwe neimwe inoshanda zvakasiyana uye inogona kunge yakakodzera kune vamwe vanhu.

3,4-diaminopyridine (3,4-DAP) mushonga une hukama hwepedyo unoshanda zvakafanana neamifampridine. Vamwe vanhu vasingapinduri kune mumwe vanogona kubudirira nemumwe, kunyangwe vaine mativi akafanana ekushanda.

Pyridostigmine imwe sarudzo inoshanda nekudzivirira kuparara kweacetylcholine, ichiita kuti kemikari iyi yakakosha iwanikwe zvakanyanya pakukonana kwemhasuru. Inowanzo shandiswa pamwe chete neamifampridine kuti iwedzere mhedzisiro.

Kune vanhu vane autoimmune-related LEMS, mishonga inodzivirira immune system yakaita seprednisone kana azathioprine inogona kubatsira. Izvi zvinoshanda nekuderedza kurwisa kwemuviri kune nerve endings.

Plasma exchange kana intravenous immunoglobulin (IVIG) ndiyo mishonga inogona kupa kuvandudzwa kwenguva pfupi muzviitiko zvakakomba. Izvi zvinowanzo chengeterwa vanhu vasingapinduri zvakakwana kumishonga yemuromo.

Ko Amifampridine Zviri Nani Pane Pyridostigmine?

Amifampridine ne pyridostigmine zvinoshanda kuburikidza nemaitiro akasiyana, uye iyo imwe iri

Chiremba wako achafunga nezvezvinhu zvakaita sezviratidzo zvako zvakajeka, mamwe mamiriro ehutano, uye kuti unotsungirira sei mushonga wega wega paunenge uchisarudza nzira yakanakisisa yekurapa kwauri.

Mibvunzo Inowanzo Bvunzwa Nezve Amifampridine

Amifampridine Yakachengeteka Here Kune Vanhu vane Chirwere Chemoyo?

Amifampridine inoda kufungwa zvakanyanya kana uine chirwere chemoyo, sezvo ichikwanisa kukanganisa rhythm yemoyo. Chiremba wako achada kuongorora mamiriro ako chaiwo emoyo uye anogona kuraira electrocardiogram (EKG) asati atanga kurapwa.

Kana uine chirwere chemoyo chinyoro, unogona kukwanisa kutora amifampridine nekutarisa pedyo. Chiremba wako anogona kuda kukuona kakawanda uye anogona kuraira nguva nenguva moyo rhythm checks kuti ave nechokwadi chekuti mushonga hausi kukonzera matambudziko.

Vanhu vane mamwe matambudziko akakomba emoyo rhythm, senge prolonged QT syndrome, vanofanira kudzivisa amifampridine. Mushonga unogona kuwedzera mamiriro aya uye zvinogona kutungamira kune njodzi moyo rhythms.

Ndingaita Sei Kana Ndikashandisa Amifampridine Yakawandisa Netsaona?

Kana ukatora amifampridine yakawanda netsaona kupfuura yakarairwa, taura nachiremba wako kana nzvimbo yekudzora chepfu nekukasira. Kutora zvakanyanya kunogona kuwedzera njodzi yako yekubatwa nezvirwere uye matambudziko emoyo rhythm.

Tarisa zviratidzo zve overdose, izvo zvinogona kusanganisira kunzwa kunorwadza zvakanyanya, dzungu, kukurumidza kurova kwemoyo, kana kuvhiringidzika. Kana uine zvirwere kana kurasikirwa nepfungwa, fonera masevhisi ekukurumidzira nekukasira.

Usaedze kuzviita kurutsa kunze kwekunge wakarairwa zvakananga nemupi wehutano. Chengeta bhodhoro remushonga newe paunenge uchitsvaga kutarisirwa kwekurapa kuitira kuti vapi vehutano vazive chaizvo zvawakatora uye zvakawanda sei.

Ndingaita Sei Kana Ndikakanganwa Dose ye Amifampridine?

Kana ukakanganwa dose ye amifampridine, itore paunenge uchiziva, kunze kwekunge yava nguva yechikamu chako chinotevera. Muchiitiko ichocho, skip the missed dose uye uenderere mberi nehurongwa hwako hwenguva dzose.

Usambofa wakawedzera mishonga kuti uzadze iyo yausina kutora, nekuti izvi zvinogona kuwedzera njodzi yako yekuwana mhedzisiro. Kutora yakawanda panguva imwe chete kunogona kuva nenjodzi uye kunogona kukonzera matambudziko emoyo kana kubatwa nechando.

Kana iwe uchikanganwa mishonga kazhinji, funga kuisa zviyeuchidzo pafoni yako kana kushandisa chirongwa chemishonga. Kutora mishonga nguva dzose kwakakosha kuchengetedza kusimba kwemhasuru.

Ndingamira Rini Kutora Amifampridine?

Unofanira kungomira kutora amifampridine pasi pekutungamirirwa nachiremba wako. Vanhu vazhinji vane LEMS vanoda kurapwa kwenguva refu kuti vachengetedze kusimba kwemhasuru yavo, uye kumira kunogona kukonzera kuti zviratidzo zvidzoke.

Chiremba wako angangofunga kumisa mushonga kana iwe ukawana mhedzisiro yakakomba isingagoni kugadziriswa, kana kana mamiriro ako ari nani zvakanyanya. Sarudzo iyi inofanira kugara ichiitwa pamwe chete nemupi wako wehutano.

Kana iwe uchida kumisa amifampridine, chiremba wako anogona kuderedza dose zvishoma nezvishoma pane kumira kamwe kamwe. Izvi zvinobatsira kuderedza njodzi yezviratidzo zvekubviswa uye zvinopa nguva yekugadzirisa mamwe marapirwo kana zvichidikanwa.

Ndinganwa Doro Ndiri Kutora Amifampridine?

Zvakanaka kuderedza kunwa doro uchitora amifampridine, sezvo zvese zviri zviviri zvinogona kukanganisa tsinga dzako uye zvinogona kuwedzera mhedzisiro yakaita sedzungu uye kurara. Doro rinogonawo kukanganisa kushanda kwemushonga.

Kana iwe ukasarudza kunwa dzimwe nguva, ita izvi zvine mwero uye teerera kuti unonzwa sei. Vamwe vanhu vanowana kuti kunyange huwandu hudiki hwedoro hunovaita kuti vanzwe vasina kugadzikana kana dzungu kana zvichibatanidzwa neamifampridine.

Gara uchikurukura kushandiswa kwako doro nachiremba wako, sezvo vachigona kupa zano rakagadzirirwa iwe zvichienderana nemamiriro ako chaiwo uye hutano hwese. Vanogona kukurudzira kudzivisa doro zvachose, kunyanya kana uchitanga mushonga.