Yini i-Teriflunomide: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Teriflunomide iyimithi kadokotela esetshenziselwa ikakhulukazi ukwelapha izinhlobo ze-multiple sclerosis (MS) eziphindayo. Ingaphansi kohlu lwemithi olubizwa ngokuthi ama-immunomodulators, asebenza ngokulungisa umsebenzi wesistimu yakho yokuzivikela komzimba ukusiza ukunciphisa imvamisa yokuphindeka kwe-MS futhi anciphise ukuqhubeka kokukhubazeka.

Yini i-Teriflunomide?

I-Teriflunomide iyimithi yomlomo esiza ukuphatha i-multiple sclerosis ngokushintsha indlela isistimu yakho yokuzivikela komzimba esebenza ngayo. Yilokho odokotela abakubiza ngokuthi ukwelashwa okuguqula isifo, okusho ukuthi akwelaphi nje izimpawu kodwa empeleni kusebenza ukushintsha inkambo ye-MS ngokwayo.

Le mithi ithathwa njengamaphilisi kanye ngosuku futhi yenzelwe ukusetshenziswa isikhathi eside. Ngokungafani nokwelashwa okuthile kwe-MS okudinga imijovo noma ukufakwa, i-teriflunomide inikeza lula yokuphathwa ngomlomo, okwenza kube lula ukuyifaka emsebenzini wakho wansuku zonke.

Isetshenziselwani i-Teriflunomide?

I-Teriflunomide ivunywe ngokukhethekile ukwelapha izinhlobo ze-multiple sclerosis eziphindayo kubantu abadala. Lokhu kufaka phakathi i-relapsing-remitting MS kanye ne-active secondary progressive MS lapho iziguli zisaqhubeka nokuzwa ukuphindeka.

Imithi isiza ukunciphisa inani lokuphindeka kwe-MS ongase ukuzwe minyaka yonke. Iphinde isebenze ukunciphisa ukunqwabelana kokukhubazeka ngokomzimba okungase kwenzeke nge-MS ngokuhamba kwesikhathi. Udokotela wakho angase akuncomele i-teriflunomide uma utholwe ukuthi une-MS futhi ufuna inketho yokwelashwa ngomlomo engasiza ukuphatha isimo sakho isikhathi eside.

Kwezinye izimo, odokotela bangase futhi banikeze i-teriflunomide ngaphandle kwelebula kwezinye izimo ze-autoimmune, nakuba lokhu kungavamile futhi kungacatshangelwa ngokucophelela ngokuya ngesimo sakho sezokwelapha esithile.

Isebenza kanjani i-Teriflunomide?

I-Teriflunomide isebenza ngokuvimba i-enzyme ethile ebizwa ngokuthi i-dihydroorotate dehydrogenase, okuyinto amaseli athile omzimba adinga ukuzala ngokushesha. Ngokukhawulela umsebenzi wale enzyme, umuthi unciphisa inani lamaseli omzimba asebenzayo angahlasela isembozo esivikela imicu yakho yezinzwa.

Cabanga ngakho njengokusebenzisa amabhuleki ngobumnene ekuphenduleni komzimba wakho okusebenza ngokweqile. Lo muthi uthathwa njengomuthi onamandla ngokulinganiselwe emkhakheni wokwelashwa kwe-MS - unamandla kunezindlela zokwelapha eziyisisekelo kodwa awuqinile njengokwelashwa okusebenza kahle kakhulu okudinga ukuqashwa okuvame kakhulu.

Umuthi uthatha isikhathi ukwakheka emzimbeni wakho futhi ufinyelele ekusebenzeni kwawo okuphelele. Ungase ungaboni izinguquko ezinkulu ezimpawini zakho ze-MS izinyanga eziningana ngemva kokuqala ukwelashwa, okujwayelekile futhi okulindelekile.

Kufanele Ngiyithathe Kanjani I-Teriflunomide?

Thatha i-teriflunomide ngendlela eqondile udokotela wakho ayalela ngayo, ngokuvamile kanye ngosuku ngesikhathi esifanayo nsuku zonke. Ungayithatha ngaphandle kokudla noma ngaphandle kokudla, nakuba abanye abantu bethola ukuthi ukuyithatha nokudla kusiza ukunciphisa noma yikuphi ukuphazamiseka kwesisu.

Gwinya ithebhulethi yonke ngamanzi - ungayichobozi, ungayihlafuni, noma ungayiqhekezi. Uma unenkinga yokugwinya amaphilisi, khuluma nodokotela wakho ngamasu angasiza, kodwa ungalishintshi ithebhulethi ngokwayo.

Zama ukusungula isimiso ngokuthatha umuthi wakho ngesikhathi esifanayo nsuku zonke. Abantu abaningi bakuthola kuwusizo ukuyithatha ngesidlo sasekuseni noma isidlo sakusihlwa, njengoba lokhu kudala isikhumbuzi esingokwemvelo esixhunywe ekudleni kwabo kwansuku zonke.

Akukho mingcele ethile yokudla ngenkathi uthatha i-teriflunomide, kodwa ukugcina ukudla okunempilo, okulinganiselayo kungasekela inhlalakahle yakho yonke futhi kusize umzimba wakho ukuthi usebenzise umuthi ngempumelelo.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Teriflunomide?

I-Teriflunomide yenzelwe ukusetshenziswa isikhathi eside, ngokuvamile iminyaka eminingi noma ingunaphakade, uma nje iqhubeka isebenza kahle futhi yamukeleka kahle. I-Multiple sclerosis yisimo esingamahlala-khona esidinga ukuqhubeka nokulawulwa, futhi ukuyeka ukwelashwa okuguqula isifo kungaholela ekwandeni komsebenzi wesifo.

Udokotela wakho uzohlola njalo ukuthi umzimba wakho usabela kanjani emuthini ngokuhlolwa ngezikhathi ezithile, ukuhlolwa kwegazi, kanye nokuskena kwe-MRI. Lokhu kuhlolwa kusiza ukunquma ukuthi i-teriflunomide iseyindlela efanele kuwe noma ngabe kudingeka ukulungiswa ohlelweni lwakho lokwelashwa.

Uma wena nodokotela wakho ninquma ukuyeka i-teriflunomide, cishe uzodinga ukudlula enqubweni yokuqeda imithi. Lokhu kuhlanganisa ukuthatha omunye umuthi obizwa ngokuthi i-cholestyramine cishe izinsuku eziyi-11 ukusiza ukususa i-teriflunomide emzimbeni wakho ngokushesha, ngoba ingahlala emzimbeni wakho iminyaka emibili uma kungenjalo.

Yiziphi Izimo Ezingezinhle Ze-Teriflunomide?

Njengayo yonke imithi, i-teriflunomide ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Imiphumela eminingi emibi iyalawuleka futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi ezinyangeni ezimbalwa zokuqala.

Nawa amanye emiphumela emibi evame kakhulu ongase uyithole:

• Ukuqina kweenwele noma ukuwa kweenwele, okuvame ukuba okwesikhashana futhi kulungiseke
• Ukuphuma isifo sohudo noma izitulo ezixekile, ikakhulukazi emasontweni ambalwa okuqala
• Ukucanuzela kwenhliziyo noma ukungakhululeki kwesisu
• Ikhanda
• Ukwanda kwamazinga e-enzyme ethile yesibindi
• Ukuqaqamba noma ukuluma ezandleni noma ezinyaweni
• Izimpawu ezinjenge-flu

Le miphumela emibi evamile ivame ukuthuthuka ngokuhamba kwesikhathi, futhi zikhona izindlela iqembu lakho lezempilo elingaziphakamisa ukusiza ukuzilawula uma zenzeka.

Imiphumela engavamile kodwa ebucayi idinga ukunakekelwa kwezokwelapha ngokushesha. Lokhu kufaka phakathi izimpawu zezinkinga zesibindi njengokuphuzi kwesikhumba noma amehlo, umchamo omnyama, noma isicanucanu esiqhubekayo nokuhlanza. Ukutheleleka okukhulu, ukuphuma kwegazi okungavamile noma ukulimala, noma ubunzima obukhulu bokuphefumula kufanele futhi kuqhubeke nokunakekelwa kwezokwelapha ngokushesha.

Ngokuvamile, abanye abantu bangase babe nokusabela okukhulu kwesikhumba, izinguquko ezinkulu zomfutho wegazi, noma i-peripheral neuropathy eqhubeka iba yimbi ngokuhamba kwesikhathi. Udokotela wakho uzoqapha lezi zinto ezingenzeka ngokuhlolwa okuvamile kanye nokuhlolwa kwegazi.

Ubani Ongafanele Athole I-Teriflunomide?

I-Teriflunomide ayifanele wonke umuntu, futhi udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuyinika. Umuthi awunconyelwe uma ukhulelwe, uhlela ukukhulelwa, noma uncelisa, njengoba kungabangela ukukhubazeka okukhulu kokuzalwa.

Akufanele uthathe i-teriflunomide uma unezifo zesibindi ezinzima noma ama-enzyme esibindi aphakeme kakhulu. Abantu abanezifo ezinzima noma amasistimu omzimba aqinile angase futhi adinge ukugwema lo muthi noma balinde kuze kube yilapho isimo sabo sizinzile.

Udokotela wakho uzobuye acabange ukuthi i-teriflunomide ifanele yini uma une:

• Umlando wezifo ezinkulu zegazi noma izinkinga zomnkantsha wamathambo
• Isifo sezinso esinzima
• Isifo sofuba esisebenzayo noma ezinye izifo ezinzima
• Umlando wokuphendula kwesikhumba okukhulu emithini
• Izinkinga ezinkulu zokuphefumula

Uma unezinye zalezi zimo, akusho ngempela ukuthi awukwazi ukuthatha i-teriflunomide, kodwa udokotela wakho uzodinga ukulinganisa izinzuzo nezingozi futhi angase ancome ukuqapha okwengeziwe noma ezinye izindlela zokwelapha.

Amagama Omkhiqizo we-Teriflunomide

I-Teriflunomide itholakala ngaphansi kwegama lomkhiqizo elithi Aubagio emazweni amaningi, okuhlanganisa ne-United States. Lena yindlela ejwayelekile yokunikezwa komuthi.

Uhlobo olujwayelekile lwe-teriflunomide selutholakala kwezinye izifunda, okungenzeka lunikeze inketho eshibhile ngenkathi lunikeza isithako esisebenzayo esifanayo nokusebenza kahle. Ikhemisi lakho lingakusiza ukuthi uqonde ukuthi iyiphi inguqulo etholakalayo futhi ehlanganiswe ngumshuwalense wakho.

Noma ngabe uthola i-Aubagio yegama lomkhiqizo noma i-teriflunomide ejwayelekile, umuthi usebenza ngendlela efanayo futhi kufanele unikeze izinzuzo ezifanayo zokuphatha i-MS yakho.

Ezinye izindlela ze-Teriflunomide

Imithi eminingi ehlukile iyatholakala yokwelapha izinhlobo eziphindayo ze-multiple sclerosis, ngalinye linendlela ehlukile yokusebenza, amaphrofayili emiphumela emibi, nezindlela zokuphatha. Udokotela wakho angakusiza ukuthi uhlole lezi zinketho uma i-teriflunomide ingakulungele.

Eminye imithi ye-MS yomlomo ihlanganisa i-dimethyl fumarate, fingolimod, kanye ne-siponimod. Lezi zisebenza ngezindlela ezahlukene kodwa zinikeza lula okufanayo kokuphathwa ngomlomo. Izinketho ezinjenge-interferon beta kanye ne-glatiramer acetate ziye zasetshenziswa ngempumelelo iminyaka eminingi.

Kubantu abadinga ukwelashwa okujulile, ukwelashwa okusebenza kahle kakhulu njenge-natalizumab, ocrelizumab, noma i-alemtuzumab kungase kucatshangelwe. Lezi zivame ukudinga ukumnika esikhungweni sezokwelapha kodwa kungasebenza kahle kakhulu ezinhlotsheni ezinolaka ze-MS.

Ukukhetha phakathi kwalezi ezinye izindlela kuncike ezintweni ezifana nohlobo lwakho oluthile lwe-MS, izimpendulo zokwelashwa zangaphambilini, ukubekezelelana nemiphumela emibi, nezintandokazi zomuntu siqu mayelana nezindlela zokuphatha.

Ingabe i-Teriflunomide ingcono kune-Interferon Beta?

I-Teriflunomide kanye nemithi ye-interferon beta yomibili iyindlela yokwelapha yomugqa wokuqala ye-relapsing MS, kodwa isebenza ngendlela ehlukile futhi inezinzuzo ezihlukile. Izifundo zemitholampilo zikhomba ukuthi i-teriflunomide ingasebenza kangcono kancane ekunciphiseni ukuphindeka uma kuqhathaniswa nezinye izindlela ze-interferon beta.

Inzuzo enkulu ye-teriflunomide ukuthi ithathwa ngomlomo, okutholakala kulula kubantu abaningi kunemijovo ejwayelekile edingekayo ye-interferon beta. Lokhu kungaholela ekunamatheleni okungcono emithini, okubalulekile ekuphathweni kwe-MS yesikhathi eside.

Kodwa-ke, i-interferon beta inerekhodi elide lokusetshenziswa futhi ingase itholeke kangcono ngabanye abantu, ikakhulukazi labo abathola imiphumela emibi ebalulekile evela ku-teriflunomide. Ukukhetha phakathi kwale mithi kuvame ukuncika ezintweni zomuntu ngamunye njengezintandokazi zokuphila, ukubekezelelana nemiphumela emibi, nokuthi imithi ngayinye isebenza kahle kangakanani esimweni sakho esithile.

Udokotela wakho uzocabangela umlando wakho wezokwelapha, umsebenzi wamanje we-MS, nezintandokazi zakho siqu lapho encoma phakathi kwalezi zinketho.

Imibuzo Evame Ukubuzwa Nge-Teriflunomide

Ingabe i-Teriflunomide Iphephile Kubantu Abanesifo Sikashukela?

I-Teriflunomide ngokuvamile ingasetshenziswa ngokuphepha kubantu abanesifo sikashukela, kodwa idinga ukuqapha okucophelelayo. Umuthi awuthinti ngokuqondile amazinga kashukela egazini, kodwa eminye imiphumela emibi efana nezifo ingase ikhathaze kakhulu kubantu abanesifo sikashukela.

Udokotela wakho uzofuna ukuqinisekisa ukuthi isifo sakho sikashukela silawulwa kahle ngaphambi kokuqala i-teriflunomide futhi angase ancome ukuhlolwa okuvame kakhulu ukuqapha noma yiziphi izinkinga. Kubalulekile ukugcina ukulawulwa okuhle kashukela egazini futhi uqhubeke nemithi yakho yesifo sikashukela njengoba kunqunyiwe ngenkathi uthatha i-teriflunomide.

Ngingenzani Uma Ngenhlanhla Ngithatha I-Teriflunomide Eningi Kakhulu?

Uma ngengozi uthatha ngaphezu komthamo wakho onqunyiwe we-teriflunomide, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ukuthatha okuningi kungakhuphula ingozi yemiphumela emibi engathi sína, ikakhulukazi izinkinga zesibindi noma ukwehla okukhulu kwenani lamaseli amhlophe egazi.

Ungazami "ukulungisa" umthamo owengeziwe ngokuqaqa imithamo yesikhathi esizayo. Kunalokho, buyela esimisweni sakho esivamile sokuthatha imithi njengoba uqondiswe ngumhlinzeki wakho wezempilo. Bangase bafune ukukuqapha eduze noma benze ezinye izivivinyo zegazi ukuze baqinisekise ukuthi awutholi imiphumela emibi.

Kufanele Ngenzeni Uma Ngeqa Umthamo We-Teriflunomide?

Uma uqaqa umthamo we-teriflunomide, yithathe ngokushesha nje lapho ukhumbula, ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo. Kulokho, qasha umthamo oqashiwe bese uqhubeka neshejuli yakho ejwayelekile.

Ungathathi imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo oqashiwe, ngoba lokhu kungandisa ingozi yakho yemiphumela emibi. Uma uvame ukukhohlwa imithamo, cabanga ukusetha i-alamu yansuku zonke noma usebenzise umhleli wamaphilisi ukukusiza ukhumbule.

Uma uqaqa imithamo eminingi ilandelana, xhumana nodokotela wakho ukuze uthole isiqondiso sokuthi ungaqala kanjani kabusha imithi yakho ngokuphepha.

Ngingayeka Nini Ukuthatha I-Teriflunomide?

Akufanele uyeke ukuthatha i-teriflunomide ngaphandle kokuxoxa ngayo nodokotela wakho kuqala. Ukuyeka imithi ye-MS ngokuzumayo kungaholela ekwandeni komsebenzi wesifo futhi kungenzeka kube nokubuyela emuva okwengeziwe.

Udokotela wakho angase ancome ukuyeka i-teriflunomide uma uthola imiphumela emibi engathí sina, uma imithi ingalawuli i-MS yakho ngempumelelo, noma uma uhlela ukukhulelwa. Kulezi zimo, cishe bazoncoma ukwelashwa okuhlukile ukuze baqinisekise ukuthi i-MS yakho ihlala ilawulwa kahle.

Uma udinga ukuyeka i-teriflunomide, udokotela wakho ngokuvamile uzonquma i-cholestyramine ukusiza ukuqeda imithi ohlelweni lwakho ngokushesha, ikakhulukazi uma uhlela ukuqala ukwelashwa okuhlukile kwe-MS noma ukukhulelwa.

Ngingakwazi Yini Ukuphuza Utshwala Ngenkathi Ngithatha I-Teriflunomide?

Nakuba kungekho ukuvinjelwa okuphelele ekuphuzeni utshwala ngenkathi uthatha i-teriflunomide, kuvamile ukunconywa ukuthi unciphise ukusetshenziswa kotshwala noma ukukugwema ngokuphelele. Kokubili utshwala ne-teriflunomide kungathinta isibindi sakho, futhi ukukuhlanganisa kungase kwandise ingozi yezinkinga zesibindi.

Uma ukhetha ukuphuza utshwala ngezikhathi ezithile, kwenze ngokulinganisela futhi uqinisekise ukuthi udokotela wakho uyakwazi ukusetshenziswa kotshwala kwakho. Bangase bafune ukuqapha ukusebenza kwesibindi sakho ngokucophelela noma balungise uhlelo lwakho lokwelapha ngokufanele.

Khumbula ukuthi utshwala bungase futhi buqhubekisele phambili ezinye izimpawu ze-MS futhi bungase luphazamise impilo yakho yonke nenhlalakahle, ngakho-ke kufanelekile ukuxoxa ngemikhuba yakho yokuphuza ngokusobala nethimba lakho lokunakekelwa kwezempilo.