Ama-Patch E-GLP-1: Ingabe Ayasebenza?

Ama-patch e-GLP-1 awanawo umuthi we-GLP 1. Leso yisigwebo esisodwa esiwusizo kakhulu kulo lonke lesi sihloko, futhi konke okungezansi kwakhelwe phezu kwaso.

Imikhiqizo ethengiswa ku-inthanethi njengama-"patch e-GLP 1" izitikha ezincamathelayo eziyiqukethe izithako zemvelo njenge-berberine, isigaxa setiye eliluhlaza, kanye nesinamoni. Awanawo i-semaglutide. Awanawo i-tirzepatide. Awanazo izimvume ze-FDA. Awanqunywanga odokotela. Futhi ayikho ubufakazi besayensi bokuthi ayikhiqiza ukuncipha komzimba okubalulekile.

Uma wafuna i-"GLP-1 patches" ngethemba lokuthola inguqulo ye-Ozempic noma i-Wegovy engadingi imijojo futhi engabizi, awuwedwa. Izigidi zabantu zifunile lokhu. Imikhiqizo ikhona ngoba isidingo sikhulu kakhulu. Kodwa isayensi ayikho, futhi ukuqonda ukuthi kungani kungakonga imali nenhlupheko. Leli bhukwana lichaza ukuthi la ma-patch aqukethe ini ngempela, ukuthi kungani imithi yangempela ye-GLP 1 ingalethwa nge-patch, nokuthi yini ngempela esebenzayo uma ufuna ukugwema imijojo.

Ingabe ama-patch e-GLP 1 ayasebenza?

Cha. Ayikho ubufakazi be-clinical bokuthi ama-patch e-GLP 1 angaphandle kwe-counter akhiqiza ukuncipha komzimba okufana nemithi ye-GLP-1 kadokotela.

Isizathu siwubunjwa bomzimba, akuyona nje imithetho. Ama-GLP-1 receptor agonists njenge-semaglutide-subcutaneous-route" target="_blank" rel="noopener noreferrer">semaglutide ne-tirzepatide-subcutaneous-route" target="_blank" rel="noopener noreferrer">tirzepatide amakhemikhali amakhulu e-peptide. Anamakhulu kakhulu, achitha kakhulu emanzini, futhi anomoya kagesi ophakeme kakhulu ukuba angadabula isikhumba sakho esingaphandle ( stratum corneum) futhi angene egazini lakho. UDkt. Sheldon Markowitz, umphathi we-endocrinology e-Episcopal Health Services eNew York, uthe noma ngabe i-patch yayiqukethe umuthi wangempela we-GLP 1, bekungeke kwenzeke ukuyiletha nge-skin kusetshenziswa ubuchwepheshe bamanje.

Lokho akuyona inkinga eyingqayizivele kuma-patch. Kungakho yonke imithi ye-GLP-1 egunyazwe yi-FDA ingenye imijojo (eqeda ngqo isikhumba) noma iphilisi elenziwe ngokukhethekile (elisebenzisa ubuchwepheshe bokuthuthukisa ukumuncwa emathunjini). Ayikho indlela yesithathu yokulethwa esebenza njengamanje.

Ezinye zezithako kulezi patch, njenge-berberine, zineziqinisekiso ezimfushane zemiphumela kashukela egazini uma zithathwa ngomlomo. Kodwa "zithathwe ngomlomo" yisigwebo esibalulekile. Izifundo ezikhombise i-berberine yehlisa ushukela egazini zazihlanganisa abantu abagwinya amaphilisi, hhayi ukunamathela ama-patch esihlakaleni. Noma ngabe i-berberine noma isigaxa setiye eliluhlaza siyimuncwa esikhunjeni ngamanani abalulekile akukahlolwa.

Yini empeleni esemakini kuma-patch e-GLP 1?

Izinhla zezithako eziningi zama-patch e-GLP-1 zihlanganisa okunye kwalokhu okulandelayo:

• I-Berberine (ikhambi elingathinta ushukela egazini uma ligwinywa)

• Isigaxa setiye eliluhlaza (EGCG, i-stimulant ne-antioxidant)

• Isigaxa sesinamoni

• I-Garcinia cambogia

• Isigaxa se-pomegranate

• Ukuluma kukasawoti we-apula

• I-L-glutamine (i-amino acid)

• Amavithamini B

• Isigaxa sezimpande zikagolide

Akekho kulawa imithi kadokotela. Akekho kuwo ama-GLP-1 receptor agonists. I-FDA iye yaqinisekisa ukuthi ayikho ama-patch e-GLP-1 agunyazwe yi-FDA futhi ayikho imikhiqizo yemithi egunyazwe yi-FDA equkethe i-berberine.

Kubalulekile ukuqonda ukuthi yenzani isithako esivame kakhulu, i-berberine, lapho ithathwa njengesithasiselo somlomo. Izifundo zikhombise ukuthi amaphilisi e-berberine anganciphisa kancane ushukela egazini ne-cholesterol kubantu abanesifo sikashukela sohlobo 2. Umphumela wangempela kodwa mncane, ufana nemithi kadokotela yesifo sikashukela i-metformin kakhulu. Kodwa lezo zifundo zazihlanganisa abantu abagwinya ama-mg angu-500 kuya ku-1,500 nsuku zonke ngendlela yepilisi. I-berberine emuncwa esikhunjeni? Lokho akukahlolwa kunoma iyiphi inhlolovo yomuntu eshicilelwe. Akekho oye wabonisa ukuthi uthola umthamo ofanele wokwelapha nge-patch.

Isigaxa setiye eliluhlaza (EGCG) sineziqinisekiso zokuthuthukisa kancane imetabolism lapho sithathwa njengesiphuzo noma iphilisi. Umphumela ufana namakhilogremu angu-1 kuya ku-3 okuncipha komzimba ngezinyanga ezimbalwa. Futhi, lokho yilapho sigwinywa. Noma ngabe i-EGCG idabula esikhunjeni ngamanani awusizo nge-patch encamathelayo akwaziwa.

Ezinye izinhlobo ziqale ukuziguqula ngokuthula amagama emikhiqizo yazo. I-Kind Patches, enye yezinhlobo ezithandwa kakhulu ku-TikTok, yaguqulela i-"GLP 1 patches" yayo yaba yi-"berberine patches" ngemuva kokucwaningwa, yize ukwakheka kwayo kungazange kushintshe. Lokho kubuyekezwa kukutshela okuthile ngendlela umkhangiso wokuqala wawubekwe ngayo.

Kungani ama-patch e-GLP-1 ethandwa kangaka uma angasebenzi?

Izizathu ezintathu, futhi zonke ziyazwakalanga ngombono womthengi.

Okokuqala, imithi ye-GLP-1 kadokotela iyabiza. Ngisho nezinhlelo zomkhiqizi, inketho yomkhiqizo ewubheke emhlophe ibiza u-R149 ngenyanga. Ama-patch e-GLP-1 athengisa phakathi kuka-R20 kuya ku-R40 inyanga. Uma ukhipha imithi yangempela, i-patch engu-R30 ethi yenza okufanayo iyavutha.

Okwesibili, abantu abaningi abafuni imijojo. Ukwesaba izinaliti kuvamile. I-patch onamathelisa esikhunjeni sakho izwakala kulula, ingewona eyemithi, ingafisi kakhulu.

Okwesithathu, ukumaketha kuhle. Izikhangiso zemidiya yokuxhumana nabantu zalemikhiqizo zakhelwe ukuba zibukeke sengathi zihlobene nemithi ye-GLP-1 kadokotela. Zisebenzisa ulimi olufanayo ("ukontrola ukudla," "ukweseka imetabolism," "ukuthuthukisa i-GLP-1") kanye nesitayela esifanayo sokubukwa. Uma ungayifundi imininingwane emincane, ungacabanga kalula ukuthi uthenga inguqulo eshibhe kakhulu yento efanayo.

Inkinga akuwona ukuthi abantu bafuna indlela elula. Leso yisifiso esifanele. Inkinga ukuthi le mikhiqizo ethize ayifezi isethembiso. Isayensi yokulethwa komuthi esikhunjeni ayiyisekelwa ngamavolumu anjalo.

Ingabe kukhona ama-patch e-GLP-1 angempela athuthukiswayo?

Yebo. Abacwaningi bemithi baye basebenza kubuchwepheshe be-microneedle patch obungadala ukuthi bulethe imithi ye-GLP-1 esikhunjeni. La ma-patch angasebenzisa imicu emincane kakhulu (incane kakhulu ukuthi ingazwakala) egwaza kancane nje ukuze ifinyelele umgodi ongaphansi komngcele wangaphandle wesikhumba, lapho umuthi ungazongena khona egazini.

Ukubuyekezwa kwe-2024 kuphephandaba i-Advanced Drug Delivery Reviews kwakuhlanganisa inqubekela phambili ezinhlelweni zokulethwa kwe-microneedle zemithi ye-peptide okubandakanya ama-GLP-1 receptor agonists. Iqembu lezicwaningo eziningana libonise ubufakazi be-concept kumamodeli ezilwane, futhi okungenani uhlelo olulodwa lwesigaba se-clinical (lwe-exenatide) seluhlolile i-microneedle patch kubantu ngemiphumela emihle yokuqala.

Kodwa ayikho kuzo etholakala ngokuhweba. Ubuchwepheshe busesigabeni se-clinical, futhi ayikho imvume ye-FDA ye-GLP-1 microneedle patch enikeziwe noma elindelwe esikhathini esingekude. Uma inkampani yezemithi esemthethweni ikhipha eyodwa, kuzoba umkhiqizo kadokotela, hhayi into oyithenga ku-TikTok ngo-R30.

Yini empeleni esebenzayo uma ungawafuni imijojo?

Uma ukwenqaba kwakho okuyinhloko kwemithi ye-GLP-1 kuyinaliti, manje sezinemikhiqizo emibili yomlomo egunyazwe yi-FDA engadingi imijojo nhlobo. Kubantu abaphila nokukhuluphala okudlulele abafuna okuthile okulula kunomjovo wamasonto onke, lawa maphilisi angalokhu okufana nalokho okwethulwa ngama-patch e-GLP-1, ngaphandle kokuthi empeleni aqukethe umuthi wangempela futhi anedatha yokukuphasa. ukuqinisekisa.

Iphilisi le-Wegovy (semaglutide yomlomo) iphilisi leminyaka yonke eligunyazwe ukuncipha komzimba. Nge-NovoCare Pharmacy, intengo yokukhokhela yedwa iqala ku-R149 ngenyanga ngemithamo ephansi kakhulu. Inomthetho oqine kakhulu wokuthatha: uyithatha esiswini esingenalutho ngesi-sip esincane samanzi bese ulinda imizuzu engu-30 ngaphambi kokudla noma ukuphuza okunye.

I-Foundayo (orforglipron) iphilisi leminyaka yonke eligunyazwe ukuncipha komzimba elalethwa ekuqaleni kuka-2026. Iza ku-R149 ngenyanga ngezinye izinhlelo ezikhethiwe. Ngokungafani namaphilisi e-semaglutide, i-Foundayo ayinawo umthetho wokuthi kudingeka esiswini esingenalutho. Ungayithatha nganoma yisiphi isikhathi nokudla noma ngaphandle kokudla, okwenza kube yona inketho ye-GLP-1 elula kakhulu etholakala njengamanje.

Zombili lezi yimithi kadokotela egunyazwe yi-FDA, enemidwebo ye-clinical ekhombisa ukuncipha komzimba okungu-10 kuya ku-18%. Zibiza kakhulu kune-patch, kodwa zisebenza ngendlela eyehlolwe ezigidini zabantu abaneminyaka.

Uma intengo iyisithiyo kune-naliti, imijojo ye-semaglutide eyenziwe nge-pharmacies ezisebenzisa ilayisensi ibiza cishe u-R129 kuya ku-R269 ngenyanga, ngokuya ngeplathifomu nomthamo. Lokho kusabiza kakhulu kunama-patch, kodwa umuthi wangempela we-GLP 1 onemiphumela yangempela.

Yini okufanele uyibheke lapho uthenga imikhiqizo yokuncipha komzimba?

Imakethe yama-patch e-GLP-1 igcwele izimpawu zokuxwayisa. Nansi into okufanele uyibheke ngaphambi kokuthenga noma yini emakethe yokuncipha komzimba ku-inthanethi.

Uma umkhiqizo uthi "GLP-1" etikethini kodwa ungadingi kadokotela, awuqiniseki umuthi we-GLP 1. Yonke imithi yangempela ye-GLP 1 idinga kadokotela ovela kumhlinzeki onelayisensi. Akukho nhlobo.

Uma ithekelisi libhala "yocwaningo kuphela" noma "akufanele isetshenziswe ebantwini," lokho kuyindlela yokugwema imithetho. Kusho ukuthi umkhiqizo awukahlolwa ukuze kuphephe noma kube nesilinganiso esilungile.

Uma imakethe ithi umkhiqizo "ukweseka amazinga e-GLP-1" noma "ukuthuthukisa i-GLP 1 yemvelo," lokho kuyilwimi lwesithasiselo, hhayi ilwimi lwemithi. Umzimba wakho ukhiqiza i-GLP 1 yemvelo njalo uma udla. I-hormone ihlala imizuzwana kuya emaminithini egazini lakho. Imithi ye-GLP 1 kadokotela yenziwe ukuba ihlale isonto lonke. Isithasiselo esikhuphula kancane i-GLP-1 yakho yemvelo ngesilinganiso esincane akwenzi lutho olufanayo.

Uma umkhiqizo unezibuyekezo ezinhle ku-TikTok noma ku-Amazon kodwa ayikho idatha ye-clinical eshicilelwe, imiphumela abantu abayichazayo ingase ibe umphumela we-placebo. Ukugqoka i-patch kungamenza umuntu azi kakhulu ngokudla kwakhe, futhi lowo muzwa ungabangela ukushintsha okuncane kwamakhilogremu ambalwa. Lokho akusho ukuthi i-patch yenze lutho ngokomuthi. Uma umkhiqizo ubenemiphumela yangempela yokuncipha komzimba, ubuzohlolwa enhlanganisela ebhekelwe futhi ishicilelwe ephephandabeni elihlolwe ngokomzali. Ukungabikho kwaleyo datha akuyona isikhala, yindaba yonke.

Uma intengo ibukeka ingcono kakhulu ukuba ibe yiqiniso, iyona leyo. Imithi ye-GLP 1 kadokotela ibiza lokho eyikubizayo ngoba ukuyithuthukisa, ukuyihlola, ukuyakhela, nokuyigadla kubiza kakhulu. I-patch engu-R30 ethi yenza okufanayo nomuthi kadokotela obiza u-R149 kuya ku-R1,349 ngenyanga ayiyona indawo yokubheka. Kuyinto ehlukile.

Ngakho-ke ikuphuma kanjani lapho?

Ingabe ama-patch e-GLP 1 ayasebenza ekunciphiseni umzimba? Cha. Akukho ngendlela eboniswe emgqeni ocwaningo lwe-clinical. Amakhemikhali emithi yangempela ye-GLP-1 anamakhulu kakhulu ukuba adabule isikhumba sakho. Izithako ezikuma-patch la awabonisi ukuncipha okubalulekile komzimba lapho kulethwa ngesikhumba. Futhi i-FDA iye yaqinisekisa ukuthi akukho patch le-GLP eyagunyazwe likhona.

Ama-patch e-GLP 1 yisigaba somkhiqizo esikhona ngenxa yesidingo, hhayi ngenxa yesayensi. Abantu bafuna ukwesekwa okuncishiswe umzimba okungabizi, okungenazinaliti, futhi leso sifiso sifanele. Ama-patch ngokwawo awawona impendulo.

Uma ufuna inketho ye-GLP 1 engenaluzaliti, iphilisi le-Wegovy ne-Foundayo yimithi yangempela, egunyazwe yi-FDA etholakala njengamanje. Uma ufuna indawo efikeleleka kakhulu, zombili ziqala ngo-R149 ngenyanga. Uma ufuna ukuqonda ukuthi zonke izinketho zangempela ze-GLP-1 ziqhathaniswa kanjani ngaphambi kokunquma, ibhukwana lokuqhathanisa imithi ye-GLP-1 lichaza yonke imithi egunyazwe eceleni.

Udokotela wakho angakusiza ukuthi uqonde ukuthi umuthi we-GLP 1 ulungele isimo sakho yini nokuthi iyiphi indlela yokulethwa efaneleka empilweni yakho. Lolu hlelo lukhululekile ezindaweni eziningi zezindlu zokuqala nezingosi ze-telehealth, futhi luyagcwala kakhulu kunama-patch angu-R30.