He aha ʻo Adalimumab-adaz: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

ʻO Adalimumab-adaz he mana biosimilar o ka lāʻau adalimumab i hoʻohana nui ʻia, i hoʻolālā ʻia e mālama i nā maʻi autoimmune like ʻole ma ka hoʻomaha ʻana i kāu ʻōnaehana pale nui. E noʻonoʻo iā ia he lāʻau lapaʻau i manaʻo ʻia e kōkua i ka hoʻihoʻi ʻana i ke kaulike ke hoʻouka hewa ʻana o ka ʻōnaehana pale o kou kino i nā ʻiʻo olakino.

No kēia lāʻau lapaʻau i kahi papa i kapa ʻia ʻo TNF blockers, e hana ana ma ka ālai ʻana i kahi protein kikoʻī e hoʻoulu ai i ka mumū i nā kūlana e like me ka rheumatoid arthritis, psoriasis, a me ka maʻi ʻāʻī inflammatory. ʻO ka hoʻomaopopo ʻana i ka hana ʻana o kēia lāʻau lapaʻau hiki ke kōkua iā ʻoe e manaʻoʻiʻo i kāu huakaʻi lapaʻau.

He aha ʻo Adalimumab-adaz?

ʻO Adalimumab-adaz he lāʻau biosimilar e hoʻohālike i nā hopena o ka adalimumab kumu. ʻO ka biosimilar he mana like loa ia o kahi lāʻau lapaʻau biologic i ʻae ʻia, e hālāwai ana i nā kūlana palekana a me ka pono.

ʻO kēia lāʻau lapaʻau he monoclonal antibody, ʻo ia hoʻi, he protein i hana ʻia i ka lab i hoʻolālā ʻia e kuhikuhi i nā ʻāpana kikoʻī o kāu ʻōnaehana pale. Hāʻawi ʻia ma ke ʻano he injection ma lalo o kou ʻili, maʻamau i kou ʻūhā a i ʻole ka ʻōpū, a hana ma ka ālai ʻana i ka tumor necrosis factor (TNF), kahi protein e hana ai i ka mumū ke loaʻa i ka nui.

ʻO ka ʻāpana

Eia nā maʻi nui e hiki i kēia lāʻau lapaʻau ke kōkua i ka mālama ʻana, e hōʻike ana kēlā me kēia i kahi ala ʻokoʻa e hiki ai i kāu ʻōnaehana pale ke hana nui:

• Rheumatoid arthritis - ke hoʻouka nei kāu ʻōnaehana pale i kou mau hono, e hana ana i ka ʻeha a me ka pehu
• Psoriatic arthritis - he hui pū ʻana o ka psoriasis ʻili a me ka mumū hono
• Ankylosing spondylitis - ka mumū e pili ana i kou iwi kuamoʻo a me ka pelvis
• Maʻi ʻo Crohn - ka mumū mau o kāu ʻōnaehana digestive
• Ulcerative colitis - ka mumū a me nā ʻōpū i loko o kou kolonā a me ka rectum
• Plaque psoriasis - nā pā mānoanoa a me ka unahi ma kou ʻili
• Hidradenitis suppurativa - nā puʻupuʻu ʻeha ma lalo o kou ʻili, pinepine i nā ʻāpana lima a i ʻole nā ʻūhā

Na kāu mea mālama ola e hoʻoholo inā kūpono kēia lāʻau lapaʻau no kou maʻi kikoʻī e pili ana i kāu mau hōʻailona, ​​ka mōʻaukala olakino, a me ke ʻano o kāu pane ʻana i nā lāʻau lapaʻau ʻē aʻe. ʻO ka pahuhopu ka hōʻemi ʻana i ka mumū a hoʻomaikaʻi i kou maikaʻi o ke ola.

Pehea e hana ai ʻo Adalimumab-adaz?

Hana ʻo Adalimumab-adaz ma ka pale ʻana i ka TNF-alpha, kahi protein e hana ana e like me ka ʻelele i loko o kāu ʻōnaehana pale. Ke loaʻa iā ʻoe kahi maʻi autoimmune, hana kou kino i ka nui o ka TNF-alpha, e hoʻoulu ana i ka mumū ākea.

E noʻonoʻo i ka TNF-alpha ma ke ʻano he kiaʻi palekana nui e hoʻomau nei i ka hoʻopuka ʻana i nā ʻōlelo hoʻopunipuni. ʻO kēia lāʻau lapaʻau e haʻi aku i kēlā kiaʻi palekana e mālie, e hōʻemi ana i ka pane mumū e hana nei i kāu mau hōʻailona.

Ua manaʻo ʻia he lāʻau lapaʻau ikaika a i manaʻo ʻia, no ka mea, e ālai pono ia i hoʻokahi ala i loko o kāu ʻōnaehana pale ma mua o ka hoʻopaʻa ʻana i kāu pane pale holoʻokoʻa. Eia naʻe, no ka mea e pili ana i kāu ʻōnaehana pale, hiki iā ia ke hoʻolilo iā ʻoe i mea maʻalahi i nā maʻi, ʻo ia ke kumu e nānā pono ai kāu kauka iā ʻoe.

Hoʻomaka maʻamau nā hopena i loko o kekahi mau pule a i ʻole mau mahina ma hope o ka hoʻomaka ʻana i ka lāʻau. ʻIke kekahi poʻe i ka maikaʻi koke, aʻo kekahi poʻe e pono paha i kekahi mau mahina e ʻike i nā pōmaikaʻi piha.

Pehea e lawe ai au i ka Adalimumab-adaz?

Hāʻawi ʻia ka Adalimumab-adaz ma ke ʻano he injection subcutaneous, ʻo ia hoʻi, komo ia i loko o ka ʻiʻo momona ma lalo pono o kou ʻili. E hoʻomaka paha ʻoe me kahi mahele hoʻouka, a laila e hahai ʻia e nā injection mālama maʻamau i kēlā me kēia pule ʻē aʻe.

E aʻo aku kāu mea mālama ola iā ʻoe pehea e hoʻokomo ai i ka lāʻau lapaʻau iā ʻoe iho, a i ʻole hiki i kahi lālā o ka ʻohana ke aʻo e kōkua iā ʻoe. Hoʻololi maʻamau nā wahi injection ma waena o kou ʻūhā a me ka ʻōpū, e noho ana ma kahi o hoʻokahi ʻīniha mai kou piko.

Eia nā mea e pono ai ʻoe e ʻike e pili ana i ka lawe pono ʻana i kāu lāʻau lapaʻau:

• Wehe i ka lāʻau lapaʻau mai ka pahu hau 15-30 mau minuke ma mua o ka injection e ʻae iā ia e hiki i ka mahana o ka lumi
• E hoʻomaʻemaʻe i ka wahi injection me kahi swab waiʻona a e maloʻo loa
• E hoʻokomo mālie a paʻa i ka lāʻau lapaʻau, e hahai ana i nā ʻōlelo aʻoaʻo a kāu mea mālama ola
• E hoʻololi i nā wahi injection e pale ai i ka huhū o ka ʻili a i ʻole ka paʻakikī
• E hoʻolei i nā nila a me nā syringes i loko o kahi pahu ʻoi

Hiki iā ʻoe ke lawe i kēia lāʻau lapaʻau me ka ʻole o ka meaʻai, no ka mea, ʻaʻole ia e pili i ka absorption. ʻAʻole pono ka manawa o kāu injection e kūlike me nā meaʻai, akā e hoʻāʻo e hoʻokomo iā ia i ka manawa like i kēlā me kēia pule ʻelua e mālama i nā pae kūlike i kāu ʻōnaehana.

Pehea ka lōʻihi e lawe ai au i ka Adalimumab-adaz?

He ʻokoʻa nui ka lōʻihi o ka mālama ʻana me ka adalimumab-adaz ma muli o kou kūlana kikoʻī a me ka maikaʻi o kou pane ʻana i ka lāʻau lapaʻau. Pono ka hapa nui o ka poʻe me nā maʻi autoimmune i ka mālama lōʻihi no ka mea he mau maʻi maʻamau kēia e pono ai ka mālama mau.

E loiloi mau kāu kauka i kou pane ʻana i ka lāʻau lapaʻau, maʻamau i kēlā me kēia 3-6 mahina i ka wā mua, a laila e emi pinepine paha ke paʻa kou maʻi. E nānā lākou i nā mea e like me ka hoʻomaikaʻi ʻana o nā hōʻailona, ​​nā hōʻailona o ka mumū i loko o ka hale hana, a me nā hopena ʻaoʻao āu e ʻike nei.

Pono paha kekahi poʻe e hoʻomau i kēia lāʻau lapaʻau no nā makahiki, a ʻo nā mea ʻē aʻe e hiki ke hōʻemi i ke alapine a i ʻole e hoʻololi i kahi lāʻau lapaʻau ʻē aʻe inā e hoʻomaikaʻi nui ko lākou maʻi. ʻO ke kī, ʻo ka hana pili loa me kāu hui mālama ola e ʻimi i ke kaulike kūpono ma waena o ka mālama ʻana i kāu mau hōʻailona a me ka hōʻemi ʻana i nā pilikia hiki ke loaʻa.

Mai hooki i ka lawe ʻana i ka adalimumab-adaz me ka ʻole e kūkākūkā i kāu kauka, ʻoiai inā ʻoe e ʻoi aku ka maikaʻi. ʻO ka hooki ʻana koke ʻana hiki ke alakaʻi i ka piʻi ʻana o kou maʻi maʻi, ʻoi aku ka paʻakikī o ka mālama ʻana ma mua.

He aha nā hopena ʻaoʻao o Adalimumab-adaz?

E like me nā lāʻau lapaʻau a pau e pili ana i kāu ʻōnaehana pale, hiki i ka adalimumab-adaz ke hana i nā hopena ʻaoʻao, ʻoiai e ʻae maikaʻi ka poʻe he nui. ʻO ka hoʻomaopopo ʻana i ka mea e manaʻo ai hiki ke kōkua iā ʻoe e ʻike i ka wā e pono ai kekahi mea i ka lāʻau lapaʻau e kūʻē i nā hopena maʻamau, hiki ke mālama ʻia.

ʻO nā hopena ʻaoʻao maʻamau he maʻamau a maʻamau e hoʻomaikaʻi i ka wā e hoʻoponopono ai kou kino i ka lāʻau lapaʻau:

• Nā hopena o ka pūnaewele injection - ʻulaʻula, pehu, a i ʻole ka ʻūhā kahi āu e hoʻokomo ai
• Nā maʻi hanu luna - nā hōʻailona e like me ke anu a i ʻole ka congestion sinus
• Nā poʻo - maʻamau ka maʻalahi a hiki ke mālama ʻia me nā mea hōʻoluʻolu ʻeha ma luna o ka pāʻani
• Rash - nā hopena ʻili e ʻike ʻia ma nā wahi a pau o kou kino

Pono nā hopena ʻaoʻao koʻikoʻi i ka lāʻau lapaʻau koke, ʻoiai ʻaʻole maʻamau lākou. Hiki mai kēia no ka mea e pili ana ka lāʻau lapaʻau i ka hiki o kāu ʻōnaehana pale e hakakā i nā maʻi a ʻike i nā cell abnormal:

• Nā maʻi nui - ke kuni, nā hōʻailona e like me ka maʻi flu, a i ʻole nā hōʻailona o nā maʻi bacteria, viral, a i ʻole fungal
• Luhi a nāwaliwali paha i maʻa ʻole e hoʻomaikaʻi me ka hoʻomaha
• Ke kuni mau, nā sweats pō, a i ʻole ka lilo ʻana o ke kaumaha i wehewehe ʻole ʻia
• Nā hōʻailona neurological hou a i ʻole e ʻino nei e like me ka ʻehaʻeha, ka ʻūlū, a i ʻole nā loli ʻike

ʻO nā hopena ʻaoʻao laha ʻole akā koʻikoʻi e komo pū ana me ka hoʻāla hou ʻana o ka hepatitis B (inā ua loaʻa iā ʻoe ma mua), kekahi mau ʻano maʻi ʻaʻai, a me nā hopena maʻi maʻi koʻikoʻi. E nānā kāu kauka iā ʻoe no kēia mau mea pilikia ma mua o ka hoʻomaka ʻana i ka lāʻau a e nānā iā ʻoe i nā manawa a pau.

ʻO wai ka mea pono ʻole e lawe iā Adalimumab-adaz?

ʻAʻole kūpono ʻo Adalimumab-adaz no nā mea a pau, ʻoiai ʻo ka poʻe me kekahi mau maʻi a i ʻole nā maʻi ʻōnaehana pale. E nānā pono kāu kauka i kāu mōʻaukala olakino a me ke kūlana olakino i kēia manawa ma mua o ke kau ʻana i kēia lāʻau.

ʻAʻole pono ʻoe e lawe iā adalimumab-adaz inā loaʻa iā ʻoe kahi maʻi koʻikoʻi i kēia manawa, o kēlā me kēia ʻano. Pākuʻi ʻia kēia me nā maʻi bacteria, viral, a i ʻole fungal e hakakā nei kou kino, no ka mea, hiki i ka lāʻau ke hoʻonui i kēia mau maʻi a i ʻole e paʻakikī ke mālama.

ʻO nā kūlana koʻikoʻi ʻē aʻe e pale ai iā ʻoe mai ka lawe ʻana i kēia lāʻau lapaʻau:

• ʻO ka maʻi tuberculosis ikaika a i ʻole ka mōʻaukala o ka tuberculosis i mālama ʻole ʻia
• Maʻi maʻi hepatitis B (ikaika a i ʻole maʻi mau)
• ʻO ka maʻi puʻuwai koʻikoʻi (Class III a i ʻole IV)
• Nā maʻi maʻi i ʻike ʻia i adalimumab a i ʻole kekahi o kāna mau mea
• Nā lāʻau lapaʻau ola hou a i ʻole i hoʻolālā ʻia

E akahele loa kāu kauka inā he mōʻaukala kou o ka maʻi ʻaʻai, nā maʻi hou, ka maʻi diabetes, a i ʻole ka maʻi ate. ʻAʻole pono kēia mau kūlana e pale iā ʻoe mai ka lawe ʻana i ka lāʻau, akā pono lākou i ka nānā ʻana a me nā hoʻolālā lapaʻau i hoʻololi ʻia.

Nā inoa inoa Adalimumab-adaz

Hoʻolaha ʻia ʻo Adalimumab-adaz ma lalo o ka inoa inoa ʻo Hyrimoz ma ʻAmelika Hui Pū ʻIa. Ua hoʻomohala ʻia kēia biosimilar e Sandoz a ua ʻae ʻia e ka FDA ma ke ʻano he koho haʻahaʻa kumukūʻai i ka lāʻau adalimumab mua.

Hiki nō hoʻi iā ʻoe ke lohe i nā mea mālama ola e kuhikuhi ana iā ia ma kona inoa generic, adalimumab-adaz, kahi e kōkua ai ka suffix "adaz" e hoʻokaʻawale iā ia mai nā biosimilars adalimumab ʻē aʻe ma ka mākeke. Hiki i nā ʻāina like ʻole ke loaʻa nā inoa inoa like ʻole no ka lāʻau lapaʻau like.

Ke kūkākūkā ʻana i kāu lāʻau lapaʻau me nā lāʻau lapaʻau a i ʻole nā mea mālama ola ʻē aʻe, he mea kōkua ke haʻi i ka inoa inoa (Hyrimoz) a me ka inoa generic (adalimumab-adaz) e hōʻoia i ka hōʻike ʻana o nā mea a pau i ka lāʻau lapaʻau like.

Nā Koho ʻē aʻe o Adalimumab-adaz

Nui nā koho ʻē aʻe inā ʻaʻole hana maikaʻi ʻo adalimumab-adaz iā ʻoe a i ʻole inā ʻike ʻoe i nā hopena ʻaoʻao nui. Hiki i kāu kauka ke noʻonoʻo i nā mea pale TNF ʻē aʻe, e hana like ana akā he mau papa hana ʻokoʻa a i ʻole nā ​​hopena ʻaoʻao.

ʻO nā koho ʻē aʻe o ka TNF blocker e komo pū ana me etanercept (Enbrel), infliximab (Remicade), certolizumab (Cimzia), a me golimumab (Simponi). Loaʻa i kēlā me kēia me nā ʻano like ʻole e pili ana i ka pinepine o kou lawe ʻana iā lākou a pehea e lawelawe ʻia ai.

Ma waho aʻe o nā TNF blockers, ua manaʻo nā ʻano lāʻau lapaʻau hou i nā ʻāpana like ʻole o ka ʻōnaehana pale:

• Nā mea pale IL-17 e like me secukinumab (Cosentyx) a i ʻole ixekizumab (Taltz)
• Nā mea pale IL-23 e like me ustekinumab (Stelara) a i ʻole guselkumab (Tremfya)
• JAK inhibitors e like me tofacitinib (Xeljanz) a i ʻole baricitinib (Olumiant)
• DMARDs kuʻuna e like me methotrexate a i ʻole sulfasalazine

Aia ke koho o ke koho ʻē aʻe i kāu kūlana kikoʻī, pehea ʻoe i pane ai i nā lāʻau lapaʻau mua, kāu mau makemake ola, a me kāu mau mea pilikia pilikino. E hana kāu kauka me ʻoe e ʻimi i ke koho kūpono loa inā ʻaʻole kūpono ʻo adalimumab-adaz.

ʻOi aku ka maikaʻi o Adalimumab-adaz ma mua o Humira?

Ua hoʻolālā ʻia ʻo Adalimumab-adaz e like ka maikaʻi me Humira (ka adalimumab kumu), akā me nā kumukūʻai haʻahaʻa paha. Loaʻa i nā lāʻau ʻelua ka mea hana like a hana ma ke ʻano like e hōʻemi i ka mumū.

Pono ka FDA i nā biosimilars e like me adalimumab-adaz e hōʻike i ko lākou like loa me ka lāʻau kumu ma ke ʻano o ka palekana a me ka pono. ʻO ia hoʻi, pono ʻoe e manaʻo i nā hopena like inā ʻoe e lawe ana iā Humira a i ʻole adalimumab-adaz.

ʻO nā mea maikaʻi nui o adalimumab-adaz ma luna o Humira e pili pinepine ana i ke kumukūʻai a me ka hiki ke loaʻa. No ka mea, ʻoi aku ka liʻiliʻi o nā biosimilars ma mua o ka lāʻau kumu, hiki iā lākou ke kūʻai aku iā ʻoe a i ʻole makemake ʻia e kāu hui ʻinikua.

ʻIke kekahi poʻe i nā ʻokoʻa liʻiliʻi i ka hiki ke ʻae ʻia a i ʻole nā hopena ma ka pūnaewele injection i ka wā e hoʻololi ai ma waena o nā huahana adalimumab like ʻole, akā he mea liʻiliʻi kēia mau mea. Inā maikaʻi ʻoe i kēia manawa ma Humira, hiki i kāu kauka ke ʻōlelo e noho me ka mea e hana nei, ʻoiai e hiki i nā mea maʻi hou ke hoʻomaka me ke koho biosimilar.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Adalimumab-adaz

Palekana anei ʻo adalimumab-adaz no ka hāpai ʻana?

Holo ʻo Adalimumab-adaz i ka placenta a hiki ke hoʻopilikia i ka ʻōnaehana pale o kāu pēpē e ulu nei. Inā hāpai ʻoe a i ʻole e hoʻolālā ana e hāpai, e kūkākūkā pono i kēia me kāu kauka, no ka mea, pono lākou e kaupaona i nā pōmaikaʻi o ka mālama ʻana i kou maʻi autoimmune e kūʻē i nā pilikia i kāu pēpē.

Nui nā wahine me nā maʻi autoimmune e hoʻomau i ka adalimumab i ka wā hāpai ke ʻoi aku ka maikaʻi ma mua o nā pilikia. Eia naʻe, hiki i kāu kauka ke hoʻololi i kāu hoʻolālā lapaʻau a i ʻole e hōʻike i nā ala ʻē aʻe. Inā ʻoe e lawe i ka adalimumab i ka wā hāpai, pono paha kāu pēpē i ka nānā kūikawā no nā maʻi ma hope o ka hānau ʻana.

He aha kaʻu e hana ai inā ua hoʻohana hewa au i ka nui o adalimumab-adaz?

Inā ua hoʻokomo hewa ʻoe i ka adalimumab-adaz ʻoi aku ma mua o ka mea i kauoha ʻia, e hoʻokaʻaʻike koke aku i kāu mea mālama ola, ʻoiai inā maikaʻi kou manaʻo. ʻOiai he kakaikahi nā mea i ʻoi aku ka nui o kēia lāʻau, hiki i ka lawe ʻana i ka nui ke hoʻonui i kou pilikia o nā maʻi koʻikoʻi a i ʻole nā pilikia ʻē aʻe.

Mai hoʻāʻo e "kaulike" i ka nui o ka lāʻau ma ka haʻalele ʻana i kāu lāʻau aʻe. Akā, e ʻae i kāu kauka e hoʻoholo i ke ala maikaʻi loa, e komo paha i ka nānā pinepine ʻana a i ʻole ka hoʻoponopono ʻana i kāu papa hana injection aʻe.

He aha kaʻu e hana ai inā e poina iaʻu kahi lāʻau adalimumab-adaz?

Inā poina iā ʻoe kahi lāʻau, e lawe koke iā ia ke hoʻomanaʻo ʻoe, a laila e hoʻomau me kāu papa hana maʻamau. Eia naʻe, inā kokoke ka manawa no kāu lāʻau i hoʻonohonoho ʻia aʻe, e haʻalele i ka lāʻau i poina a hoʻomaka hou i kāu hana maʻamau.

Mai lawe i ʻelua lāʻau kokoke i kekahi i kekahi e hoʻopiha i kahi lāʻau i poina. Inā ʻaʻole ʻoe maopopo e pili ana i ka manawa, e hoʻokaʻaʻike aku i kāu mea mālama ola no ke alakaʻi. ʻO ka poina ʻana i nā lāʻau i kekahi manawa ʻaʻole ia e hoʻopilikia koke, akā e hoʻāʻo e mālama i ka kūlike no nā hopena maikaʻi loa.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka adalimumab-adaz?

Pono ʻoe e hooki i ka lawe ʻana i ka adalimumab-adaz ma lalo o ke alakaʻi a kāu kauka, ʻoiai inā maikaʻi kou manaʻo. ʻO nā maʻi autoimmune he maʻamau ka maʻi mau, ʻo ia hoʻi e pono lākou i ka mālama mau ʻana e pale ai i nā flare-ups.

Hiki i kāu kauka ke noʻonoʻo e hōʻemi i ke alapine o nā injections a i ʻole ke hooki ʻana i ka lāʻau inā ua paʻa kou maʻi no ka manawa lōʻihi, akā pono e hana mau kēia hoʻoholo. ʻO ka hooki ʻana i ka wā mua e alakaʻi pinepine i ka hoʻi hou ʻana o nā hōʻailona, ​​i kekahi manawa ʻoi aku ka paʻakikī ma mua o ka mālama ʻana.

Hiki iaʻu ke inu i ka waiʻona i ka wā e lawe ana i ka adalimumab-adaz?

ʻO ka inu ʻana i ka waiʻona maʻalahi he mea maʻamau i ka wā e lawe ana i ka adalimumab-adaz, akā e kūkākūkā i kāu mau hana inu me kāu kauka. No ka mea hiki i ka waiʻona a me kēia lāʻau ke hoʻopilikia i kou ate a me ka ʻōnaehana pale, hiki i kāu kauka ke ʻōlelo e kaupalena i ka inu waiʻona.

Inā e lawe pū ana ʻoe i nā lāʻau ʻē aʻe e like me ka methotrexate me adalimumab-adaz, ʻoi aku paha ke koʻikoʻi o nā kapu waiʻona. Hiki i kāu mea mālama ola ke hāʻawi iā ʻoe i ke alakaʻi kikoʻī e pili ana i kāu hoʻolālā lapaʻau piha a me ke kūlana olakino holoʻokoʻa.