Cha. I-Naproxen ayiyona imithi yokubhidliza igazi, ayiyona i-narcotic, futhi ayiyona i-muscle relaxer. Kuyinto i-NSAID (nonsteroidal anti-inflammatory drug) ephatha ubuhlungu, umkhuhlane, nokuvuvukala. Iyanciphisa ukusebenza kwamapuleti, okungandisa ubungozi bokopha, kodwa ayinikezwa ukwelapha ukugeleza kwegazi.

NGAMAFFUSHANE: Okubalulekile

  • I-Naproxen iyi-NSAID, ifana ne-ibuprofen ne-diclofenac.
  • Akuyona i-anticoagulant, kodwa inesebenza yangempela ku-antiplatelet.
  • Akuyona i-narcotic futhi ayinazo izinhlu zedivayisi ye-DEA.
  • Akuyona i-muscle relaxer futhi ayisoze yaqeda ukuthuthumela noma ikwenze ulale.
  • Ububungozi bangempela bungukuyihlanganisa ne-warfarin, i-DOAC, noma i-aspirin.

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Ngokuvamile yebo, kodwa cela umuntu ozokwenza inqubo leyo. Ngenxa yokuthi umphumela we-naproxen emaplatelet (amaseli egazi) uhlala isikhathi eside njengoba umuthi usebenza, futhi isikhathi esiwuthathayo ukuphuma emzimbeni side kunese-ibuprofen, odokotela abahlinzayo bavame ukucela ukuba umise ukuyisebenzisa ezinsukwini ezimbalwa ngaphambi kokuhlinzwa, hhayi amahora angama-24 kuphela. Isikhathi esiqondile sincike engozini yokopha ehambisana nenqubo yakho kanye neminye imithi oyiphuzayo, ngakho-ke thola imiyalo eqondile kudokotela wakho ohlinzayo noma kadokotela wamazinyo.

Hhayi kakhulu, kodwa ithatha isikhathi eside. Zombili ziyimithi yohlobo lwe-NSAID esebenza ngokunciphisa ukunamathelana kwama-platelet. I-naproxen ihlala emzimbeni isikhathi eside kakhulu, ngakho ukuyiphuza kabili ngosuku kwenza umuthi uhlale uhlezi ohlelweni lomzimba wakho, kanti umphumela we-ibuprofen uya ngokuphela phakathi kwemithamo. Ayikho kule mithi engenza umonakalo unomphela njengoba kwenza i-aspirin, yingakho i-aspirin isasetshenziswa ngokuqondile ukuvimba amahlule egazi.

Impendulo eqondile: i-naproxen ayiyona imithi yokubhidliza igazi, kodwa iyayehla ukopha

Ingabe i-naproxen iyagayela igazi? Cha. I-Naproxen iyi-NSAID, ayiyona i-anticoagulant noma imithi ye-antiplatelet enikezwa ukuvimbela ukwakheka kwamahlulela. Noma kunjalo, ama-NSAID angakhethi njenge-naproxen ayavimbela ukuhlanganiswa kwamapuleti, ngakho-ke umthelela ekopha uyangempela noma ngabe isigaba sihlukile. I-Warfarin ne-apixaban zikhona ukuvimbela ukwakheka kwamahlulela. I-Naproxen ikhona ukuphatha ubuhlungu, umkhuhlane, nokuvuvukala.

I-Naproxen futhi ayiyona i-narcotic futhi ayiyona i-muscle relaxer. Zombili lezi zinkolelo ezingalungile zinemvelaphi ethile, eqondakalayo, futhi zombili kufanele ziqedwe kahle. Izingxenye ezingezansi zenza kanye kanye lokho.

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Ngokujwayelekile yebo. I-acetaminophen ayinawo umphumela wokunciphisa ukujiya kwegazi futhi ayicasuli isisu, ngakho ngokuvamile iyona yokuqala ekhethwayo kubantu abaphuzayo imithi yokunciphisa ukujiya kwegazi. Into eyodwa okufanele uyazi: ukuyisebenzisa kakhulu isikhathi eside kungakhuphula inkomba ye-INR kubantu abaphuza i-warfarin. Ngakho-ke, uma udinga ukuyiphruza nsuku zonke isikhathi esingaphezu kwezinsuku ezimbalwa, tshela udokotela wakho oqapha ukujiya kwegazi lakho.

Cha. I-naproxen akuyona i-opioid futhi ayihloliwe ezivivinyweni ezijwayelekile zokubheka imithi emzimbeni emsebenzini noma ezibhedlela. Izivivinyo zakudala zazinokukhipha imiphumela engamanga ngezinye izikhathi ngokuhlangana neminye imithi ye-NSAID, kodwa ukuhlolwa okuqinisekisiwe kukususa lokho. Uma kukhona ukuhlolwa okuzayo, vele usho ukuthi uyayisebenzisa i-naproxen phakathi kwemithi yakho, kubandakanya naleyo oyithenga ngaphandle kwencwadi kadokotela.

Khohlwa isigaba, okubalulekile ukuthi i-naproxen yenzani kumapuleti akho

Ingabe i-naproxen iyawathinta amapuleti? Yebo, futhi le ngxenye ebalulekile empilweni yakho. I-Naproxen ivimbela ama-enzyme amabili, i-COX-1 ne-COX-2. I-COX-1 yiyona amapuleti akho awasebenzisayo ukwenza i-thromboxane A2, imiyalezo yokuxhumana eyitshela amapuleti ukuthi ahlangane futhi enze i-plug. I-thromboxane encane kusho ukuthi amapuleti ayihlanganisi kahle. Lokho kuyindlela yonke, futhi yilokho okwenza i-naproxen iziphathe kancane njengemithi yokubhidliza igazi ngaphandle kokuthi ibe yiyo.

Indlela efanayo, imithi ehlukile. I-Warfarin ihlanganyela nezici zokopha ezincikile ku-vitamin K; i-apixaban ne-rivaroxaban ivimba i-factor Xa. I-Naproxen ayenzi nanoma yikuphi kwalokho. Yenza nje amapuleti akho angabi namunamathelisi njengomphumela wokuvimbela ukuvuvukala.

Enye umehluko obalulekile ku-aspirin: i-aspirin ivimbela i-COX-1 unomphela impilo yalo mphlet. I-Naproxen iyaguquguquka futhi ihlala nje ngenkathi imithi isazungeza. Ngakho-ke umbuzo wokusiza awufe ngaso sonke isikhathi ukuthi i-naproxen ihlala eshalofini elingakanani ekhemisi. Yikho i-naproxen eyenza kumapuleti akho nasemgqeni wesisu sakho ngesikhathi esifanayo nanoma yini enye oyithathayo.

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Yebo, kokubili. Imithi ye-NSAID ibangela umzimba ugcine usawoti namanzi, okungakhuphula umfutho wegazi futhi kwenze izinyawo zivuvuke kakhulu. Futhi inciphisa ukusebenza kwemithi yomfutho wegazi (njengama-ACE inhibitors nama-diuretics), futhi ukusebenzisa le mithi ndawonye kungabeka izinso zakho engozini. Uma uphuza noma yimuphi waleyo mithi, qiniseka ukuthi uwuhlola njalo umfutho wegazi lakho ngenkathi usebenzisa i-naproxen.

I-Naproxen ingeyesigaba se-NSAID, hhayi isigaba se-opioid noma se-relaxant

Ingabe i-naproxen iyi-NSAID? Yebo, futhi leyo nto eyodwa ixazulula iningi lodideko kulana khasi. Isigaba semithi ye-naproxen singama-nonsteroidal anti-inflammatory drugs, futhi izihlobo zayo yi-ibuprofen, i-aspirin, ne-diclofenac. Bonke basebenza ngendlela efanayo ye-COX pathway. I-MedlinePlus ibala izindlela zayo eziqhakazisiwe njengobuhlungu, umkhuhlane, nokuvuvukala kusuka ku-arthritis, i-tendinitis, i-bursitis, i-gout, kanye nemibono yesikhathi.

Ukuba sesigabeni esijwayelekile akusho ukuthi izingozi zincane. Ukumakwa kweklasi okubhalelwa yi-FDA kusho ukuthi ama-NSAID ngaphandle kwe-aspirin andisa ingozi yesifo senhliziyo, ukwehluleka kwenhliziyo, kanye nesifo sohlangane, okungaba yingozi. Ukumakwa okufanayo kuxwayisa ngokuphuma kwegazi okubucayi, kwesinye isikhathi okubulalayo, esiswini noma emathunjini.

I-Naproxen ayiyona i-narcotic, ayiyona into elawulwa nhlobo

Ingabe i-naproxen iyona i-narcotic? Cha, futhi ayiyona ngisho into elawulwa. Ama-narcotics angempela (ama-opioids) ayi-Schedule II kuya ku-V ngaphansi komthetho wezwe. I-Naproxen ayinayo i-DEA schedule nhlobo.

Ukudideka kunezinhlanga ezimbili. I-naproxen enemithamo ephezulu iza njengezibhebhe ze-250, 375, ne-500 mg, ezizwakala njengezinhlungu ezinokwelashwa ezinezinhlungu ezingathandeki ezifana ne-220 mg ye-naproxen sodium ongayithola njenge-Aleve. Futhi ivame ukunikezwa ngemuva kokulimala, ukwelashwa kwamazinyo, noma ukuhlinzwa, izindawo ezifanayo lapho ama-opioids avele khona. I-Naproxen ayisebenzi kuma-opioid receptors, ayibangeli i-euphoria, futhi ayihlotshaniswa nokuphatheka noma ukuhoxiswa okudala ama-opioids.

Ngokwempractice, lokho kusho ukuthi akukho mizila yokugcwalisa kabusha futhi akukho iphepha le-pharmacy elilawulwa yizidakamizwa. Akusho ukuthi i-naproxen ayilona ubuthakathi. Ubungobungozi bokopha nokwehluleka kwenhliziyo bungokoqobo futhi buxhomeke kumthamo.

I-Naproxen iphatha ubuhlungu bemisipha ngaphandle kokuba i-muscle relaxer

Ingabe i-naproxen iyona i-muscle relaxer? Cha, noma ngabe iphakethe lenza kube lula ukucabanga ngendlela ehlukile. Kukhona umkhiqizo we-naproxen we-OTC obhalwe ikakhulukazi ubuhlungu bemigxolo nemisipha, futhi odokotela bavame ukunikeza i-naproxen kanye ne-cyclobenzaprine noma i-methocarbamol ngomgqumo wangemuva. Izibhebhe ezimbili zenkinga eyodwa zizwakala njengezinguqulo ezimbili zemithi efanayo.

Azisebenzi ndawo. Izixazululi zemisipha ye-skeletal zisebenza ohlelweni lwezinzwa oluphakathi ukunciphisa ukuthuthumela, yingakho zivame ukubangela ukulala. I-Naproxen isebenza ngaphandle ekuxazululeni ukuvuvukala kanye nokuxilisa ubuhlungu.

Umphumela ungowangempela: i-naproxen ngeke yaqeda ukuthuthumela kwangempela kwemisipha, ngakho uma ukuthuthumela kuyinkinga yakho, i-naproxen eyedwa ingase ikudumaze. Okunye kungenxa yokuthi i-naproxen ayibangeli ukozela okwenza izixazululi zingaphephi ukushayela ngazo.

Ukuhlanganisa i-naproxen nemithi yangempela yokubhidliza igazi yikona lapho ingozi yangempela ihlala khona

I-Naproxen nemithi yokubhidliza igazi kuyinto engakwenza ingozi, futhi le ngxenye yombuzo ibalulekile ukuthi uyinake. Ukumakwa kwe-FDA kusho ukuthi i-naproxen nama-anticoagulants afana ne-warfarin anomthelela ohlanganyele ekuphumeni kwegazi, futhi iqondisa odokotela ukuthi babheke ukuphuma kwegazi uma zombili zisetshenziswa kanye. Ukuhlanganisa okubeka engozini enkulu ukuthi kufanele ukwazi ngamagama: i-warfarin, i-apixaban ne-rivaroxaban ye-DOACs, kanye ne-aspirin ne-clopidogrel ye-antiplatelets.

I-Aspirin ifanelwe isaziso sayo, ngoba le nhlanganyelo iyabuyela nangalapha. Ocwaningweni olulawulwayo olucashunwe ekumakeni, izinsuku eziyi-10 ze-naproxen engu-220 mg ngosuku zazinciphisa umthelela we-aspirin ongadala ukugeleza kwegazi ngomthamo ophansi, okwakubonakala kakhulu lapho i-naproxen ithathwa ngaphambi kwe-aspirin. Ukumakwa kusho ukuthi ukusetshenziswa okuhlangene ne-aspirin yomuthi wobuhlungu akukhuthazwa ngokujwayelekile. Uma uthatha i-aspirin nsuku zonke enhliziyweni yakho, i-naproxen ingasebenza ngokumelene nayo ngenkathi ngokwehlukile ikwandisa ingozi yakho yokuphuma kwegazi.

Ubukhulu bezinganiso kufanele bubonakale ngokuhlangene, ngoba cishe akekho obukuhlanganisa. Ngokwe-DailyMed, i-naproxen sodium ye-OTC yi-tablet eyi-1 (220 mg) njalo emahoreni angu-8 kuye kuya ku-12, kufika ezibhebheni ezi-2 kumthamo wokuqala, futhi akufanele kwedlule ezibhebheni ezi-3 (660 mg) emahoreni angu-24. Futhi ngokwe-DailyMed, umthamo omkhulu onconywayo wokupreskriphishini ngu-1,500 mg ngosuku. Lokho kungaphezu kokuphindeka kabili kokuphakeme kwe-OTC, okuyikho kanye okwenza izifundo zokupreskriphishini kufanele zibhekwwe futhi zibe zifushane.

Izimo eziyingozi zokopha ezikwehlelayo: iminyaka engu-60 noma ngaphezulu, umlando wokuvuvukala esiswini noma izinkinga zokuphuma kwegazi, ukuthatha i-anticoagulant noma i-steroid, ukuthatha omunye umkhiqizo oqukethe i-NSAID, ukuphuza iziphuzo ezi-3 noma ngaphezulu zotshwala nsuku zonke, noma ukudlula umthamo noma isikhathi esinconywayo.

Isikwele: ama-NSAID aphinde aqhubekisele phezulu ingcindezi yegazi futhi agcine uketshezi, okuyingxenye yezizathu zokuthi isexwayiso senhliziyo sikhona. Uma usevele ulawula ingcindezi yegazi ephezulu, amaviki ambalwa e-naproxen nsuku zonke akuyona into engathandeli, ngisho nangemithamo ye-OTC.

Yazi ukuthi yiziphi izimpawu zokuphuma kwegazi ezisho ukuthi kufanele uyeke bese uthola usizo manje

Shayela ku-911 noma uye egumbini leziguli eziphuthumayo manje uma:

  • Ubuhlungu besifuba, ukushoda komoya, ubuthakathaka ohlangothini olulodwa lomzimba, noma ukukhuluma okungacacile (okungaba yisifo senhliziyo noma sohlangane)
  • Ukuhlanza igazi noma into efana nezinhlamvu zekhofi
  • Izindlela ezimnyama, ezijubane, noma ezinobubende, noma okunye igazi ezindleleni zakho
  • Ukuvuvukala kobuso, izindebe, ulimi, noma umphimbo, noma ubunzima bokuphefumula noma ukugwinya

Bhukha ukuvakashela phakathi neviki elilandelayo uma:

  • Izinhlungu ezingekho emgqeni noma eziqhubekayo esiswini
  • Ukuphaphatheka kwesikhumba noma amehlo, noma umchamo omnyama
  • Ukuncipha kokuchama, ukuvuvukala kwezinqe noma imilenze, noma ukuzuza isisindo okungachazeki
  • Ukugqekezeka kalula noma ukuphuma kwegazi okuncane okuhlale ukubona, kufaka phakathi igazi emgqonyeni wempumulo yakho

Khuluma nodokotela ngaphambi kokuba uqale uma: uthatha i-warfarin, i-apixaban, i-rivaroxaban, i-clopidogrel, noma i-aspirin nsuku zonke; uneminyaka engu-60 noma ngaphezulu; unomlando wokuvuvukala noma ukuphuma kwegazi esifubeni; unesisifo sezinso, sesibindi, noma senhliziyo; noma usuvele uthatha omunye umuthi we-NSAID. Lolo xoxiswano lufushane futhi luyashintsha uhlelo kaningi kunalokho abantu abakulindele. Ukuvakashela okungaphakathi kwe-inthanethi kwe-$39 kuka-August kukuxhumanisa nodokotela onelayisensi yase-US ongabuyekeza uhlu lwakho lwemithi futhi anqume ukuthi ngabe kukhona umuthi ofanele yini. Okungeke kwenziwe yividiyo ukuvakashela ukuhlola ukuphuma kwegazi okukhona. Ukuhlanza igazi, izindlela ezimnyama, noma ukuphuma kwegazi okungayeki kudinga ukunakekelwa ubuso nobuso noma izimo eziphuthumayo.

Imibuzo ebuzwa njalo

Ngidinga ukuphuza i-naproxen ngaphambi kokuhlinzwa noma ukwelashwa kwamazinyo?

Ngokuvamile yebo, kodwa buza umuntu owenza inqubo. Ngoba umthelela we-naproxen kumapuleti uhlala ngenkathi imithi isebenza futhi isikhathi sayo sokuba sesiswini side kune-ibuprofen, odokotela abahlinzayo bavame ukucela ukuyeka izinsuku ezimbalwa ngaphambi kokuba kube amahora angu-24. Inombolo eqondile incike engcupheni yokuphuma kwegazi yenqubo neminye imithi yakho, ngakho-ke thola kumhlinzisi wakho noma udokotela wamazinyo.

Ingabe i-naproxen yenza okuningi ekopha kune-ibuprofen?

Hhayi ngamandla amakhulu, kodwa isikhathi eside. Zombili ziyizinhlobo ezihlanganisa i-NSAID ehlanganisa ukunciphisa ukuhlanganiswa kwamapuleti okuyaguquguquka. Isikhathi sokuba khona kwe-naproxen side kakhulu, ngakho-ke ukuphuza kabili ngosuku kugcina imithi isisendaweni usuku lonke, ngenkathi umthelela we-ibuprofen uhlehla phakathi kwamithamo. Akukho noyedwa unomphela njengoba kunjalo nge-aspirin, yingakho i-aspirin ihlala iyona esetshenziswa ngabomu ukuvimbela ukwakheka kwamahlulela.

Ingabe i-acetaminophen iyindlela ephephile yobuhlungu uma ngithatha i-warfarin noma i-apixaban?

Ngokuvamile yebo. I-Acetaminophen ayinayo i-antiplatelet activity futhi ayibangeli ukucasuka esiswini, ngakho-ke yiyona eyindlela yokuqala ejwayelekile kubantu abasebenzisa ama-anticoagulants. Isaziso esibalulekile okufanele usazi: imithamo ephezulu eqhubekayo ingaphakamisa i-INR kubantu abathatha i-warfarin, ngakho-ke uma uyidinga nsuku zonke isikhathi esingaphezu kwezinsuku ezimbalwa, tshela udokotela olawula ukwelashwa kwakho ngegazi.

Ingabe i-naproxen izovela esivivinyweni sezidakamizwa?

Cha. I-Naproxen ayiyona i-opioid futhi ayihlolwa kumaphaneli ajwayelekile ezidakamizwa emsebenzini noma emtholampilo. Izivivinyo ezindala ze-immunoassay kwesinye isikhathi zazikhiqiza imiphumela emibi yamakhannabinoide noma ama-barbiturate ngezinye izinhlobo ze-NSAID, kodwa ukuhlolwa okuqinisekisayo kuyayilungisa leyo nto. Uma kukhona ukuhlolwa okuzayo, vele ufake i-naproxen ohlwini lwemithi yakho, okuhlanganisa nohlobo lwe-over-the-counter.

Ingabe i-naproxen ingakhuphula ingcindezi yegazi yami noma iyakubanga nenkinga nemithi yokwehlisa ingcindezi yegazi?

Yebo, zombili. Ama-NSAID abangela ukugcinwa kukasawoti noketshezi, okungaphakamisa ingcindezi yegazi ngamaphuzu ambalwa futhi kukuphazamise ukuvuvukala kwezinqe. Aphinde anciphise ukuthi ama-ACE inhibitors, ama-ARB, nama-diuretics asebenza kahle kangakanani, futhi inhlanganisela ye-NSAID kanye ne-diuretic kanye ne-ACE inhibitor ilayisha izinso. Uma uthatha noma yikuphi kwalokhu, hlola ingcindezi yakho ngenkathi usebenzisa i-naproxen njalo.

Okubaluleke Kakhulu

Ingabe i-naproxen iyagayela igazi? Cha, futhi ayiyona i-narcotic noma i-muscle relaxer. Kuyinto i-NSAID enomthelela wangempela ku-antiplatelet, okuyinto into ehlukile kune-anticoagulant. Yahlule ngendlela eyenzayo, hhayi ngesigaba: hlala ngaphakathi komthamo omkhulu, futhi ubheke noma yikuphi ukuhlangana ne-warfarin, i-DOAC, noma i-aspirin njengengxoxo okufanele ube nayo ngaphambi kokuba uqale kunokuba ube nayo kamuva.

Isitatimende: Leli khasi liqukethe ulwazi kuphela futhi akuyona iseluleko sezokwelapha. Ngaso sonke isikhathi thintana nomhlinzeki wokunakekelwa kwezempilo onesiqiniseko ukuze uthole ukuxilongwa kanye nezinqumo zokwelashwa. Uma ubhekene nesimo esiphuthumayo sezokwelapha, shayela u-911 noma uye egumbini leziguli eziphuthumayo eliseduze ngokushesha.