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Hepatitis B

Overview

Hepatitis B is a liver infection caused by a virus called HBV. Most people have a short-term (acute) infection. This means the infection lasts for less than six months, and often people recover completely without needing any special treatment. However, for some people, the infection becomes long-term (chronic). This happens when the infection lasts longer than six months. A chronic hepatitis B infection can increase the risk of serious problems like liver failure, liver cancer, and a condition called cirrhosis, where the liver becomes scarred.

Adults who get hepatitis B often recover fully, even if they feel very sick. Babies and young children are more likely to develop a chronic, long-lasting infection.

Fortunately, a vaccine can prevent hepatitis B. If someone does get infected, treatment depends on whether it's an acute or chronic infection. Some people with acute hepatitis B don't need any medicine. For others, especially those with a chronic infection that causes significant liver damage, medicine is necessary. In some severe cases of chronic hepatitis B, a liver transplant might be needed. If you have hepatitis B, there are also steps you can take to avoid spreading the virus to others, such as using clean needles and practicing safe sex.

Symptoms

Hepatitis B can cause symptoms that range from mild to severe. These symptoms typically appear about one to four months after you've been infected with the hepatitis B virus (HBV). However, some people might notice symptoms as early as two weeks after infection. Importantly, some people, especially young children, may not experience any symptoms at all, even if they have the infection.

Common symptoms of hepatitis B include:

  • Stomach pain: This pain might be felt in your abdomen.
  • Dark urine: Your urine might look unusually dark.
  • Fever: You might experience a fever.
  • Joint pain: Your joints might ache.
  • Loss of appetite: You might not feel like eating.
  • Upset stomach and vomiting: You might feel nauseous and vomit.
  • Weakness and fatigue: You might feel unusually tired and weak.
  • Jaundice: This is a yellowing of the whites of your eyes and skin. The change in color might be more or less noticeable depending on your natural skin tone.

If you've been exposed to hepatitis B, contact your doctor immediately. A preventative treatment is available and can significantly reduce your risk of getting infected if you receive it within 24 hours of exposure. If you think you are experiencing symptoms of hepatitis B, contact your healthcare provider. Early diagnosis and treatment are crucial for managing the infection and preventing potential complications.

When to see a doctor

If you think you've been exposed to the hepatitis B virus, contact your doctor immediately. Getting treatment within 24 hours of exposure can significantly reduce your chances of becoming infected. Hepatitis B is a liver infection.

If you're experiencing any symptoms like fatigue, abdominal pain, nausea, or jaundice (yellowing of the skin and eyes), contact your doctor. These are possible signs of hepatitis B infection. Early diagnosis and treatment are crucial for managing the condition.

Causes

Hepatitis B is a disease caused by the hepatitis B virus (HBV). This virus spreads through contact with blood, semen, or other bodily fluids. It's important to know that HBV doesn't spread through coughs or sneezes.

Here's how HBV is typically spread:

  • Sexual Contact: If you have unprotected sex with someone who has hepatitis B, you can become infected. The virus can enter your body through blood, saliva, semen, or vaginal fluids. Using condoms during sex can significantly reduce the risk.
  • Sharing Needles: HBV spreads easily through needles and syringes contaminated with infected blood. Sharing needles, especially for injecting drugs, greatly increases your chance of getting hepatitis B.
  • Accidental Needlesticks: Healthcare workers and others who come into contact with human blood are at risk of hepatitis B through accidental needle pricks or exposure to infected blood.
  • Mother to Child: A pregnant person with hepatitis B can pass the virus to their baby during childbirth. Fortunately, newborns can be vaccinated to prevent infection in most cases. If you are pregnant or plan to become pregnant, talk to your doctor about getting tested for hepatitis B.

Hepatitis B infections can be either short-term (acute) or long-term (chronic).

  • Acute Hepatitis B: This type of infection lasts less than six months. In most cases, your body's immune system clears the virus, and you recover completely within a few months. Most adults who get HBV have acute infections. However, some acute infections can develop into chronic infections.
  • Chronic Hepatitis B: This type of infection lasts six months or longer. Your immune system is unable to fight off the virus, and the infection persists. A chronic hepatitis B infection can last a lifetime. It can lead to serious health problems like cirrhosis (scarring of the liver) and liver cancer. Some people with chronic hepatitis B don't experience any symptoms, while others may have ongoing tiredness and mild symptoms similar to acute hepatitis.

Getting hepatitis B at a young age, especially as a newborn or child under five, increases your risk of developing a chronic infection. Sometimes, chronic hepatitis B goes undetected for many years until it causes significant liver damage.

Risk factors

Hepatitis B is a virus that spreads through contact with blood, semen, or other bodily fluids from an infected person. This means you're more likely to get it if:

  • You have unprotected sex with multiple partners or someone who has hepatitis B. Having sex with multiple partners increases your risk because you're exposed to more people's bodily fluids. Similarly, if your partner has hepatitis B, there's a higher chance of transmission during sexual contact.

  • You share needles for injecting drugs. Sharing needles allows infected blood to directly transfer to another person. This is a very high-risk behavior.

  • You are a man who has sex with men. This group has a higher risk of HBV infection due to the nature of sexual contact.

  • You live with someone who has a long-term hepatitis B infection. Living in close contact increases the potential for exposure to infected bodily fluids.

  • You were born to a pregnant person with hepatitis B. Babies can contract the virus during birth if the mother is infected.

  • Your job involves contact with human blood. Healthcare workers, first responders, and others who work in environments where they might be exposed to blood have a higher risk.

  • You have hepatitis C or HIV. These conditions can weaken your immune system, making you more vulnerable to hepatitis B infections.

  • You require dialysis. Dialysis treatments can increase the risk of exposure to contaminated blood or fluids.

  • You are or have been incarcerated. Shared living conditions in prisons can lead to a higher risk of exposure to infected blood or bodily fluids.

  • You take medications that weaken your immune system (like chemotherapy). A weakened immune system makes it harder for your body to fight off infections, including hepatitis B.

  • You travel to areas with a high rate of hepatitis B infections. Areas in Asia, the Pacific Islands, Africa, and Eastern Europe have higher rates of the virus, making travel there a potential risk factor.

It's important to note that not everyone exposed to the virus will get infected. Talk to your doctor if you have concerns about your risk of hepatitis B or if you think you might have been exposed. Vaccination is a highly effective way to prevent hepatitis B.

Complications

Chronic hepatitis B infection can cause serious problems, called complications. These include:

Liver scarring (cirrhosis): Hepatitis B can cause inflammation (swelling) in the liver. This inflammation can lead to cirrhosis, a condition where the liver becomes scarred. Cirrhosis can make it hard for the liver to do its job properly.

Liver cancer: People with chronic hepatitis B have a much higher chance of developing liver cancer than people who don't have the infection.

Liver failure: Liver failure happens when the liver stops working correctly. In severe cases, a liver transplant is needed to stay alive.

Viral reactivation: In some people with chronic hepatitis B, the virus levels might be low or undetectable. Sometimes, the virus suddenly starts making more copies of itself, a process called reactivation. This reactivation can cause liver damage or even liver failure.

Why does reactivation happen? Reactivation often affects people with weakened immune systems. This can be due to medical treatments like high doses of corticosteroids or chemotherapy. These medications can suppress the immune system, making it harder for the body to fight the hepatitis B virus. It's crucial to get tested for hepatitis B before starting medications that might weaken your immune system. If you have hepatitis B, talk to a liver specialist (hepatologist) before taking any medication that could affect your immune system.

Other potential problems: People with chronic hepatitis B may also develop kidney disease or inflammation of the blood vessels.

Prevention

The hepatitis B vaccine is the best way to prevent hepatitis B infection. This vaccine comes in a series of shots. You might get two shots, one month apart, or three or four shots over six months. The number of shots depends on the specific vaccine you receive. Crucially, you cannot get hepatitis B from the vaccine itself.

The medical experts in the U.S. recommend the vaccine for infants soon after birth. If you didn't get vaccinated as a baby or child, it's recommended for everyone up to age 59. If you're 60 or older and haven't been vaccinated, you should get the vaccine if you have a chance of being exposed to the hepatitis B virus. Even if you're not at high risk, people 60 and older who haven't been vaccinated can still choose to get the shot.

The hepatitis B vaccine is strongly advised for:

  • Babies: It's essential for newborns.
  • Children and teens: If they weren't vaccinated as babies.
  • People who work or live in facilities for people with developmental disabilities: This helps protect vulnerable populations.
  • People who live with someone who has hepatitis B: Close contact increases the risk of exposure.
  • Healthcare workers and emergency responders: Their work often involves exposure to blood.
  • People with sexually transmitted infections (STIs), including HIV: This group is at higher risk.
  • Men who have sex with men (MSM): MSM face a higher risk.
  • People with multiple sexual partners: More partners mean more potential exposure.
  • Sexual partners of someone with hepatitis B: Protecting partners is crucial.
  • People who inject drugs (IDUs) or share needles: Sharing needles spreads the infection.
  • People with chronic liver disease or end-stage kidney disease: These conditions make people more vulnerable.
  • Travelers to areas with high hepatitis B rates: This protects travelers when they are in regions with a higher likelihood of infection.

You can also lower your risk of hepatitis B through these steps:

  • Know your partners' health status: Don't have unprotected sex unless you know your partner is hepatitis B-free and doesn't have other STIs.
  • Use condoms: Always use a new latex or polyurethane condom during sex if you don't know your partner's health status. Condoms reduce, but don't eliminate, the risk of getting hepatitis B.
  • Avoid injecting drugs: If you inject drugs, get help to stop. If you can't stop, use a sterile needle each time. Never share needles.
  • Be careful about body piercings and tattoos: Choose reputable shops that use sterile needles and clean equipment. Ask questions if you're unsure.
  • Ask about vaccines before traveling: If you're traveling to a region where hepatitis B is common, talk to your doctor about the vaccine beforehand. It's usually given as a series of three shots over six months.
Diagnosis

Diagnosing Hepatitis B: Finding Out If You Have It

Doctors use several steps to figure out if someone has hepatitis B. This process is called diagnosis. First, the doctor does a physical exam to check for signs of liver problems. These signs might include yellowing skin (jaundice) and tummy pain.

Several tests can help confirm a hepatitis B diagnosis or identify any complications.

  • Blood Tests: These tests look for the hepatitis B virus in your blood. They also help determine if the infection is a short-term (acute) or long-term (chronic) problem. A blood test can also show if you're immune to hepatitis B.

  • Liver Ultrasound (Transient Elastography): This special ultrasound uses sound waves to create a picture of the liver. It can measure the amount of liver damage. This is a less invasive way to see how much damage the liver has.

  • Liver Biopsy: In some cases, a doctor might take a small piece of liver tissue for testing. This is called a liver biopsy. A thin needle is inserted into the liver through the skin to collect a sample. The lab then examines this tissue to see if the liver is damaged.

Who Should Be Tested for Hepatitis B?

Doctors sometimes test healthy people for hepatitis B. This is called screening. Hepatitis B can harm the liver even before you have symptoms. Talk to your doctor about getting screened if you:

  • Are pregnant: Hepatitis B can be passed from a pregnant mother to her baby.
  • Live with someone who has hepatitis B: Exposure can occur through close contact.
  • Have had many sexual partners: This increases your risk of exposure.
  • Have had sex with someone who has hepatitis B: This is a significant risk factor.
  • Are male and have sex with men: This group has a higher risk of hepatitis B infection.
  • Have a history of sexually transmitted infections (STIs): This can increase vulnerability.
  • Have HIV or hepatitis C: These conditions can increase your risk of hepatitis B complications.
  • Have unusual liver enzyme test results: This could indicate a problem needing further investigation.
  • Receive kidney dialysis: This treatment can increase the risk of certain infections.
  • Take medicines that suppress your immune system: Examples include those after organ transplants.
  • Use injected street drugs: Sharing needles can spread infections.
  • Are incarcerated (in prison): This environment can increase exposure risk.
  • Were born in a region where hepatitis B is common: This includes parts of Asia, the Pacific Islands, Africa, and Eastern Europe.
  • Have parents or adopted children from regions where hepatitis B is common: This is crucial to consider for preventative measures.

Important Note: Always discuss any concerns about hepatitis B with your healthcare provider. They can recommend the best course of action for your individual situation.

Treatment

Preventing and Treating Hepatitis B

Hepatitis B is a viral infection that can harm your liver. If you think you've been exposed to the hepatitis B virus (HBV), contact a healthcare provider immediately. It's important to talk to your doctor about whether you've had the hepatitis B vaccine. They will need to know when you were exposed and the type of exposure.

Preventing HBV Infection After Exposure:

A medicine called hepatitis B immune globulin (HBIG) can help prevent you from getting sick with HBV. You need to get this shot within 24 hours of exposure. This medicine provides short-term protection, so getting the hepatitis B vaccine at the same time is also crucial if you haven't already been vaccinated.

Treating Acute HBV Infection:

Most cases of acute (short-term) HBV infection clear up on their own. Your healthcare provider might recommend rest, a healthy diet, plenty of fluids, and close monitoring as your body fights the infection. If your symptoms are severe, you might need antiviral medications or hospitalization to prevent complications.

Treating Chronic HBV Infection:

Many people with chronic (long-term) HBV infection need treatment for the rest of their lives. Whether you need treatment depends on several factors, including:

  • Liver damage: Is the virus causing inflammation or scarring (cirrhosis) of your liver?
  • Other infections: Do you have other infections, such as hepatitis C or HIV?
  • Weakened immune system: Is your immune system weakened by medication or illness?

Treatment for chronic HBV helps reduce the risk of liver disease and stops you from spreading the infection to others.

Treatment Options for Chronic HBV:

Treatment often involves:

  • Antiviral medications: These drugs can help fight the virus and slow its damage to your liver. Common examples include entecavir (Baraclude), tenofovir (Viread), lamivudine (Epivir), and adefovir (Hepsera). You usually take these medications by mouth, possibly for a long time. Sometimes, a doctor might combine two antiviral medications, or they might combine one with interferon.
  • Interferon shots: Interferon is a man-made version of a substance your body produces to fight infection. Peginterferon alfa-2a (Pegasys) is an example. This type of treatment is often used for a shorter period than oral antiviral medications but has more side effects, such as upset stomach, vomiting, trouble breathing, and depression. It's particularly considered for younger people who don't need long-term treatment, or for women who might want to get pregnant in the near future. Women should use birth control during interferon treatment, and it's not recommended during pregnancy. People with cirrhosis or acute liver failure should not receive interferon.
  • Liver transplant: If your liver is badly damaged, a liver transplant might be an option. In this procedure, a damaged liver is replaced with a healthy one, usually from a deceased donor, but sometimes from a living donor.

Ongoing Research:

Researchers are constantly developing new medications to treat HBV.

Important Note: This information is for general knowledge and does not constitute medical advice. Always consult with a healthcare professional for diagnosis and treatment of any medical condition.

Self-care

Living with hepatitis B can be challenging, but there are ways to manage it. A good first step is learning about hepatitis B. The Centers for Disease Control and Prevention (CDC) website has a wealth of information.

Staying connected with friends and family is crucial. Hepatitis B isn't spread through everyday contact, so don't isolate yourself. Having a support network is important for managing any health condition.

Taking care of your overall health is also key. A balanced diet rich in fruits and vegetables, regular exercise, and enough sleep are vital for your well-being. This helps your body fight off illness and recover.

Protecting your liver is also essential. Avoid alcohol, and always talk to your doctor before starting any new medications. Your liver plays a vital role in your body's functions, so it's important to take care of it.

Finally, getting tested for hepatitis A and C is a good idea. Hepatitis A can be prevented with a vaccine, so if you haven't had it, talk to your doctor about getting vaccinated.

These tips can help you manage your hepatitis B and maintain a healthy lifestyle. Remember, reaching out for support and taking proactive steps towards your health are important.

Preparing for your appointment

Dealing with Possible Hepatitis B: A Guide for Patients

If you're concerned about hepatitis B, your first step is to see your family doctor. They might refer you to a specialist right away. Doctors who specialize in hepatitis B include gastroenterologists (digestive health), hepatologists (liver health), and doctors who treat infectious diseases.

Getting Ready for Your Appointment:

It's helpful to prepare for your doctor's visit. Before your appointment, check if there are any special instructions or restrictions, such as dietary changes. This will help ensure that you're ready to get the most out of the appointment.

  • Write down your symptoms: Include everything you're experiencing, even if it seems unrelated to hepatitis B. Detailed notes will help your doctor understand the whole picture.
  • Record key personal information: Include major stresses, recent life changes, and any other relevant details.
  • List all medications, vitamins, and supplements: Include the dosage of each.
  • Bring a friend or family member: Having someone with you can help you remember the information shared by your healthcare team.
  • Prepare questions: Think about what you want to know. Important questions about hepatitis B include:
    • What's the likely cause of my symptoms?
    • Are there other possible causes?
    • What tests do I need?
    • Is this a short-term or long-term condition?
    • Has hepatitis B damaged my liver or caused other problems (like kidney issues)?
    • What's the best treatment plan?
    • Are there other treatment options besides the one suggested?
    • If I have other health conditions, how can I manage them together?
    • Are there any restrictions I need to follow?
    • Should I see a specialist?
    • Should my family get tested?
    • How can I protect others from hepatitis B?
    • Is there a generic version of the medication?
    • Can I get any printed information or brochures?
    • Are there any recommended websites?

What to Expect During Your Appointment:

Your doctor will likely ask you questions about your symptoms, such as:

  • When did your symptoms start?
  • Have you had yellowing of your eyes or skin (jaundice), or clay-colored stool?
  • Have you been vaccinated against hepatitis B?
  • Are your symptoms constant or occasional?
  • How severe are your symptoms?
  • What seems to improve or worsen your symptoms?
  • Have you ever had a blood transfusion?
  • Do you inject drugs?
  • Have you had unprotected sex?
  • How many sexual partners have you had?
  • Have you been diagnosed with hepatitis before?

By gathering this information, your doctor can get a clear picture of your health and develop the best possible treatment plan for you. Remember, open communication and thorough preparation will help you get the best care.

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