Maʻi Ate Momona ʻaʻohe Waiʻona

Hoʻohālikelike ʻia me ka ate olakino (luna), ʻoi aku ka nui a me ka loli o ke kala o ka ate momona (lalo). Hōʻike nā laʻana o nā pūnaewele i ka momona hou aku i ka maʻi ate momona ʻaʻohe waiʻona, ʻoiai ʻike ʻia ka mumū a me ka ʻeha nui i ka steatohepatitis ʻaʻohe waiʻona.

ʻO ka maʻi ate momona ʻaʻohe waiʻona, i kapa pinepine ʻia ʻo NAFLD, he pilikia ate ia e pili ana i nā kānaka e inu iki a ʻaʻohe waiʻona. I ka NAFLD, nui loa ka momona e kūkulu ʻia i loko o ka ate. ʻIke pinepine ʻia i nā kānaka momona a momona loa.

Ke lilo nei ka NAFLD i mea maʻamau, ʻoi aku hoʻi ma nā ʻāina o ke Hikina Waena a me ke Komohana e like me ka piʻi ʻana o ka nui o nā kānaka momona. ʻO ia ke ʻano maʻamau loa o ka maʻi ate ma ka honua. Hoʻololi ka NAFLD i ka nui mai ka hepatic steatosis, i kapa ʻia ʻo ka ate momona, a i kahi ʻano maʻi ʻoi aku ka nui i kapa ʻia ʻo nonalcoholic steatohepatitis (NASH).

Hoʻopilikia ka NASH i ka ate e pehu a hōʻino ʻia ma muli o nā waihona momona i loko o ka ate. Hiki i ka NASH ke ʻoi aku ka ʻino a alakaʻi paha i ka ʻeha nui o ka ate, i kapa ʻia ʻo cirrhosis, a hiki i ke kanesa ate. Hoʻohālikelike kēia hōʻino i ka hōʻino i hana ʻia e ka hoʻohana nui ʻana i ka waiʻona.

Ke hele nei kahi neʻe e hoʻololi i ka inoa maʻi ate momona ʻaʻohe waiʻona i ka maʻi ate steatotic pili i ka hana ʻole o ka metabolism (MASLD). Ua ʻōlelo pū nā poʻe akamai e hoʻololi i ka inoa nonalcoholic steatohepatitis i ka metabolic dysfunction-associated steatohepatitis (MASH).

ʻO ke ate ka ʻōnaehana kino kūloko nui loa i loko o ke kino. He nui ia e like me ka pōpō pôpeku. Aia ia ma ka hapa nui o ka ʻākau o luna o ka ʻōpū, ma luna o ka ʻōpū.

ʻAʻole pinepine ka NAFLD i nā hōʻailona. Ke loaʻa, hiki iā lākou ke komo pū me:

• Luhi.
• ʻAʻole maikaʻi ka manaʻo, a i ʻole malaise.
• ʻEha a i ʻole ʻoluʻolu ʻole ma ka ʻākau o luna o ka ʻōpū.

ʻO nā hōʻailona hiki ke loaʻa i ka NASH a me ka cirrhosis, a i ʻole ka hōʻino nui ʻana, e komo pū me:

• ʻIli kuni.
• Pehu ʻana o ka ʻōpū, i kapa ʻia hoʻi ʻo ascites (uh-SY-teez).
• Pōkole o ka hanu.
• Pehu ʻana o nā wāwae.
• Nā kīʻaha koko e like me ka ʻumiʻumi ma lalo pono o ka ʻili.
• Pehu ʻana o ka spleen.
• Nā lima ʻulaʻula.
• Melemele ʻana o ka ʻili a me nā maka, a i ʻole jaundice.

E hoʻokaʻaʻike i kekahi lālā o kāu hui mālama ola inā loaʻa iā ʻoe nā hōʻailona mau e hopohopo nei iā ʻoe.

ʻAʻole maopopo pono i nā kauka ke kumu o ka hōʻiliʻili ʻana o ka momona i loko o ke ake o kekahi poʻe, ʻaʻole hoʻi i loko o ke ake o nā poʻe ʻē aʻe. ʻAʻole maopopo pono iā lākou ke kumu o ka lilo ʻana o ke ake momona i NASH.

Hoʻopili ʻia nā NAFLD a me nā NASH i kēia mau mea:

• Genetics.
• Kaumaha nui a momona paha.
• Pale kūʻē i ka insulin, kahi e hana ai i ka wā ʻaʻole e lawe nā sela i ke kō ma muli o ka hormone insulin.
• Ka maʻi diabetes type 2, i kapa ʻia ʻo ke kō kiʻekiʻe a i ʻole ka hyperglycemia.
• Nā kiʻekiʻe o nā momona, ʻo nā triglycerides ka mea nui, i loko o ke koko.

Hiki i kēia mau pilikia olakino i hui pū ʻia ke hoʻokomo i ka ake momona. Eia naʻe, loaʻa i kekahi poʻe ka NAFLD ʻoiai ʻaʻole lākou i loaʻa kekahi mau mea pilikia.

He nui nā maʻi a me nā pilikia olakino e hiki ke hoʻonui i kou pilikia o ka NAFLD, me kēia mau mea: Ka mōʻaukala ʻohana o ka maʻi ate momona a i ʻole ka momona. Ka nele o ka hormone ulu, ʻo ia hoʻi ʻaʻole lawa ka hormone i hana ʻia e ke kino no ka ulu ʻana. Ka cholesterol kiʻekiʻe. Nā kiʻekiʻe o nā triglycerides i loko o ke koko. Ke kū'ē ʻana i ka insulin. Ka maʻi metabolic. Ka momona, ʻoi aku ka nui o ka momona i waenakonu o ka pūhaka. Ka maʻi polycystic ovary syndrome. Ka maʻi obstructive sleep apnea. Ka maʻi diabetes type 2. Ka thyroid hana ʻole, i kapa ʻia hoʻi he hypothyroidism. Ka pituitary gland hana ʻole, a i ʻole hypopituitarism. ʻOi aku ka nui o ka NASH i kēia mau hui: Nā kānaka ma mua o 50 mau makahiki. Nā kānaka me kekahi mau kumu pilikia genetic. Nā kānaka me ka momona. Nā kānaka me ka maʻi diabetes a i ʻole ke kō koko kiʻekiʻe. Nā kānaka me nā hōʻailona o ka maʻi metabolic, e like me ke koko kiʻekiʻe, nā triglycerides kiʻekiʻe a me ka nui o ka pūhaka. He paʻakikī ke hoʻokaʻawale i ka NAFLD mai ka NASH me ka ʻole o ka loiloi lapaʻau a me ka ho'āʻo ʻana.

ʻO ke akepaʻa olakino, ma ka hema, ʻaʻohe hōʻailona o ka ʻiliʻili. I ka cirrhosis, ma ka ʻākau, ua pani ka ʻiliʻili i ka ʻiʻo akepaʻa olakino.

ʻO nā varices esophageal he mau veins nui i loko o ka esophagus. Hoʻomaka pinepine lākou ma muli o ka pale ʻana o ke kahe koko ma o ka vein portal, ka mea e lawe ai i ke koko mai ka ʻōpū a i ke akepaʻa.

Hoʻomaka ka maʻi kanesa akepaʻa i nā sela akepaʻa. ʻO ke ʻano maʻamau loa o ka maʻi kanesa akepaʻa e hoʻomaka ana i nā sela i kapa ʻia ʻo hepatocytes a ua kapa ʻia ʻo hepatocellular carcinoma.

ʻO ka ʻiliʻili koʻikoʻi o ke akepaʻa, a i ʻole cirrhosis, ʻo ia ka pilikia nui o ka NAFLD a me ka NASH. Hana ʻia ka Cirrhosis ma muli o ka hōʻeha ʻana o ke akepaʻa, e like me ka pōʻino i hana ʻia e ka mumū i ka NASH. I ka ho'āʻo ʻana o ke akepaʻa e hoʻopau i ka mumū, hana ia i nā wahi o ka ʻiliʻili, i kapa ʻia hoʻi ʻo fibrosis. Me ka mumū mau, e pālahalaha ka fibrosis a lawe i ka ʻiʻo akepaʻa hou aku.

Inā ʻaʻohe mea i hana ʻia e hoʻopau i ka ʻiliʻili, hiki i ka cirrhosis ke alakaʻi i:

• Ka hōʻiliʻili wai i ka wahi ʻōpū, i kapa ʻia ʻo ascites.
• Nā veins pehu i kou esophagus, a i ʻole esophageal varices, ka mea hiki ke haki a kahe koko.
• Huikau, hiamoe a me ka ʻōlelo palupalu, i kapa ʻia hoʻi ʻo hepatic encephalopathy.
• Spleen overactive, a i ʻole hypersplenism, ka mea hiki ke hana i ka liʻiliʻi o nā platelets koko.
• Maʻi kanesa akepaʻa.
• Ka hāʻule ʻana o ke akepaʻa i ka hopena, ʻo ia hoʻi ua pau ka hana ʻana o ke akepaʻa.

Manaʻo nā loea he 24% o nā mākua ma ʻAmelika Hui Pū ʻIa he NAFLD, a ma kahi o 1.5% a 6.5% he NASH.

E ho'emi i kou pilikia o ka NAFLD:

• E ai i ka ʻai olakino. E ai i ka ʻai olakino piha i nā hua, nā huaʻai, nā huaola holoʻokoʻa a me nā momona olakino.
• E kaupalena i ka waiʻona, nā kō maʻalahi a me ka nui o nā ʻāpana. E pale i nā mea inu kō e like me ka soda, nā mea inu haʻuki, nā wai a me ka tī ʻono. Hiki i ka inu ʻawaʻawa ke hōʻino i kou ate a pono e pale ʻia a i ʻole e ho'emi ʻia.
• E mālama i ke kaumaha olakino. Inā nui kou kaumaha a momona paha, e hana pū me kāu hui mālama ola e ho'emi mālie i ke kaumaha. Inā kaumaha olakino ʻoe, e hana e mālama ia ma ka ʻai ʻana i ka ʻai olakino a me ka hoʻoikaika kino.
• E hoʻoikaika kino. E hana i nā lā nui o ka hebedoma. E kiʻi i ka ʻae mai kāu hui mālama ola ma mua inā ʻaʻole ʻoe i hoʻoikaika kino mau.

No ka mea, ʻaʻole pinepine ka NAFLD i hōʻike i nā hōʻailona, loaʻa pinepine ʻia ia i ka wā e kuhikuhi ai nā hoʻokolohua i hana ʻia no nā kumu ʻē aʻe i kahi pilikia ate. No ka laʻana, hiki i ka hoʻokolohua koko i hana ʻia i ka wā o ka nānā makahiki ke hōʻike i nā kiʻekiʻe o nā enzyme ate, kahi e alakaʻi ai i ka hoʻokolohua hou aku a me kahi ʻike NAFLD. ʻO nā hoʻokolohua i hana ʻia e ʻike i ka NAFLD, e kāpae i nā maʻi ʻē aʻe a ʻike i ka nui o ka pōʻino o ka ate, e komo pū me: Nā hoʻokolohua koko Helu koko piha. Nā haʻawina hao, kahi e hōʻike ai i ka nui o ka hao i loko o kou koko a me nā sela ʻē aʻe. Nā hoʻokolohua enzyme ate a me nā hana ate. Nā hoʻokolohua no ka hepatitis viral maʻi (hepatitis A, hepatitis C a me nā mea ʻē aʻe). Hoʻokolohua palekana maʻi celiac. Kūpono koko wikiwiki. Hemoglobin A1C, kahi e hōʻike ai i ka paʻa o kou kō koko. ʻO ka ʻike lipid, kahi e ana ai i nā momona koko, e like me ka cholesterol a me nā triglycerides. Nā kaʻina hana kiʻi ʻO nā hoʻokolohua kiʻi i hoʻohana ʻia e ʻike i ka NAFLD e komo pū me: Ultrasound ʻōpū, kahi pinepine ka hoʻokolohua mua i hoʻohana ʻia i ka wā e kānalua ʻia ai ka maʻi ate. ʻO ka magnetic resonance imaging (MRI) a i ʻole ka computerized tomography (CT) scanning. ʻOi aku ka maikaʻi o kēia mau hoʻokolohua i ka ʻike ʻana i ka fibrosis ate māmā akā ʻaʻole hiki ke ʻike i ka NASH mai ka NAFLD. Transient elastography, kahi ʻano ultrasound hou e ana i ka paʻakikī o kou ate. ʻO ka paʻakikī o ka ate he hōʻailona ia o ka fibrosis a i ʻole ka ʻeha. Magnetic resonance elastography, kahi e hoʻohui ai i ka MRI imaging me nā hawewe leo e hana i ka palapala kiʻi, a i ʻole elastogram, e hōʻike ana i ka paʻakikī o nā pūnaewele kino. Biopsy ate Inā hōʻike nā hoʻokolohua ʻē aʻe i nā hōʻailona o ka maʻi ate holomua a i ʻole NASH, a i ʻole inā maopopo ʻole kāu mau hopena hoʻokolohua, hiki i kāu kauka ke manaʻo i kahi biopsy ate. ʻO ka biopsy ate kahi kaʻina hana e wehe ai i kahi ʻāpana liʻiliʻi o ka ʻiʻo mai kou ate. Hana pinepine ʻia ia me kahi nila ma o ka paia ʻōpū. Nānā ʻia ka laʻana ʻiʻo i loko o kahi lapaʻau no nā hōʻailona o ka mumū a me ka ʻeha. ʻO ka biopsy ate ke ala maikaʻi loa e ʻike ai i ka NASH a hōʻike maopopo i ka nui o ka pōʻino o ka ate. Hiki i ka biopsy ate ke ʻoluʻolu ʻole, a loaʻa iā ia nā pilikia e hele aku kāu hui mālama ola me ʻoe i nā kikoʻī. Hana ʻia kēia kaʻina hana me kahi nila i hoʻohana ʻia ma o ka paia ʻōpū a komo i loko o ka ate. Ke nānā nei kahi radiologist Mayo Clinic i kahi magnetic resonance elastogram o ka ate e hōʻike ana i nā wahi o ka ʻeha, a i ʻole fibrosis, i ka ʻulaʻula. Mālama ma Mayo Clinic Hiki i kā mākou hui mālama o nā loea Mayo Clinic ke kōkua iā ʻoe me kāu mau pilikia olakino pili i ka maʻi ate momona ʻaʻohe waiʻona Hoʻomaka Maanei ʻIke hou aku Mālama maʻi ate momona ʻaʻohe waiʻona ma Mayo Clinic CT scan Nā hoʻokolohua hana ate Magnetic resonance elastography MRI Needle biopsy Ultrasound Hōʻike hou aku i nā ʻike pili

ʻO ka hoʻomaʻamaʻa no ka NAFLD ka mea maʻamau e hoʻomaka me ka emi ʻana o ke kaumaha. Hiki ke hana ʻia kēia ma ke ʻai ʻana i ka ʻai olakino, ka palena ʻana i nā nui o nā ʻāpana a me ka hoʻoikaika kino. Hiki i ka emi ʻana o ke kaumaha ke hoʻomaikaʻi i nā pilikia olakino ʻē aʻe e alakaʻi ana i ka NAFLD. ʻO ka maʻamau, ʻo ka emi ʻana o 10% o ke kaumaha o kou kino a ʻoi aku paha ka mea i manaʻo ʻia. Akā, ʻo ka emi ʻana o 3% a 5% paha o ke kaumaha hoʻomaka e hiki ke loaʻa nā pōmaikaʻi. Hiki nō hoʻi i ka ʻoki kino no ka emi ʻana o ke kaumaha a i ʻole nā ​​lāʻau lapaʻau ke kōkua i kekahi poʻe. Loaʻa ka lāʻau hou e mālama i nā poʻe i loaʻa ka NASH me ka hōʻino nui a koʻikoʻi paha o ke ake. Hiki i ka Resmetirom (Rezdiffra) ke kōkua i ka hoʻemi ʻana i ka nui o ka momona e hōʻiliʻili ana i loko o ke ake. ʻAʻole i manaʻo ʻia kēia lāʻau lapaʻau no nā poʻe me ka cirrhosis. No ka poʻe i loaʻa ka cirrhosis ma muli o ka NASH, pono paha ka hoʻololi ʻana o ke ake. Noi i kahi kūkā Aia kahi pilikia me ka ʻike i hōʻike ʻia ma lalo nei a hoʻouna hou i ke palapala. E kiʻi i ka ʻike olakino hou loa mai Mayo Clinic i hoʻouna ʻia i kāu pahu leka. E kau inoa no ka manuahi a loaʻa kāu alakaʻi hohonu i ka manawa. Kaomi ma aneʻi no kahi nānā leka uila. Leka uila hewa Pono ka kahua leka uila Hewa E hoʻokomo i kahi leka uila kūpono Helu 1 Kau inoa E aʻo hou e pili ana i ka hoʻohana ʻana o Mayo Clinic i ka ʻikepili. No ka hāʻawi ʻana iā ʻoe i ka ʻike pili loa a kōkua loa, a hoʻomaopopo i ka ʻikepili e pōmaikaʻi ana, hiki iā mākou ke hoʻohui i kāu leka uila a me ka ʻike hoʻohana pūnaewele me nā ʻike ʻē aʻe a mākou e loaʻa ai e pili ana iā ʻoe. Inā ʻoe he mea maʻi Mayo Clinic, hiki ke komo pū kēia me ka ʻike olakino palekana. Inā hoʻohui mākou i kēia ʻike me kāu ʻike olakino palekana, e mālama mākou i kēlā ʻike āpau ma ke ʻano he ʻike olakino palekana a e hoʻohana wale a hōʻike paha i kēlā ʻike e like me ka mea i kau ʻia i loko o kā mākou leka hoʻomaopopo o nā hana pilikino. Hiki iā ʻoe ke koho ʻole i nā kamaʻilio leka uila i kēlā me kēia manawa ma ke kaomi ʻana i ka loulou wehe inoa ma ka leka uila. Mahalo iā ʻoe no ke kau inoa ʻana E loaʻa koke kāu alakaʻi olakino digestive hohonu i loko o kāu pahu leka. E loaʻa nō hoʻi iā ʻoe nā leka uila mai Mayo Clinic e pili ana i nā nūhou olakino hou loa, noiʻi, a me ka mālama ʻana. Inā ʻaʻole ʻoe e loaʻa kā mākou leka uila i loko o 5 mau minuke, e nānā i kāu waihona SPAM, a laila e hoʻokaʻaʻike mai iā mākou ma [email protected]. ʻAʻole i kūleʻa kekahi mea me kāu kau inoa E ʻoluʻolu, e ho'āʻo hou i loko o kekahi mau minuke E ho'āʻo hou