Caplacizumab-yhdp (intravenous route, subcutaneous route)
About this medication
Caplacizumab-yhdp injection is used in combination with plasma exchange and immunosuppressive therapy (medicines to weaken the immune system) to treat acquired thrombotic thrombocytopenic purpura (aTTP). This medicine is available only with your doctor's prescription.
Before using this medication
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Appropriate studies have not been performed on the relationship of age to the effects of caplacizumab-yhdp injection in the pediatric population. Safety and efficacy have not been established. Although appropriate studies on the relationship of age to the effects of caplacizumab-yhdp injection have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of caplacizumab-yhdp injection in the elderly. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
How to use this medication
A nurse or other trained health professional will give you the first dose of this medicine at least 15 minutes before starting plasma exchange treatment in a medical facility. It is given through a needle placed into one of your veins. You may also be taught how to give your medicine at home. It is usually given as a shot under the skin of your stomach. Make sure you understand all instructions before you give yourself an injection. Do not use more medicine or use it more often than your doctor tells you to. This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions. If you use this medicine at home, you will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. This will help prevent skin problems from the injections. To use the medicine: The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. If you miss a dose of this medicine after the plasma exchange period and it iswithin 12 hoursfrom your regular schedule, take the missed dose as soon as possible. If you miss a dose and it ismore than 12 hoursfrom your regular schedule, skip the missed dose and take your next dose at your usual time. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Store in the refrigerator. Do not freeze. You may also store this medicine at room temperature in its original carton for up to 2 months. Do not return it back to the refrigerator once stored at room temperature. You may keep themixed solutionin the refrigerator for up to 4 hours.
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