He aha ʻo Aflibercept (ABZV): Nā Hoʻohana, Dosage, Nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau ʻo Aflibercept e kōkua ana i ka mālama ʻana i nā maʻi maka koʻikoʻi e hiki ke hoʻoweliweli i kou ʻike. Ua hoʻolālā ʻia e kuhikuhi i kahi protein i kapa ʻia ʻo VEGF e hoʻoulu ai i ka ulu ʻana o nā kīʻaha koko maʻamau i kou maka. Hāʻawi ʻia kēia lāʻau lapaʻau ma ke ʻano he injection pololei i loko o kou maka e kāu kauka, a ʻoiai he mea hoʻoweliweli paha ia, he lapaʻau maikaʻi ia i kōkua i nā poʻe he nui e mālama i ko lākou ʻike.

He aha ʻo Aflibercept?

He ʻano lāʻau lapaʻau ʻo Aflibercept i kapa ʻia he VEGF inhibitor e ālai ana i nā protein pōʻino i kou maka. E noʻonoʻo i ka VEGF ma ke ʻano he hōʻailona e haʻi ana i kou maka e ulu i nā kīʻaha koko hou, akā i kekahi manawa hele hewa kēia hōʻailona a hana i nā kīʻaha e kahe a i ʻole ke koko. Hana ʻo Aflibercept e like me ka pale, e ālai ana i kēia mau hōʻailona hewa a kōkua i kou maka e hoʻōla pono.

ʻO ka lāʻau lapaʻau he protein i hana ʻia i ka lab e hoʻohālike i ka hiki maoli o kou kino e kāohi i ka ulu ʻana o nā kīʻaha koko. Hāʻawi ʻia ia ma o kahi nila lahilahi loa pololei i loko o ka vitreous, ʻo ia ka mea like me ka gel e hoʻopiha ana i ke kikowaena o kou maka. ʻO kēia ʻano hāʻawi pololei e hōʻoia i ka lāʻau lapaʻau e hōʻea pololei i kahi e pono ai.

No ke aha e hoʻohana ʻia ai ʻo Aflibercept?

Mālama ʻo Aflibercept i kekahi mau maʻi maka koʻikoʻi e hiki ke alakaʻi i ka nalowale o ka ʻike inā ʻaʻole i mālama ʻia. Hiki i kāu kauka ke ʻōlelo aku i kēia lāʻau lapaʻau inā loaʻa iā ʻoe ka degeneration macular e pili ana i ka makahiki, edema macular diabetic, a i ʻole kekahi mau ʻano o nā poloka vein retinal.

ʻO ka maʻi maʻamau i mālama ʻia me ka aflibercept ʻo ia ka degeneration macular e pili ana i ka makahiki, kahi e ulu ai nā kīʻaha koko maʻamau ma lalo o ka retina a kahe i ka wai a i ʻole ke koko. Hiki i kēia kahe ʻana ke hoʻoulu i kou ʻike waena e lilo i mea palaka a i ʻole distorted, e paʻakikī ai ka heluhelu ʻana, ke kalaiwa ʻana, a i ʻole ka ʻike ʻana i nā maka.

Hiki i ka poʻe me ka maʻi diabetes ke hoʻomohala i ka edema macular diabetic, kahi e hōʻino ai ke kiʻekiʻe o ke kō koko i nā kīʻaha koko liʻiliʻi i loko o ka retina, e hoʻoulu ana iā lākou e kahe i ka wai i loko o ka macula. Hiki i kēia pehu ke hoʻopilikia nui i kou ʻike ʻoi, waena e hoʻohana ai ʻoe no nā hana kikoʻī.

Hiki nō hoʻi i kāu kauka ke hoʻohana i ka aflibercept e mālama i nā occlusion vein retinal, e hiki mai ana ke ālō ʻia nā kīʻaha koko i loko o kou retina. Hiki i kēia ālō ke hoʻoulu i ka wai e kūkulu a alakaʻi i nā pilikia ʻike e like me ka blurriness māmā a i ʻole ka nalowale ʻike nui.

Pehea e Hana ai ʻo Aflibercept?

Hana ʻo Aflibercept ma ka ālō ʻana i kahi protein i kapa ʻia ʻo VEGF e paipai ana i ka ulu ʻana o nā kīʻaha koko maʻamau i kou maka. Ke loaʻa iā ʻoe kekahi mau maʻi maka, hana kou kino i ka nui o ka VEGF, e hōʻailona ana i kou maka e hana i nā kīʻaha koko hou e palupalu a kahe maʻalahi.

Ua manaʻo ʻia kēia lāʻau lapaʻau he lāʻau lapaʻau ikaika a maikaʻi no nā kūlana e hoʻoweliweli ana i ka ʻike. Hoʻopili ia i nā protein VEGF e like me ke kī e komo ana i loko o kahi laka, e pale ana iā lākou mai ka hoʻoulu ʻana i ka ulu ʻana o nā kīʻaha koko pilikia. Ma ka hoʻōki ʻana i kēia kaʻina hana, kōkua ʻo aflibercept i ka hōʻemi ʻana i ka pehu, ke kahe ʻana, a me ka leaka wai i kou maka.

Hiki i nā hopena o ka aflibercept ke mau no kekahi mau pule a i ʻole mau mahina, ʻo ia ke kumu ʻaʻole pono ʻoe i nā lāʻau lapaʻau i kēlā me kēia lā. Hoʻoponopono mālie kou maka i ka lāʻau lapaʻau, a e nānā kāu kauka i ka maikaʻi o kāna hana ʻana ma o nā hoʻokolohua maka maʻamau a me nā hoʻokolohua kiʻi.

Pehea wau e lawe ai iā Aflibercept?

Hāʻawi ʻia ʻo Aflibercept ma ke ʻano he injection i loko o kou maka e ke kauka maka kūpono i kahi hoʻonohonoho olakino. ʻAʻole hiki iā ʻoe ke lawe i kēia lāʻau lapaʻau ma ka home, a ʻaʻole i loaʻa ma ke ʻano he kulu maka a i ʻole nā ​​pills.

Ma mua o kāu injection, e hoʻomaʻemaʻe kāu kauka i kou maka a me ka wahi a puni e pale ai i ka maʻi. E hoʻohana lākou i nā kulu numbing e hana i ke kaʻina hana e like me ka ʻoluʻolu. He mau kekona wale nō ka injection maoli, ʻoiai e hiki ke hala ka manawa holoʻokoʻa he 30 mau minuke a i hoʻokahi hola.

ʻAʻole pono ʻoe e hoʻokē ʻai a pale paha i ka ʻai ʻana ma mua o kāu manawa, akā pono ʻoe e hoʻonohonoho i kekahi e hoʻokele iā ʻoe i ka home ma hope. Hiki ke ʻoluʻolu iki kou maka a i ʻole e pōʻeleʻele iki ana kou ʻike ma hope o ka hoʻokomo ʻana.

E hāʻawi kāu kauka iā ʻoe i nā ʻōlelo kikoʻī e pili ana i nā kulu maka a i ʻole nā lāʻau lapaʻau ʻē aʻe e hoʻohana ai ma hope o ka hoʻokomo ʻana. He mea nui e hahai pono i kēia mau ʻōlelo aʻo e hōʻemi i kou pilikia o ka maʻi a kōkua i kou maka e hoʻōla pono.

Pehea ka lōʻihi e lawe ai au i ka Aflibercept?

ʻO ka lōʻihi o ka mālama ʻana me ka aflibercept e loli ana ma muli o kou kūlana kikoʻī a me ka maikaʻi o kou pane ʻana i ka lāʻau lapaʻau. Pono ka hapa nui o nā kānaka i ka mālama mau ʻana no nā mahina a i ʻole nā makahiki e mālama i kā lākou hoʻomaikaʻi ʻana i ka ʻike.

I ka wā mua, e loaʻa paha iā ʻoe nā injections i kēlā me kēia 4 a 8 pule no nā mahina mua. E nānā pono kāu kauka i kāu holomua i kēia manawa e ʻike pehea e pane ai kou maka i ka lāʻau lapaʻau. ʻIke kekahi poʻe i ka hoʻomaikaʻi ʻana i kā lākou ʻike i loko o kekahi mau pule, ʻoiai e pono ana kekahi poʻe i kekahi mau mahina e ʻike i nā loli nui.

Ma hope o ka mālama mua ʻana, hiki i kāu kauka ke hoʻolōʻihi i ka manawa ma waena o nā injections inā paʻa kou kūlana. Hiki i kekahi poʻe ke hele i 3 a 4 mau mahina ma waena o nā lāʻau lapaʻau, ʻoiai e pono ana kekahi poʻe i nā injections pinepine e mālama i kā lākou ʻike.

E hoʻohana kāu kauka maka i nā hoʻokolohua kiʻi kūikawā a me nā loiloi ʻike e hoʻoholo ai i ka papa hana lapaʻau maikaʻi loa nāu. Mai hooki i ka lapaʻau ma kāu iho, no ka mea, hiki i kēia ke alakaʻi i ka ʻino ʻana o kou kūlana a me ka hiki ke nalowale ka ʻike.

He aha nā hopena ʻaoʻao o Aflibercept?

E like me nā lāʻau lapaʻau a pau, hiki i ka aflibercept ke hana i nā hopena ʻaoʻao, ʻoiai e ʻae maikaʻi ana ka nui o nā kānaka. ʻO ka hapa nui o nā hopena ʻaoʻao he maʻalahi a he manawa pōkole, e pili ana i kou maka a i ʻole ka wahi injection.

Eia nā hopena ʻaoʻao maʻamau e hiki ai iā ʻoe ke ʻike ma hope o kāu injection:

• He ʻeha maka maʻalahi a i ʻole ka hōʻoluʻolu ʻole e mau ana no kekahi mau hola
• ʻIke pōpō iki a i ʻole ka ʻike ʻana i nā kiko a i ʻole nā mea lana
• ʻUlaʻula iki a i ʻole ka huhū a puni ka wahi i hoʻokomo ʻia ai
• Hoʻonui ʻia ka naʻau i ka mālamalama no hoʻokahi a ʻelua paha lā
• Ke manaʻo nei me he mea lā aia kekahi mea i loko o kou maka
• He poʻo maʻalahi e hoʻoponopono maʻamau i loko o hoʻokahi lā

ʻAʻole koʻikoʻi kēia mau hopena ʻaoʻao maʻamau a hoʻomaikaʻi i loko o kekahi mau lā. Eia naʻe, pono ʻoe e hoʻokaʻaʻike i kāu kauka inā e mau ana a i ʻole e ʻinoʻino ana.

He kakaikahi nā hopena ʻaoʻao koʻikoʻi akā pono e mālama koke ʻia. Aia i loko o kēia mau hōʻailona o ka maʻi e like me ka ʻeha maka nui, nā loli nui o ka ʻike, a i ʻole ka hoʻokuʻu ʻana mai kou maka. ʻO nā hōʻailona ʻē aʻe e pili ana i ke poʻo nui, ka nalowale koke o ka ʻike, a i ʻole ka ʻike ʻana i nā kukui uila.

I kekahi manawa, hiki i ka aflibercept ke hoʻoulu i nā pilikia koʻikoʻi e like me ka wehe ʻana o ka retina, ka mumū nui i loko o ka maka, a i ʻole ka piʻi ʻana o ke kaomi maka. E nānā pono kāu kauka iā ʻoe no kēia mau hopena ʻaoʻao kakaikahi akā koʻikoʻi i ka wā o kāu mau manawa mālama maʻamau.

Hiki i kekahi poʻe ke ʻike i nā hopena ʻaoʻao e pili ana i ko lākou kino holoʻokoʻa, e like me ke koko kiʻekiʻe a i ʻole ka piʻi ʻana o ka pilikia o nā koko koko. E kūkākūkā kāu kauka i kēia mau pilikia me ʻoe e pili ana i kou olakino holoʻokoʻa a me ka mōʻaukala olakino.

ʻO wai ka mea pono ʻole e lawe i ka Aflibercept?

ʻAʻole kūpono ʻo Aflibercept no nā mea a pau, a e loiloi pono kāu kauka inā palekana ia no ʻoe. ʻAʻole pono ka poʻe me nā maʻi maʻi i loko a i ʻole a puni ka maka e loaʻa i kēia lāʻau lapaʻau a hiki i ka wā e mālama ʻia ai ka maʻi.

Inā he maʻi ʻoe i ka aflibercept a i ʻole kekahi o kāna mau meaʻai, ʻaʻole pono ʻoe e loaʻa i kēia lāʻau lapaʻau. E nīnau kāu kauka e pili ana i kāu mōʻaukala maʻi ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau a hiki ke paipai i ka hoʻāʻo ʻana i ka maʻi inā pono.

Pono paha ka poʻe me kekahi mau maʻi cardiovascular i ka nānā kūikawā a i ʻole nā lapaʻau ʻē aʻe. Pākuʻi ʻia kēia i ka poʻe i loaʻa i ka puʻuwai i kēia manawa, nā hahau, a i ʻole ke koko kiʻekiʻe ʻole i ka mana. E loiloi kāu kauka i nā pōmaikaʻi o ka lapaʻau e kūʻē i kēia mau pilikia.

Pono nā wahine hāpai e pale i ka aflibercept ke ʻole ka nui o nā pōmaikaʻi ma mua o nā pilikia. Inā ʻoe e hoʻolālā nei e hāpai a i ʻole e hāpai ana, e kūkākūkā me kāu kauka e ʻimi i nā koho palekana.

Inā ʻoe e hānai ana i ka waiū, e kamaʻilio me kāu kauka inā palekana ka aflibercept iā ʻoe a me kāu pēpē. Hiki i ka lāʻau lapaʻau ke hele i loko o ka waiū umauma, ʻoiai ʻaʻole maopopo nā hopena i nā pēpē e hānai ana.

Nā inoa inoa o Aflibercept

Loaʻa ka Aflibercept ma lalo o ka inoa inoa Eylea, ʻo ia ke ʻano i kauoha pinepine ʻia o kēia lāʻau. Hana ʻia ʻo Eylea e Regeneron Pharmaceuticals a ʻo ia ka mana i hoʻohana nui ʻia e nā kauka maka no ka mālama ʻana i nā maʻi retinal.

Hiki nō hoʻi iā ʻoe ke lohe i kāu kauka e kuhikuhi ana i nā mana biosimilar o aflibercept, ʻo ia nā lāʻau lapaʻau e hana like ana me ka mea mua akā he ʻokoʻa iki paha i ke ʻano o ka hana ʻana. Pono kēia mau biosimilars e hoʻokō i nā kūlana palekana a me ka pono ma mua o ka ʻae ʻia no ka hoʻohana.

E hōʻoia mau e hoʻomaopopo i ke ʻano kikoʻī o ka aflibercept āu e loaʻa nei, a e haʻi i kāu kauka inā he hopohopo kāu e pili ana i ka hoʻololi ʻana ma waena o nā ʻano like ʻole o ka lāʻau.

Nā koho ʻē aʻe o Aflibercept

Inā ʻaʻole kūpono ka aflibercept iā ʻoe a i ʻole ʻaʻole hana maikaʻi, he nui nā koho lapaʻau ʻē aʻe i loaʻa i kāu kauka. ʻO nā mea pale VEGF ʻē aʻe e like me ranibizumab (Lucentis) a me bevacizumab (Avastin) e hana ma nā ʻano like a he mau koho maikaʻi paha no kāu kūlana.

Ua hana ʻia ʻo Ranibizumab no ka mālama ʻana i nā maka a he moʻolelo lōʻihi o ka palekana a me ka pono. Hāʻawi ʻia ia ma ke ʻano he injections e like me ka aflibercept, ʻoiai he ʻokoʻa paha ka papa hana dosing.

Ua hana mua ʻia ʻo Bevacizumab no ka mālama ʻana i ka maʻi kanesa akā ua ʻike ʻia he pono no nā maʻi maka. ʻOi aku ka liʻiliʻi o ke kumukūʻai ma mua o nā koho ʻē aʻe, ʻoiai ua hoʻohana ʻia ia ma waho o ka lepili no nā mālama maka.

No kekahi mau maʻi, hiki i kāu kauka ke ʻōlelo aku i ka laser therapy, photodynamic therapy, a i ʻole steroid injections ma kahi o a i ʻole ma waho o nā mea pale VEGF. ʻO ke koho lapaʻau maikaʻi loa e pili ana i kāu maʻi kikoʻī, ke olakino holoʻokoʻa, a me ka maikaʻi o kāu pane ʻana i nā lāʻau lapaʻau like ʻole.

Ua ʻoi aku ka maikaʻi o Aflibercept ma mua o Ranibizumab?

He mau lāʻau lapaʻau maikaʻi ʻo Aflibercept a me ranibizumab no ka mālama ʻana i nā maʻi retinal, a ʻaʻole ʻoi aku kekahi ma mua o kekahi. ʻO ke koho ma waena o lākou e pili ana i kāu maʻi kikoʻī, pehea ka pinepine e hiki ai iā ʻoe ke hele mai no nā lāʻau lapaʻau, a pehea ka pane ʻana o kou maka i kēlā me kēia lāʻau.

He mea maikaʻi paha ʻo Aflibercept i hiki ke hāʻawi pinepine ʻia ma mua o ranibizumab, ʻo ia hoʻi ka liʻiliʻi o nā huakaʻi i ke keʻena o ke kauka. Hōʻike kekahi mau haʻawina e hana maikaʻi paha ʻo aflibercept no kekahi mau ʻano maʻi maka diabetic.

Ua loaʻa ʻo Ranibizumab no ka lōʻihi a he moʻolelo palekana nui, kahi e makemake ai kekahi mau kauka a me nā mea maʻi. Ua hana kūikawā ʻia ia no nā mālama maka, ʻoiai ua hoʻohana ʻia ʻo aflibercept no nā mālama maka a me ka maʻi kanesa.

E noʻonoʻo kāu kauka maka i nā mea e like me kāu hōʻailona kikoʻī, pehea ka holomua o kou maʻi, kou olakino holoʻokoʻa, a me kāu mau makemake pilikino i ke koho ʻana ma waena o kēia mau lāʻau. Nui ka poʻe e hana maikaʻi me kekahi koho, a hiki iā ʻoe ke hoʻololi ma waena o lākou inā pono.

Nā Nīnau i Nīnau pinepine ʻia e pili ana iā Aflibercept

He palekana anei ʻo Aflibercept no ka poʻe me ka maʻi diabetes?

ʻAe, palekana maʻamau ka aflibercept no ka poʻe me ka maʻi diabetes a ʻo ia kekahi o nā lāʻau lapaʻau i makemake nui ʻia no ka edema macular diabetic. Eia naʻe, e nānā pono kāu kauka iā ʻoe inā he maʻi diabetes kou, no ka mea, aia paha ʻoe i ka pilikia nui no kekahi mau pilikia.

Pono ka poʻe me ka maʻi diabetes e mālama i ka mana maikaʻi o ke kō koko i ka wā e loaʻa ana nā lāʻau lapaʻau aflibercept. Hiki i ke kō koko kiʻekiʻe ke hoʻonui i nā pilikia o ka maka a hiki ke hōʻemi i ka maikaʻi o ka hana ʻana o ka lāʻau. E hana pū kāu kauka maka me kāu hui mālama diabetes e hōʻoia i ka loaʻa ʻana o ka lāʻau lapaʻau maikaʻi loa.

He aha kaʻu e hana ai inā ua hala au i kahi mahele o Aflibercept?

Inā ua hala ʻoe i kahi injection aflibercept i hoʻonohonoho ʻia, e hoʻokaʻaʻike i ke keʻena o kāu kauka maka i ka hiki wawe e hoʻonohonoho hou. Mai kali a hiki i kāu manawa maʻamau e hiki mai ana, no ka mea, ʻo ka hoʻopaneʻe ʻana i ka lāʻau lapaʻau hiki ke ʻae i kou maʻi e ʻino.

E hoʻoholo kāu kauka i ka manawa maikaʻi loa no kāu injection makeup e pili ana i ka manawa i loaʻa ai iā ʻoe ka lāʻau lapaʻau a me ke ʻano o ka pane ʻana o kou maʻi maka. I kekahi mau hihia, makemake paha lākou e ʻike iā ʻoe i ka wā ma mua o ka lohi e pale ai i nā pilikia i kāu holomua.

He aha kaʻu e hana ai inā loaʻa iaʻu nā hopena ʻaoʻao koʻikoʻi?

Inā loaʻa iā ʻoe ka ʻeha maka nui, ka nalowale ʻana o ka ʻike, a i ʻole nā ​​hōʻailona o ka maʻi e like me ka hoʻokuʻu ʻana a i ʻole ka ʻulaʻula nui, e hoʻokaʻaʻike koke i kāu kauka maka a i ʻole e hele i ka lumi pilikia. Hiki i kēia mau mea ke hōʻailona o nā pilikia koʻikoʻi e pono ai ka lāʻau lapaʻau wikiwiki.

ʻO nā hōʻailona ʻē aʻe e pono ai ka nānā koke ʻana, ʻo ia ka ʻeha poʻo nui, ka ʻike ʻana i nā kukui uila, a i ʻole ka piʻi koke ʻana o nā lana a i ʻole nā ​​kiko i kou ʻike. Mai kali e ʻike inā e hoʻomaikaʻi kēia mau hōʻailona iā lākou iho, no ka mea, hiki i ka lāʻau lapaʻau mua ke pale i ka pōʻino mau.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Aflibercept?

Pono e hana ʻia ka hoʻoholo e hooki i ka lapaʻau aflibercept me kāu kauka maka, ʻaʻole ma kāu iho. Pono ka hapa nui o nā kānaka i ka lapaʻau mau e mālama i kā lākou hoʻomaikaʻi ʻana i ka ʻike, a ʻo ka hooki ʻana i ka wā mua hiki ke alakaʻi i ka ʻino ʻana o kou maʻi.

E nānā mau kāu kauka i kou maʻi maka a hiki ke noʻonoʻo e hōʻemi i ke alapine o ka lapaʻau inā paʻa kou maʻi no ka manawa lōʻihi. Eia naʻe, ʻaʻole i ʻōlelo ʻia ka hooki ʻana i ka lapaʻau ke ʻole ʻoe e hoʻomohala i nā hopena ʻaoʻao koʻikoʻi a i ʻole e loli nui kou maʻi.

Hiki iaʻu ke kalaiwa ma hope o ka loaʻa ʻana o ka Aflibercept Injection?

ʻAʻole pono ʻoe e kalaiwa koke ma hope o ka loaʻa ʻana o ka aflibercept injection, no ka mea, e pōpō ʻia paha kou ʻike no ka manawa pōkole a e hoʻonui ʻia paha kou maka mai ka hoʻokolokolo ʻana. E hoʻolālā e loaʻa i kekahi e kalaiwa iā ʻoe i ka home mai kāu manawa.

Hiki i ka hapa nui o nā kānaka ke hoʻomau i nā hana maʻamau, me ke kalaiwa ʻana, i loko o hoʻokahi a ʻelua paha lā ma hope o kā lākou injection ke hoʻi hou ko lākou ʻike i ka maʻamau. Inā hoʻomau ʻoe i ka ʻike ʻana i nā pilikia ʻike ma mua o kēia manawa, e hoʻokaʻaʻike i kāu kauka ma mua o ke kalaiwa ʻana a i ʻole ka hana ʻana i nā mīkini.