Histrelin (subcutaneous route)

Supprelin LA, Vantas

Histrelin is a synthetic (man-made) hormone that is similar to a natural hormone that is produced in the brain. This medicine works in the brain to reduce the blood levels of sex hormones, such as testosterone and estrogen. It is inserted just beneath the skin of the upper arm where it releases small amounts of histrelin in the body every day for 12 months. Histrelin (Vantas®) is used to treat advanced prostate cancer in adults. It will reduce the level of testosterone, a male hormone, in the blood. Testosterone makes most prostate cancers grow. Histrelin is not a cure for prostate cancer, but it may help relieve the symptoms. Histrelin (Supprelin® LA) is used to treat central precocious puberty (CPP) in children. CPP is a condition wherein puberty begins at an unusually early age. This usually means puberty occurs before 8 years of age in girls and before 9 years of age in boys. This medicine is to be given only by or under the direct supervision of a trained healthcare professional. This product is available in the following dosage forms:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. TheVantas®form of histrelin should not be used in children. Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness ofSupprelin® LAin children 2 years of age and older. However, use in children younger than 2 years of age is not recommended. Safety and efficacy have not been established. No information is available on the relationship of age to the effects ofSupprelin® LA or Vantas®in the elderly. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially: