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Brucellosis

Overview

Brucellosis is a sickness caused by bacteria that can travel from animals to humans. A common way people get it is by eating uncooked or unpasteurized milk products, like raw cheese or milk. Sometimes, the bacteria can spread through the air or when people touch infected animals directly.

If you have brucellosis, you might experience a high temperature, aches in your joints, and feel very tired. Doctors usually treat this infection with special medicines called antibiotics. But it often takes several weeks or even months to get rid of the bacteria completely. Sometimes, the infection comes back later.

Brucellosis affects many people and animals globally. To lower your risk, avoid eating raw dairy products. Also, take care when handling animals or working in places where there might be infected animals, like a laboratory. Practicing good hygiene is important to prevent the spread of infection.

Symptoms

Brucellosis, a bacterial infection, can cause a range of symptoms that appear anywhere from a few days to several months after exposure. These initial symptoms often mimic the flu and can include:

  • High temperature (fever): This is a common sign of infection.
  • Feeling cold (chills): Chills often accompany fever.
  • Loss of interest in food (loss of appetite): This can be a significant symptom.
  • Night sweats: Sweating during sleep can be a noticeable indicator.
  • Feeling weak and tired (weakness and fatigue): These are common flu-like symptoms.
  • Pain in your joints, muscles, or back: This pain can vary in intensity.
  • Headache: A headache can be another sign of the infection.

Importantly, brucellosis symptoms can disappear for a time, sometimes for weeks or months, and then return. This can make diagnosis more challenging. For some people, the infection develops into a chronic condition, meaning they experience symptoms for years, even after treatment. These long-term symptoms can include:

  • Persistent tiredness (fatigue): This can be a significant and ongoing problem.
  • Recurring fevers: These fevers may not be as severe as initial ones, but they happen repeatedly.
  • Inflammation of the inner lining of the heart chambers (endocarditis): This is a serious complication that needs medical attention.
  • Inflammation of the joints (arthritis): This can lead to pain and stiffness in the joints.
  • Inflammation of the spinal bones (spondylitis): This can cause pain and stiffness in the spine.
  • Inflammation of the joints where the spine and pelvis connect (sacroiliitis): This condition can lead to pain and stiffness in the hip area.

It's crucial to remember that if you suspect you might have brucellosis, you should consult a doctor immediately. Early diagnosis and treatment are vital for managing the infection and preventing long-term complications.

When to see a doctor

Brucellosis is a tricky illness to spot, particularly at first. Early symptoms can be very similar to the flu, like a fever, body aches, and feeling unusually weak. If you think you might have brucellosis, or if you've been exposed to something that could cause it, it's important to see a doctor right away. This is especially true if you have a fever that keeps coming back or getting worse, along with muscle pain or unusual tiredness.

Causes

Brucellosis is a bacterial infection that can affect both wild and domestic animals. This includes a wide range of creatures, such as cattle, goats, sheep, pigs (including wild hogs), dogs (especially hunting dogs), deer, elk, bison, caribou, moose, and camels. Even marine mammals like harbor seals, porpoises, and certain whales can get a form of the disease.

The bacteria that cause brucellosis can spread from animals to humans in several ways:

  • Eating contaminated food: If an animal is infected with Brucella bacteria, the bacteria can be present in its milk, and unpasteurized milk products like raw milk, ice cream, butter, and some cheeses can transmit the infection to people. Raw or undercooked meat from infected animals can also carry the bacteria. So, it's crucial to ensure that dairy and meat products are properly processed to kill any potential bacteria.

  • Breathing contaminated air: The bacteria can be released into the air, particularly in environments where animals are handled. Farmers, hunters, laboratory workers who handle infected animals, and slaughterhouse workers are at risk of inhaling the bacteria and becoming infected.

  • Contact with infected animal fluids: Brucella bacteria can be found in the blood, semen, or placenta of infected animals. If a person has a cut or wound, and comes into contact with these fluids, the bacteria can enter the bloodstream. While everyday contact with animals, like petting or playing, is usually safe, people with weakened immune systems should avoid close contact with animals known to have brucellosis.

Brucellosis typically doesn't spread directly from one person to another. However, there are some exceptions:

  • Mother to child: In rare cases, a mother can pass brucellosis to her child during childbirth or through breastfeeding.

  • Sexual transmission: Brucellosis can, exceptionally, be spread through sexual contact.

  • Blood or organ transfusions: If blood or bone marrow transfusions are contaminated with the bacteria, the infection can be transmitted.

It's important to note that while these transmission methods exist, they are not common. Proper food handling and precautions when handling potentially infected animals significantly reduce the risk of human infection.

Risk factors

Brucellosis is not a very common illness in the United States. However, it's more widespread in other parts of the world. This includes:

  • Southern Europe: Countries like Portugal, Spain, Turkey, Italy, Greece, and parts of France have higher rates of brucellosis.
  • Eastern Europe: Brucellosis is also more frequently found in this region.
  • Latin America: Mexico, South America, and Central America are areas where brucellosis is more common.
  • Asia: Brucellosis is present in various parts of Asia.
  • Africa: Brucellosis is also found in many countries across Africa.
  • The Caribbean: This region also experiences instances of brucellosis.
  • The Middle East: Brucellosis is present in some countries of the Middle East.

Essentially, while rare in the US, brucellosis is a more significant health concern in many other parts of the world.

Complications

Brucellosis, a bacterial infection, can affect many parts of the body. This includes your reproductive organs, liver, heart, and the central nervous system. The illness can cause problems in just one organ or spread throughout your body. If left untreated, these problems can be serious. Here are some possible complications:

  • Heart problems (endocarditis): This is a severe complication where the inner lining of the heart's chambers becomes inflamed. If not treated, endocarditis can damage or destroy the heart valves. This is a major cause of death from brucellosis. Imagine the heart's delicate inner lining becoming infected and irritated, potentially leading to serious valve damage.

  • Joint pain (arthritis): Brucellosis can cause inflammation in your joints, leading to pain, stiffness, and swelling. This is especially common in the knees, hips, ankles, wrists, and spine. Inflammation in the spine (spondylitis) or the joints connecting the lower spine and pelvis (sacroiliitis) can be particularly challenging to treat and may result in lasting damage. Think of your joints becoming inflamed and painful, like having a constant ache.

  • Testicle infection (epididymo-orchitis): The bacteria that cause brucellosis can infect the epididymis, a tube that carries sperm. This infection can spread to the testicle itself, causing painful swelling. This can be a very painful experience.

  • Spleen and liver problems: Brucellosis can also affect the spleen and liver, making them swell up larger than normal. This can lead to discomfort and other health issues. Imagine your spleen and liver becoming enlarged and putting pressure on surrounding organs.

  • Brain and nervous system problems: Brucellosis can cause infections in the brain and spinal cord. These infections can be life-threatening. Examples include meningitis (inflammation of the membranes surrounding the brain and spinal cord) and encephalitis (inflammation of the brain itself). These infections can cause serious neurological symptoms. Imagine the delicate tissues of your brain and spinal cord being inflamed and damaged.

Prevention

Preventing Brucellosis: Simple Steps to Stay Safe

Brucellosis is a disease that can be spread from animals to people. Here's how to lower your risk:

1. Avoid Raw Dairy Products: In the US, brucellosis cases linked to raw milk, cheese, and ice cream from domestic animals are rare. But it's still a good idea to avoid them, no matter where they come from. If you're traveling internationally, steer clear of all raw dairy products. Raw dairy products can carry harmful bacteria, and it's safer to consume pasteurized versions.

2. Cook Meat Thoroughly: Proper cooking is key. For a whole cut of meat, cook it until its internal temperature reaches 145°F (63°C) and let it rest for at least 3 minutes. This is considered medium-done. Ground meats, however, need to reach 160°F (71°C) for safety. Poultry, including ground poultry, should be cooked to 165°F (74°C). When traveling to places where food safety standards might be different, always choose well-cooked meats.

3. Wear Protective Gear When Needed: If you work with animals, such as veterinarians, farmers, hunters, or slaughterhouse workers, use rubber gloves when handling sick, dead animals, animal tissues, or assisting animals during birth. This prevents possible exposure to the bacteria.

4. Safe Practices in High-Risk Settings: If you work in a lab, follow proper biosafety procedures when handling any animal samples. Slaughterhouses should take steps to protect workers. This might include separating areas where animals are processed from other areas and using protective clothing.

5. Vaccinate Domestic Animals (but be careful): In the United States, a widespread vaccination program has greatly reduced brucellosis in domestic livestock. However, the vaccine is a live vaccine, which means it has a small chance of causing the disease in people. If anyone gets a needle stick while vaccinating animals, they should get medical attention immediately.

Diagnosis

Doctors diagnose brucellosis, a bacterial infection, by looking for the bacteria in blood or bone marrow samples, or by checking for antibodies to the bacteria in the blood. This helps them determine if the infection is present.

To find out if the infection has caused any problems, doctors might also run other tests. These tests help figure out if the infection has spread to other parts of the body.

Here are some common additional tests:

  • X-rays: These pictures of your bones and joints can show if the infection has affected those areas. For example, they might reveal swelling or changes in the bone structure.

  • CT scans or MRIs: These detailed imaging tests, like a CT scan or MRI, are like more detailed X-rays. They can help pinpoint inflammation or pockets of pus (abscesses) in the brain or other parts of the body. These tests can show areas of damage or infection that might not be noticeable on a regular X-ray.

  • Cerebrospinal fluid (CSF) culture: This test checks a sample of the fluid surrounding the brain and spinal cord. This fluid is checked for any signs of infections like meningitis (inflammation of the membranes surrounding the brain and spinal cord) or encephalitis (inflammation of the brain itself). This is important to detect if the infection has reached the central nervous system.

  • Echocardiography: This test uses sound waves to create images of the heart. It can reveal if the infection has affected the heart muscles or valves, or if there are any signs of inflammation or damage. This is crucial to check for any potential heart-related complications from brucellosis.

Treatment

Brucellosis treatment focuses on easing symptoms, preventing the illness from coming back, and avoiding problems it might cause. This usually involves taking antibiotics for at least six weeks. It's important to understand that even after treatment, some symptoms might not disappear entirely for several months. In some cases, the illness can return and become a long-term (chronic) condition.

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