I-Metronidazole ye-BV: Indlela Inxalenye Yezinsukuphu Ehluke Ngayo Ekwelashweni Kwama-Trichomoniasis

I-Metronidazole ye-BV ngu-500 mg ngomlomo kabini ngosuku iminyaka eyisikhombisa, amaphilisi angu-14 isiyonke. Abesifazane abelashwa nge-trichomoniasis manje bathola le nkambo efanayo yezinsukuphu, kanti abesilisa basathola umthamo owodwa ka-2 g. Imithi efanayo, imithetho ehlukile ekwelashweni komlingani, ukuhlolwa kabusha, nezinketho zangaphandle.

• BV: i-metronidazole 500 mg kabini ngosuku iminyaka eyi-7, noma i-0.75% ye-vaginal gel kanye ngosuku iminyaka emihlanu.
• Trichomoniasis kubesifazane: le nkambo efanayo yezinsukuphu ngomlomo kusukela kuhlobo lwe-CDC lwangonyaka ka-2021. Kubona, umthamo owodwa ka-2 g.
• I-BV ayiyona igciwane elidluliselwa ngocansi, ngakho abalingani abavame ukwelashwa. I-Trichomoniasis yikho, ngakho wonke umlingani udinga ukwelashwa.
• Hlolwa kabusha nge-trichomoniasis emva kwezinyanga ezintathu. Akukho ukuhlolwa okujwayelekile kokwelashwa kwe-BV uma izimpawu zinyamalala.
• I-CDC ayisasekho isimemezelo sokuvinjelwa utshwala, nakuba i-metronidazole ngokwayo ingakwenza uzizwe ugula.

I-Metronidazole iphulukisa i-BV ngezinsukuphu ezisikhombisa, futhi ukuyeka ngaphambi kwesikhathi yikho eyenza ibuyele

I-Metronidazole ye-BV ngu-500 mg ngomlomo kabini ngosuku iminyaka eyisikhombisa, amaphilisi angu-14 isiyonke, inkambo yokuqala kwizindaba zokwelashwa kwe-CDC zango-2021 ze-STI. Enye indlela enconywa yi-CDC yi-0.75% ye-metronidazole vaginal gel, isifakiwe esisodwa esingu-5 g sifakwe kanye ngosuku iminyaka emihlanu. I-Flagyl iyigama lokuthengisa le-metronidazole ejwayelekile efanayo, ngakho imithi nomthamo akushintshi.

Iningi labantu libona ukuchitheka nokunuka kunciphisa ngosuku lwesibili noma lwesithathu. Lokho akuyona impi yokugcina. I-Bacterial vaginosis ukukhula kwezintubuzane ezingaphansi kwamanzi ezingezona izinto ezihamba phambili kune-lactobacilli ezivikelayo, futhi ukudambisa izimpawu kuqala kakhulu kunokucaciswa kwezinto eziphilayo. Yeka ngosuku lwesine ngoba uzizwa kangcono futhi unikeze leyo nyama ebususayo isiqalo. Ngakho yebo, i-metronidazole iyayelapha i-BV, kanti i-Flagyl ye-BV iyimithi efanayo ngaphansi kwelayibheli elihlukile. Thatha wonke amaphilisi angu-14.

"Ukwelashwa ngalolulodwa iphilisi" kuphelile: abesifazane abane-trichomoniasis manje bathola iminyaka eyi-7 efanayo ne-BV

Umthamo we-metronidazole we-trichomoniasis ushintshe ngo-2021, futhi iningi labantu alikatholanga: abesifazane abane-trichomoniasis manje bayelulekwa ukuba bathathe i-metronidazole 500 mg kabini ngosuku iminyaka eyisikhombisa, kanye le nkambo ye-BV. I-CDC yenza leso shintsho ngemuva kokuba isivivinyo esihlehlisiwe sithole ukuthi inkambo eminingi yehlise cishe ingxenye yamanani okuhlolwa okuchithekayo emva kwenyanga xa kuqhathaniswa nomthamo owodwa ka-2 g wangaphambili.

Umthamo owodwa awukadonswa. Kubona, u-2 g we-metronidazole yomlomo ethathwa kanye usengumthamo onconywayo, kanti i-tinidazole 2 g njengomthamo owodwa iyindlela kubo bobabili ubulili.

I-biology ichaza ukuthi kungani lezi zindlela ezimbili zahluka. I-BV iyingxube yezintubuzane eziningi ezingaphansi kwamanzi ezihlala ku-biofilm odongeni lwase-vagina, kanti ama-biofilm adinga ukuchayeka njalo emithini ukuze ayicele. I-trichomoniasis iyisikhunta esisodwa samaselula, i-Trichomonas vaginalis, okwakuvame ukujabulela ukuchayeka okukhulu komuthi okukodwa. Ubufakazi besivivinyo bubonise nje ukuthi ukuchayeka akuzange kuthembeke ngokwanele kwabafazi.

Umphumela ongokoqobo ubaluleke kakhulu kunama-pharmacology: amaphilisi asele kusukela kumjikelezo owodwa akufanele aephambili ekuziwelapheni kabusha kwakho enye. Uma ufuna inguqulo egcwele yalo mphikiswano, funda ukuthi kungani imithi efanayo ayisho ukuthi ukugula okufanayo.

I-BV ayiyona i-STI, futhi lokho kuguqula ukuthi ubani omunye odinga ukwelashwa

Ngabe i-Bacterial vaginosis iyigciwane elidluliselwa ngocansi? Cha. I-BV ayibhalisiwe njengegciwane elidluliselwa ngocansi, kanti i-trichomoniasis yikho, futhi lokho okukodwa kubhala konke okudlula imithi. I-CDC itshela ukuthi ukwelashwa okujwayelekile kwabalingani abangocansi akuhlongozwa kwe-BV, ngoba izivivinyo zokwelapha abalingani besilisa azizange zithuthukise amazinga okwelashwa noma zinciphise ukubuyela kwalo. Kwi-trichomoniasis, bonke abalingani abangocansi kufanele bathole ukwelashwa okufanayo ngasikhathi sinye, futhi nobhokwana kufanele niliyeke ucansi kuze kuphele ukwelashwa futhi izimpawu zidlule.

Isixwayiso esithile esilahlekile: abesifazane abatholwe ne-BV banobungozi obukhulu bokuba ne-trichomoniasis efana neyomgomo. Ukutholakala kwe-BV akukwazi ukukhipha i-STI. Uma kungekho muntu okwakukhuhla nge-trichomoniasis, buza.

Ukuqedela amaphilisi akuyona imbangela yokwelashwa kwanoma yikuphi ukugula

Ukwelashwa kwe-trichomoniasis kufaka ukuhlolwa okungaphambili, hhayi nje amaphilisi. I-CDC iyeluleka ukuthi abesifazane abasebenza ngocansi babuyele bahlole cishe emva kwezinyanga ezintathu ngemuva kokwelashwa, noma ngabe umlingani welashwa noma cha, ngoba ukubuyela kwegciwane kuvamile. Ungahloli ngaphambili kunamaviki amathathu emva kokwelashwa: i-DNA eyinsalela evela ezintubuzaneni ezifile ingase ibonise izivivinyo ezikhuthaza i-DNA.

I-BV isebenza ngendlela ehlukile. Uma izimpawu zidambisa, akukho ukuhlolwa okujwayelekile kokwelashwa okudingekayo. Kodwa ukubuyela kwale ngoma kuvamile, futhi kubantu abanokubuyela kaningi i-CDC ifaka phakathi izinketho zokunqanda: i-0.75% ye-metronidazole gel noma i-750 mg ye-metronidazole vaginal suppository kabini ngesonto iminyaka engaphezu kwemithathu.

Inkinga: leyo nzuzo ivamise ukuphela lapho ukwelashwa kokuvimbela kuphela kuphela. Ukuvimba kukunika izinyanga zokuthula, hhayi imbangela yaphakade, futhi lokho kufanele ukwazi ngaphambi kokuba uqale umzamo wezinyanga ezintathu. Izimpawu ezibuyayo azihlali zihambisana nokugula okwafika isikhathi esidlule. Hlolwa kabusha kunokuthi ugcwalise imithi yokugcina ngokukhumbula.

I-gel iyayelapha i-BV kodwa ingashiya i-trichomoniasis ingalapheki

I-Metronidazole vaginal gel iyinketho enconywa yi-CDC ye-BV kuphela: 0.75% gel, isifakiwe esisodwa esingu-5 g ngaphakathi kwesitho sangasese kanye ngosuku iminyaka emihlanu. Abanye abantu bayayithanda kakhulu, futhi ngesizathu esihle. Imithi ihlala kule ndawo, ngakho imiphumela engemihle ehambayo eyenza inkambo yomlomo ibe yinto engathandeki, ukugabha nokunambitheka okungajwayelekile kwensimbi, akuvamile kakhulu.

Ayisasebenzi ngokumelene ne-trichomoniasis, futhi hhayi njengombandela wokukhethwa kwamaviki. Isikhunta sihlala esikhunjeni somchamo namalunga omchamo, angakwazi ukufinyelelwa yi-gel yomlomo. Ukuyiqeda kudinga imithamo yomlomo ehambayo. Ungalokothi ubheke i-gel esele ngemuva kokuchayeka kwe-trichomoniasis okungaba khona.

Iseluleko sotshwala ku-metronidazole yakho siphelelwe yisikhathi

Ungaphuzwa utshwala nge-metronidazole? Ngokwe-CDC, yebo: imihlahlandlela yango-2021 ithi ukugwema utshwala ngesikhathi sokwelashwa nge-metronidazole noma i-tinidazole akudingekile. Iseluleko esijwayelekile sokuphendula njenge-disulfiram sasingenazo ubufakazi obuqinisekile besayensi, futhi i-metronidazole ayikuvimbeli i-aldehyde dehydrogenase, i-enzyme enesibopho salokho ukuphendula.

Usazobona iseluleko esidala yonke indawo: akukho utshwala ngesikhathi sokwelashwa nangamaviki ayi-24 kuya ku-72 emva kwalo, siphrintwe kumalibheli emitholampilo nasemakhasi abasebenzisi angaphambili kwesibuyekezo sobufakazi. Isibonelo esiqotho: i-metronidazole ijwayele ukubangela ukugabha nokunambitheka kwensimbi yodwa, futhi utshwala bungabenza bobabili bube bubi kakhulu, ngakho lokhu kuvunywa kunokukhuthazwa. Uma umgundisi wakho ekutshela okunye, landela iseluleko sakhe bese ubeka leyo mpikiswano naye kunokuba ucabange ukuthi imbonakalo yinhloko iyiphutha.

Ezinye izimpawu zangasese zidinga ukuhlolwa, hhayi imithi enye

Shayela u-911 noma uye ekamelweni lezenzo eziphuthumayo manje uma:

• Unomkhuhlane, ukubanda, noma ubuhlungu obubukhulu esithweni sangaphansi noma esingezansi esitho lokuvikela esithweni sangaphansi sokuphathwa kwe-pelvic.
• Uthola izimpawu zokuphendula komzimba ku-metronidazole: i-rash, izindundundu, ukuvuvukala kobuso noma komphimbo, noma ubunzima bokuphefumula.
• Ukhulelwe futhi unezimpawu zokubeletha ngaphambi kwesikhathi (izindwangu ezijwayelekile, uketshezi oluvuzayo, ukuphuma kwegazi) kanye nezimpawu zokugula.
• Unegazi eliningi noma elingachazekile emithonjeni yomlomo engahlobene nokuya esikhathini.

Bhukha ukuvakasha kungakapheli isonto elilandelayo uma:

• Izimpawu ziqhubeka ngemuva kokuba ugcwalise inkambo eyisikhombisa.
• Izimpawu zibuyela emavikini ambalwa ngemuva kokuqeda ukwelashwa.
• Umlingani uhlolwe ukuthi une-trichomoniasis.
• Wenzelwe i-BV kodwa akwaze wahlolelwa i-trichomoniasis.

Khuluma nodokotela ngaphambi kokuba uqale uma:

• Ukhulelwe, uzama ukukhulelwa, noma uyamuncisa.
• Wake waphendula kabi ku-metronidazole noma ku-tinidazole ngaphambili.
• Uphuza i-disulfiram, i-warfarin, noma i-lithium.
• Uzoqala ukusebenzisa amaphilisi asele kusukela kumithi yangaphambili.
• Wathola i-tinidazole esikhundleni se-metronidazole.

Uma udinga leyo ngxoxo ngokushesha, ukuvakasha kwe-urgent care okungama-39 e-August kukuxhumanisa nodokotela ogunyazwe yi-US ongahlola izimpawu zakho futhi anqume ukuthi imithi ifanele yini. Qaphela imikhawulo: ukubuka ngevidiyo akukwazi ukwenza ukuhlolwa kwesitho sangasese noma ukukhipha isampula lomlomo, ngakho ukuhlolwa ubuqotho kungase kube yisinyathelo esilandelayo esidingekayo.

Imibuzo ejwayelekile

I-Flagyl ye-BV ifana ne-metronidazole ejwayelekile?

Yebo. I-Flagyl iyigama lokuthengisa le-metronidazole, kanti ingxenye ejwayelekile iqukethe into efanayo esebenza ngamandla afanayo. Imitholampilo ikhipha ingxenye ejwayelekile ngokuzenzakalelayo ezimweni eziningi. Ishekeki engokoqobo lisemibhalweni kunasegama: qinisekisa ukuthi ifundeka 500 mg, ukuthi umyalelo uthi kabini ngosuku, nokuthi inani lingamaphilisi angu-14. I-gel yomlomo enegama lokuthengisa ithengiswa njenge-MetroGel-Vaginal.

Ngabe i-metronidazole iyayelapha i-BV nokugula kwezinyosi ngasikhathi sinye?

Cha. I-metronidazole ayikho mphumela ngokumelene ne-Candida, igciwane elibangela umkhuhlane womlomo, ngakho ngeke yenze lutho ekulunywa nasekuqhumeni okumhlophe okujiyile. Ukugula kwezinyosi kudinga i-antifungal efana ne-fluconazole. Ngokudidayo, ukukhula kwezinyosi ngezinye izikhathi kulandela umjikelezo wama-antibiotics, ngakho ukulunywa okusha kuyo yonke iminyaka yakho eyisikhombisa kufanele kube nengxoxo kunokuba uthathe i-antibiotic yesibili.

Ngabe umthamo owodwa we-metronidazole ungayisula i-BV?

Ngokuvamile akunjalo. Umthamo owodwa ka-2 g awuyona inkambo enconyiwe ye-CDC ye-bacterial vaginosis, futhi imithamo yomlomo yezinsukuphu iyancomeka. Lowo mthamo owodwa ungowama-trichomoniasis, ikakhulukazi kubona. Uma udokotela wakunikeza umthamo owodwa omkhulu we-BV, buza ukuthi kungani ngaphambi kokuba uwudle, ngoba ukuchayeka okufushane yiyona ndaba eyinhloko yokubuyela kwe-BV.

Ngabe i-metronidazole iphephile ukuyisebenzisa ngenkathi ukhulelwe?

Yebo. I-CDC ithi akukho mifanekiso yokuzalwa noma yokubangela ukugula kakhulu kanti ithathwa njengobungozi obuncane entweleni, ngakho-ke i-metronidazole isetshenziswa ekukhulelweni kuzo zombili izifo. I-tinidazole iyisiphetho esibalulekile futhi kufanele igwenywe ngenkathi ukhulelwe. Uma ukhulelwe noma uyancamisa, qinisekisa ukuthi iyiphi kule mithi emibili oyinikeziwe ngaphambi komthamo wakho wokuqala, ngoba amagama afana nefomu esemabhuloki.

Ngabe i-metronidazole yenza ukuthi ukulawulwa kokubeletha kwe-hormonal kube nenye imbangela yokwehluleka?

Cha. I-metronidazole ayiyona phakathi kwama-antibiotics abonakale ehlisa ukusebenza kwemithi yokulawula ukubeletha kwe-hormonal, ngakho akukho ukudingeka kokulawulwa okwengeziwe ngaleso sizathu kuphela. Ukugabha noma ukuqunjelwa okukhulu ngesikhathi sokuphathwa okugulayo kunganciphisa ukugayeka kwephilisi lomlomo, okuyisihloko esihlukile okufanele sibuze ngaso uma kwenzeka ngesikhathi somjikelezo wakho.

Isiphetho ngama-metronidazole we-BV

Izinsukuphu eziyisikhombisa, kabini ngosuku, 500 mg ye-BV. Lezi zinsukuphu eziyisikhombisa manje zabesifazane abane-trichomoniasis, nomthamo owodwa ka-2 g ogcinelwe ikakhulukazi abona. Ukwelashwa komlingani kwe-trichomoniasis kuphela. Futhi umkhawulo wotshwala kumakhasimende akho awusasekelwa yisibuyekezo sobufakazi se-CDC.

Umthetho ongaphansi kwayo yonke into ulula: fanisa inkambo nodokotela wangempela owatholayo. Hlolwa kunokuzama ukusebenzisa kabusha imithi yangaphambili, ngoba amaphilisi angase afane kakhulu ngenkathi imiyalelo ingafani.

Isitatimende: Lesi sihloko sihlose kuphela ukuze uthole ulwazi futhi asihambisani nezeluleko zezokwelapha. Njalo xhumana nomhlinzeki wezempilo oqeqeshwe kahle ukuze uthole ukwelashwa nokwelashwa. Uma ubhekene nesimo esiphuthumayo sezokwelapha, shayela u-911 noma uye egumbini lezenzo eziphuthumayo eliseduze ngokushesha.