Chii chinonzi Benralizumab: Zvazvinoshandiswa, Madosi, Matambudziko, nezvimwe

Benralizumab mushonga unopiwa nachiremba unobatsira vanhu vane asthma yakakomba kufema zviri nyore nekunangana nemaseru emuviri anokonzera kuzvimba mumhepo. Mushonga uyu unojekeswa unobva kuboka remishonga inonzi monoclonal antibodies, iyo inoshanda semabhomba anotungamirirwa kuti awane uye avharire maseru anokonzera zviratidzo zveasthma yako.

Kana uri kutarisana neasthma yakakomba isingapinduri zvakanaka kumainhalers echinyakare, chiremba wako angakurudzira benralizumab seimwe nzira yekurapa. Yakagadzirirwa vanhu vane asthma inokonzerwa nemazinga epamusoro eimwe maseru machena eropa anonzi eosinophils.

Chii chinonzi Benralizumab?

Benralizumab mushonga webiologic unonyanya kunangana nekuderedza eosinophils, rudzi rwemaseru machena eropa anogona kuita kuti zviratidzo zveasthma zviwedzere. Funga nezve eosinophils sevashandi vekuchengetedza vanopfuura mumhepo yako vanogadzira kuzvimba kwakanyanya pavanenge vachiedza kukudzivirira.

Mushonga uyu unopiwa sejojo subcutaneous, zvinoreva kuti unojekeswa pasi peganda, zvakafanana nekuti vanhu vane chirwere cheshuga vanozvipa majekiseni e insulin. Jekiseni rinowanzoitwa muruoko rwako rwekumusoro, chidya, kana dumbu.

Benralizumab ndizvo zvinodaidzwa nachiremba kuti "targeted therapy" nekuti haikanganisi muviri wako wese wekudzivirira chirwere. Pane kudaro, inotarisa pane imwe nzira chaiyo inobatsira kuzviratidzo zveasthma yakakomba.

Chii chinonzi Benralizumab chinoshandiswa?

Benralizumab inonyanya kushandiswa kurapa asthma yakakomba ye eosinophilic muvanhu vakuru nevana vane makore gumi nemaviri zvichikwira. Chiremba wako anogona kukurudzira mushonga uyu kana asthma yako isingadzorwi zvakanaka pasinei nekushandisa high-dose inhaled corticosteroids pamwe nemumwe mushonga wekudzora.

Mushonga uyu unobatsira zvikuru vanhu vane chirwere chinonzi "eosinophilic asthma," uko bvunzo dzeropa dzinoratidza mazinga akakwira eeosinophils. Masero aya anogona kukonzera kuzvimba kunoramba kuripo mumhepo yako, zvichiita kuti zvive zvakaoma kufema uye kuwedzera njodzi yako yekurwiswa neasthma.

Dzimwe nguva vanachiremba vanonyorawo benralizumab yechirwere chakabatana chinonzi eosinophilic granulomatosis with polyangiitis (EGPA), chirwere chisingawanzoitiki cheautoimmune chinogona kukanganisa nhengo dzakawanda dzinosanganisira mapapu.

Benralizumab Inoshanda Sei?

Benralizumab inoshanda nekudzivisa protein inonzi interleukin-5 receptor, iyo yakaita sechiteshi chekugadzika chinoshandiswa neeosinophils kugamuchira zviratidzo. Kana mushonga uyu ukadzivisa ma receptors aya, unodzivirira eosinophils kubva pakutambira mameseji avanoda kuti vararame uye vazhinjike.

Izvi zvinoonekwa semushonga wakasimba uye wakanangana nekuti haingodzvinyiriri zviratidzo kwenguva pfupi. Panzvimbo pezvo, inoderedza huwandu hweeosinophils muropa rako uye matishu, izvo zvinogona kutungamirira mukuzvimba kushoma mumhepo yako nekufamba kwenguva.

Mhedzisiro ye benralizumab inogona kugara kwemavhiki akati wandei mushure mejekiseni rega rega, ndosaka usingade kuitora zuva nezuva semishonga yechinyakare yeasthma. Vanhu vazhinji vanotanga kuona kuvandudzwa muzviratidzo zvavo zveasthma mukati memavhiki mashoma kusvika kumwedzi mishoma yekutanga kurapwa.

Ndinofanira Kutora Sei Benralizumab?

Benralizumab inopiwa sejekiseni repasi peganda mwedzi miviri yega yega kwemadosi matatu ekutanga, wobva wapiwa mwedzi miviri yega yega mushure meizvozvo. Mupi wako wehutano achakudzidzisa maitiro ekuzvipa iwe jekiseni kumba, kana kuti unogona kuita kuti ipiwe muhofisi yachiremba wako.

Usati wajekisa, rega mushonga uuye kutembiricha yemumba nekuiisa kunze kwefiriji maminitsi makumi matatu zvisati zvaitika. Izvi zvinobatsira kuderedza chero kusagadzikana kubva mujekiseni. Unogona kuijekisa muruoko rwako rwekumusoro, chidya, kana dumbu, uchichinjana nzvimbo dzekujekisa nguva imwe neimwe.

Hapana chikonzero chekutora benralizumab pamwe chete nechikafu kana kudzivisa kudya usati wajowa. Zvisinei, unofanira kuramba uchitora mamwe mishonga yako yeasthma sezvakanyorwa, sezvo benralizumab yakagadzirirwa kushanda pamwe chete nechirongwa chako chiripo chekurapa, kwete kuitsiva.

Nguva dzose geza maoko ako zvakanyatsonaka usati wabata jekiseni, uye usambofa wakazunza mushonga. Kana ukaona chero tumapundu kana ruvara rusina kujeka mumushonga, usashandise uye taura ne pharmacy yako kuti uwane mumwe.

Ndingatora Benralizumab Kwenguva Yakareba Sei?

Vanhu vazhinji vanotora benralizumab kwenguva yakareba, kazhinji makore, chero bedzi ichiramba ichibatsira kudzora zviratidzo zvavo zveasthma. Chiremba wako anowanzoongorora kuti mushonga uri kushanda sei mushure memwedzi inenge 4 kusvika ku6 yekurapa.

Kana uri kuona kuvandudzwa kukuru mukudzora kwako asthma, zviratidzo zvishoma, uye kuderedzwa kwekudiwa kwemishonga yekununura, chiremba wako anogona kukurudzira kuenderera mberi nebenralizumab. Vamwe vanhu vanowana kuti vanogona kuderedza mamwe mishonga yavo yeasthma vachitora benralizumab.

Sarudzo yekumisa benralizumab inoenderana nezvinhu zvakawanda, kusanganisira kuti asthma yako yakadzorwa sei, chero mhedzisiro yaungave uine, uye hutano hwako hwese. Usambofa wakamisa kutora benralizumab kamwechete usina kuzvikurukura nachiremba wako kutanga.

Ndezvipi Zvakaipa ZveBenralizumab?

Semishonga yese, benralizumab inogona kukonzera mhedzisiro, kunyangwe vanhu vazhinji vachizvitsungirira zvakanaka. Mhedzisiro yakajairika inowanzoita nyoro uye inodzoreka.

Heano mhedzisiro yaungangove uine:

• Kurwadziwa nemusoro, izvo zvinokanganisa vanhu vanenge 1 kubva pa10
• Kuhukura kana kutsamwa kwehuro
• Kuita kwenzvimbo yekujowa senge kutsvuka, kuzvimba, kana kurwadziwa kudiki
• Fivha, kunyanya mumazuva mashoma ekutanga mushure mejekiseni
• Kurwadziwa kwemusana kana kurwadziwa kwemhasuru

Mhedzisiro iyi inowanzoita nani yega mukati memazuva mashoma uye kazhinji haidi kumisa mushonga.

Mhedzisiro yakakomba asi isingawanzoitika inogona kusanganisira maitiro akakomba ekuita allergic, anogona kukonzera matambudziko ekufema, kuzvimba kwechiso chako kana huro, kana rash yakapararira. Kana ukaona chero zviratidzo izvi, tsvaga rubatsiro rwekurapa nekukurumidza.

Vamwe vanhu vanogonawo kuona kuwedzera kwekutapukirwa nezvirwere, sezvo benralizumab ichikanganisa chikamu chemuviri wako wekudzivirira chirwere. Tarisa zviratidzo zvechirwere zvakaita sefivha inoramba iripo, kuneta kusinganzwisisike, kana zviratidzo zvisingavandudzi sezvaitarisirwa.

Kazhinji, vamwe vanhu vanogona kukudziridza mamiriro anonzi hypereosinophilic syndrome, uko mazinga eeosinophil anova akanyanya. Izvi zvinonyanya kuitika muvanhu vane hutachiona hwe parasitic, saka chiremba wako achatarisa izvi usati watanga kurapwa.

Ndiani Asingafaniri Kutora Benralizumab?

Benralizumab haikodzeri munhu wese, uye chiremba wako achanyatsoongorora kana zvakakunakira. Hau faniri kutora mushonga uyu kana wakambove nemaitiro akakomba ekuita allergic ku benralizumab kana chero zvinhu zvaro zvekare.

Vanhu vane hutachiona hwe parasitic havafaniri kutanga benralizumab kusvikira hutachiona hwapera zvachose. Mushonga uyu unogona kukanganisa kugona kwemuviri wako kurwisa mamwe marudzi eparasites, zvichikonzera kuti hutachiona huwedzere.

Kana uri nepamuviri kana kuyamwisa, kurukura njodzi nemabhenefiti nachiremba wako. Kunyange zvazvo paine mashoko mashoma pamusoro pe kushandiswa kwe benralizumab panguva yekuzvitakura, inogona kuyambuka placenta uye inogona kukanganisa muviri wako wekudzivirira chirwere chemwana wako.

Vana vari pasi pemakore gumi nemaviri havafaniri kutora benralizumab, sezvo kuchengeteka kwayo nekushanda kwavo zvisina kumiswa muboka rezera iri. Chiremba wako achavawo akangwarira nezvekukuraira kana uine nhoroondo yemamwe mamiriro eautoimmune.

Vanhu vane masisitimu ekudzivirira muviri akakanganiswa kana avo vari kutora mamwe mishonga anodzvinyirira immune system vangada kuongororwa zvakakosha kana vangave vasiri vakakodzera kurapwa nebenralizumab.

Mazita eBenralizumab Brand

Benralizumab inotengeswa pasi pezita rekuti Fasenra munyika zhinji, kusanganisira United States, Canada, uye Europe. Iri ndiro zita rimwe chete remhando rinowanikwa parizvino remushonga uyu.

Fasenra inouya mumajekiseni akazadzwa kare uye mapeni e-auto-injector, zvichiita kuti zvive nyore kwauri kuzvipa iwe pachako kumba. Mushonga uyu unogadzirwa neAstraZeneca uye unoda mushonga kubva kuna chiremba wako.

Parizvino, hapana mhando dzakajairika dzebenralizumab dziripo, izvo zvinoreva kuti Fasenra ndiyo chete sarudzo kana chiremba wako akanyora mushonga uyu.

Zvimwe Zvinhu Zvokutsiva Benralizumab

Kana benralizumab isiri yakanaka kwauri, mamwe mishonga yakati wandei ye-biologic inogona kubatsira kurapa asthma yakakomba. Chiremba wako angangofunga mepolizumab (Nucala) kana reslizumab (Cinqair), iyo zvakare inotarisa eosinophils asi inoshanda zvishoma zvakasiyana.

Kune vanhu vane asthma isiri ye-eosinophilic, dzimwe sarudzo dzinosanganisira omalizumab (Xolair), iyo inotarisa IgE antibodies, kana dupilumab (Dupixent), iyo inovhara nzira dzakasiyana dzinopisa.

Zvimwe zvisiri zve-biologic zvingasanganisira madosi akakwirira e inhaled corticosteroids, long-acting bronchodilators, kana mishonga yemuromo senge montelukast kana theophylline. Chiremba wako achabatsira kuona kuti ndeipi nzira yakanakisa zvichienderana nerudzi rwako rweasthma uye nhoroondo yako yekurapa.

Dzimwe nguva musanganiswa wekurapa unoshanda zvirinani pane chero mushonga mumwe chete, saka chiremba wako angachinja chirongwa chako chose chekurapa pane kungochinja kubva kune imwe biologic kuenda kune imwe.

Ko Benralizumab Ari Nani Kudarika Mepolizumab?

Zvese benralizumab nemepolizumab mishonga inoshanda yeasthma yakakomba ye eosinophilic, asi anoshanda nenzira dzakasiyana zvishoma. Benralizumab inowanzoita kuderedza mazinga eeosinophil zvakanyanya uye kwenguva yakareba pakati pemadosi.

Chinhu chikuru chinobatsira chebenralizumab ndechekuti unongoda majekiseni mumasvondo masere ega ega mushure memadosi ekutanga, nepo mepolizumab ichida majekiseni mumasvondo mana ega ega. Izvi zvinogona kuita kuti benralizumab ive nyore kune vamwe vanhu.

Zvidzidzo zvinoratidza kuti mishonga yese iri miviri inoshanda zvakafanana pakuderedza kurwisa kweasthma uye kuvandudza basa remapapu. Zvisinei, vamwe vanhu vanogona kupindura zviri nani kumushonga mumwe pane mumwe zvichienderana nemaitiro avo emuviri wega wega.

Chiremba wako achafunga nezvezvinhu zvakaita sekuda kwako majekiseni, inishuwarenzi, uye kuti muviri wako wakapindura sei kurapwa kwakapfuura paachisarudza pakati pezvisarudzo izvi. Hapana mushonga uri wese

Usayedze "kugadzirisa" mamiriro acho nekusvetuka mushonga wako unotevera kana kuchinja chirongwa chako chejekiseni wega. Chiremba wako achapa gwara rakatarwa zvichienderana nekuti wakawana mushonga wakawanda sei uye zvakaitika rini.

Ndingaita Sei Kana Ndikakanganwa Dose yeBenralizumab?

Kana ukakanganwa jekiseni rebenralizumab rakarongwa, taura nachiremba wako nekukurumidza sezvinobvira kuti uone nzira yakanakisa yekutora. Kazhinji, unofanirwa kutora dose yakakanganwa nekukurumidza sezvaunorangarira, wobva wenderera mberi nechirongwa chako chese.

Usawedzere madhizi kuti ugadzirise jekiseni rakapotswa. Chiremba wako angachinja chirongwa chako zvishoma kuti akudzose munzira pasina kukanganisa kushanda kwemushonga.

Ndingamira Rini Kutora Benralizumab?

Unofanirwa kungomira kutora benralizumab pasi pekutungamirirwa nachiremba wako, kunyangwe uchinzwa zviri nani. Kumira kamwechete kunogona kutungamira kudzoka kwezviratidzo zvako zveasthma uye pamwe kurwisa kwakakomba kweasthma.

Chiremba wako anowanzo kuda kuona kuvandudzwa kwakagadzikana mukudzora kwako asthma kwemwedzi yakati wandei usati wafunga kana iwe unogona kumisa mushonga zvakachengeteka. Vamwe vanhu vangangoda kuenderera mberi nebenralizumab kwenguva refu kuti vachengetedze kutonga kwakanaka kweasthma.

Ndingafamba NeBenralizumab Here?

Hongu, unogona kufamba nebenralizumab, asi uchafanirwa kuronga pamberi. Mushonga unofanirwa kuchengetwa mufiriji, saka uchada firiji rekufambisa rine ice packs kune rwendo rwakareba kupfuura maawa mashoma.

Kuti ufambe nendege, tora mushonga mupaketi yawo yepakutanga pamwe chete netsamba kubva kuna chiremba wako ichitsanangura kuti unofanirwa kutakura mushonga wejekiseni. Usaise benralizumab mumutoro wakaongororwa, sezvo shanduko yekushisa mumutoro inogona kukuvadza mushonga.