I-Meloxicam Ne-Naproxen: Amandla, Ingozi Yesisu, Umthamo, Nokuthi Ungakhetha Kanjani

Akekho ozakhela. Ezivivinyweni eziqondanisayo, i-meloxicam engu-7.5 mg kanye ngosuku yanciphisa ubuhlungu be-arthritis cishe njenge-naproxen engu-750 mg ngosuku. Umehluko we-meloxicam nochungechunge lwe-naproxen ukufaneleka: i-meloxicam ifuna incwadi kadokotela, ithathwa kanye ngosuku, futhi ayilimazi kakhulu isisu kumadizi aphansi; i-naproxen iyatholakala ngaphandle kokubonisana nodokotela futhi iphatha ububanzi obubanzi bezinhlungu.

ISISHOMO: Okubalulekile

• Kumadizi ajwayelekile, le mikhiqizo emibili ilawula ubuhlungu be-arthritis ngendlela efanayo. Izibalo zamamiligrem azidlulisi phakathi kwemikhiqizo ehlukene.
• I-Meloxicam yabonisa izenzakalo ezimbalwa ezingezinhle emgudwini wokugaya ukudla kune-naproxen esivivinyweni sezinyanga ezintandathu (30.3% uma kuqhathaniswa no-44.7%).
• Lowo mkhawulo wesisu uqine kakhulu ku-7.5 mg futhi uyancipha ku-15 mg.
• Zombili zithwala isexwayiso esifanayo esivaliwe yi-FDA sohlanga lokuhlaselwa yinhliziyo, unhlangothi, nokopha kwesisu.
• Ungalokothi uzithathe ndawonye. Ukubeka ama-NSAID amabili ndawonye kwandisa ingozi ngaphandle kokungeza ukudambisa.

I-Meloxicam Ne-Naproxen: Indlela Efana Nokusebenza, Ukufinyelela Nokushelela Okwehlukile

I-Meloxicam ne-naproxen zombili imithi elwa nokuvuvukala engasebenzi ngokuvimbela ukukhiqizwa kwe-prostaglandin, yingakho zivuselela ubuhlungu nokuvuvukala ngezindlela ezifanayo. I-Meloxicam ifuna incwadi kadokotela, ithathwa kanye ngosuku, futhi ivunyelwe ikakhulukazi i-arthritis. I-Naproxen iza ngokuyalwa nodokotela nangaphandle kokuyalwa, ithathwa kabili noma kathathu ngosuku, futhi iphatha ububanzi obubanzi bezinhlungu. Kumadizi ajwayelekile, ukudambisa kufana.

Umehluko wokusebenzisa ovunyelweyo uyaphila. I-Meloxicam inikwe ilayisensi ye-i-osteoarthritis, i-rheumatoid arthritis, ne-juvenile idiopathic arthritis ezinganeni ezineminyaka engu-2 nangaphezulu, nokunye. I-Naproxen isibambelela lezi zimo ze-arthritis kanye nubuhlungu besinye, ubuhlungu bekhanda, nobuhlungu bemisipha, futhi ungayithola njenge-Aleve ngaphandle kokubona muntu.

Ngendlela yokusebenza, umehluko owodwa ubalulekile. Kumadizi aphansi, i-meloxicam ithembekile ekubambeni i-COX-2 ngaphezu kwe-COX-1, ngenkathi i-naproxen ivimbela zombili izimvubelo ngokungakhethi. I-COX-1 isiza ukugcina umugqa wesisu, futhi leyo nto eyodwa iyisisekelo esiphelele sokuduma kwe-meloxicam okungcono esiswini.

Yikuphi Okunamandla, I-Meloxicam Noma I-Naproxen? Isivivinyo Sasishilo Njengabalingani

Lapho abantu bebuzayo ukuthi yikuphi okunamandla, i-meloxicam noma i-naproxen, bavame ukuqhathanisa izinombolo zamaphilisi. Kunempendulo eqondile. Esivivinyweni esiyizinyanga eziyisithupha esiyimpumputhe kabili kubantu abane-rheumatoid arthritis, i-meloxicam engu-7.5 mg ngosuku yayisebenza njenge-naproxen engu-750 mg ngosuku. Izigameko ezingezinhle zesisu zenzeka ku-30.3% weqembu le-meloxicam kanye no-44.7% weqembu le-naproxen, futhi izilonda eziqinisekiswe yi-endoscope zatholakala eqenjini le-naproxen.

Ngakho-ke u-15 mg we-meloxicam akuwona umthamo obuthakathaka kuno-500 mg we-naproxen. Amamiligrem akala isisindo samolekyu, hhayi amandla ayo, futhi ayidlulisi phakathi kwemikhiqizo ehlukene njengoba nje amayintshi angadluliswa amakhilogremu.

Lokho kubuyekeza konke ukukhetha. Awukhethi umuthi onamandla kakhulu. Ukhetha iphrofayili yezimfihlo nezindlela zokuthatha umthamo ongaphila nawo.

• I-Meloxicam ifanele uma ufuna umthamo owodwa ngosuku wokuhlanganisa i-arthritis engapheli, uke waba nokuphazamiseka kwesisu kuma-NSAID angakhethi, noma ukukhumbula imithamo kuyinkinga yakho yangempela.
• I-Naproxen ifanele uma udinga ukufinyelela lapho udinga khona noma ngaphandle kokuyalwa, ubuhlungu bakho budlula i-arthritis buye emaqeneni, ubuhlungu bekhanda, noma ubuhlungu bemisipha, noma usuvele uphendula kahle kuyo.

Kubuhlungu be-Arthritis, Abadlali Abangukhiye Isisu Sakho, Inhliziyo Yakho, Nomthamo Wakho

Ukuqhathanisa i-naproxen ne-meloxicam kubuhlungu be-arthritis, zombili zivunyelwe yi-FDA nge-osteoarthritis ne-rheumatoid arthritis, ne-meloxicam ingeza i-juvenile idiopathic arthritis kusuka eminyakeni engu-2. Ukusebenza ngeke kuqede isikolo. Umlando wakho wokugaya ukudla, izinso, nenhliziyo uzokwenza njalo.

Nansi into amakhasi amaningi angayitsheli wena: umkhawulo wesisu we-meloxicam uncike kumthamo. Isibuyekezo se-American Family Physician sithole ukuthi umkhawulo ongcono wokuphepha kwe-GI kungowomthamo ka-7.5 mg, futhi uyancipha ku-15 mg. Uma incwadi kadokotela yakho ithi 15 mg, ungacabangi ukuthi ugcine inzuzo enhle yesisu leyo thamo eliphansi elayithola. Isibuyekezo esifanayo sithole ukuthi amazinga ezimilo ezibangela i-thromboembolic awazange enyuswe nge-meloxicam uma kuqhathaniswa ne-naproxen ngokukhethekile, okungahlanganisi inkolelo ejwayelekile yokuthi i-naproxen iyona NSAID ephephile enhliziyweni. Leyo inguqulo phakathi kwale mikhiqizo emibili, hhayi ubufakazi bokuthi i-meloxicam ivikela inhliziyo yakho.

Zombili izidakamizwa zithwala isikhombiso esivaliwe esifanayo yi-FDA: ingozi eyengeziwe yezenzakalo ezinzima, ezingabulala izenzakalo ezihlobene nenhliziyo kanye nokuphuma kwegazi okunzima emgudwini wokugaya ukudla, izilonda, nokungena, konke lokhu okungenzeka ngaphandle kwesaziso. Ingengozi ikhuphuka ubudala obudala, impilo embi jikelele, ukubhema, nokusebenzisa kabi utshwala.

Ukuphuma kwegazi okuncane e-GI kuvame ukuba yimfihlo. Ngezinye izikhathi inkomba yokuqala iy-anemia yokushoda kwensimbi ebonakala njenge imiphumela yokuhlolwa kwegazi kwe-MCV ephansi kumalabhorethri ajwayelekile, izinyanga ngaphambi kokopha okucacile. Sebenzisa umthamo ophansi kakhulu osebenzayo isikhathi esifushane esilawula i-arthritis yakho, futhi uphathe njengento okufanele ivuselelwe kunokugcwaliswa ngaphandle kokuphela.

Umthamo Owodwa Ngosuku Uyinzuzo Enkulu Ye-Meloxicam

Umehluko womthamo we-meloxicam ne-naproxen yinto ebambekayo ebahluphayo. I-Meloxicam iqala ku-7.5 mg kanye ngosuku kubuhlungu be-osteoarthritis ne-rheumatoid arthritis, ngezinga eliphezulu lika-15 mg kanye ngosuku kungakhathalekile ukuthi iyini ifomathi kanye nomkhawulo owancishisiwe ongu-7.5 mg ngosuku kubantu abathola i-hemodialysis. Uyithatha ngesikhathi esifanayo nsuku zonke, nokudla noma ngaphandle kokudla.

I-Naproxen efunekayo incwadi kadokotela ivame ukuthathwa kabili ngosuku kubuhlungu be-arthritis, kanti uhlobo olubambezelekile luyathathwa kanye ngosuku. I-Naproxen sodium etholakala ngaphandle kokuyalwa iqhutshwa ngomkhawulo onzima kakhulu: itaphulethi elilodwa njalo ngama-8 kuya ku-12 amahora, kungabi ngaphezu kwamaphilisi amabili emahoreni angu-8 kuya ku-12, futhi kungabi ngaphezu kwamaphilisi amathathu (660 mg) emahoreni angu-24, nomthamo wokuqala wamaphilisi amabili uvunyelwe ehora lokuqala.

Kungani ukwahlukana? I-Pharmacokinetics. Isikhathi esingaba isigamu se-meloxicam cishe amahora angu-20 ngokuya ngemininingwane yomkhiqizi, ngenkathi i-naproxen iseduze nama-12 kuya ku-17 amahora, ngakho i-meloxicam igcina izinga legazi eligcwele usuku lonke futhi i-naproxen idinga ukuphinde ithathwe.

Izinto ezimbili zibanga abantu. Umphumela ophelele wokulwa nokuvuvukala ungathatha isonto elilodwa kuya kwamabili ukuthi ubheke, ngakho akekho umuthi okufanele ubhekwe ngemva kwezinsuku ezimbili. Futhi ukufinyelela ngaphandle kokuyalwa kuyindlela yokudakwa ngasese kwe-naproxen: kulula ngempela ukweqa umkhawulo wama-24 amahora, noma ukuphinda ugcwalise ngomkhiqizo wobuhlungu obuningi noma wokubanda, ngaphandle kokuhlose ukwenza njalo.

Ukuthatha Zombili Ndawonye Kwephinda Kabili Ingozi Ngaphandle Kokuphinda Kabili Ukudambisa

Impendulo emfushane yokuthi ungathatha i-meloxicam ne-naproxen ndawonye iyichunge. Ukuhlanganisa ama-NSAID amabili kwandisa ingozi yokuphuma kwegazi e-GI nokulimala kwezinso ngenkathi kungeza kancane ekulawuleni ubuhlungu, ngoba zombili izidakamizwa ziyancintisana ngezimvubelo ezifanayo. Isinxoxo esifanayo siyasebenza ku-ibuprofen, diclofenac, aspirin, kanye neziqhakambisi zegazi ngaphandle uma udokotela ekutshelile.

Funda amalebula kunoma yini oyithengayo ngobuhlungu, umkhuhlane, noma ukuvaleka komoya. Ama-NSAID afihliwe kumikhiqizo ehlanganisiwe yindlela ejwayelekile abantu abathola ngayo imithamo ngengozi.

Uma udokotela wakho ekuhambisa ukusuka kwenye imithi uye kwenye, akudingi ukuwashwa okusemthethweni, kodwa ukubambisana yilokho ofuna ukukugwema. Yeka omunye, qala omunye, futhi ulindele i-meloxicam ukuthi ithathe izinsuku ezimbalwa ukuba icace ngenxa yesikhathi sayo eside. Ungalwenzi uhambo ngokungeza i-naproxen etholakala ngaphandle kokuyalwa phezu kwe-meloxicam ngenkathi ulindele ukuthi imithi emisha isebenze. Leyo yindlela kanye naleso simo isixwayiso esingenhla sichaza.

Izixwayiso Ezithile Ze-NSAID Zidinga Ukunakekelwa Namuhla, Hhayi Ekugcwalisweni Kwakho Okulandelayo

Isixwayiso esivaliwe akusona isimo esibonakalayo. Lezi zenzakalo ziyenzeka, futhi lezo ezidinga isikhathi zibalulekile ukuzibamba ngekhanda.

Shayela ku-911 noma uye egumbini lezimo eziphuthumayo manje uma:

• Unezinhlungu esifubeni, ukushoda komoya, ubuthakathaka noma ukubuyela kwemizwa okungazelelwe ngakolunye uhlangothi, noma inkulumo enobunzima.
• Uyakhafula igazi noma izinto ezibukeka njengezindunduma zekhofi.
• Izitulo zakho zimnyama, zihambisana nesikhumba, noma zinokopha.
• Unezinhlungu ezibi zesisu ezingapheli.
• Ubuso bakho noma umphimbo wakho kuvuvukala, ulwele ukuphefumula, noma uvele uqhume izinyoka ezibanzi.

Izinga elilandelayo alidramatiki kodwa lisadinga ukulinda ukuze uvakashele okujwayelekile.

Bhuka ukuvakashelwa ngesonto elilandelayo uma:

• Isikhumba sakho noma amehlo akho abukeka njenge-yellow, umchamo wakho umnyama, noma uzizwa ukhathele ngokungajwayelekile.
• Umicca kancane, noma izinyawo zakho namadolo kuvuvukala.
• Une-heartburn ephelele noma izinhlungu esiswini kumuthi owodwa.
• Izinhlungu zakho ze-arthritis zisengalawuleki ngemva kwezinsuku ezimbili ezinezimvunulo ezizinzile.

Futhi ngaphambi kokuthi uqale omunye umuthi, umlando othile ushintsha ukubala ngokuphelele.

Khuluma nodokotela ngaphambi kokuthi uqale uma:

• Uke waba nezilonda noma ukuphuma kwegazi e-GI, isifo izinso noma i-dialysis, ukwehluleka kwenhliziyo, ukuhlaselwa yinhliziyo noma unhlangothi okudala, noma umfutho wegazi ong controlwanga.
• Ukhulelwe noma uzama ukukhulelwa, noma uneminyaka engu-65 nangaphezulu.
• Uthatha iziqhakambisi, i-aspirin, ama-SSRI, ama-diuretics, noma ama-ACE inhibitors.

Uma unganqumi ukuthi yimuphi i-NSAID ofanele umlando wakho, lokho ukusetshenziswa okuhle kakhulu kokuvakashelwa kwengozi ku-$39 ye-August, lapho udokotela onemvume yase-US angabuyekeza umthamo wakho wamanje, eminye imithi yakho, kanye nezingozi zakho, futhi anqume ukuthi kunomuthi ofanele yini. Ukuvakashelwa ngevidiyo akukwazi ukuhlola ukopha okusolwayo kwe-GI, ubuhlungu esifubeni, noma izimpawu zikunhlangothi. Lezi zidinga igumbi lezimo eziphuthumayo. Abantu abadala abasebenzisa ama-NSAID esikhathi eside, uvakasho lwaminyaka yonke lwe-Medicare yindawo yemvelo yokubuyekeza ukuthi ngabe incwadi kadokotela isabalulekile yini.

Imibuzo Evame Ukubuzwa

Ngingathatha i-acetaminophen (Tylenol) ne-meloxicam noma i-naproxen?

Ngokuvamile yebo. I-Acetaminophen ayiyona i-NSAID futhi ayisebenzi endleleni ye-prostaglandin evikela umugqa wesisu sakho, ngakho odokotela bavame ukuhlanganisa kokubili ukuthola ukuhlanganiswa okungcono. Hlala ngaphakathi komthamo ojwayelekile we-acetaminophen, futhi ubalele umthombo ngamunye, kufaka phakathi imikhiqizo yokubanda kanye nama-painkillers efunekayo anayo kakade.

I-Meloxicam Ne-Naproxen Ziphephile Ukuthathwa Ngesikhathi Sokukhulelwa?

Cha. Akekho oyinketho yokuqala ngesikhathi sokukhulelwa, futhi ama-NSAID avame ukugwenywa kamuva ekukhulelweni ngenxa yemiphumela emisebenzini yomjikelezo wombungu kanye nobunzima bamanzi we-amniotic. Uma ukhulelwe, uzama ukukhulelwa, noma uncelisa, buza udokotela wakho wokubeletha ngaphambi kokuthatha omunye umuthi, kufaka phakathi i-Aleve etholakala ngaphandle kokuyalwa, kunokuba unqume kusuka kulebula.

Kufanele Ngigweme Utshwala Ngenkathi Ngithatha I-Meloxicam Noma I-Naproxen?

Hhayi ngokuphelele. Ukuphuza ngesikhathi esithile akukavunyelwa, kodwa utshwala nama-NSAID ahluphula umugqa wesisu ngezindlela ezahlukene, ngakho inhlanganisela iyande. Phuzisa utshwala ngokuphelele uma uke waba nezilonda noma waphuma igazi e-GI, futhi ungaphuzi nangesikhathi esiswini esingenalutho ngenkathi uthatha omunye umuthi njalo.

Ngingathatha i-Meloxicam Noma i-Naproxen Uma Ngithatha Imithi Yomfutho Wegazi Noma I-Diuretic?

Ngezinye izikhathi, ngokuqapha. Ama-NSAID angakhuphula umfutho wegazi futhi anciphise umphumela wama-antihypertensives, futhi ehlangene ne-diuretic noma i-ACE inhibitor anciphisa ukugeleza kwegazi ezinyeni. Tshela umqeqeshi wakho ngawo wonke umuthi womfutho wegazi owuthathayo ukuze umsebenzi wezinso nomfutho ungabhekwa.

Ngizodinga ukuhlolwa kwesihlahla segazi noma izinso uma ngiqhubeka nanoma yimuphi umuthi isikhathi eside?

Yebo, ngokuvamile. Ukusetshenziswa kwe-NSAID isikhathi eside kufanele kube nokuhlolwa njalo kwe-hemoglobin, umsebenzi wezinso, ama-enzyme esibindi, nomfutho wegazi, ngoba ukuphuma kwegazi nokucindezela izinso kuvame ukuthuthuka ngasese. Buza udokotela wakho ukuthi kaningi kangakanani, uphathe ukwehla okungachaziwe kwe-hemoglobin njengesizathu sokuphenya kunokuba kube into okufanele ibhekwe isikhathi eside.

Isiphetho Sokukhetha Phakathi Kwama-Meloxicam Nama-Naproxen

Isinqumo se-meloxicam ne-naproxen siphakathi kokufaneleka, hhayi amandla. Ukudambisa kufana kumadizi ajwayelekile, ngakho khetha ngokushintsha komthamo, iphrofayili yakho yobungozi besisu nezinso, kanye nokuthi ububanzi bezinhlungu zakho bujula kangakanani. Umkhawulo wesisu we-meloxicam uyaphila ku-7.5 mg futhi uyancipha ku-15 mg. Zombili zithwala isexwayiso esivaliwe esifanayo, futhi akekho umuthi ophephile we-NSAID wokuzisebenzisa ngaphandle kokuqapha isikhathi eside. Isinyathelo sakho esilandelayo yingxoxo eyodwa: yilethe umthamo wakho wamanje, uhlu lwakho lonke lwemithi, kanye nomlando wakho wokugaya ukudla, izinso, nenhliziyo kudokotela esikhundleni sokuzishintsha.

Isitatimende: Lesi sihloko siyelele kuphela futhi asibambisi iseluleko sezokwelapha. Njalo thintana nomhlinzeki wezempilo ofanelekayo ukuze uthole izinqumo zokuxilonga nokwelapha. Uma ubhekene nesimo esiphuthumayo sezokwelapha, shayela ku-911 noma uye egumbini lezimo eziphuthumayo eliseduze ngokushesha.