Sodium thiosulfate (intravenous route)

Pedmark

Sodium thiosulfate may be used to lessen some of the side effects of cisplatin (a cancer medicine). It is also used with another medicine in the emergency treatment of cyanide poisoning. Sodium thiosulfate is also used to reduce the risk of hearing loss in children 1 month of age and older who are receiving medicines (eg, cisplatin) for cancer that have not spread throughout the body. This medicine is to be given only by or under the immediate supervision of your doctor. This product is available in the following dosage forms:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Although there is no specific information comparing use of sodium thiosulfate in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults. Appropriate studies have not been performed on the relationship of age to the effects ofPedmark®in children younger than 1 month of age or in children with cancer that has spread (metastatic). Safety and efficacy have not been established. Use in children younger than 1 month of age is not recommended becausePedmark®may increase the risk of hypernatremia (high sodium levels in the blood). Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing the use of sodium thiosulfate in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults. No information is available on the relationship of age to the effects ofPedmark®in geriatric patients. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially: