Chii chinonzi Reslizumab: Zvazvinoshandiswa, Madosi, Migumisiro Yakaipa uye Zvimwe

Reslizumab mushonga wakakosha wakagadzirirwa kubatsira vanhu vane asthma yakakomba isingapinduri zvakanaka kurapwa kwakajairika. Iyi ndiyo kurapa kwakanangana kunoshanda nekudzivisa protein chaiyo muhurongwa hwako hwekudzivirira muviri inonzi interleukin-5, iyo inoita basa rakakosha mukukonzera kurwisa kweasthma.

Mishonga iyi ndeyeboka remishonga inonzi monoclonal antibodies. Funga nezvayo sechishandiso chechokwadi chinobatsira kudzikamisa mhinduro yekudzivirira muviri inopfuura yakanyanya iyo inoita kuti asthma yakakomba ive yakaoma kudzora nekufema kwenguva dzose uye mapiritsi.

Chii chinonzi Reslizumab chinoshandiswa?

Reslizumab inonyanya kubvumidzwa kurapa asthma yakakomba ye eosinophilic muvanhu vakuru nevana vane makore 18 nemakore. Eosinophilic asthma imhando yakakosha yeasthma yakakomba uko maseru machena eropa anonzi eosinophils anova akanyanya uye anokonzera kuzvimba mumhepo yako.

Chiremba wako anowanzo funga mushonga uyu kana asthma yako ichiramba isina kudzora kunyangwe uchishandisa high-dose inhaled corticosteroids pamwe nemumwe mushonga wekudzora. Yakachengeterwa nyaya idzo kurapwa kwetsika kusingapa zororo rakakwana kubva kuzviratidzo zvakaita sekurwisa kwakawanda kweasthma, kuoma kufema, kana kuderedzwa kwechinhu chemapapu.

Mishonga iyi inonyanya kubatsira vanhu vanowana asthma exacerbations inoda oral corticosteroids kana kushanya kukamuri rekukurumidzira. Inogona kuderedza zvakanyanya huwandu hweflare-ups yakakomba uye kuvandudza hupenyu hwako hwese.

Reslizumab inoshanda sei?

Reslizumab inoshanda nekunangana nekudzivisa interleukin-5, protein inoratidza muviri wako kuti ubudise uye uvhure eosinophils. Aya eosinophils maseru machena eropa ayo, kana akanyanya, anokonzera kuzvimba kukuru mumhepo yako uye anoita kuti zviratidzo zveasthma zive zvakanyanya.

Nekuvharira nzira iyi chaiyo, reslizumab inobatsira kuderedza huwandu hwe eosinophils muropa rako nemapapu. Izvi zvinotungamira mukuvhiringidzika kwemhepo shoma, kurwisa kweshoma kweasthma, uye kufema kuri nani nekufamba kwenguva.

Iri rinotariswa semushonga wakasimba zvine mwero unoshanda zvakasiyana kubva kumishonga yechinyakare yeasthma. Nepo ma inhalers achishanda zvakananga mumapapu ako, reslizumab inoshanda kuburikidza nemuviri wako wekudzivirira chirwere kuti utarise chikonzero cheasthma ye eosinophilic.

Ndingatora Sei Reslizumab?

Reslizumab inopiwa se intravenous infusion, zvinoreva kuti inotumirwa zvakananga muropa rako kuburikidza netsinga muruoko rwako. Iwe uchagamuchira kurapwa uku muhofisi yachiremba wako, muchipatara, kana nzvimbo yekupinza - kwete kumba.

Mushonga unowanzo piwa mwedzi woga woga, uye infusion imwe neimwe inotora maminitsi makumi maviri kusvika makumi mashanu kuti ipedzwe. Chikwata chako chehutano chichakutarisa zvakanyanya panguva uye mushure me infusion yega yega kuti uone chero maitiro.

Usati wapiwa kurapwa kwega kwega, haufanire kutevera chero zvirambidzo zvakakosha zvekudya. Zvisinei, zvakakosha kuti urambe wakanyatsogadzirwa nemvura uye udye zvakajairika kunze kwekunge chiremba wako achikurudzira zvimwe. Unofanira kuramba uchitora mishonga yako yeasthma yakajairika sezvakanyorwa, kunyangwe uchigamuchira reslizumab.

Chiremba wako achaverenga chiyero chako chaicho zvichienderana nehuremu hwemuviri wako, kazhinji 3 milligrams pa kilogram imwe neimwe yehuremu hwemuviri. Iyi dosing yakagadzirirwa munhu mumwe nemumwe inobatsira kuona kuti unogamuchira huwandu hwakakodzera zvaunoda.

Ndingatora Kwenguva Yakareba Sei Reslizumab?

Kureba kwekurapwa kwe reslizumab kunosiyana zvakanyanya kubva kumunhu nemunhu, zvichienderana nekuti unopindura sei kumushonga uye kutonga kwako kwese kweasthma. Vanhu vazhinji vanoramba vachirapwa kwemwedzi yakati wandei kusvika kumakore kuti vachengetedze mabhenefiti.

Chiremba wako anowanzoongorora kufambira mberi kwako mushure memwedzi mishoma yekutanga yekurapa. Vanoona zvinhu zvakaita sekuti unowanzoita sei kurwisa kweasthma, kana uchida mashoma ma steroid emuromo, uye kuvandudzwa mumiedzo yako yekushanda kwemapapu.

Vamwe vanhu vanoona kuvandudzwa mukati mekurapa kwemavhiki mashoma ekutanga, nepo vamwe vachida mwedzi yakati wandei kuti vawane mabhenefiti akazara. Chikwata chako chehutano chichashanda newe kuti chizive nguva yakakodzera yekurapa zvichienderana nekupindura kwako wega uye chero mhedzisiro yaungasangana nayo.

Ndezvipi Zvipingamupinyi zveReslizumab?

Kufanana nemishonga yese, reslizumab inogona kukonzera mhedzisiro, kunyangwe vanhu vazhinji vachizvitsungirira zvakanaka. Kunzwisisa zvekutarisira kunogona kukubatsira kuti unzwe wakagadzirira uye kuziva kuti ungabatana riini nechikwata chako chehutano.

Mhedzisiro yakajairika inowanzoita nyoro uye inogoneka. Izvi zvinowanzoitika panguva kana nguva pfupi mushure mekuiswa kwako uye zvinowanzoita nani muviri wako uchigadzirisa kumushonga:

• Kutemwa nemusoro uye kuneta
• Kurwadziwa kwemhasuru kana majoini
• Kutsamwa kwehuro kana kurwadziwa kwehuro
• Kuzara kwemhino
• Nausea kana kusagadzikana mudumbu
• Dizziness
• Ganda rinopindura panzvimbo yekujekesa

Mazhinji emhedzisiro yakajairika iyi inguva pfupi uye inopera yega mukati mezuva kana maviri mushure mekuiswa kwako.

Mhedzisiro yakakomba haisi yakajairika asi inoda kutarisirwa kwekurapa nekukurumidza. Izvi zvinosanganisira maitiro akakomba ekuita allergic panguva kana mushure mekuiswa, ndosaka uchizotarisa zvakanyanya panguva yekurapa:

• Maitiro akakomba ekuita allergic aine zviratidzo zvakaita sekufema kwakaoma, kuzvimba kwechiso kana huro, kana rash yakakomba
• Kudonha kukuru kweropa
• Kurwadziwa muchipfuva kana kurova kwemoyo nekukurumidza
• Dizziness yakakomba kana kufenda
• Zvirwere zvisingawanzoitiki nekuda kwemhedzisiro inogona kuitika pane yako immune system

Zvisingawanzoitika asi zvakakomba zvinogona kusanganisira njodzi yakawedzerwa yemarudzi akati wandei ekenza, kunyangwe njodzi iyi ichiita seinenge yakaderera. Chiremba wako achakurukura zvingaitika izvi zvisingawanzoitiki newe uye achazviyera pamwe chete nemabhenefiti ekurapa asthma yako yakakomba.

Ndiani Asingafaniri Kutora Reslizumab?

Reslizumab haina kukodzera munhu wese, uye chiremba wako achanyatsoongorora kana mushonga uyu wakakodzera mamiriro ako chaiwo. Zvinhu zvakati wandei zvinogona kuita kuti kurapwa uku kusakodzere kana kuda kungwarira kwakakosha.

Haufaniri kugamuchira reslizumab kana wakambove ne allergic reaction yakakomba kwairi munguva yakapfuura. Uye zvakare, mushonga uyu hauna kubvumidzwa vana vari pasi pemakore gumi nemasere, sezvo kuchengeteka uye kushanda kwavo zvisina kumiswa muvarwere vadiki.

Chiremba wako achanyatso chenjerera nezvekupa reslizumab kana uine mamiriro akati wandei anogona kuwedzera njodzi yako yematambudziko:

• Zvirwere zvazvino zviri kushanda kana nhoroondo yezvirwere zvinodzokororwa
• Zvirwere zveparasitic, kunyanya helminth infections
• Immune system yakakanganiswa kubva kune mamwe mishonga kana mamiriro
• Nhoroondo yekenza
• Kuzvitakura kana kuyamwisa
• Chirwere chakakomba chechiropa kana itsvo

Kana uine chero mamiriro aya, hazvireve kuti haugone kushandisa reslizumab, asi chiremba wako achada kuyera njodzi nemabhenefiti zvakanyanya uye anogona kuda kumwe kuongorora.

Reslizumab Mazita eBrand

Reslizumab inotengeswa pasi pezita rekuti Cinqair muUnited States nedzimwe nyika. Iri ndiro zita rekutanga rebrand rauchasangana naro paunenge uchikurukura mushonga uyu nechikwata chako chehutano kana pharmacist.

Mudzimwe nzvimbo, unogona kuzviwana pasi pemazita akasiyana emhando, asi mushonga unoshanda unogara wakafanana. Nguva dzose simbisa nachiremba wako kuti uri kuwana mushonga wakarurama, kunyanya kana uchifamba kana kuwana kurapwa mumasisitimu akasiyana ekuchengetwa kwehutano.

Zvimwe Zvinotsiva Reslizumab

Mishonga yakati wandei inoshanda zvakafanana ne reslizumab ye asthma yakakomba ye eosinophilic, ichikupa iwe nachiremba wako sarudzo dzekuwana kurapwa kwakanakisa kwezvaunoda. Zvimwe zvinotsiva izvi zvakare ma monoclonal antibodies anovavarira nzira dzakasiyana mudziviriro yemuviri.

Mepolizumab (Nucala) mumwe mushonga unovavarira interleukin-5, zvakafanana ne reslizumab. Inopiwa sejojo subcutaneous pasi peganda mumasvondo mana ega ega, izvo vamwe vanhu vanowana zviri nyore kupfuura infusions intravenous.

Benralizumab (Fasenra) inovavarira interleukin-5 receptor uye inopiwawo sejojo subcutaneous. Vamwe vanhu vanosarudza sarudzo iyi nekuti inotungamirirwa mumasvondo masere ega ega mushure memadosi ekutanga ekutanga.

Kune vanhu vane asthma ye allergic, omalizumab (Xolair) inovavarira IgE antibodies uye inogona kunge iri sarudzo iri nani. Dupilumab (Dupixent) imwe sarudzo inovavarira interleukin-4 uye interleukin-13 nzira.

Chiremba wako achabatsira kuona kuti ndeipi imwe nzira ingashanda zvakanaka zvichienderana nerudzi rwako rwe asthma, mazinga ako e eosinophil, uye zvimwe zvinhu zvakaita sekuda kwako kuwanda kwejekiseni nenzvimbo.

Reslizumab Ari Nani Kupfuura Mepolizumab Here?

Zvese reslizumab ne mepolizumab mishonga inoshanda zvakanyanya ye asthma yakakomba ye eosinophilic, uye hapana imwe yakanyatso

Reslizumab inopiwa se infusion yemu intravenous mwedzi miviri yega yega, nepo mepolizumab ichipiwa sejojo remu subcutaneous raunogona kudzidza kuzvipa iwe kumba. Vamwe vanhu vanoda nyore nyore yekuzvipa jojo, nepo vamwe vachinzwa vakasununguka ne infusions inotarisirwa.

Mishonga yese miviri inotarisa nzira imwecheteyo mumuviri wako wekudzivirira chirwere uye yakaratidza kushanda zvakafanana mumiedzo yekiriniki. Vese vanoderedza zvakanyanya kuwedzera kweasthma uye kudiwa kwema corticosteroids emuromo muvanhu vane severe eosinophilic asthma.

Sarudzo inowanzoenderana nezvinhu zvakaita sekunyaradzwa kwako nemhando dzakasiyana dzejojo, nguva yako yekushanya kukiriniki, uye kuti muviri wako unopindura sei kumushonga wega wega. Chiremba wako achafunga nezvezvinhu izvi pamwe nenhoroondo yako yekurapa kuti akubatsire kuita sarudzo yakanaka.

Mibvunzo Inowanzo Bvunzwa Nezve Reslizumab

Reslizumab Yakachengeteka Kune Vanhu vane Chirwere Chemoyo Here?

Reslizumab inogona kushandiswa zvakachengeteka muvanhu vane chirwere chemoyo, asi cardiologist wako uye pulmonologist vachada kushanda pamwechete kuti vakutarise zvakanyanya. Mushonga wacho pachako hauite zvakananga basa remoyo, asi maitiro e infusion anoda kunyatso tarisa zviratidzo zvako zvakakosha.

Kana uine chirwere chemoyo, timu yako yehutano ichanyatso tarisa kumanikidzwa kweropa rako uye kurova kwemoyo panguva ye infusions. Vanogona zvakare kugadzirisa chiyero che infusion kuti vave nechokwadi chekunyaradzwa kwako nekuchengeteka panguva yekurapa.

Ndingaita Sei Kana Ndikakanganwa Jojo re Reslizumab?

Kana ukakanganwa infusion yako ye reslizumab yakarongwa, taura nemupi wako wehutano nekukurumidza sezvinobvira kuti urongezve. Usaedze kuwedzera madosi kana kugadzirisa kurapwa kwawakakanganwa wega.

Chiremba wako anowanzoisa rimwe zuva rekutora mushonga wawakakanganwa nekukurumidza sezvinobvira, wobva watora mushonga wako wemavhiki mana nguva dzose kubva ipapo. Kukanganwa kutora mushonga kamwe chete kazhinji hakuzokonzeri matambudziko nekukurumidza, asi zvakakosha kuti utore mushonga nguva dzose kuti uwane mhedzisiro yakanaka.

Ndingaita Sei Kana Ndikawana Kurwara Nekuda Kwemushonga Panguva Yekurapwa?

Kana ukaona zviratidzo zvekurwara nekuda kwemushonga panguva yekutora reslizumab, zivisa timu yako yezvehutano nekukurumidza. Zviratidzo zvekucherechedza zvinosanganisira kuoma kufema, kuzvimba kwechiso chako kana pahuro, kuputika kwakanyanya, kana kunzwa kuneta.

Nzvimbo yako yekutora mushonga yakagadzirirwa zvakanaka kubata kurwara nekuda kwemushonga uye ichava nemishonga yekukurumidzira iripo. Vachamisa kutora mushonga nekukurumidza uye vachapa kurapwa kwakakodzera, izvo zvingasanganisira antihistamines, corticosteroids, kana epinephrine kana zvichidikanwa.

Ndingamira Rini Kutora Reslizumab?

Sarudzo yekumisa reslizumab inofanira kugara ichiitwa mukukurukura nachiremba wako, kwete wega. Timu yako yezvehutano ichaongorora nguva dzose mhinduro yako kumushonga uye ichabatsira kuona nguva yakakodzera yekufunga kumisa.

Vamwe vanhu vanogona kumira mushure mekunge asthma yavo yakadzorwa zvakanaka kwenguva yakareba, nepo vamwe vachida kuramba vachitora mushonga kwenguva refu. Chiremba wako achaongorora zvinhu zvakaita sekudzora zviratidzo zvako, kushanda kwemapapu, uye kugona kuderedza mamwe mishonga yeasthma paanoita sarudzo iyi.

Ndingagamuchira Majekiseni Ndingati Ndiri Kutora Reslizumab?

Unogona kazhinji kugamuchira majekiseni mazhinji uchiita reslizumab, asi zvakakosha kuti ukurukure izvi nemupi wako wehutano usati watora chero majekiseni. Majekiseni mhenyu angasakurudzirwe, nepo majekiseni asina simba anowanzo chengeteka.

Chiremba wako angakurudzira kuti uise majekiseni ako panguva pakati pekuiswa kwe reslizumab kuti ave nemhedzisiro yakanaka. Vachadawo kuona kuti hausi kutambura nezvirwere zviripo usati wapiwa majekiseni, sezvo izvi zvingakanganisa mhinduro yako yemuviri yekudzivirira zvirwere.