Abatacept (alaloa intravenous, alaloa subcutaneous)
Nā mea hōʻailona e loaʻa ana
Orencia
E pili ana i kēia lāʻau
Hoʻohana ʻia ka inikini ʻo Abatacept ma ke ʻano hoʻokahi a i ʻole me nā lāʻau lapaʻau ʻē aʻe e mālama i ka mumū rheumatoid arthritis nui a i ʻole koʻikoʻi. Kūleʻa ʻo Abatacept i ka pale ʻana i ka hōʻino ʻana o nā hono ma hope o ka hoʻohana ʻana i nā lāʻau lapaʻau ʻē aʻe a ʻaʻole i hana maikaʻi. Hoʻohana pū ʻia ka inikini ʻo Abatacept ma ke ʻano hoʻokahi a i ʻole me ka methotrexate e mālama i ka polyarticular juvenile idiopathic arthritis (pJIA) nui a i ʻole koʻikoʻi. Hoʻohana pū ʻia ka inikini ʻo Abatacept ma ke ʻano hoʻokahi a i ʻole me nā lāʻau lapaʻau ʻē aʻe e mālama i ka psoriatic arthritis (PsA) e hana nei, ʻo ia ke ʻano o ka mumū hono e hoʻokumu ai i ka ʻeha a me ka pehu ʻana o nā hono me nā ʻāpana o ka ʻili scaly ma kekahi mau wahi o ke kino. Hoʻohana pū ʻia ka inikini ʻo Abatacept me nā lāʻau lapaʻau ʻē aʻe (e laʻa, calcineurin inhibitor, methotrexate) e pale aku i ka acute graft-versus-host disease (aGVHD) i nā mea maʻi e komo i ka hematopoietic stem cell transplantation (HSCT) mai ka mea hāʻawi kūpono a i ʻole 1 allele-mismatched unrelated donor. Loaʻa wale kēia lāʻau lapaʻau me ke kauoha a kāu kauka. Loaʻa kēia huahana ma nā ʻano dosage e like me kēia:
Ma mua o ka hoʻohana ʻana i kēia lāʻau
I ka hoʻoholo ʻana e hoʻohana i kahi lāʻau lapaʻau, pono e kaulike ke kaumaha o ka lawe ʻana i ka lāʻau lapaʻau me ka pono e hana ai. He hoʻoholo kēia āu a me kāu kauka e hana ai. No kēia lāʻau lapaʻau, pono e noʻonoʻo i nā mea aʻe: E haʻi aku i kāu kauka inā ua loaʻa iā ʻoe kekahi hopena maʻamau ʻole a i ʻole nā hopena ʻē aʻe i kēia lāʻau lapaʻau a i ʻole nā lāʻau lapaʻau ʻē aʻe. E haʻi pū aku i kāu limahana mālama ola inā loaʻa iā ʻoe nā ʻano ʻē aʻe o nā maʻi ʻili, e like me nā meaʻai, nā mea kala, nā mea mālama, a i ʻole nā holoholona. No nā huahana kūʻai ʻole ʻia, e heluhelu pono i ka lepili a i ʻole nā mea hoʻohui pūʻolo. ʻAʻole i hōʻike nā haʻawina kūpono i hana ʻia a hiki i kēia lā i nā pilikia kūikawā pediatric e kaupalena ai i ka hoʻohana ʻana o ka inikini abatacept i nā keiki he 2 mau makahiki a ʻoi aku ka nui e mālama ai i ka pJIA, e mālama ai i ka PsA, a e pale aku ai i ka aGVHD. Eia naʻe, ʻaʻole i hoʻokumu ʻia ka palekana a me ka pono i nā keiki ʻoi aku ka liʻiliʻi ma mua o 2 mau makahiki. ʻAʻole i hōʻike nā haʻawina kūpono i hana ʻia a hiki i kēia lā i nā pilikia kūikawā geriatric e kaupalena ai i ka hoʻohana ʻana o ka inikini abatacept i nā ʻelemakule. Eia naʻe, ʻoi aku ka maʻalahi o nā poʻe ʻelemakule i nā hopena o kēia lāʻau lapaʻau ma mua o nā mākua ʻōpio a ʻoi aku ka nui o ka maʻi kanesa a me nā maʻi koʻikoʻi, kahi e pono ai ke akahele i nā mea maʻi e loaʻa ana i ka inikini abatacept. ʻAʻohe mau haʻawina lawa i nā wāhine no ka hoʻoholo ʻana i ka pilikia o ka pēpē i ka wā e hoʻohana ana i kēia lāʻau lapaʻau i ka wā hānai. E kaulike i nā pono hiki ke loaʻa me nā pilikia hiki ke loaʻa ma mua o ka lawe ʻana i kēia lāʻau lapaʻau i ka wā hānai. ʻOiai ʻaʻole pono e hoʻohana pū ʻia kekahi mau lāʻau lapaʻau, i nā hihia ʻē aʻe, hiki ke hoʻohana pū ʻia ʻelua mau lāʻau lapaʻau ʻokoʻa ʻoiai inā hiki ke loaʻa kahi pilina. I kēia mau hihia, makemake paha kāu kauka e hoʻololi i ka nui, a i ʻole nā ʻano palekana ʻē aʻe paha e pono ai. I ka wā e lawe ana ʻoe i kēia lāʻau lapaʻau, he mea nui loa ia i kāu limahana mālama ola e ʻike inā ke lawe nei ʻoe i kekahi o nā lāʻau lapaʻau i helu ʻia ma lalo nei. Ua koho ʻia nā pilina aʻe ma muli o ko lākou koʻikoʻi hiki ke loaʻa a ʻaʻole pono nā mea āpau. ʻO ka hoʻohana ʻana i kēia lāʻau lapaʻau me kekahi o nā lāʻau lapaʻau aʻe ʻaʻole i ʻōlelo ʻia, akā hiki ke koi ʻia i kekahi mau hihia. Inā kuhikuhi ʻia nā lāʻau lapaʻau ʻelua, hiki i kāu kauka ke hoʻololi i ka nui a i ʻole ka pinepine o kāu hoʻohana ʻana i hoʻokahi a i ʻole nā lāʻau lapaʻau ʻelua. Hiki i ka hoʻohana ʻana i kēia lāʻau lapaʻau me kekahi o nā lāʻau lapaʻau aʻe ke hoʻonui i ka pilikia o kekahi mau hopena ʻaoʻao, akā ʻo ka hoʻohana ʻana i nā lāʻau lapaʻau ʻelua paha ka mālama maikaʻi loa no ʻoe. Inā kuhikuhi ʻia nā lāʻau lapaʻau ʻelua, hiki i kāu kauka ke hoʻololi i ka nui a i ʻole ka pinepine o kāu hoʻohana ʻana i hoʻokahi a i ʻole nā lāʻau lapaʻau ʻelua. ʻAʻole pono e hoʻohana ʻia kekahi mau lāʻau lapaʻau i ka wā a i ʻole kokoke i ka wā e ʻai ai i ka meaʻai a i ʻole ka ʻai ʻana i kekahi mau ʻano meaʻai ʻoiai hiki ke loaʻa nā pilina. Hiki i ka hoʻohana ʻana i ka waiʻona a i ʻole ka paka me kekahi mau lāʻau lapaʻau ke hoʻokumu pū i nā pilina. E kūkākūkā me kāu limahana mālama ola i ka hoʻohana ʻana i kāu lāʻau lapaʻau me ka meaʻai, ka waiʻona, a i ʻole ka paka. Hiki i ke alo o nā pilikia olakino ʻē aʻe ke hoʻopilikia i ka hoʻohana ʻana i kēia lāʻau lapaʻau. E hōʻoia e haʻi aku i kāu kauka inā loaʻa iā ʻoe nā pilikia olakino ʻē aʻe, ʻoiai:
Pehea e hoʻohana ai i kēia lāʻau
E hāʻawi aku kahi nānaihe a i ʻole kekahi limahana ola kino i aʻo ʻia iā ʻoe a i ʻole kāu keiki i kēia lāʻau lapaʻau. Hāʻawi ʻia kēia lāʻau lapaʻau ma ke ʻano he pana ma lalo o kou ʻili a i loko paha o kahi vein. No ka mālama ʻana i ka maʻi ʻaʻai rheumatoid, ka maʻi ʻaʻai psoriatic, a me ka maʻi ʻaʻai idiopathic juvenile polyarticular: Inā hāʻawi ʻia kēia lāʻau lapaʻau ma o kahi vein i loko o kou lima, pono e hoʻokomo mālie ʻia e kāu kauka a pono e noho mau ana kāu tube IV no 30 mau minuke. E loaʻa hou iā ʻoe kēia lāʻau lapaʻau ma hope o 2 mau pule a me 4 mau pule ma hope o kāu pāpale mua a laila i kēlā me kēia 4 mau pule ma hope. No ka pale ʻana i ka maʻi acute graft-versus-host (aGVHD): Hāʻawi ʻia kēia lāʻau lapaʻau ma o kahi vein i loko o kou lima. Pono e hoʻokomo mālie ʻia e kāu kauka a pono e noho mau ana kāu tube IV no 60 mau minuke i ka lā ma mua o kou loaʻa ʻana i ka transplant (Day -1). E loaʻa hou iā ʻoe kēia lāʻau lapaʻau ma nā lā 5, 14, a me 28 ma hope o ka transplant. Hiki ke hāʻawi ʻia ʻo Abatacept ma ke ʻano he pana ma lalo o kou ʻili. Hiki ke hāʻawi ʻia i ka home i nā mea maʻi ʻaʻole pono e noho ma ka haukapila. Inā hoʻohana ʻoe a i ʻole kāu keiki i kēia lāʻau lapaʻau ma ka home, e aʻo aku kāu kauka a i ʻole nānaihe iā ʻoe pehea e hoʻomākaukau a hoʻokomo ai i ka lāʻau lapaʻau. E hōʻoia e maopopo pono iā ʻoe pehea e hoʻohana ai i ka lāʻau lapaʻau. Loaʻa kēia lāʻau lapaʻau me nā ʻōlelo aʻo no nā mea maʻi. E heluhelu a hahai pono i kēia mau ʻōlelo aʻo. E nīnau i kāu kauka a i ʻole pharmacist inā he nīnau kāu. Inā hoʻohana ʻoe i kēia lāʻau lapaʻau ma ka home, e hōʻike ʻia nā wahi o ke kino kahi e hiki ai ke hāʻawi ʻia kēia pana. E hoʻohana i kahi wahi kino ʻē aʻe i kēlā me kēia manawa āu e hāʻawi ai iā ʻoe iho a i kāu keiki paha i kahi pana. E mālama pono i kahi āu e hāʻawi ai i kēlā me kēia pana e hōʻoia e hoʻololi ʻoe i nā wahi o ke kino. E kōkua kēia e pale aku i nā pilikia ʻili. Loaʻa kēia lāʻau lapaʻau i 3 mau ʻano: kahi vial (pāpale aniani), kahi syringe i hoʻopiha mua ʻia, a i ʻole kahi ClickJect™ autoinjector. ʻO ka syringe i hoʻopiha mua ʻia a me ka ClickJect™ autoinjector nā ʻano dosage hiki iā ʻoe ke hoʻohana ma ka home. E nānā i ka wai i loko o ka syringe i hoʻopiha mua ʻia a i ʻole ka ClickJect™ autoinjector. Pono e maopopo a ʻeleʻele ʻole a i ʻole melemele iki paha. Mai hoʻohana inā ua ao, i loli ke kala, a i ʻike ʻoe i nā ʻāpana i loko. Mai hoʻohana i ka syringe i hoʻopiha mua ʻia a i ʻole ka ClickJect™ autoinjector inā ua ʻike ʻia ua haki a haki paha. E ʻae i 30 mau minuke no ka syringe e mahana i ka mahana o ka lumi. Mai hoʻomehana i kēia lāʻau lapaʻau ma kekahi ʻano ʻē aʻe. Mai wehe i ka uhi o ka nila ma ka syringe i hoʻopiha mua ʻia a i ʻole ka pāpale autoinjector ʻoiai e ʻae ana i ka lāʻau lapaʻau e hiki i ka mahana o ka lumi. E wehe wale nō inā mākaukau e hoʻohana. E nānā inā hāʻule ka nui o ka wai i loko o ka syringe i hoʻopiha mua ʻia ma a ma luna paha o ka laina piha. Inā ʻaʻohe o ka syringe i ka nui kūpono o ka wai, mai hoʻohana. Mai hoʻokomo i nā wahi ʻili ʻulaʻula, ʻūlū, palupalu, ʻiliʻili, a paʻakikī paha, a i ʻole nā ʻōpala a i ʻole nā hōʻailona hoʻonui. E ʻokoʻa ka nui o kēia lāʻau lapaʻau no nā mea maʻi like ʻole. E hahai i nā kauoha a kāu kauka a i ʻole nā kuhikuhi ma ka lepili. ʻO ka ʻike ma lalo nei e komo pū ana i nā nui awelika o kēia lāʻau lapaʻau. Inā ʻokoʻa kāu nui, mai hoʻololi inā ʻaʻole kāu kauka i haʻi aku iā ʻoe e hana pēlā. ʻO ka nui o ka lāʻau lapaʻau āu e lawe ai e hilinaʻi ana i ka ikaika o ka lāʻau lapaʻau. Eia kekahi, ʻo ka nui o nā pāpale āu e lawe ai i kēlā me kēia lā, ka manawa i ʻae ʻia ma waena o nā pāpale, a me ka lōʻihi o ka manawa āu e lawe ai i ka lāʻau lapaʻau e hilinaʻi ana i ka pilikia olakino āu e hoʻohana nei i ka lāʻau lapaʻau. Pono e hāʻawi ʻia kēia lāʻau lapaʻau ma kahi papa hana paʻa. Inā nalowale ʻoe i kahi pāpale a poina paha e hoʻohana i kāu lāʻau lapaʻau, e kāhea i kāu kauka a i ʻole pharmacist no nā ʻōlelo aʻo. E mālama i loko o ka pahu hau. Mai hoʻoilo. E mālama i kahi mamao aku o nā keiki. Mai mālama i ka lāʻau lapaʻau kahiko a i ʻole ka lāʻau lapaʻau ʻaʻole pono hou. E nīnau i kāu limahana ola kino pehea ʻoe e hoʻolei ai i kekahi lāʻau lapaʻau āu ʻaʻole e hoʻohana. E hoʻolei i nā nila i hoʻohana ʻia i loko o kahi pahu paʻakikī, pani ʻia kahi hiki ʻole i nā nila ke komo. E mālama i kēia pahu mamao aku o nā keiki a me nā holoholona.
Hōʻole: He kahua ʻike olakino ʻo ʻAukake a ʻaʻole hōʻike kāna mau pane i ka ʻōlelo aʻoaʻo lapaʻau. E kūkākūkā mau me kahi ʻoihana lapaʻau laikini kokoke iā ʻoe ma mua o ka hana ʻana i nā hoʻololi.
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