Chii chinonzi Tepotinib: Zvazvinoshandiswa, Mushonga, Migumisiro Yemuviri, nezvimwe

Tepotinib mushonga wekenza unovharira mapurotini chaiwo anobatsira mamwe makenza emapapu kukura. Iyi itsva nzira yekurapa yakagadzirirwa vanhu vane kenza isiri diki yemapapu ine shanduko yakati yegeni inonzi MET exon 14 skipping mutation.

Mushonga uyu unoshanda zvakasiyana nechemotherapy yechinyakare nekutarisa dambudziko chairo remamorekuru rinotyaira kukura kwekenza yako. Funga nezvayo sechishandiso chechokwadi panzvimbo yenzira yakafara, iyo inowanzoita kuti pave nemigumisiro mishoma yemuviri asi ichiri kushanda kurwisa kenza.

Chii chinonzi Tepotinib chinoshandiswa?

Tepotinib inorapa rudzi rwakati rwekenza isiri diki yemapapu. Chiremba wako achanyora mushonga uyu chete kana kenza yako iine shanduko yakati yegeni inonzi MET exon 14 skipping.

Shanduko iyi yegeni inoitika mune angangoita 3-4% emakenza asiri madiki emapapu, zvichiita kuti isawanzika. Shanduko iyi inoita kuti maseru ekenza akure uye apararire zvakanyanya nekukanganisa mashandiro emamwe mapurotini mumasero ako.

Vashandi vehutano vachayedza tishu yako yekenza kuti vasimbise kuti une shanduko iyi usati watanga tepotinib. Iyi nzira yekuyedza, inonzi biomarker testing, inovimbisa kuti unogamuchira kurapwa kwakakodzera kune rudzi rwekenza yako.

Tepotinib inoshanda sei?

Tepotinib inovharira purotini inonzi MET iyo inobatsira maseru ekenza kukura uye kurarama. Kana purotini iyi ikava yakanyanya kushanda nekuda kweshanduko yegeni, inotumira zviratidzo zvichiti maseru ekenza aite zvakawanda nekukurumidza.

Nekuvharira zviratidzo izvi, tepotinib inocheka mirairo yekukura kwekenza. Iyi nzira yakatarwa inogona kuderedza kana kumisa kenza kubva pakupararira kune dzimwe nhengo dzemuviri wako.

Semushonga unovavarira, tepotinib inonzi mushonga wakasimba uye unoshanda we rudzi rwakati rwegomarara remapapu rinorapa. Zvisinei, rinoshanda zvakasiyana nekemotheraphy yechinyakare, kazhinji richikonzera mhando dzakasiyana dzezvinoitika zvisingadiwi izvo zvinowanzodzoreka.

Ndingatora sei Tepotinib?

Tora tepotinib sezvinorayirwa nachiremba wako, kazhinji kamwe chete pazuva uchiita chikafu. Kuitora nechikafu kunobatsira muviri wako kutora mushonga zviri nani uye kunogona kuderedza zvinoitika zvisingadiwi zvine chekuita nedumbu.

Momedza mahwendefa ese negirazi remvura - usapwanye, utaune, kana kuapwanya. Kana uine dambudziko rekumedza mahwendefa, taura nechikwata chako chehutano nezvemhinduro dzinogoneka.

Edza kutora tepotinib panguva imwe chete zuva rega rega kuti uchengetedze mazinga akagadzikana mumuviri wako. Unogona kuitora nechikafu chipi nechipi, asi vanhu vazhinji vanoona zviri nyore kuyeuka kana vachitora nekudya kwemangwanani kana kwemanheru.

Dzivisa grapefruit uye muto we grapefruit paunenge uchitora tepotinib, sezvo izvi zvinogona kukanganisa maitiro emuviri wako ekugadzirisa mushonga. Kubatana uku kunogona kuita kuti mushonga usashande zvakanaka kana kuwedzera zvinoitika zvisingadiwi.

Ndingatora Tepotinib Kwenguva Yakareba Sei?

Unowanzoenderera mberi uchitora tepotinib chero ichishanda zvakanaka uye uchichigamuchira zvakanaka. Iyi nzira inonzi

Sezvinongoita mishonga yese yekenza, tepotinibhi inogona kukonzera matambudziko, kunyangwe kwete munhu wese achiita izvozvo. Matambudziko mazhinji anogona kudzoreka nerutsigiro rwakakodzera uye kuongororwa kubva kuchikwata chako chehutano.

Heano matambudziko anowanzoitika aunogona kusangana nawo, achikanganisa vanhu vanopfuura 20% vachitora tepotinibhi:

• Kuzvimba mumakumbo ako, zvitsitsinho, kana tsoka (edema)
• Kuneta uye kunzwa kuneta zvisingaite
• Kusvotwa uye kurutsa dzimwe nguva
• Manyoka kana zvigaro zvakasununguka
• Kuderera kwechido chekudya
• Kufema kwemhepo
• Kurwadziwa kwemhasuru kana majoini

Matambudziko aya anowanzoitika anowanzoita akapfava kusvika pakati nepakati uye anowanzoita nani sezvo muviri wako uchigadzirisa mushonga. Chikwata chako chehutano chinogona kupa nzira dzekubatsira kudzora zviratidzo izvi zvinobudirira.

Vamwe vanhu vanogona kusangana nematambudziko akakomba anoda kutariswa kwekurapa nekukasira, kunyangwe izvi zvisingawanzoitiki:

• Matambudziko akakomba emapapu (pneumonitis) nekukosora kunoramba kuripo kana matambudziko ekufema
• Matambudziko echiropa nekuita yero yeganda kana maziso
• Kuzvimba kwakanyanya kusingavandudzike nekukwidzwa
• Zviratidzo zvehutachiona nefuriza, kutonhora, kana kusimba zvisingaite
• Manyoka akakomba anotungamira mukushaya mvura mumuviri

Bata chikwata chako chehutano nekukasira kana ukaona chero chimwe chezviratidzo izvi zvakanyanya. Kupindira kwekutanga kunogona kubatsira kudzivirira matambudziko uye kukuchengetedza iwe uchichengetedza kurapwa kwako.

Ndiani Asingafaniri Kutora Tepotinibhi?

Tepotinibhi haina kukodzera munhu wese, uye chiremba wako achanyatsoongorora nhoroondo yako yekurapa usati wairaira. Vanhu vane mamiriro akati kana mamiriro anogona kuda kudzivirira mushonga uyu kana kuushandisa nekuchenjerera kwakanyanya.

Haufaniri kutora tepotinibhi kana uine allergic kwairi kana chero chimwe chezvinhu zvayo. Uye zvakare, mushonga uyu haukurudzirwi kana iwe wakazvitakura kana kuyamwisa, sezvo unogona kukuvadza vana vari kukura.

Chiremba wako achashandisa kungwarira kwakanyanya paanonyora tepotinib kana uine:

• Chirwere chakakomba chechiropa kana matambudziko ekuita basa rechiropa
• Chirwere chakakomba cheitsvo
• Nhoroondo yematambudziko emapapu kana matambudziko ekufema
• Matambudziko emoyo kana nyaya dzekuchengetedza mvura
• Zvirwere zviripo kana immune system yakakanganiswa

Mishonga mimwe inogona kushamwaridzana ne tepotinib, zvichikonzera kuti isashande zvakanaka kana kuwedzera mhedzisiro. Nguva dzose udza timu yako yehutano nezve mishonga yose, zvinowedzera, uye zvigadzirwa zvemiti zvauri kutora.

Zita reBrand reTepotinib

Tepotinib inotengeswa pasi pezita rebrand Tepmetko muUnited States neEurope. Zita iri rebrand rinobatsira kusiyanisa kubva kune mamwe mishonga yekenza uye rinovimbisa kuti unogamuchira fomu rakarurama.

Paunotora mushonga wako, tarisa kaviri kuti uri kugamuchira Tepmetko (tepotinib) uye kwete mushonga wakasiyana. Makamuri emishonga dzimwe nguva anotakura mishonga ine mazita akafanana, saka kusimbisa kunobatsira kuona kuchengeteka kwako.

Inishuwarenzi yako uye pharmacy inogona kukanganisa kuwanikwa uye mutengo. Kana uine zvinokunetsa nezvekuwana Tepmetko, bvunza timu yako yehutano nezve zvirongwa zvekubatsira varwere zvinogona kubatsira.

Zvimwe Zvingashandiswa Panzvimbo peTepotinib

Nepo tepotinib yakagadzirirwa zvakananga MET exon 14 skipping mutations, dzimwe nzira dzekurapa dziripo dzekenza yemumapapu. Chiremba wako angangofunga nezvezvimwe zvinhu zvichienderana nemamiriro ako chaiwo uye kuti tepotinib iri kushanda sei.

Mamwe marapirwo akatarisirwa ekenza yemumapapu anosanganisira capmatinib (Tabrecta), iyo zvakare inotarisa MET mutations asi inoshanda zvishoma zvakasiyana. Vamwe vanhu vanogona kupindura zviri nani kumushonga mumwe pane mumwe.

Kurapa kwechinyakare senge chemotherapy, immunotherapy, kana radiation therapy inogona kunge iri sarudzo kana kurapa kwakatarwa kusina kukodzera. Oncologist wako achakurukura nzira yakanakisa zvichienderana nemaitiro ekenza yako uye hutano hwako hwese.

Miedzo yeClinical inogona kupa mukana wekurapa kutsva kwejekerere. Bvunza timu yako yehutano kana chero zvidzidzo zvekuongorora zvichikodzera mamiriro ako.

Tepotinib iri nani pane Capmatinib here?

Vose tepotinib necapmatinib vanonangana neMET protein imwechete, asi vanoshanda zvishoma zvakasiyana uye vanogona kuva nemigumisiro yakasiyana. Hapana mushonga wakanyatso "kuti uri nani" pane mumwe - sarudzo inoenderana nemamiriro ako ega.

Vamwe vanhu vanopindura zviri nani ku tepotinib, asi vamwe vanogona kuva nemigumisiro iri nani ne capmatinib. Chiremba wako anofunga zvinhu zvakaita se shanduko yako chaiyo, hutano hwese, mamwe mishonga yaunotora, uye migumisiro inogona kuitika paunenge uchisarudza pakati pavo.

Kana mushonga mumwe ukamira kushanda kana kukonzera migumisiro isingashiviririki, chiremba wako anogona kukuchinjira kune mumwe. Iyi nzira inokupa zvimwe zvingasarudzwa zvekutarisira uye tariro yekuramba uchidzora kenza.

Mishonga yose miviri yakaratidza kushanda zvakafanana mumiedzo yeclinical, ine mhinduro dzinenge 40-50% yevanhu vane MET exon 14 vanosvetuka shanduko. Timu yako yehutano ichatarisa kufambira mberi kwako uye kugadzirisa kurapwa sezvinodiwa.

Mibvunzo Inowanzo Bvunzwa Nezve Tepotinib

Tepotinib Yakachengeteka Kune Vanhu vane Chirwere cheShuga here?

Tepotinib inogona kushandiswa zvakachengeteka muvanhu vane chirwere cheshuga, asi inoda kutariswa zvakanyanya. Mushonga hauna zvakananga kukanganisa mazinga eshuga yeropa, asi mamwe migumisiro yakaita sekuderera kwechido kana kusvotwa inogona kukanganisa maitiro ako ekudya.

Timu yako yehutano ichashanda pedyo newe kuti itarise kurapwa kwako kenza uye manejimendi echirwere cheshuga. Vanogona kuda kugadzirisa mishonga yako yechirwere cheshuga kana chirongwa chekutarisa paunenge uchitora tepotinib.

Kana ukaita kuzvimba (edema) kubva ku tepotinib, izvi dzimwe nguva zvinogona kuita kuti manejimendi echirwere cheshuga ave nematambudziko. Chiremba wako anogona kupa nzira dzekugadzirisa mamiriro ese zvakanaka uchichengetedza kurapwa kwako kenza.

Ndingaita Sei Kana Ndakatora Tepotinib Yakawandisa Netsaona?

Kana netsaona ukatora tepotinib yakawanda kupfuura yakanyorwa, fonera chiremba wako kana nzvimbo inobatsira kana uine chepfu nekukasika. Usamirira kuti uone kana zviratidzo zvichioneka - kutanga kubatsira nguva dzose kwakachengeteka.

Kutora tepotinib yakawanda zvingawedzera njodzi yako yezvinhu zvisingadiwi zvakadai sekuona kusvotwa zvakanyanya, kurutsa, kana kuzvimba. Chikwata chako chekuchengetwa kwehutano chingada kukutarisa zvakanyanya kana kupa rubatsiro rwekukubatsira kudzora chero zviratidzo.

Chengeta tepotinib mumudziyo wayo wekutanga uine mavara akajeka kubatsira kudzivirira kuwandisa netsaona. Funga kushandisa murongi wemapiritsi kana kuseta zviyeuchidzo zvefoni kukubatsira kutora chiyero chakarurama panguva yakakodzera.

Ndingaita Sei Kana Ndikakanganwa Dose yeTepotinib?

Kana ukakanganwa dose ye tepotinib, itore paunorangarira, kunze kwekunge yava nguva yechiyero chako chinotevera. Muchiitiko ichocho, rega dose yakakanganwa uye uenderere mberi nechirongwa chako chetsika.

Usambofa wakatora madosi maviri panguva imwe chete kuti ugadzirise dose yakakanganwa - izvi zvinogona kuwedzera njodzi yako yezvinhu zvisingadiwi. Kana usina chokwadi nezvenguva, fonera chikwata chako chekuchengetwa kwehutano kuti uwane gwara.

Kana iwe uchikanganwa madosi kazhinji, funga kuseta maalarm ezuva nezuva kana kushandisa chirongwa chekuyeuchidza mushonga. Kudzora nguva dzose kunobatsira kuchengetedza mazinga akagadzikana emushonga mumuviri wako kuti uve nekuita kwakanaka.

Ndingamira Rini Kutora Tepotinib?

Unofanira kungomira kutora tepotinib kana chiremba wako achiona zvakakodzera, kazhinji kana kenza ichifambira mberi pasinei nekurapa kana zvinhu zvisingadiwi zvisingadzoreki. Usambomira kutora tepotinib wega, kunyangwe uchinzwa zviri nani.

Chikwata chako chekuchengetwa kwehutano chichashandisa ma scan enguva dzose uye bvunzo dzeropa kuti chitarise kuti tepotinib iri kushanda sei. Kana mushonga uchidzora kenza yako zvinobudirira uye uchizvitsungirira zvakanaka, ungangodaro ucharamba uchiutora zvachose.

Kana muchida kumisa tepotinib, chiremba wenyu achakurukura matanho anotevera uye dzimwe nzira dzekurapa. Hapana chikonzero chekuderedza dose zvishoma nezvishoma - munogona kumisa nekukasira kana zvakakodzera zvekurapa.

Ndinganwe Doro Ndichitora Tepotinib Here?

Kunyange hazvo pasina kubatana kwakananga pakati pe tepotinib nedoro, zvakanaka kudzora kunwa doro panguva yekurapwa kwekenza. Doro rinogona kuwedzera mamwe matambudziko akadai senausea, kuneta, uye kushushikana kwechiropa.

Kana mukasarudza kunwa doro dzimwe nguva, kurukurai izvi nechikwata chenyu chekuchengetedza hutano kutanga. Vanogona kupa gwara rakagadzirirwa zvinoenderana nehutano hwenyu hwese uye kuti muri kutsungirira sei tepotinib.

Rangarirai kuti doro rinogonawo kukanganisa immune system yenyu uye mhando yekurara, izvo zvose zvakakosha pakukwanisa kwemuviri wenyu kurwisa kenza uye kupora kubva mukurapwa.