Meloxicam vs Naproxen: Simba, Ngozi yeMudumbu, Mushonga, uye Maitiro Ekusarudza

Hapana akasimba kupfuura mumwe. Mumiedzo yakatarisana, meloxicam 7.5 mg kamwe chete pazuva yakanyaradza marwadzo e arthritis zvakafanana ne naproxen 750 mg pazuva. Musiyano we meloxicam vs naproxen ndiwo maererano ne: meloxicam inongopiwa nachiremba, kamwe chete pazuva, uye inoreruka mudumbu pamadosi akaderera; naproxen inowanikwa pasina mushonga uye inorapa marwadzo akasiyana siyana.

TL;DR: Zvinonyanya Kutaurwa

• Pamadosi akajairika, mishonga miviri iyi inodzora marwadzo e arthritis zvakaenzana. Nhamba dzemilligram hadziendeswi pakati pemishonga yakasiyana.
• Meloxicam yakagadzira zviitiko zvisingafadzi mudumbu zvishoma pane naproxen mumiedzo yemwedzi mitanhatu (30.3% zvichienzaniswa ne44.7%).
• Mukana iwoyo mudumbu wakasimba pa 7.5 mg uye unodzikira pa 15 mg.
• Vose vane yambiro yakafanana yeFDA ine bhokisi yekurwadziwa nemoyo, sitiroko, uye kubuda kweropa mudumbu.
• Usambofa wakavatora pamwe chete. Kuwedzera maNSAID maviri kunowedzera njodzi pasina kuwedzera kunyaradza.

Meloxicam vs naproxen: nzira imwe chete, kuwanikwa kwakasiyana uye marhythm

Meloxicam uye naproxen ese ndiwo ma nonsteroidal anti-inflammatory drugs anovharira kugadzirwa kweprostaglandin, ndicho chikonzero chavanonyaradza marwadzo nekuzvimba nenzira dzakafanana. Meloxicam inongopiwa nachiremba, inotorwa kamwe chete pazuva, uye yakabvumirwa kunyanya pakurapa arthritis. Naproxen inowanikwa nachiremba uye pasina mushonga, inotorwa kaviri kana katatu pazuva, uye inorapa marwadzo akasiyana siyana. Pamadosi akajairika, kunyaradza kwakafanana.

Musiyano mukubvumirwa kushandiswa ndiwo chaiwo. Meloxicam inobvumirwa osteoarthritis, rheumatoid arthritis, uye juvenile idiopathic arthritis muvana vane makore 2 nekuwedzera, uye hapana chimwe. Naproxen inovhara zvirwere izvi zvearthritis pamwe chete kurwadziwa kwemwedzi, musoro, uye marwadzo emhasuru, uye unogona kuiwana seAleve pasina kuona munhu.

Pamagadziriro, musiyano mumwe chete wakakosha. Pamadosi akaderera, meloxicam inotarisisa kuvharisa COX-2 pane COX-1, nepo naproxen inovhara ma enzyme ese zvisingasaruri. COX-1 inobatsira kuchengetedza lining yedumbu, uye chokwadi ichocho ndicho chakakwana chechikonzero che mukurumbira wa meloxicam wekuti uri nyore mudumbu.

Ndeupi akasimba, meloxicam kana naproxen? Miedzo yakati yakaenzana

Vanhu pavanobvunza kuti ndeupi akasimba, meloxicam kana naproxen, vanowanzotsvaga nhamba dzemapiritsi. Pane mhinduro yakananga. Mumiedzo yemwedzi mitanhatu yakavharwa zvisingaoneki kune vanhu vane rheumatoid arthritis, meloxicam 7.5 mg pazuva yainge yakafanana ne naproxen 750 mg pazuva. Zviitiko zvisingafadzi mudumbu zvakaitika mune 30.3% yeboka re meloxicam uye 44.7% yeboka re naproxen, uye maronda akasimbiswa ne endoscopy akawanikwa muboka re naproxen.

Saka 15 mg ye meloxicam haisi dose isingasviki 500 mg ye naproxen. Milligrams dzinoyera uremu hwemolecule, kwete simba rayo, uye hadziendi pakati pemishonga yakasiyana kungofanana nemainches asingaiti mapaundi.

Izvo zvinodzosera nhaurwa yose. Haufanire kusarudza mushonga une simba kupfuura. Unosarudza nzira yezvakaipa uye marhythm yekushandiswa kwemushonga yaunogona kurarama nayo.

• Meloxicam inoenderana kana uchida dose imwe chete pazuva kuti uve nechokwadi chekurapa arthritis kwenguva refu, wakambova nezvinetso mudumbu nemishonga isingasaruri yeNSAID, kana kurangarira madosi ndicho dambudziko rako chaiwo.
• Naproxen inoenderana kana uchida kuwana pasina nguva kana pasina mushonga, marwadzo ako anopfuura arthritis achienda kumwe kusagadzikana, misoro, kana kukwinyika, kana kuti wakatozviona uchikushandira zvakanaka.

Pakurapa arthritis, zvinhu zvinonyanya kukosha ndezvekuti mudumbu mako, moyo wako, uye dose yako

Kuyedza naproxen vs meloxicam pakurapa arthritis, vose vakagamuchira mvumo yeFDA ye osteoarthritis uye rheumatoid arthritis, ne meloxicam ichiwedzera juvenile idiopathic arthritis kubva pazera remakore 2. Simba haringashandiswe pakusarudza. Nhoroondo yako yemudumbu, itsvo, uye moyo ndizvo zvichabatsira.

Hezvino zvinhu zvakawanda zvisingazokunzi: mukana wa meloxicam mudumbu unotsamira pamudziyo. Ongororo yeAmerican Family Physician yakawana kuti kuchengeteka kwakanaka kwemudumbu kunopihwa ne 7.5 mg dose, uye kunodzikira pa 15 mg. Kana mushonga wako uchitaura 15 mg, usafunganya kuti wakachengeta mukana wekuti mudumbu uri nyore wavakawana nedosi yakaderera. Ongororo iyeyo yakawana kuti zviitiko zve thromboembolic hazvina kuwedzerwa ne meloxicam kana zvichienzaniswa ne naproxen, izvo zvinosvibisa pfungwa yekuti naproxen inogara yakachengetedza moyo kupfuura maNSAID. Iyi ihwo kuenzanisa pakati pemishonga iyi miviri, kwete uchapupu hwekuti meloxicam inochengetedza moyo wako.

Mishonga yose miviri ine yakaenzana FDA boxed warning: kuwedzera njodzi yezviitiko zvakakomba, zvinogona kuuraya zvemoyo, uye kubuda kweropa kwakakomba mudumbu, maronda, uye kusvitswa, izvo zvinogona kuitika pasina yambiro. Njodzi inowedzera ne zera rakakura, hutano hwakaipa, kusvuta, uye kunwa doro zvakanyanya.

Kubuda kweropa mudumbu kwakaderera kunowanzova kwakavanzika. Dzimwe nguva chinhu chekutanga chekuona kuva kushaya iron kuonekwa se zvibvumirano zvakaderera zveongororo yeropa yeMCV pachirongwa chekutarisa kwenguva dzose, mwedzi mishoma isati yaitika chero kubuda kweropa kwakajeka. Shandisa dosi yakaderera inobatsira kwenguva pfupi chete inodzora arthritis yako, uye uinyatsoi sezvinhu zvakafanira kuongororazve pane kuzadziswa nguva dzose.

Mushonga kamwe chete pazuva ndicho chikuru chinobatsira che meloxicam

Musiyano wemushonga pakati pe meloxicam vs naproxen ndicho chinhu chakanyanya kushanda chinozviparadzanisa. Meloxicam inotanga pa 7.5 mg kamwe chete pazuva ye osteoarthritis uye rheumatoid arthritis, nechipimo che 15 mg kamwe chete pazuva zvisinei nemhando uye chiyero chakaderedzwa che 7.5 mg pazuva kune vanhu vari pa hemodialysis. Unotora panguva imwe chete zuva rega rega, kana kuti pasina chikafu.

Naproxen inopiwa nachiremba kazhinji kaviri pazuva pakurapa arthritis, nechimiro chekuwedzera chinotorwa kamwe chete pazuva. Naproxen sodium isina mushonga inoshanda zvakanyanya: 1 piritsi maawa 8 kusvika 12 ega ega, kwete mapiritsi anopfuura 2 mumaawa 8 kusvika 12 ega ega, uye mapiritsi anosvika 3 (660 mg) mumaawa 24, ne dose yekutanga yemapuritsi maviri inobvumidzwa muawa yekutanga.

Sei zvichirungwa? Pharmacokinetics. Nguva yehupenyu yaMeloxicam ingangoita 20 maawa sekureva kwemugadziri, nepo naproxen iri pakati pe12 kusvika 17 maawa, saka meloxicam inochengeta chiyero cheropa chakadzikama kwenguva yakazara, uye naproxen inoda kuwedzerwa.

Zvimwe zvinhu zvinonetsa vanhu. Kunyaradza kwakazara kunogona kutora mavhiki maviri kusvika matatu kuti kuoneke, saka hapana mushonga wakakodzera kutongwa mushure memazuva maviri. Uye kuwanikwa pasina mushonga inzira yekuzvidzora yekufungisisa: zviri nyore chaizvo kupfuura muganho weawa 24, kana kuwedzera kuburikidza nechigadzirwa chemushonga wakawanda-chirimba kana chekudzimba, pasina kana chikonzero chekuita.

Kutora vose pamwe chete kunowedzera njodzi kaviri pasina kuwedzera kunyaradza

Mhinduro ipfupi kumubvunzo wekuti unogona here kutora meloxicam uye naproxen pamwe chete ndihore-kwete. Kubatanidza maNSAID maviri kunowedzera njodzi yekubuda kweropa mudumbu nekukuvara kwetsvo uchidzidzisa zvisingawedzeri kunyanya pakudzora marwadzo, nekuti mishonga yose miviri iri kukwikwidzana pamaenzyme akazvitsanangura. Chenjedzo imwe yakafanana inoshanda kune ibuprofen, diclofenac, aspirin, uye zvinopisa ropa kunze kwekunge chiremba akazokuudzai zvakasarudzika.

Verenga zvinyorwa pane chero chinhu chaunotenga chekurwadziwa, fivha, kana kutsamwa kweziso. MaNSAID akavanzwa muzvigadzirwa zvakabatanidzwa ndiyo nzira yakajairika iyo vanhu vanowedzera madosi vasingatarisiri.

Kana chiremba wako achikufambisa kubva kune mumwe mushonga kuenda kune mumwe, hapana chiyero chekuwachisa chinodiwa, asi kuenderera ndicho chinhu chaunoda kudzivisa. Mira mumwe, tanga mumwe, uye tarisira meloxicam kuti itore mazuva mashoma kuti ibude nekuda kwenguva yakareba yehupenyu. Usasunge kiyi nekuzadza naproxen isina mushonga pamusoro pe meloxicam uchimirira kuti mushonga mutsva ubatse. Iri ndiro chipi chakafanana chiratidzo pamusoro chinotsanangura.

Zvimwe zviratidzo zveyambiro yeNSAID zvinoda kutarisirwa nhasi, kwete pakuzadziswa kwako kunotevera

Yambiro yakachengetedzwa haina kunaka. Zviitiko izvi zvinowira, uye izvo zvine nguva yekuwana zvinokodzera kuyeukwa.

Fona 911 kana enda kuchipatara chepakutanga izvozvi kana:

• Une kurwadziwa kwechipfuva, kufema kwakaoma, kusava nesimba kune rimwe divi kana kusadzvokorora, kana kutaura kwakaipa
• Unokosora ropa kana zvinhu zvakaita nekofi grounds
• Zvinyorwa zvako zvitema, zvinonamira, kana zveropa
• Une kurwadziwa kwakadzama kwakadzama mudumbu kwakandisundudza uye usingaregi
• Chiso chako kana mutsipa wako zviinzwisisa, unonetseka kufema, kana iwe ukatanga kuva nezvinyama zvisingatsamwise

Chikamu chinotevera hachinyanyoshamisa asi chinofanira kusamirira musangano wako wakajairika.

Buku musangano mukati mevhiki rinotevera kana:

• Ganda rako kana maziso ako zvitema, urini wako wakadzama, kana kuti unonzwa wakaneta zvisingaite
• Uri kurega kurega, kana makumbo ako nezvitsitsinho zviri kuzvimba
• Une kurwadziwa kwechipfuva kunoramba kuripo kana kurwadziwa mudumbu pane mumwe mushonga
• Marwadzo ako e arthritis achiri kusaongororwa mushure mevhiki rimwe kusvika maviri pamudziyo wakadzikama

Uye usati watanga mumwe mushonga, dzimwe nhoroondo dzinoderedza kukosha.

Taura nachiremba usati watanga kana:

• Wakambova nemaronda kana kubuda kweropa mudumbu, chirwere cheitsvo kana dialysis, kuputika kwemoyo, kuputika kwekutanga kwekurwadziwa kana sitiroko, kana kumanikidzwa kweropa kusingadzorwi
• Wakakanganisira kana uchiedza kuzvitakura, kana uri 65 kana kupfuura
• Unotora anticoagulants, aspirin, SSRIs, diuretics, kana ACE inhibitors

Kana uri kuenzanisa maNSAID anokodzera nhoroondo yako, izvo zvakanaka chaizvo kushandisa August's $39 online urgent care visit, uko chiremba ane rezinesi reUS anogona kuongorora dosi yako yazvino, mimwe mishonga yako, uye zvinhu zvine njodzi, uye kusarudza kana paine mushonga wakakodzera. Kushanya kwepfumo hakugoni kuongorora kubuda kweropa mudumbu, kurwadziwa kwechipfuva, kana zviratidzo zve sitiroko. Zvinoda chipatara chepakutanga. Kune vakuru vane nguva refu vachishandisa maNSAID, Medicare annual wellness visit inzvimbo yechisikigo yekudzokorora kana mushonga uchiri kukosha pane njodzi.

Mibvunzo Inowanzobvunzwa

Ndinogona kutora acetaminophen (Tylenol) ne meloxicam kana naproxen?

Kazhinji hongu. Acetaminophen haisi NSAID uye haishande pamaenzanidzo eprostaglandin anochengetedza lining yedumbu rako, saka vanachiremba vanowanzobatanidza vose kuti uwane kuvharwa kwakakwana. Gara mukati memuganhu we daily maximum we acetaminophen, uye verenga zvese zvaunenge wajekesa, kusanganisira zvinodhaka zvekudzimba uye zvinodhaka zvekubhadhara izvo zvatozvisanganisa.

Meloxicam uye naproxen zvakachengetedza kushandiswa panguva yekuzvitakura?

Kwete. Hapana chiri sarudzo yekutanga panguva yekuzvitakura, uye maNSAID anowanzodzimwa munguva yekuzvitakura nekuda kwezvakaitika pakuonekwa kwemwana mudumbu uye uwandu hwemvura yakakomberedza.

Ndinofanira kudzivisa doro ndichitora meloxicam kana naproxen?

Kwete zvachose. Kunwa kamwe chete hakusi kunorambidzwa nguva dzose, asi doro uye maNSAID zvinokanganisa lining yedumbu nenzira dzakasiyana, saka kuwedzera kunowedzera. Skip doro zvachose kana wakambova nemaronda kana kubuda kweropa mudumbu, uye usambofa wakanywa mudumbu risina chinhu uchitora mushonga wacho nguva dzose.

Ndinogona here kutora meloxicam kana naproxen kana ndiri pamushonga wekumanikidzwa kweropa kana diuretic?

Dzimwe nguva, nekutarisa. MaNSAID anogona kusimudza kumanikidzwa kweropa uye kuderedza simba remishonga yekumanikidzwa kweropa, uye kana akabatanidzwa ne diuretic kana ACE inhibitor vanoderedza kuyerera kweropa kumitsvo. Taura kune wako anopa mushonga nezve mushonga wekumanikidzwa kweropa wese waunotora kuitira kuti zvinokwanisa kuongororwa kweitsvo uye kumanikidzwa.

Ndichada kutarisa kweropa kana itsvo kana ndikaramba ndichitora mushonga wacho kwenguva refu?

Hongu, kazhinji. Kushandiswa kwenguva refu kweNSAID kunoda kutarisa kwenguva nenguva kwehemoglobin, kushanda kweitsvo, enzyme chiropa, uye kumanikidzwa kweropa, nekuti kubuda kweropa nekumanikidzwa kweitsvo zvinowanzokura zvakavanzika. Bvunza chiremba wako kuti zvinowanzoitika sei, uye tora kudzikira kusingatsananguriki kwehemoglobin sezvinhu zvinokosha kuti zviongororwe pane kungozviona nguva dzose.

Pasi pemutsara pakusarudza pakati pe meloxicam ne naproxen

Chisarudzo che meloxicam vs naproxen ndechekuenderana, kwete simba. Kunyaradza kwakafanana pamadosi akajairika, saka sarudza pamusoro pe rhythm yekushandiswa kwemushonga, njodzi yemudumbu nezvitsva zvako, uye kuti marwadzo ako akapararira sei. Mukana wa meloxicam mudumbu unowanikwa pa 7.5 mg uye unodzikira pa 15 mg. Vose vane yambiro yakafanana, uye hapana chiri NSAID yakachengetedza yekushandiswa kwenguva refu pasina kutariswa. Danho rako rinotevera ndinhanho imwe chete: huya nemudziyo wako wezvino, zvinyorwa zvako zvose zvemishonga, uye nhoroondo yako ye GI, itsvo, uye moyo kune chiremba pane kuti ushanduke wega.

Disclaimer: Chinyorwa ichi chinongorongedzwa kuti chipe ruzivo chete uye hachisi kurapwa kwemishonga. Nguva dzose taura nachiremba akakodzera kuti uwane kuongorora uye sarudzo dzekurapa. Kana uchiita dambudziko rekurapa, fonera 911 kana enda kuchipatara chepakutanga nekukurumidza.