He aha ʻo Abatacept: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau ʻo Abatacept i kuhikuhi ʻia e kōkua i ka hoʻomaha ʻana i kahi ʻōnaehana pale i hana nui ʻia, ʻoiai no ka poʻe me ka rheumatoid arthritis a me nā maʻi autoimmune ʻē aʻe. E noʻonoʻo iā ia he kaʻa mālie no kāu ʻōnaehana pale ke hoʻouka hewa nei i kāu mau ʻiʻo olakino ponoʻī.

Loaʻa kēia lāʻau lapaʻau i ʻelua ʻano: nā infusions intravenous (IV) i hāʻawi ʻia ma kahi keʻena lapaʻau, a me nā injections subcutaneous hiki iā ʻoe ke hāʻawi iā ʻoe iho ma ka home. Hana like nā mea ʻelua akā hāʻawi i nā pae maʻalahi like ʻole e pili ana i kou ola a me nā pono olakino.

He aha ʻo Abatacept?

ʻO Abatacept kahi lāʻau lapaʻau olaola e pili ana i kahi papa i kapa ʻia ʻo nā mea hoʻololi costimulation koho. Hana ia ma ka pale ʻana i kekahi mau hōʻailona ma waena o nā cell immune e hoʻoulu ai i ka mumū a me ka pōʻino hui.

ʻAʻole like me kekahi mau mea hoʻopau immunosuppressants ikaika, lawe ʻo abatacept i kahi ala i manaʻo ʻia. ʻAʻole ia e pani i kāu ʻōnaehana pale holoʻokoʻa akā hoʻoponopono maikaʻi i nā ala kikoʻī e kōkua ai i nā maʻi autoimmune. ʻO kēia ka mea e lilo ai i koho mālie ʻoiai e pono ana.

Hana ʻia ka lāʻau lapaʻau mai nā protein a pono e mālama ʻia i loko o ka pahu hau. Ua ʻae ʻia e ka FDA mai ka makahiki 2005 a ua kōkua i nā miliona o nā kānaka e mālama i ko lākou mau maʻi autoimmune me ka ʻoluʻolu.

No ke aha e hoʻohana ʻia ai ʻo Abatacept?

Hoʻohana nui ʻia ʻo Abatacept no ka rheumatoid arthritis i nā pākeke a me nā keiki ma luna o 6 mau makahiki. Ua ʻae ʻia nō hoʻi no ka psoriatic arthritis a me ka juvenile idiopathic arthritis.

Hiki i kāu kauka ke ʻōlelo aku iā abatacept ke hāʻawi ʻole nā ​​lāʻau lapaʻau ʻē aʻe i ka hōʻoluʻolu lawa, a i ʻole ma ke ʻano he lāʻau lapaʻau mua i kekahi mau hihia. He mea kōkua nui ia no ka poʻe i ʻike i ka ʻoʻoleʻo kakahiaka nui, ka pehu hui, a me ka luhi mai ko lākou maʻi autoimmune.

Hoʻohana kekahi mau kauka i ka abatacept ma waho o ka lepili no nā maʻi autoimmune ʻē aʻe e like me ka lupus a i ʻole kekahi mau ʻano vasculitis. Eia naʻe, pili kēia i kou kūlana kikoʻī a me ka mōʻaukala olakino.

Pehea e Hana ai ʻo Abatacept?

Hana ʻo Abatacept ma ka pale ʻana i kahi pilina kikoʻī ma waena o nā pūnaewele immune i kapa ʻia ʻo T-cells a me nā pūnaewele e hōʻike ana i ka antigen. Ke kamaʻilio kūpono ʻole kēia mau pūnaewele, hoʻoulu lākou i ka mumū e hōʻino i kou mau hono a me nā ʻiʻo.

Hana ka lāʻau lapaʻau e like me ka luna hoʻoponopono mālie, e pale ana i kēia mau kamaʻilio ʻino ma waena o nā pūnaewele immune me ka ʻole e hoʻopau loa i ka hiki o kou kino ke hakakā i nā maʻi. ʻO kēia ala i manaʻo ʻia ai ʻo abatacept he lāʻau lapaʻau ikaika waena ma mua o ka immunosuppressant kaumaha.

Hiki iā ʻoe ke hoʻomaka e ʻike i nā hoʻomaikaʻi ʻana i loko o 2-3 mau mahina, ʻoiai ʻike kekahi poʻe i nā pōmaikaʻi ma mua. Hoʻomohala pinepine nā hopena piha ma luna o 6 mau mahina i ka wā e hōʻemi mālie ai ka lāʻau lapaʻau i ka mumū ma kou kino.

Pehea wau e lawe ai iā Abatacept?

ʻO ke ala āu e lawe ai iā abatacept e pili ana i ke ʻano i kauoha ʻia e kāu kauka. Hāʻawi ʻia nā infusions IV ma kahi keʻena lapaʻau ma kahi o 30 mau minuke, ʻoiai hiki ke hana ʻia nā injections subcutaneous ma ka home.

No ka mālama ʻana i ka IV, e loaʻa iā ʻoe nā infusions i 2 mau pule, 4 mau pule, a laila i kēlā me kēia 4 mau pule ma hope o kāu mahele mua. ʻAʻole pono ʻoe e hoʻokē ʻai ma mua, akā ʻo ka noho ʻana i ka wai maikaʻi hiki ke kōkua iā ʻoe e ʻoluʻolu i ka wā o ka infusion.

Inā ʻoe e hoʻohana ana i ke ʻano subcutaneous, e hoʻokomo ʻoe i hoʻokahi manawa i kēlā me kēia pule, maʻamau i kou ʻūhā, ʻōpū, a i ʻole ka lima luna. E aʻo kāu hui mālama ola iā ʻoe i ke ʻano o ka injection kūpono a me ka hoʻololi ʻana o nā wahi injection e pale ai i ka huhū.

Hana like nā ʻano ʻelua, no laila e pili pinepine ka koho i kāu makemake no ka maʻalahi e kūʻē i ka hōʻoia o ka mālama ʻana i ka lāʻau lapaʻau. Makemake kekahi poʻe i nā injections home i kēlā me kēia pule no ka maʻalahi, ʻoiai makemake nā poʻe ʻē aʻe i nā kipa ʻana i ka haukapila i kēlā me kēia mahina no ka nānā ʻana.

Pehea ka lōʻihi e lawe ai au i ka Abatacept?

He lāʻau lōʻihi ka Abatacept, ʻo ia hoʻi, e hoʻomau paha ʻoe i ka lawe ʻana iā ia i ka wā e kōkua ana i kou maʻi a ʻaʻole e hana i nā hopena ʻaoʻao nui. Lawe ka hapa nui o nā kānaka iā ia no nā makahiki ma mua o nā mahina.

E nānā kāu kauka i kāu pane i kēlā me kēia 3-6 mahina e loiloi inā e hana pono ana ka lāʻau. Inā maikaʻi nā hōʻailona a ʻaʻole ʻoe e ʻike i nā hopena ʻaoʻao pilikia, ʻo ka hoʻomau ʻana i ka lāʻau lapaʻau e hāʻawi maʻamau i nā hopena maikaʻi loa.

Pono paha kekahi poʻe e hooki no ka manawa pōkole inā loaʻa iā lākou kekahi mau maʻi a i ʻole pono i ke ʻoki. E alakaʻi kāu kauka iā ʻoe ma nā wā hoʻomaha e pono ai a kōkua iā ʻoe e hoʻomaka hou me ka palekana i ka wā kūpono.

He aha nā hopena ʻaoʻao o Abatacept?

Hoʻomanawanui ka hapa nui o nā kānaka i ka abatacept, akā e like me nā lāʻau lapaʻau a pau, hiki iā ia ke hana i nā hopena ʻaoʻao. ʻO ka hoʻomaopopo ʻana i ka mea e manaʻo ai hiki ke kōkua iā ʻoe e manaʻoʻiʻo i kāu lapaʻau.

He maʻalahi a hiki ke mālama ʻia nā hopena ʻaoʻao maʻamau. Hoʻopilikia kēia mau hopena i kēlā me kēia lā i nā kānaka he nui akā ʻaʻole pono e hooki i ka lāʻau:

• ʻEha poʻo a me ka luhi maʻalahi
• Nā maʻi hanu luna e like me ke anu
• Nausea a i ʻole ka ʻōpū
• Nā hopena ma ka pūnaewele injection (ʻulaʻula, pehu, a i ʻole ka ʻeha maʻalahi)
• ʻO ka ʻūlū i ka wā a i ʻole ma hope o nā infusions IV

Hoʻomaikaʻi pinepine kēia mau hopena ʻaoʻao maʻamau i ka wā e hoʻoponopono ai kou kino i ka lāʻau i nā pule a i ʻole nā mahina mua.

ʻAʻole maʻamau nā hopena ʻaoʻao koʻikoʻi, akā pono e mālama koke ʻia. ʻOiai he mea maʻamau, pono kēia mau kūlana i ka loiloi wikiwiki:

• Nā hōʻailona o ka maʻi koʻikoʻi (fiva, nāwaliwali, ʻūlū mau, luhi ʻole)
• Nā hopena maʻi maʻi koʻikoʻi (paʻakikī ka hanu ʻana, pehu, ʻeha nui)
• Ke kahe ʻana a i ʻole ka ʻeha ʻole
• Nausea mau, luaʻi, a i ʻole ka ʻeha o ka ʻōpū
• Nā ʻeha ʻili hou a i ʻole e ʻino ana

ʻO ka nūhou maikaʻi, ʻo ia ka mea e loaʻa ai nā hopena ʻaoʻao koʻikoʻi ma lalo o 5% o nā kānaka e lawe ana i ka abatacept, a hiki ke mālama pono ʻia ka hapa nui ke hopu ʻia i ka wā mua.

ʻO wai ka mea pono ʻole e lawe i ka Abatacept?

ʻAʻole kūpono ka Abatacept no nā mea a pau, a ʻo kekahi mau maʻi olakino e hana ʻole ai a i ʻole e koi ai i nā hana kūikawā. E nānā pono kāu kauka i kāu moʻolelo olakino ma mua o ke kau ʻana.

ʻAʻole pono ʻoe e lawe i ka abatacept inā he maʻi koʻikoʻi kou, me ka maʻi tuberculosis, a i ʻole inā ua loaʻa iā ʻoe nā hopena maʻi koʻikoʻi i ka lāʻau ma mua. Pono paha ka poʻe me kekahi mau ʻano maʻi maʻi e pale aku a i ʻole e kali a pau kā lākou lapaʻau.

Pono ka mālama kūikawā inā he moʻolelo kou o nā maʻi hou, hepatitis B a i ʻole C, a i ʻole kekahi mau maʻi māmā. E kauoha paha kāu kauka i nā hoʻokolohua hou a me ka nānā ʻana inā loaʻa iā ʻoe kēia mau maʻi akā pono nō ʻoe i ka abatacept.

Pono nā wāhine hāpai a i ʻole e hānai ana i ka waiū e kūkākūkā pono i nā pilikia a me nā pōmaikaʻi me kā lākou kauka, no ka mea, ʻaʻole i maopopo loa nā hopena i nā pēpē e ulu ana.

Nā inoa inoa o Abatacept

Kūʻai ʻia ka Abatacept ma lalo o ka inoa inoa ʻo Orencia ma nā ʻano IV a me nā ʻano subcutaneous. ʻO kēia ka inoa maʻamau āu e ʻike ai ma nā palapala kauoha a me nā palapala ʻinikua.

ʻAʻohe mana generic o ka abatacept i loaʻa i kēia manawa, no ka mea, he lāʻau lapaʻau biologic paʻakikī e paʻakikī ke hana hou. Eia naʻe, hiki ke loaʻa nā mana biosimilar i ka wā e hiki mai ana.

Hiki i kekahi mau hui ʻinikua ke koi i ka ʻae mua no Orencia ma muli o ke kumukūʻai, akā hiki i ka hapa nui o ka poʻe me ka rheumatoid arthritis ke loaʻa ka uhi ʻana ke hoʻokumu ʻia ka pono olakino.

Nā koho ʻē aʻe o Abatacept

Inā ʻaʻole kūpono ka abatacept iā ʻoe, hana like kekahi mau lāʻau lapaʻau biologic no nā maʻi autoimmune. Aia kēia mau mea i ka adalimumab (Humira), etanercept (Enbrel), a me rituximab (Rituxan).

ʻO nā lāʻau lapaʻau e hoʻololi ai i ka maʻi (DMARDs) e like me methotrexate a i ʻole sulfasalazine e hoʻāʻo pinepine ʻia ma mua a i ʻole e hoʻohana pū ʻia me nā biologics. He ʻano hana like ʻole kēia mau lāʻau lapaʻau a me nā ʻano hopena ʻaoʻao.

E noʻonoʻo kāu kauka i nā mea e like me kou kūlana kikoʻī, nā pilikia olakino ʻē aʻe, nā makemake o ke ola, a me ka uhi ʻinikua i ke koho ʻana i ka koho maikaʻi loa. I kekahi manawa, ʻo ka hoʻāʻo ʻana i kahi lāʻau lapaʻau ʻē aʻe hiki ke hāʻawi i nā hopena maikaʻi a i ʻole nā hopena ʻaoʻao liʻiliʻi.

Ua ʻoi aku ka maikaʻi o Abatacept ma mua o Methotrexate?

Hana ʻokoʻa ʻo Abatacept a me methotrexate a hoʻohana pinepine ʻia pū kekahi ma mua o nā koho hoʻokūkū. ʻO Methotrexate ka lāʻau lapaʻau mua no ka rheumatoid arthritis, ʻoiai ua hoʻohui pinepine ʻia ʻo abatacept ke lawa ʻole ka methotrexate wale nō.

ʻO Methotrexate kahi lāʻau lapaʻau kahiko, i hoʻokumu maikaʻi ʻia e lawe ʻia ma ke ʻano he mau pila a i ʻole nā injections a ʻoi aku ka liʻiliʻi o ke kumukūʻai ma mua o abatacept. Eia naʻe, hiki iā ia ke hoʻoulu i ka ʻōpū a pono e nānā mau i ke koko no ka hana ate.

ʻOi aku ka maikaʻi o Abatacept no ka poʻe i hiki ʻole ke ʻae i ka methotrexate a i ʻole pono i ka mana hou o ka mumū. Nui ka poʻe e lawe pū ana i nā lāʻau lapaʻau ʻelua no nā hopena maikaʻi loa, no ka mea, hoʻopili lākou i nā hopena o kekahi.

Nā nīnau i nīnau pinepine ʻia e pili ana iā Abatacept

He palekana ʻo Abatacept no ka poʻe me ka maʻi diabetes?

ʻAe, palekana ʻo abatacept no ka poʻe me ka maʻi diabetes. ʻAʻole pili pololei ka lāʻau lapaʻau i nā pae kōpaʻa koko a ʻaʻole hoʻopilikia i nā lāʻau lapaʻau diabetes.

Eia naʻe, hiki i ka loaʻa ʻana o ka maʻi diabetes ke hoʻonui i kou pilikia o nā maʻi, a hoʻonui iki ʻo abatacept i ka pilikia o ka maʻi. E nānā kāu kauka iā ʻoe a ʻōlelo paha i nā hana hou e like me ka nānā pinepine ʻana i ke kōpaʻa koko i ka wā maʻi.

He aha kaʻu e hana ai inā hoʻohana hewa au i ka nui o Abatacept?

Inā ua hoʻokomo ʻoe i ka abatacept ʻoi aku ma mua o ka mea i kauoha ʻia, e kelepona koke i kāu kauka a i ʻole ka lāʻau lapaʻau. ʻOiai he kakaikahi nā overdoses me nā syringes i hoʻopiha mua ʻia, he mea nui e kiʻi i ke alakaʻi olakino.

Mai hoʻāʻo e "kaulike" i ka nui o ka lāʻau ma ka haʻalele ʻana i kāu injection i hoʻonohonoho ʻia. E aʻo aku kāu kauka iā ʻoe i ke ala palekana loa e hoʻi ai i ke ala me kāu papa hana maʻamau.

He aha kaʻu e hana ai inā ua hala wau i kahi lāʻau abatacept?

Inā ua hala ʻoe i kahi injection subcutaneous, e lawe koke iā ia ke hoʻomanaʻo ʻoe, a laila e hoʻi i kāu papa hana pule maʻamau. Mai pāpālua i nā lāʻau e hoʻopiha ai i kahi injection i hala.

No nā infusions IV, e kelepona i ke keʻena o kāu kauka e hoʻonohonoho hou i ka hiki wawe. Hiki iā lākou ke hoʻoponopono i kāu mau manawa e hiki mai ana e hoʻihoʻi iā ʻoe i ka papa hana maikaʻi loa no kāu mālama ʻana.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka abatacept?

Pono ʻoe e hooki i ka lawe ʻana i ka abatacept ma lalo o ka mālama ʻana a kāu kauka. ʻO ka hooki ʻana i ka hikiwawe hiki ke alakaʻi i ka hōʻeha ʻana o kou maʻi autoimmune i loko o nā pule a i ʻole nā mahina.

Hiki i kāu kauka ke ʻōlelo e hooki inā loaʻa iā ʻoe nā hopena ʻaoʻao koʻikoʻi, e hoʻokō i ka remission lōʻihi, a i ʻole pono e hoʻololi i kahi lāʻau lapaʻau ʻē aʻe. E hana lākou i kahi hoʻolālā e nānā pono iā ʻoe i ka wā o nā hoʻomaha lapaʻau.

Hiki iaʻu ke kiʻi i nā lāʻau lapaʻau i ka wā e lawe ana i ka abatacept?

He palekana ka hapa nui o nā lāʻau lapaʻau maʻamau i ka wā e lawe ana i ka abatacept, akā pono ʻoe e pale i nā lāʻau lapaʻau ola e like me ka nasal flu spray a i ʻole ka lāʻau lapaʻau shingles. E ʻōlelo aku kāu kauka i ka pana flu injectable ma kahi.

He mea nui e noho i ka lāʻau lapaʻau i ka wā e pili ana i ka abatacept, no ka mea, hiki i ka lāʻau lapaʻau ke hoʻolilo iā ʻoe i mea maʻalahi i kekahi mau maʻi. E hoʻolālā e kiʻi i kāu mau lāʻau lapaʻau ke maikaʻi ʻoe a ʻaʻole ʻoe e ʻike i nā maʻi ikaika.