What is Hexachlorophene: Uses, Dosage, Side Effects and More

Hexachlorophene is a prescription antiseptic medication that kills bacteria on your skin's surface. This topical treatment works by disrupting the cell walls of harmful bacteria, making it particularly effective against certain types of infections that can cause serious skin problems.

You might encounter hexachlorophene in hospital settings or receive it from your doctor for specific bacterial skin conditions. It's considered a strong antiseptic that requires careful medical supervision due to its potent effects.

What is Hexachlorophene Used For?

Hexachlorophene treats bacterial skin infections, particularly those caused by gram-positive bacteria like Staphylococcus. Your doctor might prescribe it when you have stubborn skin infections that haven't responded to gentler treatments.

The medication works especially well for preventing infections in newborns in hospital nurseries. Healthcare providers also use it as a surgical scrub to reduce bacteria on the skin before medical procedures.

Common conditions that may require hexachlorophene include recurring skin infections, certain types of dermatitis with bacterial involvement, and situations where you need powerful antibacterial protection. Your doctor will determine if this strong antiseptic is right for your specific situation.

How Does Hexachlorophene Work?

Hexachlorophene works by breaking down the protective walls that surround bacteria cells. When these walls are damaged, the bacteria can't survive and multiply on your skin.

This medication is considered a strong antiseptic because it can penetrate deeper into skin layers than many other topical antibacterials. It continues working for several hours after application, providing longer-lasting protection against bacterial growth.

The active ingredient specifically targets gram-positive bacteria, which are responsible for many common skin infections. However, this strength also means hexachlorophene requires more careful handling than milder antiseptics.

How Should I Take Hexachlorophene?

Apply hexachlorophene exactly as your doctor prescribes, typically as a thin layer to clean, dry skin. Wash your hands thoroughly before and after applying the medication to prevent spreading bacteria to other areas.

You should clean the affected area gently with mild soap and water before application. Pat the skin dry completely, then apply a small amount of hexachlorophene, spreading it evenly over the infected area.

Don't use this medication on broken or severely damaged skin unless specifically directed by your doctor. The medication can absorb more deeply through damaged skin, potentially causing unwanted effects.

Avoid getting hexachlorophene in your eyes, mouth, or nose. If accidental contact occurs, rinse immediately with plenty of clean water and contact your healthcare provider if irritation persists.

How Long Should I Take Hexachlorophene For?

The duration of hexachlorophene treatment depends on your specific condition and how well your skin responds to the medication. Most people use it for several days to a few weeks under medical supervision.

Your doctor will monitor your progress and determine when to stop treatment. Never continue using hexachlorophene longer than prescribed, as extended use can lead to skin irritation or other complications.

Some people see improvement within a few days, while others may need longer treatment periods. The key is following your doctor's instructions precisely and reporting any concerns during treatment.

What Are the Side Effects of Hexachlorophene?

Hexachlorophene can cause side effects ranging from mild skin irritation to more serious reactions. Understanding these potential effects helps you know when to contact your healthcare provider.

Common side effects you might experience include skin redness, dryness, or mild burning at the application site. These reactions are usually temporary and improve as your skin adjusts to the medication.

Here are the more common side effects to watch for:

• Skin irritation or redness
• Dryness or peeling
• Mild burning sensation
• Temporary skin discoloration

More serious side effects require immediate medical attention. These can occur if the medication absorbs too deeply into your system or if you have an allergic reaction.

Rare but serious side effects include:

• Severe skin reactions like blistering or severe burning
• Signs of systemic absorption like dizziness or confusion
• Allergic reactions with swelling, difficulty breathing, or widespread rash
• Neurological symptoms like tremors or seizures (very rare)

Contact your doctor immediately if you experience any serious side effects. These reactions, while uncommon, require prompt medical evaluation to ensure your safety.

Who Should Not Take Hexachlorophene?

Certain people should avoid hexachlorophene due to increased risks of complications. Your doctor will review your medical history to determine if this medication is safe for you.

People with known allergies to hexachlorophene or similar antiseptics should not use this medication. If you've had reactions to other topical antibacterials, inform your doctor before starting treatment.

Specific groups who should avoid hexachlorophene include:

• Infants under certain age limits (as determined by your doctor)
• People with extensive skin damage or burns
• Those with kidney or liver problems
• Individuals with neurological conditions
• Pregnant or breastfeeding women (unless benefits outweigh risks)

People with sensitive skin or eczema may also need special consideration. Your doctor can determine if hexachlorophene is appropriate or if alternative treatments would be safer for your situation.

Hexachlorophene Brand Names

Hexachlorophene is available under several brand names, though availability varies by location and pharmacy. The most common brand name is pHisoHex, which you might find in hospitals or specialty pharmacies.

Other brand names include Septisol and various generic formulations. Your pharmacist can help you identify which specific brand or generic version your doctor has prescribed.

Always check with your healthcare provider or pharmacist if you're unsure about which formulation you're receiving. Different brands may have slightly different concentrations or additional ingredients.

Hexachlorophene Alternatives

Several alternatives to hexachlorophene exist for treating bacterial skin infections. Your doctor might recommend these options if hexachlorophene isn't suitable for your situation.

Milder antiseptics like chlorhexidine or povidone-iodine can treat many bacterial skin infections with fewer side effects. These alternatives work well for people who need gentler treatment options.

Other alternatives include:

• Topical antibiotics like mupirocin or fusidic acid
• Antiseptic washes containing benzoyl peroxide
• Silver-based antimicrobial treatments
• Prescription antibiotic creams or ointments

Your doctor will choose the best alternative based on your specific infection type, medical history, and treatment goals. Sometimes combining different approaches works better than using a single strong antiseptic.

Is Hexachlorophene Better Than Chlorhexidine?

Hexachlorophene and chlorhexidine are both effective antiseptics, but they work differently and have distinct advantages. The "better" choice depends on your specific needs and medical situation.

Hexachlorophene is stronger against certain gram-positive bacteria and provides longer-lasting effects. However, chlorhexidine is generally safer for regular use and has a broader spectrum of activity against different types of bacteria.

Chlorhexidine causes fewer side effects and can be used more safely on damaged skin. It's also less likely to cause systemic absorption problems, making it a preferred choice for many routine applications.

Your doctor will choose between these medications based on the specific bacteria causing your infection, your skin condition, and your overall health status. Both medications are effective when used appropriately for the right conditions.