Kuvamile futhi ngokuvamile akubanga yisizathu sokukhathazeka uma uphuthelwa isikhathi sakho ngenxa yokuthi awukhulelwanga. Uma kukhulunywa ngezikhathi ezibambezelekile noma eziphuthelwe ngenxa yesinye isizathu—ingcindezi, ukuhluka okukhulu kwesisindo, ukuzivocavoca umzimba kakhulu, izinkinga ze-thyroid, kanye nezigulo ezifana ne-PCOS kungabangela isikhathi esiphuthelwe noma ukulibazisa. Kungabangelwa futhi ukulawulwa kokuzalwa ngama-hormone, i-perimenopause, neminye imithi. Izikhathi ezivela ngokwephuza (noma eziphuthelwe) kulungile. Uma ungenazo ezintathu zilandelana, noma ezinye izimpawu ezifana nobuhlungu noma ukukhula kwezinwele okungajwayelekile, funa usizo lwezokwelapha.