Yini iLesinurad ne-Allopurinol: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Lesinurad ne-allopurinol kuyinhlanganisela yemithi esiza abantu abanegout ukuthi balawule isimo sabo ngempumelelo enkulu. Lokhu kwelashwa okusebenza kabili kusebenza ngokunciphisa ukukhiqizwa kwe-uric acid nokusiza izinso zakho ukuthi zikhiphe i-uric acid eningi emzimbeni wakho.

Uma ubulokhu ulwa nokuvuvukala kwe-gout ngaphandle kokuthatha i-allopurinol yodwa, le nhlanganisela ingase ibe yinto ngqo udokotela wakho ayincomayo. Ukuhlanganiswa kwale mithi emibili kungahlinzeka ngokuqapha okungcono kwe-uric acid kunanoma iyiphi imithi esetshenziswa yodwa.

Yini iLesinurad ne-Allopurinol?

Le mithi ihlanganisa imithi emibili ehlukene esebenza ndawonye ukwehlisa amazinga e-uric acid egazini lakho. I-Allopurinol inciphisa ukuthi umzimba wakho ukhiqiza kangakanani i-uric acid, kuyilapho i-lesinurad isiza izinso zakho ukuthi zikhiphe i-uric acid esivele ikhona.

Uzothola le nhlanganisela ithengiswa ngaphansi kwegama lomkhiqizo elithi Duzallo. Iza njengemithi eyodwa equkethe womabili amakhambi, okwenza kube lula ukuthatha ukwelashwa kwakho kwe-gout ngaphandle kokujaha amaphilisi amaningi.

Le nhlanganisela yakhelwe ngqo abantu abane-gout engalawulwa kahle nge-allopurinol yodwa. Cabanga ngayo njengokwengeza umsizi ukuze ukwelashwa kwakho okukhona kube ngempumelelo.

Isetshenziselwani i-Lesinurad ne-Allopurinol?

Le mithi iphatha i-gout kubantu abadala abamazinga e-uric acid abo ahlala ephezulu kakhulu ngaphandle kokuthatha i-allopurinol yodwa. I-Gout yenzeka lapho amakristalu e-uric acid akha emalungeni akho, okubangela ubuhlungu obukhulu obungazelelwe nokuvuvukala.

Udokotela wakho ngokuvamile uzoncoma le nhlanganisela uma ubulokhu uthatha i-allopurinol okungenani amasonto ayisithupha kodwa amazinga akho e-uric acid asenqenqemeni olungaphezulu. Umgomo uwukuthola i-uric acid yakho ingaphansi kuka-6 mg/dL, okusiza ukuvimbela ukuhlaselwa kwe-gout okuzayo.

Lena akuyona imithi yokwelapha ukuqubuka kwe-gout okusebenzayo. Kunalokho, isebenza njengesu lokuvimbela isikhathi eside ukunciphisa imvamisa nobukhulu bokuhlaselwa okuzayo.

Isebenza Kanjani I-Lesinurad ne-Allopurinol?

Le mithi ehlanganisiwe ithathwa njengokwelashwa okuqinile okulinganiselwe okubhekana ne-uric acid kusuka ezinhlangothini ezimbili ezihlukene. I-Allopurinol ivimba i-enzyme ebizwa nge-xanthine oxidase, umzimba wakho oyisebenzisela ukwenza i-uric acid kusuka kuma-purines ekudleni.

I-Lesinurad isebenza ngendlela ehlukile ngokuvimba amaprotheni ezinso zakho avame ukumunca i-uric acid emuva egazini lakho. Lokhu kusho ukuthi i-uric acid eningi ikhishwa ngomchamo wakho esikhundleni sokuhlala emzimbeni wakho.

Ngokuhlangene, le mithi idala ukushaya okunamandla okukodwa-kabili ngokumelene ne-uric acid eyeqile. Wenza okuncane kwayo futhi uqeda okuningi kwalokho okukhiqizayo.

Kufanele Ngiyithathe Kanjani I-Lesinurad ne-Allopurinol?

Thatha le mithi ngendlela eqondile udokotela wakho ayiyalayo, ngokuvamile kanye ngosuku ekuseni ngokudla. Ukuyithatha ngokudla kusiza ukunciphisa isisu esibuhlungu futhi kuthuthukisa ukuthi umzimba wakho uyimunca kahle kangakanani imithi.

Phuza amanzi amaningi usuku lonke ngenkathi uthatha le mithi. Ukuhlala unamanzi kahle kusiza izinso zakho ukuthi zisebenze kahle futhi kunciphisa ingozi yamatshe ezinso, okungaba yinkinga ngale mithi.

Ungagxobi, uhlafune, noma uhlukanise amaphilisi. Gwinya wonke ngenkomishi yamanzi egcwele. Uma unenkinga yokugwinya amaphilisi, khuluma nodokotela wakho mayelana nezinye izinketho.

Udokotela wakho cishe uzoqala ngomthamo ophansi futhi awunyuse kancane kancane ngokuya ngokuthi usabela kahle kangakanani. Le ndlela eqaphelayo isiza ukunciphisa imiphumela emibi ngenkathi uthola umthamo olungile kuwe.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Lesinurad ne-Allopurinol?

Lena ngokuvamile imithi yesikhathi eside ozoyithatha izinyanga noma iminyaka ukuze ugcine i-gout yakho ilawulwa. Abantu abaningi badinga ukuhlala ekwelashweni okunciphisa i-uric acid unomphela ukuvimbela ukuhlaselwa kwe-gout okuzayo.

Udktela wakho uzoqapha amazinga akho e-uric acid njalo, ngokuvamile njalo ezinyangeni ezimbalwa ekuqaleni. Uma amazinga akho ezinzile ebangeni eliqondiwe, ungase ube nokuhlolwa kwegazi kaningi.

Ungayeki ukuthatha lo muthi kungazelelwe, ngisho noma uzizwa ungcono. I-Gout yisimo esingamahlalakhona, futhi ukuyeka ukwelashwa kuvame ukuholela emazingeni e-uric acid enyuka futhi ukuqubuka kwe-gout kubuya.

Yiziphi Imiphumela Eceleni ye-Lesinurad ne-Allopurinol?

Njengayo yonke imithi, le nhlanganisela ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Ukuqonda ukuthi yini okufanele uyibheke kukusiza ukuthi wazi ukuthi ungaxhumana nini nomhlinzeki wakho wezempilo.

Imiphumela emibi evame kakhulu ongase uyibone ihlanganisa ikhanda, izimpawu ezinjenge-flu, nokwanda kwengcindezi yegazi. Lokhu kuvame ukwenzeka emasontweni ambalwa okuqala okwelashwa futhi kuvame ukuthuthuka njengoba umzimba wakho uzivumela.

Nansi imiphumela emibi ongase uyithole:

• Ikhanda
• Izimpawu ezinjenge-flu (umkhuhlane, ama-chills, ubuhlungu bomzimba)
• Ukwehla kwengcindezi yegazi
• Ukucanuzela kwenhliziyo noma ukuqaqamba kwesisu
• Ukukhathala
• I-Gastroesophageal reflux (isifuba)

Le miphumela emibi evamile ivame ukuba mnene futhi ilawuleka. Udktela wakho angakusiza ukuthi uthole izindlela zokunciphisa noma yikuphi ukuqaqamba okutholayo.

Abanye abantu bangase babe nemiphumela emibi kakhulu edinga ukunakekelwa kwezempilo ngokushesha. Nakuba lokhu kungavamile, kubalulekile ukwazi izimpawu zokuxwayisa.

Xhumana nodokotela wakho ngokushesha uma uthola noma iyiphi yale miphumela emibi engavamile kodwa engathi sína:

• Izimpawu zezinkinga zezinso (izinguquko ekuchameni, ukuvuvukala emilenzeni noma ezinyaweni)
• Ukuphendula kwesikhumba okukhulu (ukuqubuka, ukuvuvukala, ukuxebuka)
• Izimpawu zezinkinga zesibindi (ukuphuzi kwesikhumba noma amehlo, umchamo omnyama, ukukhathala okukhulu)
• Ukuphendula okukhulu komzimba (ubunzima bokuphefumula, ukuvuvukala ebusweni noma emqaleni)
• Ukuphuma kwegazi okungavamile noma ukulimala
• Ubuhlungu obukhulu besisu

Lezi zimo ezingathi sína azivamile, kodwa ukuzibona ngokushesha kungasiza ekuvikeleni izinkinga. Ithimba lakho lezempilo lilapho ukuzokusekela nganoma yiziphi izinkathazo.

Obani okungafanele basebenzise i-Lesinurad ne-Allopurinol?

Lo muthi awulungelwe wonke umuntu, futhi udokotela wakho uzohlola ngokucophelela ukuthi ukufanele yini. Ezinye izimo zempilo nemithi kungenza le nhlanganisela ingaphephile noma ingasebenzi kahle.

Akufanele usebenzise lo muthi uma unezifo ezinzima zezinso noma usebenzisa i-dialysis. Ingxenye ye-lesinurad ingenza ukusebenza kwezinso kube kubi kakhulu kubantu abanezinkinga eziphambili zezinso.

Abantu abanezimo ezithile zofuzo ezithinta indlela imizimba yabo eprosesa ngayo imithi kungenzeka badinge nokugwema le nhlanganisela. Udokotela wakho angase ayale ukuhlolwa kofuzo uma esola ukuthi ungomunye walezi zimo.

Nazi izimo eziyinhloko lapho lo muthi ngokuvamile unganconywa khona:

• Isifo esinzima sezinso (ukususwa kwe-creatinine okungaphansi kuka-30 mL/min)
• Ukwelashwa nge-dialysis
• Ukungezwani okwaziwayo ne-allopurinol noma i-lesinurad
• Isifo esinzima sesibindi
• Ukukhulelwa noma ukuncelisa
• Ukuthatha imithi ethile exhumana ngendlela eyingozi

Udokotela wakho uzobuyekeza umlando wakho wezokwelapha ophelele nemithi yamanje ngaphambi kokukuyalela le nhlanganisela. Ukwethembeka ngazo zonke izimo zakho zempilo kusiza ekuqinisekiseni ukuphepha kwakho.

Amagama Omkhiqizo we-Lesinurad ne-Allopurinol

Inhlanganisela ye-lesinurad ne-allopurinol itholakala ngaphansi kwegama lomkhiqizo elithi Duzallo. Leli okwamanje yilona kuphela igama lomkhiqizo elitholakala ngale nhlanganisela ethile e-United States.

I-Duzallo iza ngesimo samaphilisi ngamandla ahlukene ukuze kuvunyelwe ukulinganisa okufanele. Udokotela wakho uzokuyalela amandla athile alungele isimo sakho.

Ngenkathi izinhlobo ezivamile ze-allopurinol zodwa zitholakala kabanzi, inhlanganisela ne-lesinurad itholakala kuphela njengegama lomkhiqizo elithi Duzallo. Lokhu kungathinta ukumbozwa komshuwalense nezindleko eziphuma ephaketheni.

Ezinye izindlela ze-Lesinurad ne-Allopurinol

Uma le nhlanganisela ingakulungele, ezinye izinketho eziningana zikhona zokuphatha i-gout namazinga aphezulu e-uric acid. Udokotela wakho angakusiza ukuthi uhlole lezi ezinye izindlela ngokusekelwe ezidingweni zakho ezithile.

I-Allopurinol yodwa isahlala iyona muthi ovame ukunqunywa wokwehlisa i-uric acid. Abantu abaningi benza kahle nge-allopurinol ngokwayo, ikakhulukazi lapho umthamo ulungiswa kahle.

Nazi ezinye izindlela eziyinhloko udokotela wakho angazicabangela:

• I-Febuxostat (Uloric) - enye i-xanthine oxidase inhibitor
• I-Probenecid - isiza izinso ukususa i-uric acid
• I-Pegloticase (Krystexxa) - ye-gout eqinile, engamelani nokwelashwa
• I-Colchicine - yokuvimbela ukuqubuka kwe-gout ngesikhathi sokwelashwa
• Ukuguqulwa kwendlela yokuphila kanye nezinguquko zokudla

Ukukhetha enye indlela kuncike ezintweni ezinjengokusebenza kwezinso zakho, ezinye izimo zempilo, nokuthi wenze kahle kangakanani ekwelashweni kwangaphambilini. Udokotela wakho uzosebenza nawe ukuthola indlela engcono kakhulu.

Ingabe i-Lesinurad ne-Allopurinol ingcono kune-Allopurinol yodwa?

Kubantu abangakafinyeleli emigomweni yabo ye-uric acid nge-allopurinol yodwa, ukwengeza i-lesinurad kungahlinzeka ngezinzuzo ezinkulu. Izifundo zikhombisa ukuthi le nhlanganisela isebenza kahle ekwehliseni amazinga e-uric acid kune-allopurinol ngokwayo.

Nokho, lokhu akusho ukuthi le nhlanganisela ingcono ngokuzenzakalelayo kuwo wonke umuntu. Uma wenza kahle nge-allopurinol yodwa futhi amazinga akho e-uric acid asemgqeni, asikho isidingo sokwengeza omunye umuthi.

Le nhlanganisela inengqondo kakhulu uma i-allopurinol yodwa ingakutholi i-uric acid yakho ngaphansi kuka-6 mg/dL naphezu komthamo owanele. Kulezi zimo, ukwengeza i-lesinurad kungakusiza ukuthi ufinyelele amazinga akho omgomo ngempumelelo.

Udokotela wakho uzocabangela ukusabela kwakho ngakunye ku-allopurinol, amazinga akho e-uric acid, kanye nempilo yakho yonke lapho enquma ukuthi inhlanganisela ifanele yini ukuzama. Umgomo uhlala ukuthola ukwelashwa okuphumelela kakhulu ngemiphumela emibi embalwa.

Imibuzo Evame Ukubuzwa Mayelana ne-Lesinurad kanye ne-Allopurinol

Ingabe i-Lesinurad kanye ne-Allopurinol iphephile kubantu abanezifo zezinso?

Le nhlanganisela idinga ukucatshangelwa ngokucophelela uma unezinkinga zezinso. Ngenkathi ukukhubazeka kwezinso okuncane kungase kungakuvimbi ukuthatha lo muthi, isifo sezinso esibi kakhulu ngokuvamile senza kungaphephile.

Udokotela wakho uzohlola ukusebenza kwezinso zakho ngezivivinyo zegazi ngaphambi kokuqala lo muthi futhi akuqaphele njalo ngesikhathi sokwelashwa. Uma ukusebenza kwezinso zakho kwehla, kungase kudingeke ukuthi balungise umthamo wakho noma bashintshe ekwelashweni okuhlukile.

Isici se-lesinurad singase sibe nomthelela omubi ekusebenzeni kwezinso, ikakhulukazi uma woma. Yingakho ukuhlala unamanzi kahle kubaluleke kakhulu lapho uthatha lo muthi.

Ngingenzani uma ngiphuthelwa ukuthatha i-Lesinurad kanye ne-Allopurinol?

Uma ngengozi uthatha okungaphezu komthamo wakho obekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ukuthatha okuningi kungakhuphula ingozi yakho yemiphumela emibi engathí sina, ikakhulukazi izinkinga zezinso.

Ungazami ukulungisa ukweqisa ngokweqa umthamo wakho olandelayo. Esikhundleni salokho, thola iseluleko sezokwelapha mayelana nendlela yokuqhubeka ngokuphepha.

Izimpawu zokweqisa zingase zihlanganise isicanucanu esibi, ukuhlanza, noma izinguquko ekuchameni. Uma uhlangabezana nanoma yiziphi izimpawu ezikhathazayo ngemva kokuthatha okuningi, funa ukunakekelwa kwezokwelapha ngokushesha.

Ngingenzani uma ngiphuthelwa umthamo we-Lesinurad kanye ne-Allopurinol?

Uma uphuthelwa umthamo, wuthatha ngokushesha lapho ukhumbula, uma nje kungesona isikhathi esicishe sibe sesikhathini somthamo wakho olandelayo. Uma sekuseduze nesikhathi somthamo wakho olandelayo, weqa umthamo ophuthelwe futhi uqhubeke neshejuli yakho evamile.

Ungaphindi izilinganiso ukuze ulungise leyo oyiphuthelwe. Ukuthatha izilinganiso ezimbili ngokusondelene kungakhuphula ingozi yakho yemiphumela engemihle ngaphandle kokuhlinzeka ngezinzuzo ezengeziwe.

Uma uvame ukukhohlwa izilinganiso, cabangela ukusetha i-alamu yansuku zonke noma ukusebenzisa umhleli wamaphilisi ukukusiza ukuthi ukhumbule. Ukuthatha imithi nsuku zonke ngokuqhubekayo kubalulekile ekugcineni amazinga e-uric acid azinzile.

Ngingayeka nini ukuthatha i-Lesinurad ne-Allopurinol?

Kufanele uyeke kuphela ukuthatha lo muthi ngaphansi kokuqondisa kukadokotela wakho. I-Gout yisimo esingamahlalakhona, futhi ukuyeka ukwelashwa okunciphisa i-uric acid ngokuvamile kuholela ekunyukeni kwamazinga e-uric acid nasekuhlaselweni kwe-gout okubuyayo.

Udokotela wakho angase acabangele ukulungisa ukwelashwa kwakho uma ugcine amazinga e-uric acid okuhlosiwe isikhathi eside futhi wenze izinguquko ezinkulu zokuphila. Kodwa-ke, abantu abaningi badinga ukuqhubeka nohlobo oluthile lokwelashwa okunciphisa i-uric acid isikhathi eside.

Uma uhlangabezana nemiphumela engemihle ekhathazayo, khuluma nodokotela wakho mayelana nokulungisa umthamo wakho noma ukushintshela emuthini ohlukile kunokuyeka ukwelashwa ngokuphelele.

Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Lesinurad ne-Allopurinol?

Ngenkathi kungekho ukuvinjelwa okuphelele kotshwala, ukuphuza kungaphazamisa ukuphathwa kwakho kwe-gout ngezindlela eziningana. Utshwala bungakhuphula amazinga e-uric acid futhi bungase buholele ekuhlaselweni kwe-gout.

Ubhiya nemimoya kunenkinga ngoba iqukethe ama-purines futhi ingakhuphula ukukhiqizwa kwe-uric acid. Iwayini ngokuvamile liyabekezeleleka kangcono, kodwa ukulinganisela kusabalulekile.

Uma ukhetha ukuphuza, yenza kanjalo ngokulinganisela futhi uhlale unamanzi kahle. Xoxa ngokusebenzisa kwakho utshwala nodokotela wakho ukuze bakwazi ukukufaka ohlelweni lwakho lokwelashwa olujwayelekile.