Yini i-Reslizumab: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Reslizumab iyimithi ekhethekile eyenzelwe ukusiza abantu abanesifuba esikhulu esingaphenduli kahle ekwelashweni okujwayelekile. Kuyindlela yokwelapha eqondiwe esebenza ngokuvimba iphrotheni ethile ohlelweni lwakho lomzimba lokuzivikela ekubizwa ngokuthi i-interleukin-5, edlala indima ebalulekile ekubangeleni ukuhlaselwa yisifuba.

Lo muthi ungowesigaba semithi ebizwa ngokuthi ama-monoclonal antibodies. Cabanga ngayo njengethuluzi eliqondile elisiza ukuthulisa impendulo yomzimba yokuzivikela emsebenzini ngokweqile okwenza isifuba esikhulu sibe nzima kangako ukusilawula ngamaphilisi namaphilisi ajwayelekile.

Yini i-Reslizumab Esetshenziselwa Yona?

I-Reslizumab ivunyelwe ngokuqondile ukwelapha isifuba esikhulu se-eosinophilic kubantu abadala kanye nezingane ezineminyaka engu-18 nangaphezulu. Isifuba se-Eosinophilic wuhlobo oluthile lwesifuba esikhulu lapho amaseli amhlophe egazi athile abizwa ngokuthi ama-eosinophils eba nomsebenzi ngokweqile futhi abangele ukuvuvukala emoyeni wakho.

Udokotela wakho ngokuvamile uzocabangela lo muthi lapho isifuba sakho singalawulwa kahle naphezu kokusebenzisa ama-corticosteroids aphezulu aphezulu kanye nomunye umuthi wokulawula. Igcinelwe amacala lapho ukwelashwa kwendabuko kungazange kunikeze ukukhululeka okwanele ezimpawini ezinjengokuhlaselwa yisifuba esivamile, ubunzima bokuphefumula, noma ukuncipha komsebenzi wamaphaphu.

Umuthi ulusizo ikakhulukazi kubantu abahlangabezana nokwanda kwesifuba esivamile okudinga ama-corticosteroids omlomo noma ukuvakashelwa egumbini eliphuthumayo. Kunganciphisa kakhulu inani lokuqubuka okukhulu futhi kuthuthukise izinga lakho lempilo.

Isebenza Kanjani i-Reslizumab?

I-Reslizumab isebenza ngokugxila nokuvimba i-interleukin-5, iphrotheni ekhomba umzimba wakho ukuthi ukhiqize futhi usebenzise ama-eosinophils. Lawa ma-eosinophils amaseli amhlophe egazi, lapho esebenza ngokweqile, abangela ukuvuvukala okukhulu emoyeni wakho futhi enze izimpawu zesifuba zibe zimbi kakhulu.

Ngokuvala le ndlela ethile, i-reslizumab isiza ukunciphisa inani le-eosinophils egazini lakho nasemaphapheni. Lokhu kuholela ekunciphiseni ukuvuvukala komoya, ukuhlaselwa kwe-asthma okuncane, nokuthuthuka kokuphefumula ngokuhamba kwesikhathi.

Lokhu kuthathwa njengemithi eqinile ngokulinganisela esebenza ngendlela ehlukile kunokwelashwa kwe-asthma kwendabuko. Ngenkathi ama-inhalers esebenza ngqo emaphapheni akho, i-reslizumab isebenza kuyo yonke i-immune system yakho ukuze ibhekane nembangela ye-asthma ye-eosinophilic.

Kufanele Ngiyithathe Kanjani I-Reslizumab?

I-Reslizumab inikezwa njenge-intravenous infusion, okusho ukuthi ihanjiswa ngqo egazini lakho ngomthambo engalweni yakho. Uzothola lokhu kwelashwa ehhovisi likadokotela wakho, esibhedlela, noma esikhungweni sokufaka umuthi - ungalokothi ekhaya.

Umuthi uvame ukunikezwa njalo emavikini amane, futhi ukufakwa ngakunye kuthatha imizuzu engaba ngu-20 kuya kwengama-50 ukuqedela. Ithimba lakho lezempilo lizokuqapha eduze ngesikhathi nangemva kokufakwa ngakunye ukuze libheke noma yiziphi izindlela zokuphendula.

Ngaphambi kokwelashwa ngakunye, awudingi ukulandela noma yimiphi imikhawulo ekhethekile yokudla. Kodwa-ke, kubalulekile ukuhlala unamanzi kahle futhi udle ngokujwayelekile ngaphandle kwalapho udokotela wakho ekweluleka ngenye indlela. Kufanele uqhubeke nokuthatha imithi yakho ye-asthma ejwayelekile njengoba kunqunywe, ngisho nalapho uthola i-reslizumab.

Udokotela wakho uzobala umthamo wakho oqondile ngokusekelwe esisindweni somzimba wakho, ngokuvamile ama-milligrams angu-3 ngekhilogramu yesisindo somzimba. Lokhu kulinganisa komuntu siqu kusiza ukuqinisekisa ukuthi uthola inani elifanele lezidingo zakho ezithile.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Reslizumab?

Ubude bokwelashwa nge-reslizumab buhlukahluka kakhulu kumuntu nomuntu, kuye ngokuthi uphendula kahle kangakanani emuthini nokulawulwa kwakho kwe-asthma. Abantu abaningi baqhubeka nokwelashwa izinyanga eziningana kuya eminyakeni ukuze bagcine izinzuzo.

Udktela wakho ngokuvamile uzohlola inqubekela phambili yakho ngemva kwezinyanga zokuqala zokwelashwa. Bazobheka izinto ezinjengokuthi uvame kangakanani ukuba nezifo zomoya, ukuthi ngabe udinga ama-steroid ambalwa omlomo, kanye nokuthuthuka ekuhlolweni komsebenzi wamaphaphu akho.

Abanye abantu babona ukuthuthuka ngaphakathi kokwelashwa kokuqala, kanti abanye bangase badinge izinyanga eziningana ukuze bathole izinzuzo ezigcwele. Ithimba lakho lezempilo lizosebenza nawe ukunquma ubude bokwelashwa obufanele ngokusekelwe ekuphenduleni kwakho komuntu ngamunye kanye nanoma yimaphi imiphumela engemihle ongase uyithole.

Yini Imiphumela Engemihle ye-Reslizumab?

Njengayo yonke imithi, i-reslizumab ingabangela imiphumela engemihle, nakuba abantu abaningi beyibekezelela kahle. Ukuqonda ukuthi yini ongayilindela kungakusiza ukuthi uzizwe ulungiseleleke kakhulu futhi wazi ukuthi ungaxhumana nini nethimba lakho lezempilo.

Imiphumela engemihle evame kakhulu ngokuvamile imnene futhi iyalawuleka. Lezi zimo zivame ukwenzeka ngesikhathi noma ngemva nje kokufakwa kwakho futhi zivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi:

• Ikhanda nokukhathala
• Ubuhlungu bemisipha noma amalunga
• Ukucasuka komphimbo noma umphimbo obuhlungu
• Ukuvaleka kwamakhala
• Isicanucanu noma ukungakhululeki kwesisu
• Isiyezi
• Ukuphendula kwesikhumba endaweni yokujova

Iningi lale miphumela engemihle evamile imane nje yesikhashana futhi iyazixazulula yona ngaphakathi kosuku olulodwa noma ezimbili ngemva kokufakwa kwakho.

Imiphumela engemihle engathi sína ayivamile kodwa idinga ukunakekelwa kwezokwelapha ngokushesha. Lokhu kufaka phakathi ukusabela okukhulu komzimba ngesikhathi noma ngemva kokufakwa, yingakho uzoqashwa eduze ngesikhathi sokwelashwa:

• Ukusabela okukhulu komzimba ngezimpawu ezinjengobunzima bokuphefumula, ukuvuvukala kobuso noma umphimbo, noma ukuqubuka okukhulu
• Ukwehla okukhulu kwengcindezi yegazi
• Ubuhlungu besifuba noma ukushaya kwenhliziyo okusheshayo
• Isiyezi esikhulu noma ukuquleka
• Izifo ezingavamile ngenxa yemiphumela engaba khona ohlelweni lwakho lomzimba lokuzivikela ezifweni

Imiphumela emibi engavamile kodwa ebucayi ingabandakanya ingozi eyengeziwe yezinye izinhlobo zomdlavuza, nakuba le ngozi ibonakala iphansi kakhulu. Udokotela wakho uzoxoxa nawe ngalezi zinto ezingavamile futhi azilinganise nezinzuzo zokwelashwa komoya wakho oqinile.

Ubani Ongafanele Athole i-Reslizumab?

I-Reslizumab ayifanele wonke umuntu, futhi udokotela wakho uzohlola ngokucophelela ukuthi lo muthi ulungele yini isimo sakho esithile. Izinto eziningana zingenza lokhu kwelashwa kungafaneleki noma kudingeke izinyathelo zokuphepha ezikhethekile.

Akufanele uthole i-reslizumab uma uke waba nokusabela okukhulu komzimba okungalungile kuyo esikhathini esidlule. Ngaphezu kwalokho, lo muthi awuvunyelwe ezinganeni ezingaphansi kweminyaka engu-18 ubudala, njengoba ukuphepha nokusebenza kungakahlolwa ezigulini ezincane.

Udokotela wakho uzoba nokuqapha okukhethekile mayelana nokunikeza i-reslizumab uma unezimo ezithile ezingase zikhuphule ingozi yakho yezinkinga:

• Izifo ezisebenzayo zamanje noma umlando wezifo eziphindaphindayo
• Izifo ze-parasitic, ikakhulukazi izifo ze-helminth
• Isistimu yokuzivikela komzimba ekhubazekile evela kweminye imithi noma izimo
• Umlando womdlavuza
• Ukukhulelwa noma ukuncelisa
• Isifo esibi sesibindi noma sezinso

Uma unezinye zalezi zimo, akusho ngaso sonke isikhathi ukuthi awukwazi ukusebenzisa i-reslizumab, kodwa udokotela wakho uzodinga ukulinganisa izingozi nezinzuzo ngokucophelela futhi angase adinge ukuqapha okwengeziwe.

Amagama Omkhiqizo we-Reslizumab

I-Reslizumab ithengiswa ngaphansi kwegama lomkhiqizo elithi Cinqair e-United States nakwamanye amazwe. Leli yigama eliyinhloko lomkhiqizo ozohlangana nalo lapho uxoxa ngalo muthi nethimba lakho lezempilo noma usokhemisi.

Kwezinye izifunda, ungase ukuthole ngaphansi kwamagama ahlukene omkhiqizo, kodwa isithako esisebenzayo sihlala singashintshi. Njalo qinisekisa nodokotela wakho ukuthi uthola imithi efanele, ikakhulu uma uhamba noma uthola ukwelashwa ezinhlelweni ezihlukene zokunakekelwa kwezempilo.

Ezinye izindlela zokwelapha ze-Reslizumab

Eminye imithi eminingi isebenza ngendlela efana ne-reslizumab ye-asthma eqinile ye-eosinophilic, ikunikeza wena nodokotela wakho izinketho zokuthola ukwelashwa okungcono kakhulu kwezidingo zakho ezithile. Lezi ezinye izindlela zokwelapha nazo zingama-antibody e-monoclonal aqondise izindlela ezihlukene ohlelweni lomzimba lokuzivikela.

I-Mepolizumab (Nucala) ngomunye umuthi oqondise i-interleukin-5, efana ne-reslizumab. Inikezwa njengesijovo esingaphansi kwesikhumba njalo emavikini amane, okuthile abantu bakuthola kulula kakhulu kunokufakwa ngemithambo.

I-Benralizumab (Fasenra) iqondise i-interleukin-5 receptor futhi nayo inikezwa njengesijovo esingaphansi kwesikhumba. Abanye abantu bakhetha le nketho ngoba inikezwa njalo emavikini ayisishiyagalombili ngemuva kwemithamo yokuqala.

Kubantu abane-asthma ye-allergic, i-omalizumab (Xolair) iqondise ama-antibody e-IgE futhi ingaba yindlela engcono. I-Dupilumab (Dupixent) enye inketho eqondise izindlela ze-interleukin-4 ne-interleukin-13.

Udkt. wakho uzosiza ekunqumeni ukuthi iyiphi enye indlela engasebenza kahle kakhulu ngokuya ngohlobo lwakho oluthile lwe-asthma, amazinga akho e-eosinophil, nezinye izinto ezinjengokukhetha kwakho imvamisa yokujova nendawo.

Ingabe i-Reslizumab ingcono kune-Mepolizumab?

Kokubili i-reslizumab ne-mepolizumab ziyimithi esebenza kahle kakhulu ye-asthma eqinile ye-eosinophilic, futhi akukho noyedwa othi “ungcono” kunomunye. Ukukhetha phakathi kwabo kuvame ukwehla ezintweni ezingokoqobo nakuzintandokazi zomuntu ngamunye.

I-Reslizumab inikezwa njenge-infusion ye-intravenous njalo emavikini amane, kanti i-mepolizumab inikezwa njenge-subcutaneous injection ongase ufunde ukuzinika yona ekhaya. Abanye abantu bakhetha ukulula kokuzijova, kanti abanye bazizwa bekhululekile ngama-infusion aqashwe.

Zombili lezi zithako zikhomba indlela efanayo ohlelweni lwakho lomzimba lokuzivikela ezifweni futhi zikhombise ukusebenza okufanayo ezivivinyweni zomtholampilo. Zombili zinciphisa kakhulu ukwanda kwe-asthma kanye nesidingo sama-corticosteroids omlomo kubantu abane-asthma enzima ye-eosinophilic.

Isinqumo sivame ukuncika ezintweni ezinjengokuthi uzizwa ukhululekile kangakanani ngezinhlobo ezahlukene zokujova, ukutholakala kwakho kweshejuli yokuya emtholampilo, nokuthi umzimba wakho usabela kanjani emuthini ngamunye. Udokotela wakho uzocabangela lezi zinto kanye nomlando wakho wezokwelapha ukukusiza ukhethe okungcono kakhulu.

Imibuzo Evame Ukubuzwa Mayelana ne-Reslizumab

Ingabe i-Reslizumab iphephile kubantu abanezifo zenhliziyo?

I-Reslizumab ngokuvamile ingasetshenziswa ngokuphepha kubantu abanezifo zenhliziyo, kodwa udokotela wakho wenhliziyo kanye nodokotela wamaphaphu kuzodingeka basebenzisane ukuze bakuqaphe ngokucophelela. Umuthi ngokwawo awuthinti ngokuqondile ukusebenza kwenhliziyo, kodwa inqubo ye-infusion idinga ukuqapha eduze izimpawu zakho ezibalulekile.

Uma unezifo zenhliziyo, ithimba lakho lezempilo lizobheka ngokukhethekile umfutho wegazi lakho nesilinganiso senhliziyo ngesikhathi se-infusion. Bangase futhi balungise izinga le-infusion ukuze baqinisekise ukunethezeka kwakho nokuphepha ngaso sonke isikhathi sokwelashwa.

Ngingenzani uma ngiphuthelwa ngengozi umthamo we-Reslizumab?

Uma uphuthelwa yi-infusion yakho ye-reslizumab eshejuliwe, xhumana nomhlinzeki wakho wezempilo ngokushesha ngangokunokwenzeka ukuze uhlele kabusha. Ungazami ukuphinda imithamo noma ukwenza ukwelashwa okungaphuthelwanga wedwa.

Udktela wakho ngokuvamile uzohlela kabusha umthamo wakho owuphuthelwe ngokushesha nje lapho kulula, bese uqhubeka neshejuli yakho evamile yamasonto amane kusukela ngaleso sikhathi. Ukuphuthelwa umthamo owodwa ngokuvamile ngeke kubangele izinkinga ngokushesha, kodwa kubalulekile ukugcina ukuqina ukuze uthole imiphumela engcono kakhulu.

Kufanele Ngenzeni Uma Ngizwa Ukusabela Okungalungile Ngesikhathi Sokwelashwa?

Uma uzwa izimpawu zokusabela okungalungile ngesikhathi sokufakwa kwe-reslizumab, yazisa ithimba lakho lezempilo ngokushesha. Izimpawu okufanele uziqaphele zihlanganisa ubunzima bokuphefumula, ukuvuvukala kobuso bakho noma umphimbo, ukuqubuka okukhulu, noma ukuzwa sengathi uyaphela amandla.

Isikhungo sakho sokufaka imithi silungiswe kahle ukubhekana nokusabela okungalungile futhi sizoba nemithi ephuthumayo etholakalayo kalula. Bazoyeka ukufakwa ngokushesha futhi banikeze ukwelashwa okufanele, okungase kuhlanganise ama-antihistamines, ama-corticosteroids, noma i-epinephrine uma kudingeka.

Ngingayeka Nini Ukuthatha i-Reslizumab?

Isinqumo sokuyeka i-reslizumab kufanele senziwe ngaso sonke isikhathi ngokubonisana nodokotela wakho, hhayi wedwa. Ithimba lakho lezempilo lizohlola njalo ukusabela kwakho ekwelashweni futhi lizosiza ekunqumeni isikhathi esifanele sokucabangela ukuyeka.

Abanye abantu bangase bakwazi ukuyeka ngemva kokuba isifuba sabo somoya silawulwe kahle isikhathi eside, kanti abanye bangase badinge ukuqhubeka nokwelashwa isikhathi eside. Udokotela wakho uzocabangela izinto ezinjengokulawulwa kwezimpawu zakho, ukusebenza kwamaphaphu, kanye nekhono lokunciphisa eminye imithi yesifuba somoya lapho enza lesi sinqumo.

Ngingakwazi Ukuthola Imithi Yokugoma Ngesikhathi Ngithatha i-Reslizumab?

Ngokuvamile ungafaka imithi yokugoma eminingi ngenkathi uthatha i-reslizumab, kodwa kubalulekile ukuxoxa ngalokhu nomhlinzeki wakho wezempilo ngaphambi kokuthola noma yikuphi ukugoma. Imithi yokugoma ephilayo kungenzeka inganconwa, kuyilapho imithi yokugoma engasebenzi ngokuvamile iphephile.

Udkt wakho angase ancome ukuhlela imijovo yakho phakathi kokufakwa kwe-reslizumab ukuze kusebenze kahle. Bazofuna futhi ukuqinisekisa ukuthi awunazo izifo ezisebenzayo ngaphambi kokuthola imithi yokugoma, njengoba lokhu kungase kuthinte ukusabela komzimba wakho.