Guselkumab (subcutaneous route)
Available brands
Tremfya, Tremfya PEN, Tremfya PFS
About this medication
Guselkumab injection is used to treat moderate to severe plaque psoriasis in patients who may benefit from receiving phototherapy (ultraviolet light treatment) or other treatments. Plaque psoriasis is a skin disease with red patches and white scales that do not go away. Guselkumab injection is also used alone or with other medicines (eg, methotrexate) to treat active psoriatic arthritis, a type of arthritis that causes pain and swelling in the joints along with patches of scaly skin on some areas of the body. Psoriatic arthritis usually occurs with a skin condition called psoriasis. This medicine is also used to treat moderate to severe active ulcerative colitis. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms:
Before using this medication
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Appropriate studies have not been performed on the relationship of age to the effects of guselkumab injection in the pediatric population. Safety and efficacy have not been established. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of guselkumab injection in the elderly. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
How to use this medication
This medicine is available in 4 forms:vial,One-Press® injector,prefilled pen, andprefilled syringe. Vial: A nurse or other trained health professional will give you this medicine in a medical facility. It is given through an IV catheter that is placed in one of your veins to treat ulcerative colitis. It must be given slowly, so the IV catheter will have to remain in place for at least 1 hour. One-Press® injector, prefilled pen, and prefilled syringe: You may also be taught how to give your medicine at home. It is usually given as a shot under the skin of your stomach, thigh, or upper arm. Make sure you understand all instructions before you give yourself an injection. Do not use more medicine or use it more often than your doctor tells you to. This medicine comes with a Medication Guide and patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions. You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. This will help prevent skin problems from the injections. Do not inject the medicine into areas where the skin is tender, bruised, red, hard, thick, scaly, affected by psoriasis, or areas with scars or stretch marks. Allow the medicine to warm to room temperature for 30 minutes before you use it. Do not warm it in any other way. Check the liquid in theprefilled pen,prefilled syringe, orOne-Press® injector. It should be clear and colorless or slightly yellow and may contain small particles. Do not use this medicine if it is cloudy, discolored, or has large particles in it. Do not shake. To use theOne-Press® injector: To use theprefilled pen: To use theprefilled syringe: You might not use all of the medicine in eachprefilled syringeorOne-Press® injector. Use eachprefilled syringeorOne-Press® injectoronly 1 time. Do not save an opensyringeorOne-Press® injector. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Store in the refrigerator. Do not freeze. Keep the medicine in its original carton until you are ready to use it. Protect from light. Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.
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