Yini i-Amisulpride (Indlela yokufaka ngemithambo yegazi): Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Amisulpride enikezwa ngemithambo yegazi iyimithi esiza ekuvikeleni isicanucanu nokuhlanza ngemva kokuhlinzwa noma izinqubo zezokwelapha. Lo muthi we-antipsychotic usebenza ngendlela ehlukile uma usetshenziselwa isicanucanu uma uqhathaniswa nokusetshenziswa kwawo kwezengqondo, uqondisa izamukeli ezithile zobuchopho ezilawula isifiso sokuhlanza. Ithimba lakho lezokwelapha lizokunika lo muthi ngqo emthanjeni wakho, ngokuvamile esibhedlela noma emtholampilo lapho bengakwazi ukukuqapha eduze.

Yini i-Amisulpride?

I-Amisulpride iyimithi eyingxenye yeqembu elibizwa ngokuthi ama-antipsychotics, kodwa ungavumeli lelo gama likukhathaze. Uma inikezwa ngemithambo yegazi, isebenza ngenjongo ehluke ngokuphelele kunokwelapha izimo zempilo yengqondo. Lo muthi usebenza ngokuvimba izithunywa zamakhemikhali athile ebuchosheni bakho abizwa ngokuthi ama-dopamine receptors.

Ngefomu layo lokufaka ngemithambo yegazi, i-amisulpride yenzelwe ngokuqondile ukuvimbela nokwelapha isicanucanu nokuhlanza okungenzeka ngemva kokuhlinzwa noma ukwelashwa okuthile kwezokwelapha. Inguqulo ye-IV ivumela imithi ukuthi isebenze ngokushesha nangempumelelo uma kungenzeka ukuthi awukwazi ukuthatha amaphilisi ngomlomo.

Isetshenziselwani i-Amisulpride?

Isizathu esikhulu sokuthi odokotela basebenzise i-IV amisulpride ukuvimbela isicanucanu nokuhlanza ngemva kokuhlinzwa, okuthinta abantu abaningi ngemva kokuhlinzwa. Lo mphumela ongamnandi eceleni unganciphisa ukululama kwakho futhi kukwenze uzizwe ungajabuli lapho kufanele uphole.

Ithimba lakho lezempilo lingase likhethe lo muthi uma usengozini enkulu yokuba nesicanucanu ngemva kokuhlinzwa. Ezinye izinto ezenyusa le ngozi zihlanganisa ukuba ngowesifazane, ukuba nomlando wokugula kokunyakaza, ukungabhemi, noma ukuba nezinhlobo ezithile zokuhlinzwa njengalezo ezihilela isisu noma indlebe yangaphakathi.

Kwezinye izimo, odokotela bangasebenzisa i-IV amisulpride ukwelapha isicanucanu esibi nokuhlanza okubangelwa ukwelashwa okuthile kwezokwelapha lapho eminye imithi ingasebenzi kahle ngokwanele. Isinqumo sokusebenzisa lo muthi othile sincike esimweni sakho esithile kanye nomlando wezokwelapha.

Isebenza Kanjani I-Amisulpride?

I-Amisulpride isebenza ngokuvimba ama-dopamine receptors engxenyeni ethile yobuchopho bakho ebizwa ngokuthi i-chemoreceptor trigger zone. Le ndawo isebenza njengesikhungo sakho sokulawula isicanucanu somzimba, ithola izinto ezingakugulisa futhi zibangele ukuhlanza.

Lapho i-amisulpride ivimba lawa ma-receptors, empeleni ibeka ibhuleki elithambile ezimpawini ezingakwenza uzizwe unesiyezi. Lokhu kuthathwa njengendlela eqinile ngokulinganisela yokuvimbela isicanucanu, enamandla kunezinye izidakamizwa eziyisisekelo zokulwa nesicanucanu kodwa esetshenziswa ngokucophelela ngenxa yamandla ayo.

Umuthi uqala ukusebenza ngokushesha uma unikezwa nge-IV, ngokuvamile phakathi kwemizuzu eyi-15 kuya kwengama-30. Lesi senzo esisheshayo senza ukuthi sibe wusizo ikakhulukazi ezindaweni zezokwelapha lapho ukukhululeka okusheshayo kubalulekile.

Kufanele Ngiyithathe Kanjani I-Amisulpride?

Ngeke uzithathele wena i-IV amisulpride - ithimba lakho lezempilo lizokunika yona nge-tube encane efakwe emthanjeni wakho. Lokhu kuvame ukwenzeka esibhedlela, esikhungweni sokuhlinzwa, noma emtholampilo lapho ochwepheshe bezokwelapha bengakuqapha ngokucophelela.

Umuthi uvame ukunikezwa njengomjovo ohamba kancane emgqeni wakho we-IV, okuthatha imizuzu embalwa nje. Akudingeki ukhathazeke ngokuyihlela nokudla noma iziphuzo ngoba iya ngqo egazini lakho. Ithimba lakho lezokwelapha lizosingatha zonke izici zobuchwepheshe zokuphatha.

Ngaphambi kokuthola umuthi, yazisa abahlinzeki bakho bezempilo nganoma yimiphi eminye imithi oyithathayo, okuhlanganisa izidakamizwa ezingaphandle kwe-counter kanye nezithasiselo. Bazofuna futhi ukwazi nganoma yikuphi ukungezwani komzimba noma ukusabela kwangaphambilini emithini.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Amisulpride?

I-IV amisulpride ngokuvamile inikezwa njengomthamo owodwa noma imithamo embalwa esikhathini esifushane, ngokuvamile ngesikhathi sokuhlinzwa kwakho noma inqubo yezokwelapha. Lena akuyona imithi ozoyithatha amasonto noma izinyanga njengokunye ukwelashwa.

Imiphumela yomthamo owodwa ingahlala amahora amaningana, okuvame ukwanele ukukusiza ukuthi udlule esikhathini lapho isicanucanu ngemva kokuhlinzwa singenzeka kakhulu. Ithimba lakho lezokwelapha lizinqumela ukuthi ngabe udinga imithamo eyengeziwe ngokuya ngokuthi uzizwa kanjani futhi usabela kanjani ekwelashweni.

Ezimweni eziningi, ngeke kudingeke uqhubeke nanoma iyiphi imithi yokuhlanza uma uzizwa ungcono futhi ukwazi ukudla nokuphuza ngokujwayelekile. Abahlinzeki bakho bezempilo bazokuqondisa kulolu hlelo futhi bakwazise ukuthi yini ongayilindela.

Yiziphi Imiphumela Eceleni ye-Amisulpride?

Njengayo yonke imithi, i-IV amisulpride ingabangela imiphumela emibi, yize abantu abaningi beyibekezelela kahle uma isetshenziswa isikhathi esifushane. Imiphumela eminingi emibi imnene futhi yesikhashana, inyamalala njengoba imithi iphuma emzimbeni wakho.

Imiphumela emibi evame kakhulu ongase uyithole ihlanganisa ukuzizwa ukozela noma ulele, okuyinto ejwayelekile ngempela ngemuva kokuhlinzwa. Ungase futhi uqaphele isiyezi esithile, ikakhulukazi lapho uvuka ulala phansi, noma uzizwe unokuthile okungazinzi noma ukucasuka.

Abanye abantu bathola okuthiwa izimpawu ze-extrapyramidal, ezizwakala zethusa kepha ngokuvamile zibandakanya ukuqina kwemisipha emnene noma ukunyakaza okungahleliwe. Le miphumela ngokuvamile yesikhashana futhi kungenzeka kakhulu ngemithamo ephezulu noma ukusetshenziswa okuphindaphindiwe.

Imiphumela emibi engavamile kepha ebucayi ingabandakanya izinguquko esigqi senhliziyo, ikakhulukazi isimo esibizwa ngokuthi i-QT prolongation. Yingakho ithimba lakho lezokwelapha likuqapha ngokucophelela, ikakhulukazi uma unezinkinga zenhliziyo noma uthatha eminye imithi engathinta isigqi senhliziyo.

Ngokuvamile, abanye abantu bangase bahlangabezane nokusabela okukhulu komzimba, ukwehla okungazelelwe kwengcindezi yegazi, noma isimo esibizwa ngokuthi i-neuroleptic malignant syndrome. Lezi zimo ezinzima azivamile kodwa zidinga ukunakekelwa kwezempilo ngokushesha, yingakho lo muthi unikezwa kuphela ezindaweni zezokwelapha.

Ubani Ongafanele Athathe I-Amisulpride?

Abantu abathile kufanele bagweme i-IV amisulpride ngenxa yengozi eyengeziwe yezinkinga. Uma wazi ukuthi unokungezwani komzimba ne-amisulpride noma imithi efanayo, ithimba lakho lezempilo lizokhetha elinye elinye ukwelashwa kokulwa nesicanucanu.

Abantu abanezimo ezithile zenhliziyo, ikakhulukazi labo abanokushaya kwenhliziyo okungajwayelekile noma umlando wokwelulwa kwe-QT, bangase bangabi ngabantu abafanelekayo kulo muthi. Ithimba lakho lezokwelapha lizobuyekeza impilo yakho yenhliziyo futhi lingase lenze i-electrocardiogram (ECG) ngaphambi kokunquma ukuthi i-amisulpride iphephile yini kuwe.

Uma unezinkinga ezinzima zezinso, odokotela bakho bangase bakhethe omunye umuthi ngoba i-amisulpride icutshungulwa ngezinso zakho. Ukucatshangelwa okufanayo kuyasebenza uma unezimo ezithile zesibindi noma uthatha imithi engase ihlangane ngendlela eyingozi ne-amisulpride.

Abesifazane abakhulelwe kanye nomama abancelisa izingane ngokuvamile bagwema lo muthi ngaphandle uma izinzuzo zicacile ukuthi zidlula izingozi. Ithimba lakho lezempilo lizoxoxa ngezindlela eziphephile uma ukhulelwe noma uncelisa.

Amagama Omkhiqizo we-Amisulpride

Uhlobo lwe-intravenous lwe-amisulpride lutholakala ngaphansi kwegama lomkhiqizo elithi Barhemsys e-United States. Lena inguqulo evunywe yi-FDA eyenzelwe ngqo ukusetshenziswa kwe-IV ekuvikeleni isicanucanu nokuhlanza ngemva kokuhlinzwa.

Emazweni angaphandle, ungase uhlangabezane namagama omkhiqizo ahlukene noma amafomula, kodwa isithako esisebenzayo sihlala sifana. Ithimba lakho lezempilo lizokwazi ukuthi yimuphi umkhiqizo othile abawusebenzisayo futhi lingaphendula noma yimiphi imibuzo mayelana nefomula ethile oyitholayo.

Ezinye Izindlela Zokwelapha ze-Amisulpride

Eminye imithi eminingi ingavimbela futhi iphathe isicanucanu nokuhlanza ngemva kokuhlinzwa uma i-amisulpride ingakulungele. I-Ondansetron ingenye yezinye izindlela ezisetshenziswa kakhulu, esebenza ebuchosheni obuhlukene kodwa ithola imiphumela efanayo.

Ezinye izinketho zihlanganisa i-dexamethasone, i-steroid enciphisa ukuvuvukala nesicanucanu, noma i-droperidol, omunye umuthi we-antipsychotic osetshenziselwa ngqo isicanucanu. Ithimba lakho lezokwelapha lingase futhi licabangele i-promethazine, i-metoclopramide, noma imithi emisha efana ne-palonosetron.

Ukukhetha enye indlela kuncike esimweni sakho sezokwelapha esithile, eminye imithi oyithathayo, kanye nomlando wakho siqu wokuthi usabele kanjani ekwelashweni kokulwa nesicanucanu esikhathini esidlule. Abahlinzeki bakho bezempilo bazokhetha inketho ephephe kakhulu nephumelelayo ecaleni lakho elithile.

Ingabe i-Amisulpride Ingcono Kune-Ondansetron?

Kokubili i-amisulpride ne-ondansetron ziyasebenza ekuvikeleni isicanucanu nokuhlanza ngemva kokuhlinzwa, kodwa zisebenza ngezindlela ezihlukene kancane. I-Amisulpride ivimba ama-dopamine receptors ngenkathi i-ondansetron ivimba ama-serotonin receptors, inikeza odokotela izinketho ezisuselwe ezidingweni zakho ezithile.

Ucwaningo luphakamisa ukuthi i-amisulpride ingase isebenze kangcono kancane kune-ondansetron kwezinye izimo, ikakhulukazi kubantu abasengozini enkulu yesicanucanu ngemva kokuhlinzwa. Kodwa-ke, i-ondansetron isetshenziswe isikhathi eside futhi ineprofayili yokuphepha esungulwe kahle odokotela abaningi abakhululekile ngayo.

Ukukhetha

I-Amisulpride idinga ukucatshangelwa ngokucophelela uma unesifo senhliziyo, ikakhulukazi izimo ezithinta ukushaya kwenhliziyo yakho. Umuthi ungenza i-QT prolongation, ethinta umsebenzi kagesi wenhliziyo yakho futhi engaholela ezinkingeni eziyingozi zokushaya.

Ithimba lakho lezokwelapha cishe lizokwenza i-electrocardiogram (ECG) ngaphambi kokukunika i-amisulpride uma unezimo zokugula kwenhliziyo. Bazophinde baqaphe ukushaya kwenhliziyo yakho ngesikhathi nangemva kokwelashwa. Uma unezinkinga ezinkulu zokushaya kwenhliziyo, cishe bazokhetha omunye umuthi wokulwa nesicanucanu ophephe kakhulu esimweni sakho esithile.

Q2. Kufanele Ngenzeni Uma Ngithola I-Amisulpride Eningi Ngengozi?

Njengoba i-IV amisulpride inikezwa ochwepheshe bezempilo endaweni yezokwelapha, ukweqisa ngengozi akuvamile. Ithimba lezokwelapha libala ngokucophelela umthamo wakho ngokusekelwe esisindweni sakho kanye nesimo sezokwelapha, futhi likuqapha kuyo yonke inqubo.

Uma ukweqisa kwenzeka, ubuzobe usendaweni efanele yokwelashwa ngokushesha. Izimpawu ze-amisulpride eningi zingabandakanya ukozela okukhulu, ukuqina kwemisipha, noma izinguquko ekushayeni kwenhliziyo. Ithimba lakho lezokwelapha liqeqeshwe ukubona nokwelapha lezi zimpawu ngokushesha uma zenzeka.

Q3. Kufanele Ngenzeni Uma Ngeqa Umthamo We-Amisulpride?

Ukuqa umthamo ngokuvamile akuyona into ekhathazayo nge-IV amisulpride ngoba ivamise ukunikezwa njengokwelashwa okukodwa ngesikhathi sokuhlinzwa noma izinqubo zezokwelapha. Ithimba lakho lezempilo liphatha isikhathi futhi lizokunika umuthi uma udingeka kakhulu.

Uma uhlelelwe ukuhlinzwa futhi ukhathazekile ngokuvimbela isicanucanu, vele uxoxe ngalokhu nethimba lakho lezokwelapha. Bazoqinisekisa ukuthi uthola ukwelashwa okufanele kokulwa nesicanucanu ngesikhathi esifanele, kungakhathaliseki ukuthi yi-amisulpride noma omunye umuthi ofanele.

Q4. Ngingayeka Nini Ukuthatha I-Amisulpride?

Akudingeki ukhathazeke ngokuyeka i-IV amisulpride njengoba ngokuvamile inikezwa njengomthamo owodwa noma uchungechunge olufushane lwemithamo. Umuthi ngokwemvelo uyaphuma emzimbeni wakho emahoreni ambalwa, futhi akukho inqubo yokuhoxisa noma isidingo sokunciphisa umthamo kancane kancane.

Imiphumela iyaphela yodwa, ngokuvamile kungakapheli amahora angu-8 kuya kwangu-12 ngemva komthamo wakho wokugcina. Ithimba lakho lezokwelapha lizokuqapha ngalesi sikhathi futhi liqinisekise ukuthi uzizwa ukhululekile njengoba imiphumela yomuthi iphela futhi ubuyela kokujwayelekile.

Q5. Ngingashayela ngemva kokuthola i-IV Amisulpride?

Akufanele ushayele noma usebenzise imishini ngemva kwamahora ambalwa ngemva kokuthola i-IV amisulpride. Umuthi ungabangela ukozela, isiyezi, kanye nezinguquko esikhathini sokusabela okwenza ukushayela kungaphephile.

Njengoba cishe uzobe ululama emsebenzini wokuhlinzwa noma inqubo yezokwelapha, imikhawulo yokushayela ngokuvamile iyingxenye yohlelo lwakho lokululama olujwayelekile. Ithimba lakho lezempilo lizokunikeza isiqondiso esiqondile mayelana nokuthi kuphephile nini ukuqhubeka nemisebenzi ejwayelekile, okuhlanganisa ukushayela, ngokusekelwe kokubili ku-amisulpride kanye nesimo sakho sezokwelapha esijwayelekile.