Ipilimumab (intravenous route)

Yervoy

Ipilimumab injection is used in combination with nivolumab to treat melanoma (a type of skin cancer) that has spread or cannot be removed by surgery. It is a monoclonal antibody that changes the immune system to help control the growth of cancer cells in the skin. Ipilimumab injection is also used to help prevent melanoma from coming back after surgical removal. Ipilimumab injection is used in combination with other medicines (eg, nivolumab) to treat patients with kidney cancer that has spread throughout the body. Ipilimumab injection is used with nivolumab to treat microsatellite instability high (MSI-H) or mismatch repair deficient (dMMR) colorectal cancer (cancer of the colon or rectum) that has spread. It is given to patients who have received other cancer treatments (eg, fluoropyrimidine, oxaliplatin, irinotecan) but did not work well. Ipilimumab injection is also used with nivolumab to treat liver cancer. It is given to patients who have previously received treatment with sorafenib. Ipilimumab injection is also used with nivolumab as first-line treatment for metastatic (cancer that has already spread) non-small cell lung cancer (NSCLC) in patients whose tumors express PD-L1 and do not have an abnormal EGFR or ALK gene. Your doctor will perform a test to check for the PD-L1 tumor before you receive this medicine. Ipilimumab injection is also used with nivolumab and two cycles of cancer treatment that contains platinum and another cancer medicine as first-line treatment for metastatic (cancer that has already spread) or recurrent (cancer that has come back) non-small cell lung cancer (NSCLC) in patients whose tumors do not have an abnormal EGFR or ALK gene. Your doctor will perform a test before you receive this medicine. Ipilimumab injection is also used with nivolumab as first-line treatment for malignant pleural mesothelioma (cancer that affects the lining of the lungs and chest wall) that cannot be removed by surgery. Ipilimumab injection is also used with nivolumab as first-line treatment for squamous cell carcinoma of the esophagus that has spread or cannot be removed by surgery. This medicine is to be given only by or under the immediate supervision of your doctor. This product is available in the following dosage forms:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of ipilimumab injection totreat melanoma, tohelp prevent melanoma from coming back after surgical removal, and to treatmicrosatellite instability high (MSI-H) or mismatch repair deficient (dMMR) colorectal cancerin children 12 years of age and older. Safety and efficacy have not been established in children younger than 12 years of age to treat other approved conditions. Appropriate studies have not been performed on the relationship of age to the effects of ipilimumab injection totreat kidney cancerin the pediatric population. Safety and efficacy have not been established. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ipilimumab injection in the elderly. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially: