Yini i-Brexanolone: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Brexanolone iyikhambi elisha elenzelwe ngqo ukwelapha ukucindezeleka okukhulu ngemva kokubeletha konina abasha. Linikezwa ngomjovo we-IV emahoreni angama-60 endaweni yasesibhedlela, okwenza kube ukwelashwa kokuqala okuvunywe yi-FDA okuqondiswe ngqo ezingeni eliyingqayizivele lezinguquko zamakhemikhali obuchopho ezenzeka ngemva kokuzalwa.

Lo muthi unikeza ithemba konina abahlangabezana nokucindezeleka okukhulu ngemva kokuba nomntwana. Ngokungafani nama-antidepressants esintu angathatha amasonto ukuthi asebenze, i-brexanolone ivame ukunikeza impumuzo ezinsukwini ezimbalwa, isiza ukubuyisela ukuxhumana ngokomzwelo phakathi komama nomntwana ngalesi sikhathi esibucayi sokubopha.

Yini i-Brexanolone?

I-Brexanolone iyinguqulo yokwenziwa ye-allopregnanolone, i-hormone eyenzeka ngokwemvelo eveliswa ubuchopho bakho ngesikhathi sokukhulelwa. Le hormone idlala indima ebalulekile ekulawuleni imizwa kanye namazinga okukhathazeka, futhi yehla kakhulu ngemva kokuzalwa.

Umuthi uza njengesixazululo esicacile, esingenambala okumele sinikezwe ngomjovo we-IV oqhubekayo. Yenziwa ngaphansi kwegama lomkhiqizo elithi Zulresso futhi imelela indlela entsha ngokuphelele yokwelapha ukucindezeleka ngemva kokubeletha ngokufaka ngqo i-hormone elahlekile esikhundleni sokuzama ukuthuthukisa amanye amakhemikhali obuchopho.

Okuthokozisayo nge-brexanolone ukuthi isebenza kuma-receptors e-GABA ebuchosheni bakho. Lawa ma-receptor asiza ukuthulisa umsebenzi wemizwa futhi anciphise imizwa yokukhathazeka nokucindezeleka okungahlula omama abasha.

Isetshenziselwani i-Brexanolone?

I-Brexanolone ivunyelwe ngokuqondile ukwelapha ukucindezeleka ngemva kokubeletha kwabesifazane abazale. Yenzelwe omama abahlangabezana nokucindezeleka okuphakathi nendawo kuya kokukhulu okuthinta kakhulu ukusebenza kwabo kwansuku zonke kanye nekhono labo lokuzinakekela bona kanye nezingane zabo.

Udktela wakho angase ancome i-brexanolone uma uhlangabezana nosizi oluqhubekayo, ukukhathazeka, noma ukungabi nathemba ngemva kokuzala okungathuthuki ngemithi ejwayelekile. Lo muthi ulusizo ikakhulu komama abazizwa behlukene nezingane zabo noma abahlupheka ngemizwa eminingi yokunganeleki.

Lokhu kwelashwa kubuye kucatshangelwe lapho ezinye izidambisi zokucindezeleka zingasebenzi kahle noma lapho kudingeka ukuthuthuka okusheshayo. Abanye omama bathola ukuthi imithi yendabuko ithatha isikhathi eside ukuhlinzeka ngosizo ngesikhathi esibucayi sokubopha nezingane zabo ezisanda kuzalwa.

Isebenza Kanjani I-Brexanolone?

I-Brexanolone isebenza ngokulingisa i-allopregnanolone, i-hormone evame ukukhuphuka ngesikhathi sokukhulelwa bese yehla ngokushesha ngemva kokubeletha. Lolu shintsho olukhulu lwe-hormonal lungabangela ukucindezeleka okukhulu kwabesifazane abathile, futhi i-brexanolone isiza ukubuyisela ibhalansi ye-hormonal ebuchosheni.

Lo muthi usebenza kuma-GABA receptors, afana nohlelo lwakho lobuchopho lwamabhuleki emvelo. Uma la ma-receptors esetshenzisiwe, asiza ukuthulisa izindlela ze-neural ezigxilile ezinomthelela ekucindezelekeni nasekukhathazekeni. Lokhu kudala umphumela ozolile ongaphakamisa imizwa futhi unciphise ukucindezeleka ngokomzwelo.

Ngokungafani nezidambisi zokucindezeleka zendabuko ezisebenza ku-serotonin noma ezinye izithunywa ze-neurotransmitters, i-brexanolone iqondisa ukungalingani okuthile kwe-hormonal okwenzeka ngemva kokubeletha. Le ndlela eqondiwe ivame ukukhiqiza imiphumela esheshayo, nabesifazane abaningi behlangabezana nokuthuthuka phakathi kwamahora angu-24 kuya kwangu-48 ekuqaleni kokwelashwa.

Kufanele Ngiyithathe Kanjani I-Brexanolone?

I-Brexanolone kufanele inikezwe esibhedlela ngendlela yokufakwa kwe-IV okuqhubekayo ngamahora angu-60 ngqo. Kuzodingeka uhlale esibhedlela ngesikhathi sonke sokwelashwa, esivame ukuthatha cishe izinsuku ezingu-2.5, ukuze abasebenzi bezokwelapha bakwazi ukukuqapha eduze.

Ukunikezwa komuthi kuqala ngomthamo ophansi bese kwenyuka kancane kancane ngosuku lokuqala, bese kugcinwa izinga eliqhubekayo ngaphambi kokuthi lehle kancane kancane. Akudingeki wenze lutho olukhethekile ngokudla noma isiphuzo, kodwa kufanele ugweme utshwala ngokuphelele ngesikhathi sokwelashwa nangemva kwezinsuku ezimbalwa.

Ngesikhathi sokunikezwa komuthi, uzoxhunywa emishinini yokuqapha elandela izimpawu zakho ezibalulekile futhi ibheke noma yiziphi izimpawu ezikhathazayo. Umugqa we-IV uzolungiswa ngokucophelela ukuze ukwazi ukuhamba emakamelweni akho futhi uphumule ngokunethezeka ngenkathi uthola ukwelashwa.

Ithimba lakho lezempilo lizokuvakashela njalo phakathi namahora angu-60. Bazohlola imizwa yakho, baqaphe imiphumela emibi, futhi baqinisekise ukuthi ukunikezwa komuthi kuqhubeka ngokuphepha. Ungaba nezivakashi futhi uhlanganyele emisebenzini elula, kodwa kuzodingeka uhlale endaweni eqashwe.

Kufanele Ngithathe Isikhathi Esingakanani I-Brexanolone?

I-Brexanolone inikezwa njengenkambo eyodwa yokwelashwa yamahora angu-60, futhi abesifazane abaningi abadingi ukuphindwa kokunikezwa komuthi. Umuthi wenzelwe ukuhlinzeka ngokuqeda izimpawu zokucindezeleka ngemva kokubeletha ezingaqhubeka amasonto noma izinyanga ngemva kokuphela kokunikezwa komuthi.

Izifundo zomtholampilo zibonisa ukuthi abesifazane abaningi bathola ukuthuthuka okuqhubekayo okungenani izinsuku ezingama-30 ngemva kokuqeda ukunikezwa komuthi. Omama abathile bathola ukuthi izinzuzo zihlala isikhathi eside, zibasiza ngezinyanga zokuqala ezibucayi zobumama lapho ukubopha nokuzivumelanisa kubaluleke kakhulu.

Uma izimpawu zakho zibuyela emva kwamasonto ambalwa, udokotela wakho angase acabangele enye inkambo yokwelashwa, nakuba lokhu kungavamile. Bazosebenza nawe ukuze banqume ukuthi i-brexanolone eyengeziwe noma ezinye izindlela zokwelapha zingaba usizo kakhulu esimweni sakho esithile.

Yiziphi Imiphumela Emibi ye-Brexanolone?

I-Brexanolone ingabangela imiphumela emibi, kodwa iningi liyalawuleka futhi okwesikhashana. Imiphumela emibi evame kakhulu ukulala ngobuthongo nesiyezi, yingakho udinga ukuhlala esibhedlela lapho abasebenzi bezokwelapha bengakugcina uphephile.

Nawa amanye amaphutha ongase uhlangabezane nawo ngesikhathi sokwelashwa, futhi kujwayelekile ukuzizwa ukhathazekile ngala mathuba:

• Ukozela nokukhathala okungakwenza uzizwe ulele kakhulu
• Isiyezi noma ukuzizwa ungaqinile uma umi noma uhamba
• Umlomo owomile nezinguquko ekunambitheni
• Isicanucanu noma isisu esibuhlungu
• Ikhanda elivame ukuba lincane noma libe phakathi nendawo
• Ukuzizwa ushisa noma ukuba nokushisa
• Ukuphendula kwendawo yokujova lapho kufakwa khona i-IV

Le miphumela evamile ngokuvamile iyathuthuka njengoba umzimba wakho ujwayela imithi futhi ngokuvamile iyanyamalala ngokuphelele ezinsukwini ezimbalwa ngemuva kokuqeda ukwelashwa.

Kukhona nemiphumela emibi engavamile kodwa ebucayi edinga ukunakekelwa kwezempilo ngokushesha. Nakuba lokhu kungenzeki njalo, kubalulekile ukukwazi ukuze ukwazi ukwazisa ithimba lakho lezempilo ngokushesha:

• Ukuzola okukhulu okwenza kube nzima ukuvuka noma ukuhlala uqaphile
• Ukulahlekelwa ngokuphazima kwengqondo noma ukuzizwa udidekile
• Ukuphefumula kanzima noma ukuphefumula ngokushesha
• Ubuhlungu besifuba noma ukushaya kwenhliziyo okusheshayo
• Ukuphendula okukhulu komzimba okune-rash, ukuvuvukala, noma ubunzima bokugwinya
• Ukudideka noma ukulahlekelwa yisikhathi okubonakala kungavamile

Ukuqapha esibhedlela kuqinisekisa ukuthi noma yimiphi imiphumela emibi ebucayi ibanjwa ngokushesha futhi iphathwe ngendlela efanele. Ukuphepha kwakho kuyinto eza kuqala kuyo yonke inqubo yokwelashwa.

Ubani Ongafanele Athole I-Brexanolone?

I-Brexanolone ayifanele wonke umuntu, futhi udokotela wakho uzohlola ngokucophelela ukuthi iphephile yini kuwe. Umuthi udinga ukuqapha okuseduze ngoba ungenza ukozela okukhulu kanye nokuzola okuyingozi kwabanye abantu.

Akufanele uthole i-brexanolone uma unomlando wokuphendula komzimba okukhulu emuthini noma kunoma yiziphi izithako zawo. Abesifazane abanezimo ezithile zenhliziyo, izinkinga zokuphefumula, noma isifo sesibindi bangase badinge ezinye izindlela zokwelashwa.

Udaktela wakho uzophinda acabangele ukuthi ngabe usebenzisa eminye imithi engase ihlangane ngendlela eyingozi ne-brexanolone. Eminye imithi ebangela ukozela, njengemithi ethile yokwelapha ubuhlungu noma izithuthukisi zokulala, ingakhuphula ingozi yokuthulisa ngokweqile uma ihlanganiswe nalolu hlobo lokwelashwa.

Uma uncelisa, kuzodingeka uxoxe ngezingozi nezinzuzo nodokotela wakho. Ngenkathi amanani amancane e-brexanolone engase adlulele obisini lwebele, isikhathi esifushane sokwelashwa sisho ukuthi noma yikuphi ukuchayeka kumntwana wakho kungaba kuncane.

Igama Lomkhiqizo we-Brexanolone

I-Brexanolone itholakala ngaphansi kwegama lomkhiqizo elithi Zulresso, elikhiqizwa yi-Sage Therapeutics. Leli yilo kuphela igama lomkhiqizo elitholakalayo njengamanje ngalo muthi, njengoba kuyindlela yokwelapha entsha ethola imvume ye-FDA ngonyaka ka-2019.

I-Zulresso itholakala kuphela ngezikhungo zezempilo eziqinisekisiwe eziqede izinhlelo zokuqeqeshwa ezikhethekile. Lokhu kuqinisekisa ukuthi abasebenzi bezokwelapha baqonda ukuthi bangawunika kanjani umuthi ngokuphepha futhi baqaphe iziguli phakathi nenkathi yokufakwa kwemizuzu engama-60.

Azikho izinhlobo ezivamile ze-brexanolone ezitholakalayo okwamanje, okusho ukuthi i-Zulresso iyona kuphela inketho yalolu hlobo oluthile lokwelashwa. Umshwalense wakho nezinhlelo zosizo lwezezimali zingasiza ngezindleko zalokhu kwelashwa okukhethekile.

Ezinye izindlela zokwelapha i-Brexanolone

Uma i-brexanolone ingakulungele, kunezinye izindlela eziningi zokwelapha ezisebenzayo zokucindezeleka ngemuva kokubeletha. Imithi yokucindezeleka yendabuko efana ne-sertraline noma i-paroxetine ivame ukuba yizindlela zokwelapha zokuqala futhi ingasetshenziswa ngokuphepha ngenkathi uncelisa.

I-Psychotherapy, ikakhulukazi i-cognitive behavioral therapy kanye ne-interpersonal therapy, ingasebenza kakhulu ekucindezelekeni ngemuva kokubeletha. Lezi zindlela zikusiza ukuthi uthuthukise amasu okubhekana nezinkinga futhi ubhekane nezinselelo ezingokomzwelo zobungomama obusha ngaphandle kwemithi.

Abanye besifazane bayazuza ekwelashweni ngamaphilisi e-hormone, ikakhulukazi uma ukucindezeleka kwabo kuhlobene eduze nezinguquko ze-hormone ngemva kokuzala. Udokotela wakho angase acebise amachashazi e-estrogen noma izithasiselo ze-progesterone njengengxenye yohlelo lokwelapha olubanzi.

Ama-support group kanye nokwelulekwa kontanga kungahlinzeka ngosizo olubalulekile lwemizwa ngalesi sikhathi esinzima. Omama abaningi bathola ukuthi ukuxhumana nabanye abaqonda okuhlangenwe nakho kwabo kusiza ekunciphiseni imizwa yokuzihlukanisa nokuba namahloni.

Ingabe i-Brexanolone ingcono kunezinye izidambisi zokucindezeleka?

I-Brexanolone inikeza izinzuzo eziyingqayizivele ngaphezu kwezidambisi zokucindezeleka zendabuko, ikakhulukazi ukuqala kwayo okusheshayo kokusebenza. Ngenkathi izidambisi zokucindezeleka eziningi zithatha amasonto angu-4-6 ukukhombisa imiphumela ephelele, i-brexanolone ivame ukuhlinzeka ngokuphumula kungakapheli amahora angu-24-48 ekuqaleni kokwelashwa.

Umuthi futhi uqondise izinguquko ezithile ze-hormone ezenzeka ngemva kokuzala, okwenza ukuthi ilungele ukucindezeleka kwangemva kokubeletha. Izidambisi zokucindezeleka zendabuko zisebenza kumakhemikhali ahlukene obuchopho futhi kungenzeka zingaqedi ukungalingani kwe-hormone okubangela izifo zemizwa zangemva kokubeletha.

Nokho, i-brexanolone idinga ukulaliswa esibhedlela nokuqapha okukhulu, okungasebenzi kubo bonke besifazane. Izidambisi zokucindezeleka zendabuko zingathathwa ekhaya futhi azidingi isikhathi sokuhamba kude nomntwana wakho nomndeni, okwenza zifinyeleleke kalula kumama abaningi.

Ukukhetha phakathi kwe-brexanolone nezinye izindlela zokwelapha kuncike ezimweni zakho ezithile, okuhlanganisa ubunzima bokucindezeleka kwakho, uhlelo lwakho lokusekela, kanye nekhono lakho lokuchitha isikhathi esibhedlela. Udokotela wakho uzokusiza ukuthi ulinganise lezi zinto ukuze unqume indlela engcono kakhulu yesimo sakho.

Imibuzo Evame Ukubuzwa Mayelana ne-Brexanolone

Ingabe i-Brexanolone iphephile ekunceliseni?

I-Brexanolone ingasetshenziswa ngenkathi uncelisa, kodwa kuzodingeka uxoxe ngesikhathi nodokotela wakho. Inani elincane lemithi lidlulela obisini, kodwa amazinga ngokuvamile athathwa njengaphephile ezinganeni.

Ngenxa yokuthi ukwelashwa kuthatha amahora angama-60 kuphela, noma yikuphi ukuchayeka kwengane yakho ngobisi lwebele kungaba okwesikhashana. Omama abaningi baqhubeka nokuncelisa ngesikhathi sokwelashwa, ikakhulukazi njengoba izinzuzo zokwelapha ukucindezeleka okukhulu ngemva kokubeletha ngokuvamile zidlula izingozi ezincane enganeni.

Udokotela wakho uzokusiza ukuthi wenze isinqumo esinolwazi ngokusekelwe esimweni sakho esithile nempilo yengane yakho. Bangase baphakamise ukukhipha ubisi lwebele bese ulugcina ngaphambi kokwelashwa noma ukusebenzisa ifomula okwesikhashana ngesikhathi sokufakwa.

Kufanele ngenzeni uma ngithola i-Brexanolone eningi ngengozi?

Akudingeki ukhathazeke ngokuthola i-brexanolone eningi ngengozi ngoba imithi inikezwa ochwepheshe bezokwelapha abaqeqeshiwe besebenzisa amaphampu afakwa ngokuqondile. Abasebenzi basemtholampilo baqapha izinga lokufakwa ngokuqhubekayo futhi banemithetho yokuphepha endaweni yokuvimbela ukweqisa.

Uma uzwa ukozela okungavamile, ubunzima bokuhlala uvukile, noma ubunzima bokuphefumula ngesikhathi sokufakwa kwakho, yazisa ithimba lakho lezempilo ngokushesha. Lokhu kungaba yizimpawu zokuthi uthola imithi eningi kakhulu noma ukuthi umzimba wakho uzwela kakhulu ekwelashweni.

Abasebenzi bezokwelapha bazolungisa izinga lakho lokufakwa uma kudingeka futhi bangase banikeze ukunakekelwa okusekelayo ukukusiza ukuthi uzizwe ukhululekile. Khumbula ukuthi usendaweni ephephile, eqashwe ngaso sonke isikhathi senqubo yokwelashwa.

Kufanele ngenzeni uma ngiphuthelwa umthamo we-Brexanolone?

Ukuphuthelwa umthamo akuyona into okumele ukhathazeke ngayo nge-brexanolone ngoba inikezwa njengokufakwa okuqhubekayo esibhedlela. Imithi igeleza ngokuqhubekayo ngomugqa wakho we-IV isikhathi esiphelele sama-60 amahora, ngakho-ke awekho imithamo eyodwa okufanele uyikhumbule noma uyiphuthelwe.

Uma umugqa wakho we-IV uqhekezeka noma uyeka ukusebenza kahle, ithimba lakho lezempilo lizobona ngokushesha ngemishini yokuqapha. Bazoxhuma kabusha ngokushesha noma bashintshe umugqa ukuze baqinisekise ukuthi uthola ukwelashwa okuphelele njengoba kunqunywe.

Abasebenzi basemtholampilo bagcina amarekhodi aqinile okuthi ungakanani umuthi owutholile futhi bazolungisa ukumnika uma kwenzeka noma yikuphi ukuphazamiseka. Uhlelo lwakho lokwelashwa lwenzelwe ukubala izinkinga ezincane zobuchwepheshe ezingase zivele phakathi nesikhathi esingamahora angama-60.

Ngingayeka nini Ukuthatha i-Brexanolone?

Akudingeki ukuthi wenze izinqumo mayelana nokuyeka i-brexanolone ngoba inikezwa njengenkambo eyodwa, enqunywe ngaphambilini yokwelashwa. Ukumnika kuncipha ngokuzenzakalelayo futhi kuyeka ngemva kwamahora angama-60 ngqo, kulandela isimiso esiklanywe ngokucophelela.

Umuthi wenzelwe ukuhlinzeka ngezinzuzo ezihlala isikhathi eside eziqhubeka amasonto noma izinyanga ngemva kokuphela kokumnika. Ngeke uzwe izimpawu zokuhoxiswa lapho ukwelashwa kuyeka ngoba inqubo yokunciphisa isiza umzimba wakho ukuthi ulungiswe kancane kancane.

Uma unezinkathazo mayelana nokuyeka ukumnika ngaphambi kwesikhathi ngenxa yemiphumela emibi, xoxa ngalokhu nethimba lakho lezempilo. Bangalungisa uhlelo lokwelashwa uma kudingeka, kodwa abesifazane abaningi bayakwazi ukuqeda inkambo ephelele yamahora angama-60 ngaphandle kwezinkinga ezinkulu.

Ibiza Malini i-Brexanolone?

I-Brexanolone iyindlela yokwelashwa ebiza kakhulu, izindleko zivame ukusuka ku-$20,000 kuya ku-$35,000 ngokuqeda ukumnika kwamahora angama-60 nokuhlala esibhedlela. Kodwa-ke, izinhlelo eziningi zomshuwalense manje zimboza lokhu kwelashwa, ikakhulukazi uma kuthathwa njengokudingekayo ngokwezokwelapha ekucindezelekeni okukhulu ngemva kokubeletha.

Ukuvikelwa komshuwalense wakho kuzoncika ohlelweni lwakho oluthile nokuthi ngabe udokotela wakho angabonisa yini ukuthi ezinye izindlela zokwelapha azisebenzanga. Izinkampani eziningi zomshuwalense zidinga imvume yangaphambilini, okusho ukuthi udokotela wakho udinga ukuthumela imibhalo echaza ukuthi kungani udinga lokhu kwelashwa okuthile.

Uma umshwalense ungahlanganisi izindleko eziphelele, izinhlelo zokusiza iziguli zingase zitholakale ngomkhiqizi noma izinhlangano ezingenzi nzuzo. Ithimba lakho lokunakekelwa kwezempilo lingakusiza ukuthi uhlole izinketho zezezimali futhi ufake izicelo zezinhlelo zokusiza ezinganciphisa izindleko zakho eziphuma ephaketheni.