He aha ʻo Acalabrutinib: Nā Hoʻohana, Nā Ana, Nā ʻAoʻao ʻAoʻao a me nā mea hou aku

He lāʻau lapaʻau maʻi maʻi i manaʻo ʻia ʻo Acalabrutinib e kōkua i ka mālama ʻana i kekahi mau ʻano maʻi maʻi koko ma ka pale ʻana i nā protein kikoʻī e pono ai nā sela maʻi e ulu a ola. No ka papa o nā lāʻau i kapa ʻia ʻo BTK inhibitors kēia lāʻau lapaʻau waha, e hana ana e like me ke kī e kūpono i loko o kahi laka kikoʻī ma nā sela maʻi, e kāohi ana iā lākou mai ka hoʻonui ʻana.

Inā ua kauoha ʻia ʻoe a i ʻole kekahi āu e mālama nei i ka acalabrutinib, e manaʻo ana paha ʻoe i ka hui ʻana o ka manaʻolana a me ka hopohopo. He mea maoli loa ia. ʻO ka hoʻomaopopo ʻana i ka hana ʻana o kēia lāʻau a me ka mea e manaʻo ai hiki ke kōkua iā ʻoe e ʻoi aku ka hilinaʻi i kāu huakaʻi lapaʻau.

He aha ʻo Acalabrutinib?

He lāʻau maʻi maʻi pololei ʻo Acalabrutinib e manaʻo ana i kahi protein kikoʻī i kapa ʻia ʻo Bruton's tyrosine kinase (BTK). E noʻonoʻo iā BTK ma ke ʻano he kuapo e haʻi ana i kekahi mau sela maʻi e ulu a laha. Hana ʻo Acalabrutinib ma ka hoʻopau ʻana i kēia kuapo, e kōkua ana i ka hoʻolohi ʻana a i ʻole ka hoʻōki ʻana i ka maʻi mai ka ʻino.

ʻO kēia lāʻau lapaʻau ka mea a nā kauka e kapa ai he

Hiki i kāu kauka ke kuhikuhi iā acalabrutinib inā loaʻa iā ʻoe ka CLL a i ʻole SLL i hoʻi mai ma hope o nā lāʻau lapaʻau ʻē aʻe a i ʻole inā ua ʻike ʻia ʻoe a ʻaʻole kūpono nā lāʻau lapaʻau ʻē aʻe iā ʻoe. Hoʻohana ʻia nō hoʻi no ka lymphoma cell mantle, kekahi ʻano maʻi koko e pili ana i nā lymph nodes a me nā ʻōkana ʻē aʻe.

He maikaʻi loa ka lāʻau lapaʻau no nā maʻi maʻi i loaʻa nā ʻano genetic. E hana kāu hui mālama ola i nā hoʻokolohua kikoʻī ma kāu mau sela maʻi e hoʻoholo ai inā e hana pono ʻo acalabrutinib no kāu kūlana.

Pehea e hana ai ʻo Acalabrutinib?

Hana ʻo Acalabrutinib ma ka pale ʻana i ka protein BTK, e like me kahi kikowaena kamaʻilio e hoʻohana ai nā sela maʻi e loaʻa ai nā hōʻailona ulu. Ke ālai ʻia kēia protein, ʻaʻole hiki i nā sela maʻi ke loaʻa nā memo e pono ai lākou e ola a hoʻonui.

Ua manaʻo ʻia kēia lāʻau lapaʻau he lāʻau lapaʻau i manaʻo ʻia. ʻOiai ua lawa ka ikaika e mālama pono i nā maʻi koko, ʻoi aku ka maʻalahi o kou kino ma mua o ka chemotherapy kuʻuna no ka mea e kuhikuhi pono ana i nā sela maʻi ma mua o nā sela e ulu wikiwiki ana.

Kūkulu ka lāʻau i loko o kāu ʻōnaehana i ka manawa, no laila pono ʻoe e lawe mau i kēlā me kēia lā e hana pono ai. ʻO ka hapa nui o nā kānaka e hoʻomaka ana e ʻike i nā hopena i loko o kekahi mau pule a i ʻole mau mahina, ʻoiai e nānā kāu kauka i kāu holomua ma o nā hoʻokolohua koko maʻamau a me nā loiloi.

Pehea wau e lawe ai iā Acalabrutinib?

E lawe iā acalabrutinib e like me ke kauoha a kāu kauka, ʻelua manawa i ka lā ma kahi o 12 mau hola. Hiki iā ʻoe ke lawe me ka ʻole o ka meaʻai, akā e hoʻāʻo e lawe iā ia i nā manawa like i kēlā me kēia lā e kōkua i ka mālama ʻana i nā pae paʻa i loko o kou kino.

E ale i nā capsules holoʻokoʻa me ka wai. Mai wehe, haki, a nau paha iā lākou, no ka mea hiki i kēia ke hoʻopilikia i ke ʻano o ka lawe ʻia ʻana o ka lāʻau. Inā pilikia ʻoe i ka ale ʻana i nā capsules, e kamaʻilio me kāu hui mālama ola e pili ana i nā koho ʻē aʻe ma mua o ka hoʻāʻo ʻana e hoʻololi iā ʻoe iho i nā capsules.

He mea nui e pale i ka huaʻōlelo a me ka wai huaʻōlelo i ka wā e lawe ana i ka acalabrutinib, no ka mea, hiki iā lākou ke hoʻonui i ka nui o ka lāʻau lapaʻau i loko o kou koko i nā pae weliweli. E hāʻawi kāu kauka i kahi papa inoa piha o nā meaʻai a me nā lāʻau lapaʻau e pale aku ai.

Pehea ka lōʻihi e lawe ai au i ka Acalabrutinib?

E lawe paha ʻoe i ka acalabrutinib no ka lōʻihi e hoʻomau ana ia e hana pono a ke ʻae nei ʻoe iā ia. No ka hapa nui o nā kānaka me nā maʻi maʻi koko, ʻo ia hoʻi ka lawe ʻana iā ia no ka manawa pau ʻole, no ka mea, ʻo ka hoʻōki ʻana i ka lāʻau lapaʻau e hiki ai i ka maʻi maʻi ke hoʻomaka hou e ulu.

E nānā mau kāu hui mālama ola i kāu pane ʻana i ka lāʻau lapaʻau ma o nā hoʻokolohua koko, nā kiʻi kiʻi, a me nā hoʻokolohua kino. Kōkua kēia mau nānā ʻana e hoʻoholo inā ke hana nei ka lāʻau lapaʻau a inā pono e hana i nā hoʻololi i kāu hoʻolālā lapaʻau.

Pono paha kekahi poʻe e hoʻomaha mai ka acalabrutinib inā loaʻa iā lākou nā hopena ʻaoʻao nui. E hana pū kāu kauka me ʻoe e ʻimi i ke kaulike kūpono ma waena o ka mālama ʻana i kāu maʻi maʻi a me ka mālama ʻana i kou maikaʻi o ke ola.

He aha nā hopena ʻaoʻao o Acalabrutinib?

E like me nā lāʻau lapaʻau a pau, hiki i ka acalabrutinib ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole ʻike nā kānaka a pau iā lākou. Hiki ke mālama ʻia ka hapa nui o nā hopena ʻaoʻao me ka mālama kūpono a me ka nānā ʻana mai kāu hui mālama ola.

ʻO nā hopena ʻaoʻao maʻamau e hiki iā ʻoe ke ʻike me nā headaches, diarrhea, muscle and joint pain, a me ka luhi. Hoʻomaikaʻi pinepine kēia mau hopena i ka wā e hoʻoponopono ai kou kino i ka lāʻau lapaʻau, maʻamau i loko o nā pule mua o ka lāʻau lapaʻau.

Eia nā hopena ʻaoʻao maʻamau i hōʻike ʻia e nā maʻi:

• Nā ʻeha poʻo e like paha me nā ʻeha poʻo
• Ka maʻi palahī e hiki ke mālama ʻia me nā loli meaʻai
• ʻEha ʻiʻo a me nā ʻeha hui, e like me nā hōʻailona e like me ka maʻi flu
• Luhi e hiki ke hele mai a hele aku i ka lā
• ʻO ka ʻeha maʻalahi ma mua o ka maʻamau
• Ke kahe koko liʻiliʻi, e like me ke kahe ʻana o ka ihu a i ʻole ke kahe ʻana o nā ʻāʻī
• Nā maʻi hanu luna e like me nā hōʻailona anu

ʻO ka hapa nui o kēia mau hopena ʻaoʻao he maʻalahi a he kūpono a hiki ke mālama ʻia me ka mālama kākoʻo. E hāʻawi kāu hui mālama ola i nā hoʻolālā kikoʻī no ka hana ʻana me kēlā me kēia.

ʻO kekahi mau hopena ʻaoʻao maʻamau ʻole akā ʻoi aku ka koʻikoʻi e koi i ka lāʻau lapaʻau koke. ʻOiai e hana ana kēia mau mea i kahi pākēneka liʻiliʻi o nā maʻi, he mea nui e ʻike i ka mea e nānā ai.

E hoʻokaʻaʻike koke i kāu mea mālama ola inā ʻoe e ʻike:

• Ke kahe koko ʻano ʻē ʻaʻole e pau maʻalahi
• Nā hōʻailona o ka maʻi e like me ke kuni, nā anu, a i ʻole ka ʻū ʻana
• Ka maʻi palahī nui e alakaʻi i ka maloʻo
• Ka puʻuwai puʻuwai ʻole a i ʻole ka ʻeha o ka umauma
• Nā hopena ʻili nui a i ʻole ka ʻōpala
• Melemele o ka ʻili a i ʻole nā maka

Hiki ke mālama ʻia kēia mau hōʻailona ke hopu ʻia i ka wā mua, no laila mai kānalua e hoʻopili i kāu hui mālama inā hopohopo ʻoe e pili ana i nā loli i ke ʻano o kou manaʻo.

I kekahi manawa, hiki i ka acalabrutinib ke hana i nā pilikia koʻikoʻi e pili ana i kahi pākēneka liʻiliʻi loa o nā maʻi. E nānā pono kāu kauka iā ʻoe no kēia mau mea ma o ka hoʻāʻo maʻamau a me nā loiloi.

ʻO wai ka mea pono ʻole e lawe iā Acalabrutinib?

ʻAʻole kūpono ʻo Acalabrutinib no nā mea a pau, a e loiloi pono kāu kauka inā kūpono ia iā ʻoe ma muli o kou olakino holoʻokoʻa a me ka mōʻaukala olakino. Pono paha ka poʻe me kekahi mau maʻi i nā lāʻau lapaʻau ʻē aʻe a i ʻole ka nānā ʻana.

ʻAʻole pono ʻoe e lawe i ka acalabrutinib inā he maʻi ʻoe iā ia a i ʻole kekahi o kāna mau mea. E nānā kāu hui mālama ola i nā maʻi āpau i ʻike ʻia ma mua o ka kau ʻana i kēia lāʻau lapaʻau e hōʻoia i ka palekana iā ʻoe.

E akahele loa kāu kauka i ka kau ʻana i ka acalabrutinib inā loaʻa iā ʻoe:

• He moʻolelo o nā maʻi koko a i ʻole e lawe ana i nā lāʻau e lahilahi ai ke koko
• Nā maʻi ikaika a i ʻole kahi ʻōnaehana pale maʻi nāwaliwali
• Nā pilikia o ka puʻuwai a i ʻole nā ​​maʻi puʻuwai ʻē aʻe
• Nā pilikia o ke ake a i ʻole nā ​​enzyme ate kiʻekiʻe
• He moʻolelo o ka maʻi ʻili a i ʻole nā ​​maʻi maʻi lua ʻē aʻe

ʻAʻole kēia mau kūlana e kāpae ʻakomi iā ʻoe mai ka lawe ʻana i ka acalabrutinib, akā pono paha lākou i ka nānā ʻana a i ʻole nā ​​hoʻoponopono ʻana i ka dosage e hōʻoia i kou palekana.

Inā hāpai ʻoe, e hoʻolālā ana e hāpai, a i ʻole e hānai ana i ka waiū, ʻaʻole ʻōlelo ʻia ka acalabrutinib no ka mea hiki ke hōʻeha i kāu pēpē. E kūkākūkā kāu hui mālama ola i nā ʻano hana hoʻomalu hānau kūpono inā he makahiki hānau kāu.

Nā inoa inoa inoa o Acalabrutinib

Kūʻai ʻia ka Acalabrutinib ma lalo o ka inoa inoa ʻo Calquence. ʻO kēia wale nō ka inoa inoa i loaʻa i kēia manawa no kēia lāʻau lapaʻau, no ka mea, he lāʻau lapaʻau i manaʻo ʻia he mea hou i hoʻomohala ʻia e AstraZeneca.

Hiki paha iā ʻoe ke ʻike i nā inoa ʻelua i hoʻohana ʻia ma ke ʻano like i kāu mau moʻolelo lapaʻau a i ʻole nā ​​hue ʻōlelo. Inā kuhikuhi kāu kauka iā ia ma ke ʻano he acalabrutinib a i ʻole Calquence, ke kamaʻilio nei lākou e pili ana i ka lāʻau lapaʻau like.

ʻAʻole i loaʻa nā mana generic o acalabrutinib, no laila ʻo Calquence wale nō ke koho no ka loaʻa ʻana o kēia lāʻau lapaʻau. E hoʻoholo kāu ʻinikua a me nā pōmaikaʻi o ka hale kūʻai lāʻau lapaʻau i kāu mau kumukūʻai mai ka ʻeke no kēia lāʻau lapaʻau inoa inoa.

Nā koho ʻē aʻe o Acalabrutinib

Inā ʻaʻole kūpono ʻo acalabrutinib iā ʻoe a i ʻole e pau ka hana pono ʻana, aia kekahi mau koho lapaʻau ʻē aʻe no nā maʻi koko. E kōkua kāu hui mālama ola iā ʻoe e ʻimi i kēia mau koho ʻē aʻe e pili ana i kou kūlana kikoʻī a me ka mōʻaukala olakino.

ʻO nā mea pale BTK ʻē aʻe e like me ibrutinib (Imbruvica) a me zanubrutinib (Brukinsa) e hana like me acalabrutinib akā he ʻokoʻa paha nā hopena ʻaoʻao. Ua ʻae kekahi poʻe i kekahi mea pale BTK ma mua o kekahi, no laila he mea kōkua ka hoʻololi ʻana ma waena o lākou.

Hiki i nā koho lapaʻau hou ke komo:

• Nā lāʻau lapaʻau i manaʻo ʻia e like me venetoclax (Venclexta)
• Nā kino monoclonal antibody e like me rituximab a i ʻole obinutuzumab
• Nā hui chemotherapy kuʻuna
• Nā lāʻau lapaʻau immunotherapy
• Nā hoʻokolohua lapaʻau e hoʻāʻo ana i nā lāʻau lapaʻau hou

E noʻonoʻo kāu kauka i nā mea e like me nā ʻano kikoʻī o kāu maʻi maʻi, kou olakino holoʻokoʻa, nā lāʻau lapaʻau mua, a me nā makemake pilikino i ka wā e ʻōlelo ai i nā koho ʻē aʻe. ʻO ka pahuhopu ka loaʻa ʻana o ka lāʻau lapaʻau maikaʻi loa me nā hopena ʻaoʻao liʻiliʻi loa no kou kūlana kūikawā.

Ua ʻoi aku ka maikaʻi o Acalabrutinib ma mua o Ibrutinib?

ʻO Acalabrutinib a me ibrutinib nā mea pale BTK e hana ana ma nā ʻano like, akā he mau ʻokoʻa nui ko lākou e hiki ai ke kūpono kekahi iā ʻoe ma mua o kekahi. ʻAʻole ʻoi aku ka maikaʻi o kekahi – ʻo ke koho maikaʻi loa e pili ana i kou mau kūlana pilikino.

Manaʻo pinepine ʻia ʻo Acalabrutinib he liʻiliʻi nā hopena ʻaoʻao e pili ana i ka puʻuwai i hoʻohālikelike ʻia me ibrutinib. Hōʻike nā haʻawina e hiki i ka poʻe e lawe ana i ka acalabrutinib ke loaʻa ka puʻuwai puʻuwai ʻole a me ke koko kiʻekiʻe, he mea nui kēia inā he maʻi puʻuwai kou.

He like ka maikaʻi o nā lāʻau lapaʻau ʻelua i ka mālama ʻana i nā maʻi koko, akā hiki i ka acalabrutinib ke hoʻoulu i ka liʻiliʻi o ka maʻi maʻi a me ka ʻeha hui i kekahi poʻe. Eia naʻe, ʻokoʻa nā pane pilikino, a ʻo ka mea e hana maikaʻi loa no kekahi kanaka ʻaʻole ia he mea kūpono no kekahi.

E kōkua kāu kauka iā ʻoe e ana i nā pōmaikaʻi a me nā pilikia o kēlā me kēia koho e pili ana i kāu mōʻaukala olakino, ke kūlana olakino o kēia manawa, a me nā ʻano kikoʻī o kāu maʻi ʻaʻai. He pinepine ka hoʻoholo ʻana i ka lāʻau lapaʻau e hāʻawi nui iā ʻoe i ke ola maikaʻi loa i ka wā e mālama pono ai i kou maʻi.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Acalabrutinib

He Palekana ʻo Acalabrutinib no ka poʻe me ka maʻi puʻuwai?

Hiki ke hoʻohana palekana ʻia ʻo Acalabrutinib i ka poʻe me ka maʻi puʻuwai, akā pono ʻoe e nānā pono ʻia ma mua o ka mea ʻaʻole i loaʻa nā maʻi puʻuwai. Hōʻike nā haʻawina i ka liʻiliʻi o nā hopena ʻaoʻao e pili ana i ka puʻuwai i hoʻohālikelike ʻia me kekahi mau mea pale BTK ʻē aʻe.

E hana pū kāu cardiologist a me ka oncologist e nānā i ke olakino o kou puʻuwai i ka wā e lawe ana ʻoe i ka acalabrutinib. Hiki iā lākou ke ʻōlelo i nā hoʻokolohua hana puʻuwai maʻamau a me nā loiloi koko e hōʻoia i ka hopena ʻole o ka lāʻau lapaʻau i kāu ʻōnaehana cardiovascular.

Inā he mōʻaukala kou o ka puʻuwai puʻuwai ʻole a i ʻole nā pilikia o ka puʻuwai, e ana kāu hui mālama ola i nā pōmaikaʻi o ka mālama ʻana i ka maʻi ʻaʻai e kūʻē i nā pilikia e hiki mai ana i kou puʻuwai. ʻO ka pinepine, ʻoi aku ka nui o nā pōmaikaʻi o ka mālama ʻana i ka maʻi ʻaʻai ma mua o nā pilikia, ʻoiai me ka nānā pono ʻana.

He aha kaʻu e hana ai inā ua lawe hewa au i ka nui o Acalabrutinib?

Inā ua lawe hewa ʻoe i ka nui o ka acalabrutinib ma mua o ka mea i kuhikuhi ʻia, e hoʻokaʻaʻike koke i kāu mea mālama ola a i ʻole ke kikowaena hoʻomalu i ka lāʻau make. Mai kali e ʻike inā ʻoe e ʻike i nā hōʻailona, ​​no ka mea, ʻoi aku ka palekana o ka loaʻa ʻana o ke alakaʻi mua.

ʻO ka lawe ʻana i ka nui o ka acalabrutinib hiki ke hoʻonui i kou pilikia o nā hopena ʻaoʻao e like me ke kahe ʻana, ka puʻuwai puʻuwai ʻole, a i ʻole ka maʻi maʻi nui. Hiki i kāu hui mālama ola ke makemake e nānā pono iā ʻoe a i ʻole e hāʻawi i ka mālama kākoʻo e mālama i nā hōʻailona e ulu ana.

E mālama i kāu lāʻau lapaʻau i loko o kahi pahu i kaha ʻia a noʻonoʻo e hoʻohana i kahi mea hoʻonohonoho pila e kōkua ai i ka pale ʻana i ka overdose ulia. Inā noho ʻoe me nā poʻe ʻē aʻe, e hōʻoia ʻaʻole lākou e lawe i kāu lāʻau lapaʻau, no ka mea, ua kauoha ʻia no kou maʻi.

He aha kaʻu e hana ai inā e poina iaʻu kahi mahele o Acalabrutinib?

Inā e poina iā ʻoe kahi mahele o acalabrutinib a ua hala ma mua o 3 mau hola mai kou manawa i hoʻonohonoho ʻia, e hele a lawe. Inā ua hala ma mua o 3 mau hola, e lele i ka mahele i poina a lawe i kāu mahele i hoʻonohonoho ʻia e hiki mai ana i ka manawa maʻamau.

Mai lawe i kahi mahele pālua e hoʻoponopono ai i ka mea i poina, no ka mea, hiki i kēia ke hoʻonui i kou pilikia o nā hopena ʻaoʻao. Akā, e hoʻomau wale me kāu papa hana maʻamau a e hōʻike i kāu hui mālama ola e pili ana i ka mahele i poina i kāu manawa e hiki mai ana.

Hiki i ka hoʻonohonoho ʻana i nā ʻōhua kelepona a i ʻole ka hoʻohana ʻana i kahi polokalamu hoʻomanaʻo lāʻau lapaʻau ke kōkua iā ʻoe e noho ma ke ala me kāu papa hana. ʻO ka manawa kūpono e kōkua ai i ka mālama ʻana i nā pae paʻa o ka lāʻau lapaʻau i loko o kāu ʻōnaehana no ka maikaʻi loa.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Acalabrutinib?

Pono ʻoe e hooki i ka lawe ʻana iā acalabrutinib ma lalo o ke alakaʻi pololei a kāu hui mālama ola. No ka hapa nui o nā poʻe me nā maʻi koko, pono e lawe ʻia kēia lāʻau lapaʻau no ka wā lōʻihi e mālama ai i ka maʻi ma lalo o ka mana.

E loiloi mau kāu kauka inā e hana pono ana ʻo acalabrutinib a inā e hoʻomau nā pōmaikaʻi i ka lanakila ʻana i nā hopena ʻaoʻao āu e ʻike nei. Hiki iā lākou ke hoʻoponopono i kāu mahele a i ʻole e hoʻomaha i ka lāʻau no ka manawa inā pono, akā ʻo ka hooki ʻana i ka piha e koi i ka noʻonoʻo pono.

Inā ʻoe e ʻike nei i nā hopena ʻaoʻao e pili ana i kou maikaʻi o ke ola, e kamaʻilio me kāu hui mālama ola e pili ana i nā hoʻolālā hoʻokele ma mua o ka hooki ʻana i ka lāʻau lapaʻau iā ʻoe iho. ʻO ka pinepine, hiki ke mālama ʻia nā hopena ʻaoʻao i ka wā e hoʻomau ana i ka lāʻau lapaʻau maʻi maikaʻi.

Hiki iaʻu ke inu i ka waiʻona i ka wā e lawe ana iā Acalabrutinib?

He mea maikaʻi ka palena ʻana i ka inu ʻana i ka waiʻona i ka wā e lawe ana i ka acalabrutinib, akā hiki ke ʻae ʻia nā mea liʻiliʻi e pili ana i kou olakino holoʻokoʻa. Hiki i ka waiʻona ke hoʻonui i kou pilikia o ke kahe ʻana o ke koko a hiki ke keakea i ka hiki o kou kino ke hakakā i nā maʻi.

E kamaʻilio me kāu hui mālama ola e pili ana i ka nui o ka waiʻona, inā he, palekana iā ʻoe iho. E noʻonoʻo lākou i nā mea e like me ka hana o kou ate, nā lāʻau lapaʻau ʻē aʻe āu e lawe nei, a me kou kūlana olakino holoʻokoʻa i ka wā e hana ai i nā ʻōlelo aʻoaʻo.

Inā koho ʻoe e inu i ka waiʻona i kekahi manawa, e nānā i ke ʻano o ka hopena iā ʻoe, no ka mea, hiki i ka acalabrutinib ke hoʻololi i ke ʻano o ka hana ʻana o kou kino i ka waiʻona. E hāʻawi mau i ka mea nui i kou olakino a me ka mālama ʻana i ka maʻi ma mua o ka inu ʻana i ka nohona.