Chii chinonzi Cisplatin: Zvazvinoshandiswa, Mishonga, Zvazvinokonzeresa uye Zvimwe

Cisplatin mushonga une simba wechemotherapy vanachiremba vanoshandisa kurapa mhando dzakasiyana dzekenza. Mushonga uyu wakavakirwa pa platinum unoshanda nekukanganisa kugona kwemasero ekenza kukamukana nekukura, pakupedzisira kubatsira kuderedza tumor kana kudzivirira kenza kubva pakupararira. Iwe uchagamuchira cisplatin kuburikidza neIV drip muchipatara kana nzvimbo yekurapa kenza, uko nyanzvi dzezvokurapa dzinogona kukutarisa zvakanyatso panguva yese yacho.

Chii chinonzi Cisplatin?

Cisplatin ndeyemukirasi wemishonga inorwisa kenza inonzi platinum compounds kana alkylating agents. Funga nezvazvo semushonga unotarwa uyo unonyanya kurwisa masero anokamukana nekukurumidza, ndizvo chaizvo zvinoitwa nemasero ekenza. Mushonga uyu wakatanga kuwanikwa muma1960s uye kubvira ipapo wava mumwe wemishonga inoshanda zvikuru yemamwe marudzi ekenza.

Mushonga uyu unogara uchipiwa intravenously, zvinoreva kuti unoenda zvakananga muropa rako kuburikidza nemuviri. Hauzotore cisplatin semupiritsi kana jekiseni kumba. Panzvimbo pezvo, iwe uchaiwana munzvimbo yekurapa inodzorwa uko vanopa hutano vanogona kuona kuchengeteka kwako uye kubata chero mhedzisiro inogona kuitika.

Cisplatin Inoshandiswa Kunei?

Cisplatin inorapa mhando dzakawanda dzekenza, kazhinji sechikamu chekurapa kwakabatanidzwa nemimwe mishonga yechemotherapy. Oncologist yako inogona kukurudzira cisplatin kana uine testicular cancer, ovarian cancer, bladder cancer, kana mamwe marudzi ekenza yemumapapu. Inoshandiswawo kune misoro nemutsipa, cervical cancer, uye mamwe mapundu muuropi.

Mushonga uyu unoshanda zvakanaka kune testicular cancer, uko wakavandudza zvakanyanya mitengo yekurapa mumakumi emakore apfuura. Kune mamwe marudzi ekenza, cisplatin inogona kushandiswa kuderedza tumors pamberi pekuvhiyiwa, kubvisa masero ekenza akasara mushure mekuvhiyiwa, kana kudzora kenza yepamusoro yakapararira kune dzimwe nhengo dzemuviri wako.

Nguva pfupi yapfuura

Dzimwe nguva vanachiremba vanoshandisa cisplatin pamwe chete ne radiation therapy kuti radiation ive inoshanda zvakanyanya. Iyi nzira yekubatanidza inogona kubatsira zvakanyanya pakurapa mamwe marudzi ekenza yemusoro nemutsipa kana kenza yemuromo wechibereko.

Cisplatin Inoshanda Sei?

Cisplatin inonzi mushonga une simba we chemotherapy unoshanda nekukuvadza DNA mukati memasero ekenza. Kana masero ekenza aedza kukamukana nekuwanda, haakwanise kugadzirisa kukuvadzwa kweDNA uku, izvo zvinoita kuti afe. Iyi nzira inoitika nyore nyore mumasero ekenza anokamukana nekukurumidza kupfuura mumasero mazhinji ane hutano.

Mishonga inonamatira kune DNA tambo uye inogadzira cross-links pakati pavo, zvichinyatsovhiringidza zvinhu zve genetic. Masero ekenza anovimba zvakanyanya nekukwanisa kwawo kukamukana nekukurumidza, saka kana cisplatin ichipindira mune iyi nzira, inonyatso kumisa kenza kubva pakukura nekupararira.

Nepo cisplatin ichinyanya kutarisisa masero ekenza, inogonawo kukanganisa mamwe masero ane hutano anokamukana nekukurumidza, senge ayo ari mumafollicles ako ebvudzi, digestive tract, uye bone marrow. Ichi ndicho chikonzero nei iwe ungave uine mhedzisiro yakaita sekurasikirwa nebvudzi, kusvotwa, kana shanduko mukuverenga kweropa rako panguva yekurapa.

Ndingatora Sei Cisplatin?

Iwe uchagamuchira cisplatin kuburikidza ne IV infusion muchipatara, nzvimbo yekenza, kana kiriniki yekunze. Mushonga uyu unouya semvura yakajeka inosanganiswa nemhinduro yesaline uye inodonhedzwa zvishoma nezvishoma mutsinga yako kwemaawa akati wandei. Chikwata chako chekuchengetedza hutano chichaisa IV line mumaoko ako kana kushandisa central line kana uine imwe.

Usati watora cisplatin yako, iwe unowanzo gamuchira pre-medications kubatsira kudzivirira kusvotwa nekutsvuka. Chikwata chako chekurapa chichakupawo mvura yakawanda kuburikidza ne IV yako kudzivirira itsvo dzako, sezvo cisplatin inogona kukanganisa basa reitsvo. Iyi nzira yekunyudza inowanzoitika zvese pamberi uye mushure me cisplatin infusion yako.

Hamufaniri kudzivisa chikafu musati mapiwa mushonga wecisplatin, asi mungada kudya chikafu chakareruka musati mapiwa mushonga uyu nekuti mishonga inopiwa musati mapiwa cisplatin inogona kukonzera kurara. Vanhu vazhinji vanoona zvichibatsira kuuya nezvokudya zvidiki, mvura, uye zvekuzvivaraidza nazvo kwemaawa akati wandei achanzi mapiwe mushonga uyu.

Vashandi venyu vezvokurapa vachatarisa zviratidzo zvenyu zvakakosha, huwandu hwemvura mumuviri menyu, uye manzwiro enyu panguva yese yamuchapiwa mushonga. Vachatarisawo ropa renyu nguva dzose kuti vaone kuti itsvo dzenyu, nzeve, uye huwandu hweropa zvinoramba zviri munzvimbo dzakachengeteka.

Ndingapiwa Cisplatin kwenguva yakareba sei?

Kureba kwemushonga wenyu wecisplatin kunoenderana nerudzi rwenyu rwegomarara, kuti rakakura sei, uye kuti munopindura sei kumushonga. Vanhu vazhinji vanopiwa cisplatin mumakore, vachipiwa mishonga mumasvondo 3-4 ega ega kwemwedzi yakati wandei. Gore rega rega rinopa muviri wenyu nguva yekupora pakati pemishonga.

Kwemarudzi egomarara emuzvinyama zvevarume, mungapiwa makore 3-4 emishonga yekenza inobva ku cisplatin. Kurapwa kwegomarara remazai emukadzi kazhinji kunosanganisira makore 6, nepo mamwe magomarara angada hurongwa hwakasiyana. Chiremba wenyu wezve oncology achagadzira chirongwa chekurapa chakagadzirirwa mamiriro enyu chaiwo uye achachigadzirisa zvichienderana nekuti munopindura sei.

Chiremba wenyu achatarisa kufambira mberi kwenyu kuburikidza nekutarisa nguva dzose, bvunzo dzeropa, uye kuongororwa kwemuviri. Kana gomarara richipindura zvakanaka uye mativi emishonga achidzoreka, munogona kupedzisa nzira yakarongwa yekurapa. Zvisinei, kana mativi emishonga akava akanyanya kana gomarara risingapinduri, chiremba wenyu angachinja chirongwa chenyu chekurapa.

Ndezvipi Zviri Zvakaipa ZveCisplatin?

Cisplatin inogona kukonzera mativi akasiyana-siyana nekuti inokanganisa masero egomarara nemamwe masero ane hutano mumuviri wenyu. Kunzwisisa zvekutarisira kunogona kukubatsira kugadzirira uye kuziva kuti ungabatana riini nevashandi venyu vezvokurapa.

Zvimwe zvinokonzera zvinowanzoitika zvaungasangana nazvo zvinosanganisira kusvotwa, kurutsa, kuneta, uye kurasikirwa bvudzi kwenguva pfupi. Izvi zvinogona kugadziriswa nemishonga uye rubatsiro, uye zvakawanda zvinovandudzika mushure mekunge kurapwa kwapera.

Hezvino zvimwe zvinowanzoitika zvinokonzeresa vanhu vazhinji vanosangana nazvo:

• Kusvotwa uye kurutsa, izvo zvinogona kudzora nemishonga inorwisa kusvotwa
• Kuneta uye kushaya simba zvinogona kugara mazuva akati wandei mushure mekurapwa kwega kwega
• Kurasikirwa bvudzi, izvo zvinowanzo kutanga 2-3 mavhiki mushure mekutanga kurapwa
• Kuderera kwechido uye shanduko mukuravira
• Kuderera kwehuwandu hweropa, zvichikuita kuti uve nyore kutapukirwa kana kubuda ropa
• Dhiria kana kuvharika
• Maronda mumuromo kana muromo wakaoma

Izvi zvinowanzoitika zvinokonzeresa zvinowanzoitika kwenguva pfupi uye zvinogadziriswa nerutsigiro rwakakodzera kubva kuchikwata chako chehutano.

Vamwe vanhu vanogona kusangana nezvimwe zvinokonzeresa zvakanyanya zvinoda kutarisa zvakanyanya. Chikwata chako chekurapa chichatarisa izvi uye chichagadzirisa kurapwa kwako kana zvichidikanwa.

Zvimwe zvinokonzeresa zvakanyanya zvinogona kusanganisira:

• Matambudziko eitsvo, ndosaka uchagamuchira mvura yakawanda uye uine bvunzo dzeropa dzenguva dzose
• Kurasikirwa kunzwa kana kurira munzeve (tinnitus), kunyanya nemadosi akakwirira
• Kusanzwa kana kunzwa tsinga mumawoko netsoka (peripheral neuropathy)
• Maitiro akakomba ekugadzirisa muviri panguva yekuiswa
• Matambudziko emoyo, kunyanya muvanhu vane matambudziko emoyo aripo
• Kuderera kwakanyanya kwehuwandu hweropa hunowedzera njodzi yekutapukirwa

Nepo izvi zvinokonzeresa zvakanyanya zvisingawanzoitiki, chikwata chako chehutano chinokutarisa zvakanyanya kuti ubate chero matambudziko ekutanga uye uagadzirise zvakakodzera.

Kune zvakare zvimwe zvisingawanzoitiki asi zvinogona kuva nemigumisiro yakakomba yenguva refu iyo chiremba wako achakurukura newe. Izvi zvinogona kusanganisira kurasikirwa kwekunzwa kusingaperi, kukuvadzwa kwematsvo, kana kuwedzera njodzi yekuvandudza gomarara rechipiri makore gare gare. Zvisinei, kune vanhu vazhinji, mabhenefiti ekurapa gomarara razvino anopfuura njodzi idzi.

Ndiani Asingafaniri Kutora Cisplatin?

Vanhu vakati wandei vangave vasiri vakakodzera kurapwa ne cisplatin nekuda kwehutano huripo kana zvimwe zvinhu. Chiremba wako weoncologist achanyatsoongorora kana cisplatin yakakukodzera zvichienderana nehutano hwako hwese uye nhoroondo yezvokurapa.

Ungasagona kugamuchira cisplatin kana uine chirwere chakakomba cheitsvo, kurasikirwa kukuru kwekunzwa, kana mamwe mamiriro emoyo. Vanhu vane hutachiona hunoshanda kana masisitimu ekudzivirira muviri akakomba vanogonawo kuda kumirira kana kufunga nezveimwe nzira dzekurapa.

Mamiriro chaiwo anogona kudzivirira kushandiswa kwe cisplatin anosanganisira:

• Chirwere chakakomba cheitsvo kana kukundikana kwematsvo
• Kurasikirwa kukuru kwekunzwa kana kukuvadzwa kwetsinga dzekunzwa
• Kukundikana kwemoyo kwakanyanya kana kurwisa kwemoyo kwemazuva ano
• Hutachiona hunoshanda, husina kudzora
• Kunyanya kuora kwemuzongoza wemupengo
• Kuzvitakura kana kuyamwisa
• Zvakanyanya allergic reactions kune platinum compounds

Chiremba wako achafungawo nezve zera rako, huwandu hwehutano hwese, uye kurapwa kwapfuura paachifunga kana cisplatin yakakukodzera.

Kana iwe usingakwanise kugamuchira cisplatin, usanetseka. Kazhinji kune mamwe madhiragi echemotherapy anogona kushanda zvakanyanya kumhando yako yegomarara. Chiremba wako weoncologist achashanda newe kuti awane sarudzo yakanakisa yekurapa iyo inoenzanisa kushanda nezvido zvako zvehutano.

Cisplatin Mazita eBrand

Cisplatin inowanikwa pasi pemazita akati wandei emhando, kunyangwe zvipatara zvakawanda uye nzvimbo dzekenza dzichishandisa vhezheni yechinyakare. Zita rinowanzozivikanwa nderekuti Platinol, iyo yaive imwe yemhando dzekutanga dzaivepo dzechirwere.

Mamwe mazita emhando anosanganisira Platinol-AQ, iyo iri mhinduro yemvura (yakavakirwa pamvura) iyo isingade kusanganiswa kwakakosha isati yatanga kushandiswa. Dzimwe nzvimbo dzinogona kushandisa Cisplatin Injection kana mamwe mafomula akajairika ane chinhu chimwe chete chinoshanda.

Zvisinei nezita remhando, mishonga yese ye cisplatin ine mushonga mumwe chete unoshanda uye inoshanda nenzira imwechete. Chikwata chako chekuchengetedza hutano chichashandisa chero fomula yakakodzera zvakanyanya kune yako kurapwa uye zvaunoda zvekurapa.

Zvimwe Zvinhu Zviri Panzvimbo yeCisplatin

Kana cisplatin isina kukodzera iwe, mishonga yakati wandei yekemotherapu inogona kushanda kune akawanda emhando dzakafanana dzekenza. Oncologist yako ichasarudza imwe nzira yakanakisa zvichienderana nerudzi rwako rwekenza, hutano, uye zvinangwa zvekurapa.

Carboplatin inowanzoita imwe nzira yekutanga kufungwa, sezvo yakafanana ne cisplatin asi kazhinji inokonzera matambudziko mashoma eitsvo nekunzwa. Inonyanya kubatsira kune vanhu vasingakwanise kutsungirira mhedzisiro ye cisplatin asi vachiri kuda platinum-based chemotherapy.

Zvimwe zvingasarudzwa zvinogona kusanganisira:

• Carboplatin ye ovarian, mapapu, kana musoro nemutsipa kanseri
• Oxaliplatin yemamwe marudzi ekenza yeropa
• Paclitaxel kana docetaxel yemarudzi akasiyana e solid tumors
• Gemcitabine yemapapu, pancreatic, kana bladder kanseri
• Etoposide ye testicular kana mapapu kanseri
• Bleomycin ye testicular kanseri kana lymphomas

Dzimwe nguva chiremba wako anogona kukurudzira marapirwo matsva akatarisirwa kana mishonga ye immunotherapy panzvimbo yekemotherapu yechinyakare, zvichienderana nezvinhu zvakakosha zvekenza yako uye genetic markers.

Cisplatin Zviri Nani Pane Carboplatin Here?

Ose ari maviri cisplatin uye carboplatin mishonga inoshanda ye platinum-based chemotherapy, asi imwe neimwe ine zvainobatsira nezvazvakaipa. Sarudzo pakati pavo inoenderana nerudzi rwako rwekenza, hutano hwese, uye kugona kutsungirira mhedzisiro.

Cisplatin inowanzofungidzirwa kuti inoshanda zvishoma kune mamwe marudzi ekenza, kunyanya kenza yemapfupa, uko yakaburitsa mitengo inoshamisa yekurapa. Izvo zvakare ndiyo sarudzo inofarirwa kune mamwe marudzi ekenza yemusoro nemutsipa uye mamwe marudzi ekenza yemumapapu kana akabatanidzwa ne radiation therapy.

Zvisinei, carboplatin inokonzera mashoma matambudziko akakomba, kunyanya kukuvara kushoma kwematsvo, kurasikirwa kwekunzwa, uye matambudziko etsinga. Izvi zvinoita kuti ive sarudzo iri nani kune vanhu vakuru, vane matambudziko ematsvo kana ekunzwa, kana vane mamwe mamiriro ehutano anoita kuti cisplatin ive njodzi zvakanyanya.

Kenza yeovari, zvidzidzo zvakaratidza kuti carboplatin inogona kushanda zvakanyanya se cisplatin apo ichiita kuti zvive nyore kutsungirira. Vazhinji oncologists zvino vanosarudza carboplatin yekenza yeovari kurapwa, kunyanya kune varwere vakuru kana avo vane dzimwe nyaya dzehutano.

Oncologist wako achayerera mabhenefiti anogona kuitika nenjodzi dzemushonga wega wega zvichibva pamamiriro ako ega. Dzimwe nguva sarudzo inouya pasi pekuyera mukana mukuru wekurapa kenza yako uchichengetedza hupenyu hwako panguva uye mushure mekurapa.

Mibvunzo Inowanzo Bvunzwa Nezve Cisplatin

Q1. Cisplatin Yakachengeteka Kune Vanhu vane Chirwere cheMatsuwo here?

Cisplatin inogona kuve inonetsa kune vanhu vane matambudziko ematsvo aripo nekuti mushonga unogona kukonzera kumwe kukuvara kwematsvo. Chiremba wako achanyatsoongorora kushanda kwematsvo ako kuburikidza nemiedzo yeropa asati akurudzira cisplatin kurapwa.

Kana uine matambudziko ematsvo akapfava, chiremba wako angangokwanisa kushandisa cisplatin aine kungwarira kwakawanda, senge mamwe mvura yeIV uye kuongorora kakawanda. Zvisinei, kana uine chirwere chematsvo chakati wandei, oncologist wako anozokurudzira carboplatin kana imwe imwe nzira inonyoro pamatsvo.

Kunyangwe vanhu vane itsvo dzinoshanda zvakanaka vanogamuchira mvura yakawanda vasati vatanga uye pashure pe cisplatin kudzivirira itsvo dzavo. Chikwata chako chekurapa chichatarisa kushanda kweitsvo dzako zvakanyanya panguva yekurapa uye chichachinja chirongwa chako chekutarisira kana paine matambudziko achimuka.

Q2. Ndingaita Sei Kana Ndikagamuchira Cisplatin Yakawandisa Netsaona?

Cisplatin overdose haina kumbowanikwa nekuti mushonga unogara uchipiwa munzvimbo yekurapa inodzorwa nevashandi vakadzidziswa. Zvisinei, kana uine hanya nekugamuchira mushonga wakawandisa, usazeza kutaura uye kubvunza mibvunzo pamusoro pemwero wako.

Chikwata chako chehutano chinoverenga mwero wako we cisplatin zvakanyanya zvichienderana nehukuru hwemuviri wako, kushanda kweitsvo, uye hutano hwese. Vanotarisa kaviri mwero kakawanda vasati vapa uye vanokutarisa zvakanyanya panguva yekurapa.

Kana overdose ikaitika, chikwata chako chekurapa chingamisa kubaya ipapo ipapo uye chipe rutsigiro. Izvi zvinogona kusanganisira mvura yakawanda ye IV, mishonga yekudzivirira itsvo dzako, uye kutariswa kwepedyo kwezviratidzo zvako zvakakosha uye basa reropa. Kurapa chaiko kuchatsamira pamushonga wakawanda wawakagamuchira uye nekukurumidza kwakawanikwa dambudziko.

Q3. Ndingaita Sei Kana Ndikakanganwa Dose ye Cisplatin?

Sezvo cisplatin ichipiwa munzvimbo yekurapa zvinoenderana nehurongwa chaihwo, kukanganwa dose kazhinji zvinoreva kuronga zvakare kugadzwa kwako. Kana usingakwanise kuita kurapwa kwako kwakarongwa, taura nechikwata chako cheoncology nekukurumidza sezvinobvira kuti uronge kugadzwa kutsva.

Chiremba wako angada kugadzirisa chirongwa chako chekurapa zvichienderana nekuti sei wakakanganwa dose. Kana usiri kunzwa zvakanaka kana uine hutachiona, vanogona kuda kumirira kusvikira wanzwa zviri nani usati waenderera mberi nekurapa.

Usayedza "kugadzirisa" mushonga wakapotswa nekutora huwandu hukuru gare gare. Chirongwa chako chekurapa chakarongeka zvakanaka kuti muviri wako uve nenguva yekupora pakati pemishonga uchichengetedza kushanda kwemushonga kurwisa kenza yako.

Q4. Ndingamira Rini Kutora Cisplatin?

Haufanire kumisa kurapwa kwecisplatin wega, kunyangwe uri kusangana nemigumisiro kana kunzwa zviri nani. Chiremba wako weoncologist achasarudza kuti zvakakodzera rini kumisa kurapwa zvichienderana nekuti kenza yako iri kupindura sei uye kuti uri kutsungirira sei mushonga.

Vanhu vazhinji vanopedzisa nzira yavo yakarongwa yekurapa cisplatin, iyo inogona kunge iri 3-6 cycles zvichienderana nerudzi rwekenza yavo. Chiremba wako achashandisa scans, bvunzo dzeropa, uye bvunzo dzemuviri kuti aongorore kufambira mberi kwako uye asarudze kana uchida kuenderera mberi nekurapa.

Kana migumisiro ikava yakanyanya, chiremba wako anogona kumbomisa kurapwa kwenguva pfupi kuti muviri wako upore, kana kuti vanogona kukuchinjira kumushonga wakasiyana. Sarudzo yekumisa kurapwa nekukurumidza inogona kuitwa chete kana njodzi dzichikunda mabhenefiti kana kana kenza yako isingapinduri kumushonga.

Q5. Ndingashanda Here Ndichigamuchira Kurapwa kweCisplatin?

Vanhu vazhinji vanokwanisa kuenderera mberi vachishanda panguva yekurapwa kwecisplatin, kunyangwe iwe uchida kuita zvimwe zvigadziriso kuchirongwa chako. Zuva rekurapa nemazuva mashoma mushure meizvozvo ndipo paunowanzo kunzwa kuneta zvakanyanya, saka unogona kuda kuronga mazuva ekushanda akareruka kana kutora nguva yekuzorora panguva iyi.

Kukwanisa kwako kushanda kuchatsamira pazvinhu zvakati wandei, kusanganisira rudzi rwebasa rako, maitiro ako kumushonga, uye simba rako rose. Vamwe vanhu vanonzwa zvakanaka zvakakwana kushanda pamazuva ari pakati pekurapa, nepo vamwe vachida nguva yakawanda yekuzorora nekupora.

Taura nemushandirwi wako nezvekugadzirisa zvirongwa kana kushanda uri kumba kana zvichibvira. Nzvimbo zhinji dzebasa dzinonzwira tsitsi nezvekurapwa kwekurapa uye dzinogona kukwanisa kugadzirisa zvaunoda panguva ino. Chikwata chako chekuchengetwa kwehutano chinogona zvakare kupa zvinyorwa kana uchida kutora zororo rekurapa.