I-Suprax Ne-Cefixime Ejwayelekile: Intengo, Amafomu Omsebenzi, Nezenzakalo Ezingemihle Ziqhathaniswa

I-Suprax igama lomkhiqizo we-cefixime, futhi i-cefixime ejwayelekile iyimithi efanayo ngamandla afanayo. I-FDA iyakudinga lokho. Ukusebenza kanye nezenzakalo ezingezinhle akuhlanganisi. Intengo yayo iyahluka: i-cefixime ejwayelekile ibiza cishe kusuka ku-$14 kuye ku-$85 ngokheshi kuye ngekhemisi, inani, nekponi, kusukela ngesikhathi sokushicilela.

Isifinyezo: Okubalulekile Okubalulekile

• Umkhiqizo kanye newejwayelekile kuyimolekhuli eyodwa, ngakho-ke khetha ngentengo kuphela.
• I-cefixime ejwayelekile ibiza cishe kusuka ku-$14 kuye ku-$85 ngokheshi; umkhiqizo uvamise ukungabi khona futhi kufanele ucelwe ikhemisi lakho.
• Izindleko ze-cefixime ngaphandle komshwalense ziyahlukahluka cishe kabili phakathi kwezindawo zokudayisa izidakamizwa, ngakho ukuthenga okuzofakwa kuhle kunokuzibeka ethungwini kulokho okubhalwe kulotshiwe.
• Izenzakalo ezingezinhle ze-cefixime ziyafana noma ngabe yikuphi: uhudo cishe ku-16% weziguli, isicanucanu cishe ku-7%.
• I-cefixime manje iyindlela yokugula kwe-gonorrhea, hhayi esikhundleni somjovo wokuqala we-ceftriaxone.

Igama lejwayelekile le-Suprax yi-cefixime, futhi yilokho okuyikho konke okuhlukile

Igama lejwayelekile le-Suprax yi-cefixime, i-antibiotic ye-cephalosporin yesizukulwane sesithathu. Ithegi yomkhiqizo ihlala phezu kwaleyo molekhuli futhi ayiguqule lutho ngaphakathi kuyo. I-FDA idinga ukuthi zonke izidakamizwa ezijwayelekile zibe nesithako esisebenzayo, amandla, ifomu lomsebenzi, nendlela efanayo njengomkhiqizo womkhiqizo, futhi zibonise ukufakwa kwesidakamizwa okufanayo emzimbeni. Ngakho-ke le mikhiqizo emibili isebenza ngendlela efanayo, ngomsebenzi ofanayo, nezenzakalo ezingezinhle ezifanayo. Intengo kuphela kwirisidi eguqukayo.

Leli zinga akuyona isehluleki. Imigomo ye-FDA yezidakamizwa ezijwayelekile iyale umkhiqizi ukuthi afanise umkhiqizo oyisibonelo bese ebonisa ukufakwa okufanayo emzimbeni: i-90% ye-confidence interval yesilinganiso sokufakwa phakathi komkhiqizo ojwayelekile nomkhiqizo womkhiqizo kufanele ibe phakathi kuka-0.80 kuya ku-1.25. Uma ingafanga iwindi, isicelo siyahluleka.

Umkhiqizo wokuqala wawuthola imvume ye-FDA ngo-1986. Ilayisensi yakhe kanye nokuba abe yedwa ngokumaketha kwaphela kudala, yingakho izinkampani eziningi manje zithengisa i-cefixime ejwayelekile evunyiwe yi-FDA ephatha izinkomba ezifana nezinombolo ezifanayo. Akukho umehluko ongachaza ngemithi ngokusebenza noma ngezinketho ezingezinhle phakathi kwazo. Okuhlukile kuphela okugugu ngempela ukuthi ikhemisi lakho elithile nohlelo lwakho luchaza malini.

I-Suprax vs. intengo ye-cefixime: ukhokhela ithebula, hhayi imithi

Umehluko wentengo ye-Suprax vs. ye-cefixime ukhona ngenxa yesizathu esithile, hhayi ngenxa yekhwalithi. Uma nje ukuba yedwa kuphelile futhi izinkampani eziningana zifaka izicelo, ukuncintisana kwehla intengo. Ukubala kwe-FDA okwalo kubeka isilinganiso kulelo mphumela: izidakamizwa ezijwayelekile ezingene ngo-2023 zanikele ngomhlahlandlela we-$18.6 billion ukonga ezinyangeni ezilishumi nambili ngemuva kokwamukelwa, ngokusho kwihluzo ze-CDER zemincintiswano ezijwayelekile.

Nansi into eminingi yezinkundla ezizoyishoyo: akukho intengo ecashile ethembekile yomkhiqizo, ngoba amakhemisi amaningi ase-US awakasasibambi. Izindawo eziningi zentengo zikhomba isibalo sejwayelekile ngaphansi kwesihloko somkhiqizo. Lokho akufani. Umkhiqizo awuqedwanga. Uvele ungabikho eshalofini, ngakho inombolo yomkhiqizo eyodwa eyiqiniso iyileyo umeluleki wakho afunda esikrinini lapho uyicela.

Zonke izibalo zinjalo kusukela ngesikhathi sokushicilela futhi ziyashintsha ngekhemisi, ikhodi ye-ZIP, inani, nekponi. Isimo siyaphindeka kuzo zonke izigaba zemithi; intengo yomkhiqizo vs. lejwayelekile endaweni yokubeka yokulawula inzalo iyimpikiswano efanayo nezinombolo ezihlukene.

Ngaphandle komshwalense, ikhemisi olikhethayo ligudlu intengo kakhulu kunalokho okwenzeka nge-label

Izindleko ze-cefixime ngaphandle komshwalense zinciphisa kakhulu kuthebula kodwa kakhulu ukuthi yiziphi izicabha ozohamba ngazo. Idatha ye-chain eyabiwe yi-SingleCare ibonisa ukugcwaliswa okufanayo kujwayelekile cishe ku-$17.18 eKroger futhi cishe ku-$35.33 eCVS. Lokho kuphindwe kabili ngomkhiqizo ofanayo ongawumthombo ofanayo, futhi kuyakudlula noma yini umbuzo womkhiqizo vs. lejwayelekile ongakusindisa ngawo.

Imikhuba emibili ifanele ukuyakha. Gcoba amandla, inani, nefomu eliqondile ngaphambi kokuba ushiye umtholampilo, njengoba amaphilisi nomunqumo ubizwa ngokwehlukana. Futhi cela umeluleki ukuthi abalalele kokubili i-copay yakho yomshwalense kanye nentengo yokheshi neyekponi, bese ekhokhisa noma iyiphi enentshisekelo kakhulu. Ukheshi uwiné kakhulu kunalokho abantu abacabanga. Indlela efanayo, esetshenziswa kwezinye izindawo, ichazwe ku intengo ye-gabapentin ngaphandle komshwalense.

Yiliphi ifomu lomsebenzi olutholayo eligudlu okuningi mayelana nokuhlangenwe nakho kunokuthi iliphi ithebula ligudlu

Amafomu omsebenzi we-cefixime, hhayi amalebula omkhiqizo, yiwona aqinisayo agudlu ukuthi lokhu kudakwa kuzwakala kanjani ukukuphatha. Ithebula elamukelwe yi-FDA lihlanganisa amane: iphilisi elinamandla angu-400 mg elihlanganiswe ngefilimu, ikhapula elinamandla angu-400 mg, amaphilisi alugwinyayo angenamaphilisi angu-100 mg, 150 mg, kanye no-200 mg, kanye nomthamo otholakala ngokokulungiselela ube munqumo womlomo ngamanani angu-100 mg/5 mL, 200 mg/5 mL noma 500 mg/5 mL.

Umkhiqizo ojwayelekile kufanele afanise ifomu namandla omkhiqizo ukuze ukwazi ukuyishintsha ekhasini. Lokho akusho ukuthi bonke abakhiqizi banazo zonke lezo zimo zemisebenzi ye-cefixime. Ikhemisi lingaba namaphilisi angu-400 mg avela kubathengisi abathathu kanye nokugxilisa okukodwa kuphela komunqumo.

Imininingwane emibili ibaluleke kakhulu kunalokho ebukeka ngayo. Amaphilisi alugwinyayo aqukethe i-aspartame, eyenza zibe yinketho embi kunoma ngubani one-phenylketonuria. Futhi umunqumo ophilisiwe kufanele ulahlwe emva kwezinsuku ezingu-14 ngemuva kokuxubeka, ngakho-ke ikhosi labantwana elidlula leso sikhathi kusho ukukhokhela imithi oyiphonsa echibini. Umunqumo uvamile ikakhulukazi ngezingane, futhi ithebula libandakanya izingane kusuka ezinyangeni ezingu-6 ubudala.

Izenzakalo ezingezinhle azishintshi lapho ushintsha umkhiqizo ojwayelekile, futhi ziningi izinkinga zesisu

Izenzakalo ezingezinhle ze-cefixime zingezinengi kakhulu zesisu, futhi azishintshi lapho ithebula lomunye umkhiqizi lifika ebhodleleni. Ezivivinyweni zezokwelapha ngemuva kwethebula, uhudo lwenzeka cishe ku-16% weziguli, isicanucanu cishe ku-7%, kanye nokuhamba kalula cishe ku-6%. Ngoba ukufakwa okufanayo emzimbeni kuyimpoqo, lezi zingabalo zichaza i-cefixime ejwayelekile ngokunembile njengoba zichaza umkhiqizo.

Ngakho-ke "lejwayelekile lingihluphile esiswini kakhulu" akuyona imithi. Kuyinto evamile ukuba nomsebenzi owehlukile, ifomu elihlukile, noma isisu esingenalutho.

Enye inkinga yesisu ayiyona ejwayelekile: izitulo zamanzi noma ezinwegazi ezinobuhlungu besisu obukhulu noma umkhuhlane, noma ngesikhathi sokwelashwa noma izinyanga ezimbili noma ngaphezulu ngemuva kokuyeka, okungaba isignali ye-Clostridioides difficile colitis. Abazali bezingane ezithatha umunqumo kufanele bayibheke, njengoba amakhosi abantwana avame ukuhlala isikhathi eside. I-cefixime inganciphisa nokusebenza kwemishanguzo yokulawula inzalo, ngakho-ke sebenzisa indlela eyisipele phakathi naleso sikhathi nangemuva nje kokwelashwa. Lena akuyona uhlu olugcwele lwezenzakalo ezingezinhle ze-cefixime. Funda umhlahlandlela wemithi ikhemisi lakho elikunika wona nebhodlela.

Ngamanye amahlandla ukugcwalisa umkhiqizo kusengalungile

I-Suprax igama lomkhiqizo we-cefixime amakhemisi amaningi ase-US angasaphethe njengokukhetha, futhi imithetho yokushintsha ezifundeni eziningi ivumela noma iyale umeluleki ukuthi anikeze umkhiqizo ojwayelekile ofanayo ngaphandle uma umdodisi ebhalela "ukudayisa njengoba kubhalwe". Lokho kuvamise ukuba umphumela olungile. Akulona njalo.

Ukuklama kwe-Formulary ngamanye amahlandla kungabeka umkhiqizo esigabeni esifakiwe ngenkathi umkhiqizo ojwayelekile ungaphansi kwalo, ngakho-ke i-copay yomkhiqizo iba ngaphansi. Umkhiqizo ungaphinde uqalise ukugunyazwa kwangaphambili kanye nesonto lokulibazisa, okuyinto enye indlela. Ukutholakala kudlula kokubili: uma umkhiqizo owodwa kuphela onamandla alugwinyayo noma ukugxilisa umunqumo ingane eyidingayo ngempela, lowo mkhiqizo uyawinile noma ngabe yini ebhalwe ebhokisini.

Umthetho umfushane. Cela umeluleki ukuthi abale kokubili ngaphambi kokucabanga ukuthi ijwayelekile ingabiza kakhulu, futhi cela umdodisi wakho ukuthi ashiye ukushintsha kuvulekile ngaphandle uma kunesizathu esithile sokungakwenzi. Kubantu abadala abaningi abathatha amaphilisi angu-400 mg, ijwayelekile ingabiza kancane futhi ingafani.

I-Cefixime ayisewona umthamo wokushintsha komjovo we-gonorrhea

I-Suprax antibiotic iyinhlangano ye-cephalosporin yesizukulwane sesithathu, futhi ayiseyona into imihlahlandlela efinyelela kuyo yokuqala ku-gonorrhea. Ngaphansi kwezinkomba zokuphatha ze-STI ze-CDC zango-2021, ezifingqwe yi-AAFP, umjovo owodwa ongu-500 mg we-ceftriaxone emzimbeni nguwe kuphela ophakanyiswe njengokwelashwa kokuqala kwe-gonorrhea engenakulungiswa. Umsebenzi owodwa womlomo ongu-800 mg we-cefixime uyindlela, ugcinelwe lapho i-ceftriaxone ingatholakali noma kwezinye izindawo zokwelashwa ezisheshayo. Sihlanganisa lapho i-cefixime ingasetshenziswa esikhundleni somjovo we-ceftriaxone ngokuningiliziwe kwenye indawo.

Ukuziphatha kwesifo se-STI esithathelwanayo nge-cefixime esele noma ethengwe ku-inthanethi kuyinto embi. Unganciphisa izimpawu ngaphandle kokukhipha isifo, futhi uyeke ukuhlolwa okukutshela ukuthi yini ngempela onayo.

Uma ungazisi ukuthi izimpawu zakho zidinga yini i-antibiotic nhlobo, ukuvakasha kwe-August okungama-$39 ku-inthanethi kukuxhumanisa nodokotela ogunyaziwe wase-US ohlola izimpawu zakho futhi anqume ukuthi ukugunyazwa kufanele yini. Qaphela imingcele: ukubukwa ngevidiyo akukwazi ukunikeza umjovo we-ceftriaxone emzimbeni noma ukuqoqa amasampula okuhlolwa endaweni, ngakho-ke noma yini ekhombisa kulelo cala idinga umtholampilo.

Ezinye izimpendulo zisho ukuthi uyeke i-antibiotic bese ufuna usizo

Shayela u-911 noma uye ekamelweni lezimo eziphuthumayo manje uma:

• Ubuso bakho, izindebe, ulimi noma umphimbo kuvuvukile
• Uqala ukuphefumula kabi, ukuminyana esifubeni, noma ubunzima bokuphefumula noma bokugwinya
• Uqala ukuba neshabha elikhulu elihambisana namabhamuza noma isikhumba esikhwebayo, noma ishabha elinomkhuhlane

Bhukha ukuvakasha kungakapheli isonto elilodwa uma:

• Unezitulo zamanzi noma ezinwegazi ezinobuhlungu besisu obukhulu noma umkhuhlane, noma ngesikhathi sokwelashwa noma izinyanga ezimbili noma ngaphezulu ngemuva kokuyeka
• Uqala ukuba neshabha ngaphandle kwezimpawu zokuphefumula
• Izimpawu zakho azithuthuki ngemuva kwezinsuku ezimbili kuya kwezintathu usebenzisa i-antibiotic

Khuluma nodokotela ngaphambi kokuba uqale uma:

• Unomlando wokuba ne-allergy ku-penicillin noma i-cephalosporin
• Unesifo sezinso
• Wena noma ingane yakho ninayo i-phenylketonuria futhi yaphakwa amaphilisi alugwinyayo
• Ukhulelwe noma uncancisa
• Uzathemba imishanguzo yokulawula inzalo

Isixwayiso ngohudo sisebenza ngokufanayo kumkhiqizo nomkhiqizo ojwayelekile. Kungumphumela weklasi lemithi, hhayi inkinga yomkhiqizi.

Imibuzo ejwayelekile

I-Suprax ifana ne-amoxicillin noma i-Ceftin?

Cha. I-Amoxicillin iyinhlangano ye-penicillin, kanti i-Ceftin (i-cefuroxime) iyinhlangano ye-cephalosporin yesizukulwane sesibili. I-Cefixime iyinhlangano yesizukulwane sesithathu, enomkhawulo wokumboza amagciwane ohlukile kanye nomsebenzi owahlukile. Azikwazi ukushintshwa, futhi ukugunyazwa kweyodwa akukwazi ukushintshwa kwenye ekhemisi. Umdodisi wakho kuphela ongashintsha iklasi le-antibiotic.

Ngingathatha i-Suprax uma ngine-allergy ku-penicillin?

Ngezinye izikhathi. Ukubambisana okujwayelekile phakathi kwe-penicillin nama-cephalosporin esizukulwane kamuva akukho njengoba kwakucatshangwa ngaphambili, futhi abantu abaningi abane-label ye-penicillin bavumela i-cefixime. Kodwa leso sigwebo sincike kulokho okwakunjalo impendulo yakho. Amadlinga, ukuvuvukala noma i-anaphylaxis idinga ukuhlolwa kukadokotela kuqala. Isibhamu esingekho esihambisana nezingane osikhumbulayo ngokungacacile yinto ehlukile.

I-cefixime iyasebenza ngokulwa nomkhuhlane, umkhuhlane, noma ukutheleleka kwe-sinus?

Cha emikhuhlaneni nasezifweni ezibucayi, okuyizifo ezibangelwa amagciwane, futhi ngokuvamile cha ezifweni ze-sinus, eziningi zazo ziyahlangana ngaphandle kwama-antibiotics. I-label icacile ukuthi le mithi kufanele isetshenziswe kuphela ezifweni eziqinisekisiwe noma ezicabanga kakhulu ukuthi zingezamabhaktheriya. Ukuyisebenzisa kumagciwane kungeza ingozi yezinketho ezingezinhle nokucindezela ukumelana ngaphandle kwenzuzo nhlobo.

Ngingaphuza utshwala ngesikhathi ngithatha i-cefixime?

Yebo, ngokucophelela. I-Cefixime ayibangeli i-reaction efana ne-disulfiram okubangelwa amanye ama-cephalosporins, ngakho-ke ukuphuza kungekhona ukulimaza ngendlela eyikho nge-antibiotics ethile. Nokho, utshwala buququzela isisu, futhi le mithi isivele ibange uhudo cishe kumuntu oyedwa kweyisithupha. Ukwengeza kulokho akuzuzisi.

I-cefixime kufanele ithathwe ngokudla?

Noma ngabe yikuphi kuyasebenza. Ukudla akunciphisi kakhulu inani lemithi oyifakayo, ngakho ungathatha amaphilisi noma umunqumo ngaphandle kokudla noma ngaphandle kokudla. Uma isicanucanu sikuhlaphazela, ukuthatha umsebenzi ngokudla kuvamise ukusiza. Hlanganisa umunqumo kahle ngaphambi komsebenzi ngamunye, futhi usebenzise idivaysi yokulinganisa evela ekhemisi kunokuba usebenzise isipuni sasekhishini.

Isiphetho

I-Suprax ne-cefixime ejwayelekile yimithi efanayo ebhekwe ngumthetho ofanayo we-FDA, ngakho igama lomkhiqizo we-cefixime likuthengelanga okungeziwe ekusebenzeni noma ekubekezeleleni. Chitha isikhathi sakho kulezi zinto ezimbili eziguqukayo: ikhemisi olikhethayo lokugcwalisa, kanye nalokho ifomu lomsebenzi elihambisana nomuntu oyithathayo. Futhi uma i-gonorrhea yisona sizathu sokuba ufunde, hlolwa kunokuziphatha.

Umunyanya: Lesi sihloko sinokwazi kuphela futhi asisho ukweluleka ngezokwelapha. Njalo thintana nomhlinzeki wezempilo oqeqeshiwe ngezinqumo zokuxilonga nokwelapha. Uma ubhekene nesimo esiphuthumayo sezokwelapha, shayela u-911 noma uye egumbini lezimo eziphuthumayo eliseduze ngaso leso sikhathi.