Māʻi Crohn

ʻO ka maʻi Crohn kahi ʻano o ka maʻi inflammatory bowel (IBD) e hoʻoulu ai i ka pehu a me ka huhū o nā pūnaewele, i kapa ʻia ʻo ka mumū, i loko o ka ʻōnaehana digestive. Hiki i kēia ke alakaʻi i ka ʻeha ʻōpū, ka luaʻi nui, ka luhi, ka pohō kaumaha a me ka nele o ka meaʻai. Hiki i ka mumū i hoʻoulu ʻia e ka maʻi Crohn ke hoʻopili i nā wahi like ʻole o ka ʻōnaehana digestive i nā kānaka like ʻole. Hoʻopili pinepine ka maʻi Crohn i ka hopena o ka ʻōpū liʻiliʻi a me ka hoʻomaka ʻana o ka ʻōpū nui. Hoʻolaha pinepine ka mumū i nā papa hohonu o ka ʻōpū. Hiki i ka maʻi Crohn ke ʻeha a hoʻonāwaliwali hoʻi. I kekahi manawa, hiki ke alakaʻi i nā pilikia koʻikoʻi a pilikia i ke ola paha. ʻAʻohe lāʻau lapaʻau i ʻike ʻia no ka maʻi Crohn, akā hiki i nā ʻano lapaʻau ke hoʻemi nui i kona mau hōʻailona a hiki ke lawe mai i ka remission lōʻihi a me ka ho'ōla ʻana o ka mumū. Me ka mālama ʻana, hiki i nā kānaka he nui me ka maʻi Crohn ke hana maikaʻi.

ʻO nā hōʻailona maʻamau o ka maʻi Crohn's: ʻO ka luaʻi. Ka wela. Ka luhi. Ka ʻeha a me ka ʻeha ʻōpū. Ke koko i loko o ka wai ʻōpū. Nā ʻeha waha. Ka emi ʻana o ka makemake i ka ʻai a me ka pohō kaumaha. Ka ʻeha a i ʻole ka wai mai ka lua a puni ka huelo ma muli o ka mumū mai kahi lua i loko o ka ʻili, i kapa ʻia he fistula. Hiki i ka maʻi Crohn's ke hoʻopili i kekahi ʻāpana o ka ʻōpū liʻiliʻi a i ʻole ka ʻōpū nui. Hiki paha ke komo i nā ʻāpana he nui, a i ʻole paha he mau. ʻO ka hapa nui, pili ia i ka hapa hope o ka ʻōpū liʻiliʻi. I kekahi poʻe, aia wale nō ka maʻi i loko o ka colon a i ʻole ka ʻōpū nui. Hiki i nā hōʻailona o ka maʻi Crohn's ke piʻi mai ka māmā a i ka nui. Hoʻomāhuahua pinepine lākou, akā i kekahi manawa hiki ke hele koke mai, me ka ʻole o ka ʻōlelo mua. Hiki i kekahi me ka maʻi Crohn's ke loaʻa pū kekahi mau manawa me ka ʻole o nā hōʻailona. ʻIke ʻia kēia he remission. Hiki i nā kānaka me ka maʻi Crohn's nui ke loaʻa pū nā hōʻailona ma waho o ka ʻōpū, me: Ka mumū o ka ʻili, nā maka a me nā hui. Ka mumū o ke ake a i ʻole nā ​​alaloa bile. Nā pōhaku kidney. Ka nele hao, i kapa ʻia ʻo anemia. Ka hoʻopaneʻe ʻana i ka ulu ʻana a i ʻole ka hoʻomohala ʻana o ka moekolohe, i nā keiki. E ʻike i kahi loea olakino inā loaʻa iā ʻoe nā loli mau i kou mau maʻamau o ka ʻōpū a i ʻole inā loaʻa iā ʻoe kekahi hōʻailona o ka maʻi Crohn's, e like me: Ka ʻeha ʻōpū. Ke koko i loko o ka wai ʻōpū. Ka nausea a me ka luaʻi. Ka luaʻi ʻana ma mua o ʻelua pule. Ke nalowale nei i ke kaumaha me ka ho'āʻo ʻole. Wela ma kahi o kekahi o nā hōʻailona ma luna.

E ʻimi i kahi limahana mālama ola inā loaʻa iā ʻoe nā loli mau i kou mau maʻa ʻōpū a i ʻole inā loaʻa iā ʻoe kekahi mau hōʻailona o ka maʻi Crohn, e like me: ʻEha ʻōpū. Ke koko i loko o kahi pālolo. Nā ʻōpū a me ka luaʻi. Ka maʻi ʻōpū lōʻihi ma mua o ʻelua pule. Ke nalowale nei ke kaumaha me ka ho'āʻo ʻole. Ke kuni ma kahi o kekahi o nā hōʻailona ma luna.

ʻAʻole maopopo ka kumu kūpono o ka maʻi Crohn. Ma mua, ua kānalua ʻia ka meaʻai a me ke kaumaha, akā i kēia manawa, ua ʻike nā limahana olakino e hiki i kēia mau mea ke hoʻonāukiuki, akā ʻaʻole ia e hoʻokumu i ka maʻi Crohn. He nui nā mea e komo paha i loko o kona ulu ʻana. Nā Genes. ʻOi aku ma mua o 200 mau gene i pili pū ʻia me ka maʻi Crohn. Eia naʻe, ʻaʻole maopopo loa i nā mea noiʻi i kā lākou kuleana i ke kūlana. ʻO ka loaʻa ʻana o hoʻokahi a ʻoi aku paha o kēia mau gene e hiki ai ke hoʻonui i ka nui o ka loaʻa ʻana o ka maʻi Crohn. ʻŌnaehana pale. He mea hiki ke hoʻoulu ʻia ka maʻi Crohn e nā bacteria, nā virus a i ʻole nā mea ʻē aʻe o ke kaiapuni. No ka laʻana, ua kānalua ʻia kekahi mau bacteria i loko o ka microbiome o ka ʻōpū e pili ana i ka maʻi Crohn, akā ʻaʻole maopopo inā kēia mau bacteria e hoʻokumu i ka maʻi Crohn. I ka ho'āʻo ʻana o ka ʻōnaehana pale e hakakā i kahi microorganism komo a i ʻole nā mea hoʻoulu kaiapuni, hoʻokumu kahi pane pale ʻole i ka hoʻouka ʻana o ka ʻōnaehana pale i nā cell i loko o ka ʻōnaehana digestive pū kekahi.

Hōʻailona pilikia no ka maʻi Crohn's e komo pū paha: Mōʻaukala ʻohana. ʻOi aku ka nui o ka pilikia o ka poʻe me ka hoahānau koko kokoke loa, e like me ka makua, kaikuaʻana a kaikamahine paha, e loaʻa i kēia maʻi. E like me ka 1 i 5 poʻe me ka maʻi Crohn's, aia kekahi lālā ʻohana me kēia maʻi. Makahiki. Hiki ke loaʻa ka maʻi Crohn's i kēlā me kēia makahiki, akā ʻoi aku ka maʻamau o ka loaʻa ʻana o kēia kūlana i ka wā ʻōpiopio. ʻOi aku ka nui o ka poʻe i loaʻa i ka maʻi Crohn's i ʻike ʻia ma mua o ko lākou mau makahiki 30. Lāhui. ʻOiai hiki i ka maʻi Crohn's ke hoʻopili i kēlā me kēia hui lāhui, ʻoi aku ka nui o ka pilikia o nā kānaka keʻokeʻo, ʻoi aku hoʻi nā kānaka Iudaio ʻEulopa Hikina (Ashkenazi). Eia naʻe, ke piʻi nei ka nui o ka maʻi Crohn's i waena o nā kānaka ʻeleʻele e noho ana ma ʻAmelika ʻĀkau a me ke Aupuni Hui Pū ʻIa. Ke ʻike pinepine ʻia nei hoʻi ka maʻi Crohn's i ka heluna kanaka o ke Hikina Waena a me nā poʻe malihini e hele mai ana i ʻAmelika Hui Pū ʻIa. Pālolo. ʻO ka pālolo ka mea nui loa e hiki ke kaohi ʻia i ka loaʻa ʻana o ka maʻi Crohn's. Ke alakaʻi nei hoʻi ka pālolo i ka maʻi ʻoi aku ka nui a me ka nui o ka pilikia o ka hana ʻoki. Inā ʻoe e pālolo, he mea nui ia e haʻalele.

Hiki i ka maʻi Crohn ke alakaʻi i hoʻokahi a ʻoi aku paha o kēia mau pilikia: Ka pale ʻana a i ʻole ka ānai ʻana o ka ʻōpū. Hiki i ka maʻi Crohn ke hoʻopilikia i ka mānoanoa holoʻokoʻa o ka paia o ka ʻōpū. Ma hope o kekahi manawa, hiki i nā ʻāpana o ka ʻōpū ke ʻeha a hoʻoemi, kahi e pale ai i ke kahe ʻana o nā mea ʻai, i kapa pinepine ʻia he stricture. Pono paha ka ʻoki kino e hoʻonui i ka stricture a i ʻole e wehe i ka ʻāpana maʻi o ka ʻōpū. Na ʻeha. Hiki i ka mumū mau ke alakaʻi i nā ʻeha hāmama i kapa ʻia he ʻeha ma nā wahi a pau o ka ʻōnaehana digestive. Hiki ke komo pū me ka waha, ka anus a me ka wahi genital.

Na fistula. I kekahi manawa, hiki i nā ʻeha ke hoʻolōʻihi loa ma o ka paia o ka ʻōpū, e hana ana i ka pilina ma waena o nā ʻāpana kino ʻē aʻe ʻaʻole pono e noho ma laila. ʻIke ʻia kēia he fistula. Hiki i nā fistula ke ulu ma waena o ka ʻōpū a me ka ʻili, a i ʻole ma waena o ka ʻōpū a me kekahi kino ʻē aʻe. ʻO nā fistula kokoke a puni paha ka wahi anal ka mea maʻamau loa. Ke ulu nā fistula i loko o ka ʻōpū, hiki ke alakaʻi i nā maʻi a me nā hōʻiliʻili o ka pus i kapa ʻia he abscesses. Hiki ke hoʻoweliweli i ke ola inā ʻaʻole i mālama ʻia. Hiki i nā fistula ke hana ma waena o nā loop o ka ʻōpū, i loko o ka ʻōpū a i ʻole ka vagina, a i ʻole ma o ka ʻili, e hoʻopuka mau ana i ka wai o ka ʻōpū i ka ʻili.

Anal fissure. He ʻoki liʻiliʻi kēia i ka ʻiʻo e hoʻopili ana i ka anus a i ʻole i ka ʻili a puni ka anus kahi e hiki ai ke loaʻa nā maʻi. Hoʻopili pinepine ʻia me ka ʻeha o ka ʻōpala a hiki ke alakaʻi i ka fistula. Ka nele o ka meaʻai. Hiki i ka diarrhea, ka ʻeha o ka ʻōpū a me ka cramping ke paʻakikī i ka ʻai ʻana a i ʻole no ka ʻōpū e komo i nā meaʻai lawa. He mea maʻamau hoʻi ke loaʻa ka anemia ma muli o ka haʻahaʻa o ka hao a i ʻole ka huaora B-12 i hana ʻia e ka maʻi.

Ka maʻi kanesa colon. ʻO ka loaʻa ʻana o ka maʻi Crohn e hoʻopilikia ana i ka colon e hoʻonui i ka pilikia o ka maʻi kanesa colon. Ke kāhea nei nā kuhikuhi nānā maʻamau o ka maʻi kanesa colon no nā poʻe ʻaʻohe maʻi Crohn i kahi colonoscopy ma ka liʻiliʻi i kēlā me kēia makahiki 10 e hoʻomaka ana i ka makahiki 45. I nā poʻe me ka maʻi Crohn e hoʻopilikia ana i kahi ʻāpana nui o ka colon, ua manaʻo ʻia kahi colonoscopy e nānā no ka maʻi kanesa colon ma kahi o ʻewalu mau makahiki ma hope o ka hoʻomaka ʻana o ka maʻi a maʻamau e hana ʻia i kēlā me kēia 1 a 2 mau makahiki ma hope. E nīnau i kahi limahana olakino inā pono ʻoe e hana i kēia hoʻokolohua i ka wā koke a me ka pinepine.

Nā maʻi ʻili. Hiki i nā poʻe he nui me ka maʻi Crohn ke loaʻa i kahi kūlana i kapa ʻia ʻo hidradenitis suppurativa. Hoʻopili kēia maʻi ʻili i nā nodules hohonu, nā tunnels a me nā abscesses i nā armpits, groin, ma lalo o nā umauma, a ma ka wahi perianal a i ʻole genital. Hoʻonui pū kekahi mau lāʻau lapaʻau Crohn i ka pilikia o nā maʻi kanesa ʻili, no laila ua manaʻo ʻia kahi nānā ʻili maʻamau. Nā pilikia olakino ʻē aʻe. Hiki i ka maʻi Crohn ke hoʻopilikia i nā ʻāpana ʻē aʻe o ke kino. I waena o kēia mau pilikia ʻo ka hao haʻahaʻa, i kapa ʻia ʻo anemia, osteoporosis, arthritis, nā pōhaku kidney, nā pilikia maka, a me ka maʻi gallbladder a i ʻole ate.

Nā pilikia lāʻau lapaʻau. Hoʻopili ʻia kekahi mau lāʻau lapaʻau Crohn e pale ana i nā hana o ka ʻōnaehana pale i kahi pilikia liʻiliʻi o ka loaʻa ʻana o nā maʻi kanesa, me ka lymphoma a me nā maʻi kanesa ʻili. Hoʻonui pū lākou i ka pilikia o nā maʻi. Hiki ke hoʻopili ʻia nā Corticosteroids i kahi pilikia o ka osteoporosis, nā haki iwi, nā cataracts, glaucoma, diabetes a me ke koko kiʻekiʻe, i waena o nā kūlana ʻē aʻe. E hana pū me kahi limahana olakino e hoʻoholo i nā pilikia a me nā pono o nā lāʻau lapaʻau.

Nā clots koko. Hoʻonui ka maʻi Crohn i ka pilikia o nā clots koko i nā veins a me nā arteries.

Hiki paha i kahi akamai olakino ke kuhikuhi i ka maʻi Crohn ma hope wale nō o ka kāpae ʻana i nā kumu ʻē aʻe e hiki ke loaʻa i nā hōʻailona. ʻAʻohe hoʻokolohua hoʻokahi e kuhikuhi i ka maʻi Crohn. Hiki ke hoʻohana ʻia ka hui ʻana o nā hoʻokolohua e kōkua i ka hōʻoia ʻana i ka kuhikuhi ʻana o ka maʻi Crohn, me kēia mau mea: Nā hoʻokolohua Lab Nā hoʻokolohua koko. Hiki i nā hoʻokolohua koko ke nānā i nā hōʻailona o ka maʻi a i ʻole ka anemia - kahi kūlana kahi ʻaʻohe lawa o nā pūnaewele ʻulaʻula e lawe i ka oxygen lawa i nā pūnaewele. Hiki ke hoʻohana ʻia kēia mau hoʻokolohua e nānā i nā pae o ka mumū, ka hana o ke ake, a i ʻole ke alo o nā maʻi i hoʻomaha ʻia, e like me ka maʻi palupalu. Hiki nō hoʻi ke nānā ʻia ke koko no ke alo o ka pale ʻana i nā maʻi. Nā haʻawina ʻōpala. Hiki ke hoʻohana ʻia kahi laʻana ʻōpala e hoʻokolohua ai no ke koko a i ʻole nā mea ola, e like me nā bacteria e hoʻoulu ai i ka maʻi a i ʻole, ma nā manawa kakaikahi, nā parasites i loko o ka ʻōpala, e ʻimi i nā kumu o ka luaʻi a me nā hōʻailona. I kekahi manawa, ʻo ka ʻimi ʻana i nā māka ʻōpala o ka mumū, e like me ka calprotectin, hiki ke kōkua. Nā kaʻina hana Colonoscopy. Hoʻohana ka colonoscopy i kahi kāmela liʻiliʻi ma ka hopena o kahi paipu kūlou e nānā pono i ka colon holoʻokoʻa a me ka hopena loa o ka ileum. I ka wā o ke kaʻina hana, hiki ke lawe ʻia nā laʻana liʻiliʻi o ka ʻiʻo, i kapa ʻia ʻo ka biopsy, no ka loiloi hale hana. Hiki kēia ke kōkua i ka hana ʻana i kahi kuhikuhi. Hiki i nā pūʻulu o nā sela mumū i kapa ʻia ʻo granulomas ke hōʻike i kahi kuhikuhi o ka maʻi Crohn. CT scan. ʻO ka CT scan kahi ʻenehana X-ray kūikawā e hāʻawi i nā kikoʻī hou aku ma mua o ka X-ray maʻamau. Nānā kēia hoʻokolohua i ka ʻōpū holoʻokoʻa a me nā pūnaewele ma waho o ka ʻōpū. ʻO ka CT enterography kahi CT scan kūikawā e komo pū ana i ka inu ʻana i kahi mea hoʻohālike waha a loaʻa nā kiʻi hoʻohālike intravenous o nā ʻōpū. Hāʻawi kēia hoʻokolohua i nā kiʻi maikaʻi aʻe o ka ʻōpū liʻiliʻi a ua pani i nā X-rays barium i nā keʻena lapaʻau he nui. MRI. Hoʻohana ka MRI scan i kahi kahua magnetic a me nā nalu radio e hana i nā kiʻi kikoʻī o nā kino a me nā pūnaewele. Hoʻohana ʻia ka MRI me kahi wai hoʻohālike, i kapa ʻia ʻo MR enterography, he mea pono loa ia no ka loiloi ʻana i ka fistula a puni ka wahi anal a i ʻole ka ʻōpū liʻiliʻi. I kekahi manawa hiki ke hana ʻia ka MR enterography e nānā i ke kūlana a i ʻole ka holomua o ka maʻi. Hiki ke hoʻohana ʻia kēia hoʻokolohua ma kahi o ka CT enterography e hoʻemi i ka pilikia o ka radiation, ʻoi aku hoʻi i nā poʻe ʻōpio. Capsule endoscopy. Hoʻokomo kēia hoʻokolohua i ka ʻai ʻana i kahi capsule me kahi kāmela i loko. Lawe ke kāmela i nā kiʻi o ka ʻōpū liʻiliʻi a hoʻouna iā lākou i kahi mea hoʻopaʻa i kau ʻia ma kahi kāʻei. A laila hoʻoiho ʻia nā kiʻi i kahi kamepiula, hōʻike ʻia ma kahi monitor a nānā ʻia no nā hōʻailona o ka maʻi Crohn. Ke hele mai ke kāmela i waho o ke kino me ka ʻeha ʻole i loko o ka ʻōpala. Hiki ke pono ʻia ka endoscopy me ka biopsy e hōʻoia i ka kuhikuhi ʻana o ka maʻi Crohn. ʻO ka poʻe me ka maʻi Crohn o ka ʻōpū liʻiliʻi paha he pilikia kiʻekiʻe o ka pili ʻana o ka capsule i loko o ka ʻōpū, ʻoi aku hoʻi inā he mōʻaukala o ka hoʻonui ʻana a i ʻole ka ʻoki ʻana o ka ʻōpū liʻiliʻi. ʻAʻole pono e hana ʻia ka capsule endoscopy inā he kuhikuhi o kahi stricture a i ʻole ka palahalaha, i kapa ʻia hoʻi he obstruction, i loko o ka ʻōpū. Mālama ma Mayo Clinic Hiki i kā mākou hui mālama o nā loea Mayo Clinic ke kōkua iā ʻoe me kāu mau pilikia olakino e pili ana i ka maʻi Crohn Hoʻomaka Maanei ʻIke hou aku Mālama maʻi Crohn ma Mayo Clinic Barium enema Capsule endoscopy Colonoscopy CT scan Fecal occult blood test Flexible sigmoidoscopy MRI Hōʻike hou aku i ka ʻike pili

ʻAʻohe lāʻau lapaʻau i kēia manawa no ka maʻi Crohn, a ʻaʻohe lāʻau hoʻokahi e kūpono i nā kānaka a pau. Eia naʻe, aia kekahi mau lāʻau i ʻāpono ʻia no ka mālama ʻana i ka maʻi Crohn. ʻO kekahi pahuhopu o ka mālama lapaʻau, ʻo ia ka hōʻemi ʻana i ka mumū e hoʻoulu ai i nā hōʻailona. ʻO kekahi pahuhopu, ʻo ia ka hoʻomaikaʻi ʻana i ka wānana lōʻihi ma o ka kaupalena ʻana i nā pilikia. I nā hihia maikaʻi loa, hiki kēia ke alakaʻi ʻaʻole wale i ka hōʻoluʻolu ʻana i nā hōʻailona akā i ka hoʻōla lōʻihi hoʻi. Nā lāʻau lapaʻau anti-inflammatory Hoʻohana pinepine ʻia nā lāʻau lapaʻau anti-inflammatory ma ke ʻano he ʻanuʻu mua i ka mālama ʻana i ka maʻi inflammatory bowel. Loaʻa iā lākou: Corticosteroids. Hiki i nā Corticosteroids e like me ka prednisone a me ka budesonide (Entocort EC) ke kōkua i ka hōʻemi ʻana i ka mumū i ke kino, akā ʻaʻole lākou e hana no nā kānaka a pau me ka maʻi Crohn. I kekahi manawa, hoʻohana ʻia nā steroids intravenous i loko o ka halemai no ka manawa pōkole. Hiki ke hoʻohana ʻia nā Corticosteroids no ka hoʻomaikaʻi ʻana i nā hōʻailona pōkole (3 a 4 mahina) a me ka hoʻoulu ʻana i ka hoʻōla. Hiki nō hoʻi ke hoʻohana ʻia nā Corticosteroids me ka mea hoʻoneʻe ʻōnaehana pale kino e hoʻoulu ai i ka pono mai nā lāʻau ʻē aʻe. A laila, hoʻemi mālie ʻia lākou. Oral 5-aminosalicylates. Hoʻohana ʻia kēia mau lāʻau no ka maʻi Crohn māmā a waena. Loaʻa iā lākou ka sulfasalazine (Azulfidine), kahi i loaʻa ai ka sulfa, a me ka mesalamine (Delzicol, Pentasa, nā mea ʻē aʻe). Hana maikaʻi loa nā Oral 5-aminosalicylates no ka maʻi Crohn i loko o ka colon akā ʻaʻole hana maikaʻi inā aia ka maʻi i loko o ka ʻōpū liʻiliʻi. Nā mea hoʻoneʻe ʻōnaehana pale kino Hoʻemi pū kēia mau lāʻau i ka mumū, akā hoʻopili lākou i kāu ʻōnaehana pale kino, kahi e hana ai i nā mea e hoʻoulu ai i ka mumū. No kekahi poʻe, ʻoi aku ka maikaʻi o ka hui ʻana o kēia mau lāʻau ma mua o hoʻokahi lāʻau wale nō. Loaʻa i nā mea hoʻoneʻe ʻōnaehana pale kino: Azathioprine (Azasan, Imuran) a me ka mercaptopurine (Purinethol, Purixan). ʻO kēia nā mea hoʻoneʻe immunosuppressants i hoʻohana nui ʻia no ka mālama ʻana i ka maʻi inflammatory bowel. ʻO ka lawe ʻana iā lākou e koi ai iā ʻoe e hahai pono me kahi limahana olakino a nānā mau i kou koko. ʻO kēia no ka nānā ʻana i nā hopena ʻaoʻao, e like me ka hōʻemi ʻana i ke kūʻē i ka maʻi a me ka mumū o ke ate. Hiki i kēia mau lāʻau ke hoʻoulu i ka ʻōpū ʻeha a me ka luaʻi. Methotrexate (Trexall). Hoʻohana ʻia kēia lāʻau no nā kānaka me ka maʻi Crohn ʻaʻole pane maikaʻi i nā lāʻau ʻē aʻe. Pono ʻoe e hahai pono ʻia no nā hopena ʻaoʻao. Biologics Hoʻopili kēia papa o nā therapies i nā protein i hana ʻia e ka ʻōnaehana pale kino. Loaʻa nā ʻano biologics i hoʻohana ʻia no ka mālama ʻana i ka maʻi Crohn: Infliximab (Remicade), adalimumab (Humira) a me certolizumab pegol (Cimzia). ʻIke ʻia hoʻi ʻo TNF inhibitors, hana kēia mau lāʻau ma o ka hoʻoneʻe ʻana i kahi protein ʻōnaehana pale kino i ʻike ʻia ʻo tumor necrosis factor (TNF). Ustekinumab (Stelara). Mālama kēia i ka maʻi Crohn ma o ka hoʻopilikia ʻana i ka hana o ka interleukin, kahi protein i komo i ka mumū. Vedolizumab (Entyvio). He ʻano lāʻau kēia i ʻike ʻia ʻo ka monoclonal antibody. Hana ia ma o ka hoʻōki ʻana i kekahi mau molekala cell immune — integrins — mai ka hoʻopili ʻana i nā cell ʻē aʻe i loko o ka papa o ka ʻōpū. He mea hana gut-specific ʻo Vedolizumab a ua ʻāpono ʻia no ka maʻi Crohn. Risankizumab (Skyrizi). He monoclonal antibody pū kekahi ʻo Risankizumab. Hana kēia lāʻau i kahi molecule i ʻike ʻia ʻo interleukin-23. Ua ʻāpono ʻia ʻo Risankizumab i ka manawa i hala aku nei no ka mālama ʻana i ka maʻi Crohn waena a koʻikoʻi. Loaʻa nā mana synthetic o nā biologics, i kapa ʻia ʻo biosimilars, no ka mālama ʻana i ka maʻi Crohn. Hana like kēia mau lāʻau me nā mana mua o nā biologics, a hiki ke emi ke kumukūʻai. Janus kinase (JAK) inhibitors He ʻano lāʻau kēia ʻo JAK inhibitors i kapa ʻia ʻo nā molekala liʻiliʻi. Kōkua kēia mau lāʻau hou i ka hōʻemi ʻana i ka mumū ma o ka hoʻopili ʻana i nā ʻāpana o ka ʻōnaehana pale kino e hoʻoulu ai i ka mumū i loko o nā ʻōpū. Lawe ʻia lākou ma ka waha. Hiki ke kuhikuhi ʻia nā JAK inhibitors no ka maʻi Crohn ʻaʻole i pane i nā therapies ʻē aʻe. Ua ʻāpono ka U.S. Food and Drug Administration i ka JAK inhibitor upadacitinib no ka mālama ʻana i ka maʻi Crohn. ʻAʻole kuhikuhi ʻia nā JAK inhibitors no ka hoʻohana ʻana i ka wā hāpai. Antibiotics Hiki i nā Antibiotics ke hōʻemi i ka nui o ka wai mai nā fistulas a me nā abscesses a i kekahi manawa hoʻōla iā lākou i nā kānaka me ka maʻi Crohn. Manaʻo pū kekahi mau mea noiʻi e kōkua nā antibiotics i ka hōʻemi ʻana i nā bacteria ʻino e hoʻoulu ai i ka mumū i loko o ka ʻōpū. Loaʻa nā antibiotics i kuhikuhi pinepine ʻia ʻo ciprofloxacin (Cipro) a me metronidazole (Flagyl). Nā lāʻau ʻē aʻe Ma waho aʻe o ka kaohi ʻana i ka mumū, hiki i kekahi mau lāʻau ke kōkua i ka hōʻoluʻolu ʻana i nā hōʻailona. Akā e kamaʻilio me kahi limahana olakino ma mua o ka lawe ʻana i nā lāʻau āu e kūʻai ai me ka ʻole o ka palapala kauoha. Ma muli o ka nui o ka maʻi Crohn, hiki i kahi limahana olakino ke kuhikuhi i hoʻokahi a ʻoi aku paha o kēia mau mea: Anti-diarrheals. Hiki i kahi mea hoʻohui fiber, e like me ka psyllium husk (Metamucil) a i ʻole methylcellulose (Citrucel), ke kōkua i ka hōʻoluʻolu ʻana i ka diarrhea māmā a waena ma o ka hoʻohui ʻana i ka nui i ka wai. No ka diarrhea ʻoi aku ka nui, hiki ke maikaʻi ʻo loperamide (Imodium A-D). Hiki i kēia mau lāʻau ke hana ʻole a hōʻino paha i kekahi poʻe me nā strictures a i ʻole nā maʻi ʻē aʻe. E ʻoluʻolu e nīnau i kahi limahana olakino ma mua o ka lawe ʻana i kēia mau lāʻau. Nā mea hōʻoluʻolu ʻeha. No ka ʻeha māmā, hiki i kahi limahana olakino ke kuhikuhi i ka acetaminophen (Tylenol, nā mea ʻē aʻe) — akā ʻaʻole nā mea hōʻoluʻolu ʻeha maʻamau ʻē aʻe, e like me ka ibuprofen (Advil, Motrin IB, nā mea ʻē aʻe) a i ʻole naproxen sodium (Aleve). Loaʻa ka nui o kēia mau lāʻau e hoʻopilikia i nā hōʻailona a hiki ke hoʻopilikia i ka maʻi. Nā huaora a me nā mea hoʻohui. Inā ʻaʻole ʻoe e loaʻa i nā mea momona lawa, hiki i kāu limahana olakino ke kuhikuhi i nā huaora a me nā mea hoʻohui meaʻai. Ka mālama ʻai Hiki i kahi limahana olakino ke kuhikuhi i kahi meaʻai kūikawā i hāʻawi ʻia ma ka waha a i ʻole kahi tube hānai, i kapa ʻia ʻo enteral nutrition. Hiki nō hoʻi ke hāʻawi ʻia nā mea momona i loko o kahi vein, i kapa ʻia ʻo parenteral nutrition. Hiki i kēia ke hoʻomaikaʻi i ke olakino holoʻokoʻa a ʻae i ka ʻōpū e hoʻomaha. Hiki i ka hoʻomaha ʻana o ka ʻōpū ke hōʻemi i ka mumū i ka manawa pōkole. Hiki i kāu limahana mālama ke hoʻohana i ka mālama ʻai pōkole a hui pū me nā lāʻau, e like me nā mea hoʻoneʻe ʻōnaehana pale kino. Hoʻohana pinepine ʻia nā enteral a me parenteral nutrition no ka hoʻomaikaʻi ʻana i nā kānaka ma mua o ka ʻoki kino a i ʻole ke hāʻule nā lāʻau ʻē aʻe i ka kaohi ʻana i nā hōʻailona. Hiki nō hoʻi i kāu limahana mālama ke kuhikuhi i kahi meaʻai haʻahaʻa residue a i ʻole haʻahaʻa-fiber e hōʻemi i ka pilikia o ka pale ʻana o ka ʻōpū inā loaʻa iā ʻoe kahi ʻōpū i hoʻonui ʻia, i kapa ʻia ʻo ka stricture. Hoʻolālā ʻia ka meaʻai haʻahaʻa residue e hōʻemi i ka nui a me ka nui o kāu mau wai. Ka ʻoki kino Inā ʻaʻole hōʻoluʻolu nā loli meaʻai a me ke ola, nā lāʻau, a i ʻole nā mālama ʻē aʻe i nā hōʻailona, ​​hiki i kahi limahana olakino ke kuhikuhi i ka ʻoki kino. Aneane hapa o nā poʻe me ka maʻi Crohn e pono ai ma kahi o hoʻokahi ʻoki kino. Eia naʻe, ʻaʻole hoʻōla ka ʻoki kino i ka maʻi Crohn. I ka wā o ka ʻoki kino, wehe ka kauka i kahi ʻāpana i hōʻino ʻia o kāu ʻōpū a laila hoʻohui hou i nā ʻāpana olakino. Hiki nō hoʻi ke hoʻohana ʻia ka ʻoki kino e pani i nā fistulas a hoʻokahe i nā abscesses. Loaʻa ka manawa pōkole o nā pono o ka ʻoki kino no ka maʻi Crohn. Hoʻi pinepine ka maʻi, pinepine kokoke i ka ʻiʻo i hoʻohui hou ʻia. ʻO ke ala maikaʻi loa, ʻo ia ka hahai ʻana i ka ʻoki kino me ka lāʻau e hōʻemi ai i ka pilikia o ka hoʻi hou ʻana. ʻIke hou aku ka mālama ʻana i ka maʻi Crohn ma Mayo Clinic Acupuncture Home enteral nutrition Noi i kahi manawa There is a problem with information highlighted below and resubmit the form. Get the latest health information from Mayo Clinic delivered to your inbox. Subscribe for free and receive your in-depth guide to time. Click here for an email preview. Email address Error Email field is required Error Include a valid email address Address 1 Subscribe Learn more about Mayo Clinic’s use of data. 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ʻAʻole wale nō ka maʻi Crohn e pilikia i kou kino—e pilikia nō hoʻi kou manaʻo. Inā nui nā hōʻailona a me nā ʻōuli, e pili ana paha kou ola i ka pono mau loa e holo i ka halepaku. ʻOiai inā māmā kou mau ʻōuli, hiki i ka gas a me ka ʻeha ʻōpū ke paʻakikī iā ʻoe e hele i waho. Hiki i kēia mau mea a pau ke hoʻololi i kou ola a alakaʻi paha i ka manaʻo kaumaha. Eia kekahi mau mea hiki iā ʻoe ke hana: E ʻike pono. ʻO kekahi o nā ala maikaʻi loa e ʻoi aku ka manaʻo iā ʻoe iho, ʻo ia ke ʻimi i ka ʻike nui e pili ana i ka maʻi Crohn. E ʻimi i ka ʻike mai ka Crohn's & Colitis Foundation. E komo i kahi hui kākoʻo. ʻOiai ʻaʻole ia no nā kānaka a pau nā hui kākoʻo, hiki iā lākou ke hāʻawi i ka ʻike waiwai e pili ana i kou kūlana a me ke kākoʻo manaʻo. ʻIke pinepine nā lālā o ka hui i nā lāhui lapaʻau hou loa a i ʻole nā ​​​​lapaʻau hoʻohui. Hiki paha iā ʻoe ke ʻike i ka hōʻoluʻolu ma waena o nā poʻe ʻē aʻe me ka maʻi Crohn. E kamaʻilio me kahi therapist. Loaʻa i kekahi poʻe ka mea kōkua e kūkā me kahi loea olakino noʻonoʻo i ʻike i ka maʻi inflammatory bowel a me nā pilikia manaʻo e hiki ke hana. ʻOiai hiki i ke ola ʻana me ka maʻi Crohn ke hoʻohaʻahaʻa, ke hoʻomau nei ka noiʻi a ke holomua nei ka manaʻolana.