He aha ʻo Adagrasib: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aʻe

ʻO Adagrasib kahi lāʻau lapaʻau i manaʻo ʻia e pale ana i nā proteins kikoʻī e kōkua ana i kekahi mau maʻi ʻaʻai e ulu. Ua hoʻolālā ʻia e mālama i ka maʻi ʻaʻai māmā holomua a me ka maʻi ʻaʻai colorectal e lawe ana i kahi loli genetic i kapa ʻia ʻo KRAS G12C. ʻO kēia lāʻau lapaʻau waha e hōʻike ana i kahi holomua i ka lāʻau lapaʻau pololei, e hāʻawi ana i ka manaʻolana no nā maʻi i paʻakikī i ka mālama ʻana i nā lāʻau lapaʻau kuʻuna.

He aha ʻo Adagrasib?

ʻO Adagrasib kahi lāʻau lapaʻau maʻi ʻaʻai i kuhikuhi ʻia e pili ana i kahi papa i kapa ʻia ʻo KRAS G12C inhibitors. Hana ia ma ka manaʻo a me ka pale ʻana i kahi protein i hoʻololi ʻia e alakaʻi ana i ka ulu ʻana o nā cell maʻi ʻaʻai i nā ʻano maʻi ʻaʻai. Ua hoʻomohala ʻia ka lāʻau lapaʻau no nā maʻi ʻaʻai i hōʻike maikaʻi ʻia no ka loli KRAS G12C, e kū ana ma kahi o 13% o nā maʻi ʻaʻai māmā a me 3% o nā maʻi ʻaʻai colorectal.

Ua manaʻo ʻia kēia lāʻau lapaʻau he lāʻau lapaʻau i manaʻo ʻia ma mua o ka chemotherapy kuʻuna. ʻAʻole like me ka chemotherapy e pili ana i nā cell olakino a me nā cell maʻi ʻaʻai, ua manaʻo ʻo adagrasib i ka protein KRAS i hoʻololi ʻia i loaʻa i nā cell maʻi ʻaʻai wale nō. ʻO kēia ʻano hana pololei e alakaʻi pinepine i nā hopena ʻaoʻao liʻiliʻi i hoʻohālikelike ʻia me nā lāʻau lapaʻau maʻi ʻaʻai maʻamau.

No ke aha e hoʻohana ʻia ai ʻo Adagrasib?

Hoʻohana nui ʻia ʻo Adagrasib e mālama i ʻelua ʻano maʻi ʻaʻai holomua i nā pākeke. E kuhikuhi wale kāu kauka i kēia lāʻau lapaʻau inā hōʻike maikaʻi kāu maʻi i ka loli KRAS G12C ma o ka hoʻāʻo genetic kūikawā.

Mālama ka lāʻau lapaʻau i ka maʻi ʻaʻai māmā ʻole i hohola i nā ʻāpana ʻē aʻe o kou kino a i ʻole hiki ʻole ke wehe ʻia me ke ʻoki. Ua ʻae ʻia no nā maʻi i hoʻāʻo mua i hoʻokahi lāʻau lapaʻau ʻōnaehana ʻē aʻe. Nui nā maʻi me kēia ʻano maʻi ʻaʻai māmā i loaʻa nā koho lapaʻau liʻiliʻi ma mua o ka loaʻa ʻana o adagrasib.

Hoʻohana ʻia ʻo Adagrasib no ka mālama ʻana i ka maʻi ʻaʻai kolorectal holomua i laha ma waho o ka ʻōpū nui a i ʻole ka ʻōpū. No ka maʻi ʻaʻai kolorectal, hoʻohana ʻia ia i ka wā i holomua ai ka maʻi ʻaʻai ma hope o ka mālama ʻana me nā ʻano chemotherapy i hoʻokumu ʻia i ka fluoropyrimidine, oxaliplatin, a me irinotecan. He holomua nui kēia no nā maʻi me ka maʻi ʻaʻai kolorectal KRAS G12C-positive, i loaʻa i nā hopena lapaʻau maikaʻi ʻole i ka wā ma mua.

Pehea e Hana ai ʻo Adagrasib?

Hana ʻo Adagrasib ma ka pale ʻana i ka protein KRAS G12C e hana ana e like me ka hoʻololi hewa i loko o nā pūnaewele maʻi ʻaʻai. I loko o nā pūnaewele olakino, kōkua ka protein KRAS i ka mālama ʻana i ka ulu ʻana a me ka mahele ʻana o nā pūnaewele. Ke lilo kēia protein i mutated i KRAS G12C, paʻa ia i ke kūlana

Pono ʻoe e lawe i ka adagrasib me ka meaʻai e kōkua i kou kino e komo pono i ka lāʻau. ʻO ka ʻai ʻana i ka meaʻai a i ʻole ka ʻai nui ʻana i ka wā e lawe ai ʻoe i kāu mahele e hōʻemi i ka pilikia o ka ʻōpū a hoʻomaikaʻi i ka hana ʻana o ka lāʻau lapaʻau. E hoʻāʻo e lawe i kāu mau mahele i nā manawa like i kēlā me kēia lā e mālama i nā pae kūlike i loko o kou kahe koko.

E ale i nā papa holoʻokoʻa me ke aniani wai piha. Mai ʻoki, nau, a i ʻole e māhele i nā papa, no ka mea, hiki i kēia ke hoʻopilikia i ka hoʻokuʻu ʻia ʻana o ka lāʻau lapaʻau i loko o kou kino. Inā pilikia ʻoe i ka ale ʻana i nā papa, e kamaʻilio me kāu hui mālama ola e pili ana i nā hoʻolālā e kōkua ai.

E pale i ka hua waina a me ka wai hua waina i ka wā e lawe ana i ka adagrasib, no ka mea, hiki i kēia mau mea ke keakea i ka hana ʻana o kou kino i ka lāʻau lapaʻau. Eia kekahi, e haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau a i ʻole nā mea hoʻohui ʻē aʻe āu e lawe nei, no ka mea, hiki i kekahi ke launa pū me ka adagrasib.

Pehea ka lōʻihi e lawe ai au i ka Adagrasib?

E hoʻomau ʻoe i ka lawe ʻana i ka adagrasib no ka lōʻihi e kōkua ana i ka mālama ʻana i kāu maʻi maʻi a ke ʻae maikaʻi nei ʻoe. Hiki i kēia ke mau mahina a i ʻole nā makahiki, ma muli o ka pane ʻana o kāu maʻi maʻi i ka lāʻau. E nānā mau kāu kauka i kou holomua ma o nā scans a me nā hoʻokolohua koko e hoʻoholo ai inā e hana pono ana ka lāʻau lapaʻau.

He ʻokoʻa nui ka lōʻihi o ka lāʻau lapaʻau mai kēlā me kēia kanaka ma muli o nā kumu he nui. Pono paha kekahi poʻe maʻi e hoʻoponopono i ka mahele a i ʻole nā hoʻomaha manawa inā loaʻa iā lākou nā hopena ʻaoʻao. Hiki i nā mea ʻē aʻe ke hoʻomau i ka mahele like no nā manawa lōʻihi inā paʻa a emi paha kā lākou maʻi maʻi.

E hoʻonohonoho kāu oncologist i nā hōʻike maʻamau e loiloi i kāu pane ʻana i ka lāʻau a nānā i nā loli e pili ana. Hoʻopili pinepine kēia mau manawa i nā hoʻokolohua kino, ka hana koko, a me nā scans kiʻi i kēlā me kēia mahina. Ma muli o kēia mau hopena, e hoʻoholo kāu kauka inā e hoʻomau, hoʻololi, a i ʻole e hoʻōki i kāu lāʻau adagrasib.

He aha nā hopena ʻaoʻao o Adagrasib?

E like me nā lāʻau lapaʻau maʻi 'aʻai a pau, hiki i ka adagrasib ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole e loaʻa iā lākou nā mea a pau. Hiki ke mālama ʻia ka hapa nui o nā hopena ʻaoʻao me ka mālama olakino kūpono a me ka nānā ʻana. E hana pū kāu hui mālama ola me ʻoe e pale a hōʻemi paha i nā hōʻailona hōʻoluʻolu ʻole.

ʻO nā hopena ʻaoʻao maʻamau e loaʻa ana i nā maʻi he nui, ʻo ia ka luhi, ka nausea, a me ka maʻi maʻi. Hoʻomohala maʻamau kēia mau mea i nā pule mua o ka mālama ʻana i ka wā e hoʻoponopono ai kou kino i ka lāʻau lapaʻau:

• Luhi a i ʻole ka luhi ma mua o ka maʻamau
• Nausea a me ka luaʻi i kekahi manawa
• Maʻi maʻi a i ʻole nā ​​pahu ʻoluʻolu
• Hoʻemi ʻia ka ʻai
• ʻO ka ʻeha ʻiʻo a i ʻole ka hui
• ʻO ka ʻili ʻili a i ʻole ka ʻili maloʻo
• Poʻo

He maʻalahi a maʻalahi paha kēia mau hopena ʻaoʻao maʻamau a pinepine e hoʻomaikaʻi i ka wā e hoʻopili ai kou kino i ka lāʻau lapaʻau. Hiki i kāu kauka ke kau i nā lāʻau lapaʻau e kōkua i ka mālama ʻana i ka nausea a me ka maʻi maʻi inā pono.

Hiki i kekahi poʻe maʻi ke loaʻa nā hopena ʻaoʻao koʻikoʻi e koi ai i ka lāʻau lapaʻau koke. ʻOiai ʻaʻole maʻamau kēia mau mea, he mea nui e ʻike iā lākou i ka wā mua:

• Maʻi maʻi nui ʻaʻole e pane i ka lāʻau lapaʻau
• Nā hōʻailona o nā pilikia o ke akepaʻa e like me ka melemele o ka ʻili a i ʻole nā ​​maka
• Ke kahe koko ʻano ʻē a i ʻole ka ʻeha
• Luhi nui a i ʻole nāwaliwali
• Ka wela mau a i ʻole nā ​​hōʻailona o ka maʻi
• Nā hopena ʻili koʻikoʻi

E hoʻokaʻaʻike koke i kāu hui mālama ola inā loaʻa iā ʻoe kekahi o kēia mau hōʻailona koʻikoʻi. Hiki iā lākou ke hāʻawi i ke alakaʻi ʻana i ka mālama ʻana i nā hopena ʻaoʻao a hiki ke hoʻololi i kāu hoʻolālā lapaʻau inā pono.

ʻO wai ka mea ʻaʻole pono e lawe i ka Adagrasib?

ʻAʻole kūpono ka Adagrasib no nā mea a pau, a e loiloi pono kāu kauka inā kūpono ia iā ʻoe. Hiki i kekahi mau maʻi olakino a i ʻole nā ​​kūlana ke palekana ʻole a i ʻole ka maikaʻi ʻole o kēia lāʻau lapaʻau no kāu kūlana.

ʻAʻole pono ʻoe e lawe i ka adagrasib inā hāpai ʻoe a i ʻole e hoʻolālā ana e hāpai. Hiki i kēia lāʻau lapaʻau ke hōʻeha i kahi pēpē e ulu ana, no laila he mea nui ka pale ʻana i ka hāpai ʻana i ka wā e mālama ʻia ai a no kekahi mau pule ma hope o ka pau ʻana. Pono nā wahine o ka makahiki hānau e hana i nā hoʻokolohua hāpai ma mua o ka hoʻomaka ʻana i ka mālama ʻana.

ʻAʻole pono nā makuahine e hānai ana i ka waiū e lawe i ka adagrasib, no ka mea, hiki i ka lāʻau lapaʻau ke hele i loko o ka waiū umauma a hiki ke hōʻeha i kahi pēpē e hānai ana. E kūkākūkā kāu kauka i nā koho hānai palekana inā pono ʻoe i kēia lapaʻau i ka wā e loaʻa ana iā ʻoe kahi keiki ʻōpio.

ʻAʻole hiki i ka poʻe me nā pilikia ate koʻikoʻi ke lawe palekana i ka adagrasib, no ka mea, ua hana ʻia ka lāʻau lapaʻau ma o ke ake. E nānā kāu kauka i kāu hana ate me nā hoʻokolohua koko ma mua o ka hoʻomaka ʻana i ka mālama ʻana a e nānā mau ia i kāu mālama ʻana.

Inā ʻoe e lawe ana i kekahi mau lāʻau lapaʻau e launa pū me ka adagrasib, pono paha i kāu kauka e hoʻoponopono i nā ʻano lāʻau a i ʻole e koho i nā lāʻau lapaʻau ʻē aʻe. Aia kēia i kekahi mau mea hoʻokahe koko, nā lāʻau lapaʻau puʻuwai, a me nā lāʻau lapaʻau maʻi ʻē aʻe. E hāʻawi mau i kāu hui mālama ola i kahi papa inoa piha o nā lāʻau lapaʻau a me nā mea hoʻohui āu e lawe nei.

Inoa Brand Adagrasib

Kūʻai ʻia ʻo Adagrasib ma lalo o ka inoa brand Krazati ma ʻAmelika Hui Pū ʻIa. ʻO kēia wale nō ka inoa brand i loaʻa i kēia manawa no kēia lāʻau lapaʻau, no ka mea, he lāʻau lapaʻau i manaʻo ʻia i ʻae ʻia e ka FDA.

Ke kiʻi ʻoe i kāu kauoha, e ʻike ʻoe iā

No nā maʻi me nā maʻi maʻi KRAS G12C-positive, he ʻāpana ʻo adagrasib o kahi papa hana hou o nā lāʻau lapaʻau i manaʻo ʻia, akā ʻaʻole ʻo ia wale nō ke koho i loaʻa. ʻO Sotorasib (inoa inoa Lumakras) kekahi mea hoʻopaʻa KRAS G12C e hana like me adagrasib a hiki ke noʻonoʻo ʻia ma ke ʻano he lapaʻau ʻē aʻe.

Inā ʻaʻole kūpono ka lāʻau lapaʻau i manaʻo ʻia no kou kūlana, hiki i kāu oncologist ke ʻōlelo aku i nā ʻano chemotherapy kuʻuna. Hiki i kēia mau mea ke komo i nā hui chemotherapy i hoʻokumu ʻia i ka platinum, nā lāʻau immunotherapy e like me pembrolizumab, a i ʻole nā lāʻau lapaʻau i manaʻo ʻia e pili ana i nā hōʻailona genetic hou aʻe e lawe ai kāu maʻi maʻi.

Hiki i nā hoʻokolohua lapaʻau ke hāʻawi i ke komo ʻana i nā lāʻau lapaʻau hoʻokolohua hou no nā maʻi maʻi KRAS G12C-positive. Hiki i kāu kauka ke kōkua iā ʻoe e ʻimi inā hiki iā ʻoe ke pōmaikaʻi mai ka komo ʻana i nā haʻawina noiʻi e hoʻāʻo ana i nā lāʻau lapaʻau hui a i ʻole nā mea hoʻopaʻa KRAS hanauna hou.

Ua ʻoi aku ka maikaʻi o Adagrasib ma mua o Sotorasib?

Hoʻopaʻa ʻo Adagrasib a me sotorasib i ka hoʻololi KRAS G12C like, akā he mau ʻokoʻa ko lākou e hiki ai ke kūpono kekahi no kāu kūlana kikoʻī. Hōʻike nā haʻawina e hiki i ka adagrasib ke komo maikaʻi i ka lolo, he mea nui paha kēia inā loaʻa iā ʻoe ka maʻi maʻi i laha i ka lolo.

Ua like nā ʻaoʻao hopena ma waena o nā lāʻau lapaʻau ʻelua, ʻoiai e ʻae kekahi mau maʻi i kekahi ma mua o kekahi. Lawe ʻia ʻo Adagrasib ʻelua i ka lā, ʻoiai e lawe ʻia ʻo sotorasib hoʻokahi i ka lā, hiki ke hoʻopili i kāu makemake e pili ana i kou ola a me ka papa manawa.

E noʻonoʻo kāu oncologist i nā mea e like me kou olakino holoʻokoʻa, ka nui o kāu maʻi maʻi, nā lāʻau lapaʻau i loaʻa iā ʻoe, a me kāu mau makemake pilikino i ke koho ʻana ma waena o kēia mau koho. Hōʻike nā lāʻau lapaʻau ʻelua i nā holomua nui i ka mālama ʻana i nā maʻi maʻi KRAS G12C-positive, a ʻokoʻa ke koho maikaʻi loa mai kēlā me kēia kanaka.

Nā nīnau i nīnau pinepine ʻia e pili ana iā Adagrasib

He palekana anei ʻo Adagrasib no ka poʻe me ka maʻi puʻuwai?

Hiki ke hoʻohana ʻia ʻo Adagrasib i ka poʻe me ka maʻi puʻuwai, akā pono ka nānā pono ʻana e kāu hui mālama ola. Hiki i ka lāʻau lapaʻau ke hoʻopilikia i ka puʻuwai a me ke koko, no laila e hana paha kāu kauka i nā hoʻokolohua hana puʻuwai ma mua o ka hoʻomaka ʻana i ka lāʻau a e nānā pono iā ʻoe i ka wā o ka lāʻau.

Inā he moʻolelo kou o nā pilikia puʻuwai, e hana pū kāu cardiologist a me ka oncologist e hōʻoia i ka ʻoi aku o nā pōmaikaʻi o ka lāʻau lapaʻau ma mua o nā pilikia cardiovascular. Hiki iā lākou ke ʻōlelo aku i ka nānā ʻana i ka puʻuwai pinepine a i ʻole e hoʻoponopono i nā lāʻau lapaʻau ʻē aʻe āu e lawe nei no kou maʻi puʻuwai.

He aha kaʻu e hana ai inā ua hoʻohana hewa au i ka nui o Adagrasib?

Inā ua lawe hewa ʻoe i ka nui o ka adagrasib ma mua o ka mea i kauoha ʻia, e hoʻokaʻaʻike koke i kāu kauka a i ʻole ke kikowaena mana ʻawa. Mai kali e ʻike inā e ulu nā hōʻailona, no ka mea, ʻo ka lawe ʻana i ka nui hiki ke hoʻoulu i nā hopena ʻaoʻao koʻikoʻi e like me ka maʻi maʻi nui, nā pilikia o ke ake, a i ʻole nā ​​hoʻololi weliweli i kāu helu koko.

E mālama i ka manawa āu i lawe ai i ka mahele hou a me ka nui āu i lawe ai. E kōkua kēia ʻike i kāu hui mālama ola e hoʻoholo i ke ala maikaʻi loa e hana ai. Hiki iā lākou ke makemake e nānā pono iā ʻoe a i ʻole e hoʻoponopono i kāu mau mahele i hoʻonohonoho ʻia.

He aha kaʻu e hana ai inā ua hala au i kahi mahele o Adagrasib?

Inā ua hala ʻoe i kahi mahele o ka adagrasib, e lawe koke iā ia ke hoʻomanaʻo ʻoe, inā aia i loko o 6 mau hola o kou manawa i hoʻonohonoho ʻia. Inā ua hala ma mua o 6 mau hola, e lele i ka mahele i hala a lawe i kāu mahele aʻe i ka manawa maʻamau. Mai lawe i ʻelua mahele i ka manawa hoʻokahi e hoʻopiha ai i kahi mahele i hala.

E hoʻāʻo e mālama i kāu papa hana maʻamau e like me ka hiki, no ka mea, he mea nui ka pae koko mau o ka lāʻau lapaʻau no ka pono. E noʻonoʻo e hoʻonohonoho i nā ʻōhua kelepona a i ʻole e hoʻohana i kahi mea hoʻonohonoho pila e kōkua iā ʻoe e hoʻomanaʻo i kāu mau mahele.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Adagrasib?

Pono ʻoe e hooki i ka lawe ʻana i ka adagrasib ma lalo o ke alakaʻi a kāu kauka. Hana pinepine ʻia kēia ke hōʻike nā scans ʻaʻole e pane hou ana kāu maʻi kanesa i ka lāʻau, ke lilo nā hopena ʻaoʻao i mea paʻakikī loa ke mālama ʻia, a i ʻole ke komo kāu maʻi kanesa i ke kala piha a hoʻoholo kāu kauka he palekana ke hooki.

Mai hooki i ka lawe ʻana i ka adagrasib ma kāu iho, ʻoiai inā ʻoe e ʻoi aku ka maikaʻi a i ʻole e ʻike ana i nā hopena ʻaoʻao. ʻO ka hooki ʻana i ka hiki ke ʻae i kāu maʻi kanesa e ulu wikiwiki. Inā pilikia ʻoe i nā hopena ʻaoʻao, e kamaʻilio me kāu hui mālama ola e pili ana i nā ala e mālama ai iā lākou ma mua o ka hooki ʻana i ka lāʻau.

Hiki iaʻu ke lawe i ka Adagrasib me nā Lāʻau Lapaʻau Kanesa ʻē aʻe?

Hoʻohana pinepine ʻia ka Adagrasib ma ke ʻano he mea hoʻokahi, akā hiki i kāu kauka ke hoʻohui pū me nā lāʻau lapaʻau ʻē aʻe e pili ana i kāu kūlana kikoʻī. Loaʻa i kekahi poʻe maʻi me nā lāʻau lapaʻau kākoʻo a i ʻole ka radiation therapy i nā wahi kikoʻī kahi i laha ai ka maʻi kanesa.

ʻO ka hoʻohui ʻana i ka adagrasib me nā lāʻau kanesa ʻē aʻe e koi i ka hoʻolālā a me ka nānā ʻana, no ka mea, hiki i nā pilina ke hoʻopilikia i ka maikaʻi o ka hana ʻana o kēlā me kēia lāʻau a i ʻole e hoʻonui i nā hopena ʻaoʻao. E hoʻolālā kāu oncologist i kahi hoʻolālā lapaʻau e hoʻonui i nā pōmaikaʻi i ka wā e hōʻemi ana i nā pilikia e pili ana i ka noiʻi hou loa a me kāu mau pono pilikino.