He aha ʻo Aflibercept: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau kūikawā ʻo Aflibercept e hoʻokomo pololei nā kauka i loko o kou maka e mālama i nā pilikia ʻike nui. Hana kēia lāʻau lapaʻau ikaika ma ka pale ʻana i kekahi mau protein e hoʻoulu ai i ka ulu ʻana o nā kīʻaha koko a me ka hōʻiliʻili ʻana o ka wai i loko o kou retina, e kōkua ana i ka mālama ʻana a i kekahi manawa e hoʻomaikaʻi i kou ʻike.

Inā ua ʻōlelo kāu kauka iā aflibercept, ke hana nei ʻoe me kahi maʻi e pili ana i nā kīʻaha koko palupalu i kou maka. ʻOiai e manaʻo paha ka manaʻo o ka injection maka, ua kōkua kēia lapaʻau i nā miliona o nā kānaka e mālama i ko lākou ʻike a me ka maikaʻi o ke ola.

He aha ʻo Aflibercept?

No ka papa o nā lāʻau lapaʻau i kapa ʻia ʻo anti-VEGF drugs ʻo Aflibercept, ʻo ia hoʻi nā mea pale i ka vascular endothelial growth factor. E noʻonoʻo iā VEGF ma ke ʻano he hōʻailona e haʻi ana i kou kino e ulu i nā kīʻaha koko hou, e kōkua maʻamau i ka hoʻōla a me ka ulu.

Eia naʻe, ke hana nui kou maka i ka VEGF, hiki iā ia ke hoʻoulu i nā kīʻaha koko pilikia e ulu i kahi e pono ʻole ai. Hoʻokuʻu pinepine kēia mau kīʻaha ʻino i ka wai a i ʻole ke koko, e hōʻino ana i kou retina a me ka hoʻoweliweli ʻana i kou ʻike. Komo ʻo Aflibercept e ālai i kēia mau hōʻailona VEGF ʻino.

Hele mai ka lāʻau lapaʻau ma ke ʻano he hopena maopopo e hoʻokomo pololei kāu kauka maka i loko o ka vitreous, ka mea like me ka gel i loko o kou maka. Hāʻawi kēia ala i ka lāʻau lapaʻau i kahi e pono ai.

No ke aha e hoʻohana ʻia ai ʻo Aflibercept?

Mālama ʻo Aflibercept i kekahi mau maʻi maka koʻikoʻi e hiki ke alakaʻi i ka nalowale o ka ʻike inā ʻaʻole i mālama ʻia. Hiki i kāu kauka ke ʻōlelo i kēia lāʻau lapaʻau inā loaʻa iā ʻoe ka degeneration macular pili i ka makahiki, diabetic macular edema, a i ʻole diabetic retinopathy.

ʻO ke kūlana maʻamau i mālama ʻia me ka aflibercept, ʻo ia ka maʻi macular degeneration (AMD) e pili ana i ka makahiki. Hiki kēia i ka wā e ulu ai nā moku koko ʻokoʻa ma lalo o kāu macula, ka ʻāpana o kou retina e mālama ana i ka ʻike ʻoi a me ke kikowaena. E kahe ana kēia mau moku i ka wai a me ke koko, e hoʻoulu ana i ka hoʻololi ʻana o ka ʻike a me ka makapō.

ʻO ka maʻi maka diabetic kekahi kumu nui e kuhikuhi ai nā kauka i ka aflibercept. Hiki i nā pae kōpaʻa koko kiʻekiʻe ke hōʻino i nā moku koko liʻiliʻi i loko o kou retina i ka manawa. Ke alakaʻi nei kēia i ka edema macular diabetic, kahi e hōʻiliʻili ai ka wai i loko o kāu macula, a i ʻole ka retinopathy diabetic, kahi e hiki ai i nā moku i hōʻino ʻia ke kahe a i ʻole ke ulu ʻokoʻa.

ʻAʻole maʻamau, hiki ke hoʻohana ʻia ka aflibercept no ka occlusion vein retinal, kahi maʻi e paʻa ai nā moku koko i loko o kou retina. Hiki i kēia paʻa ke hoʻoulu i ka pehu a me nā pilikia ʻike e hiki ai i ka lāʻau lapaʻau ke kōkua.

Pehea e Hana ai ka Aflibercept?

Ua manaʻo ʻia ʻo Aflibercept he lāʻau lapaʻau ikaika a i manaʻo ʻia e hana ana ma ke ʻano he mea hoʻopunipuni no nā mea ulu ʻino i loko o kou maka. Hoʻopili ka lāʻau i ka VEGF-A, VEGF-B, a me ka placental growth factor, e pale ana i kēia mau protein mai ka hoʻoulu ʻana i ka ulu ʻana o nā moku koko ʻokoʻa.

Ke hiki ʻole i kēia mau mea ulu ke hana i kā lākou hana, e pau ka ulu ʻana o nā moku koko pilikia a hiki ke emi. ʻO nā moku e kahe ana i kēia manawa e lilo pinepine i mea paʻa, e hōʻemi ana i ka hōʻiliʻili ʻana o ka wai i loko o kou retina. Kōkua kēia hana i ka mālama ʻana i kāu ʻike i kēia manawa a hiki ke hoʻomaikaʻi iā ia i kekahi mau hihia.

Noho ka lāʻau lapaʻau i loko o kou maka no kekahi mau pule a i ʻole mau mahina, ʻo ia ke kumu ʻaʻole pono ʻoe i nā lāʻau lapaʻau i kēlā me kēia lā. E wāwahi mālie kou kino a hoʻopau i ka lāʻau, ʻo ia ke kumu e pono ai nā injections hou e mālama i kāna mau pōmaikaʻi.

Pehea e Lawe ai au i ka Aflibercept?

Hāʻawi ʻia ka Aflibercept e kāu kauka maka a i ʻole kekahi loea lapaʻau i hoʻomaʻamaʻa ʻia i kahi hoʻonohonoho lapaʻau maʻemaʻe. ʻAʻole hiki iā ʻoe ke lawe i kēia lāʻau lapaʻau ma ka home, no ka mea, pono ia i ka ʻenehana injection pololei a me nā kūlana maʻemaʻe e pale ai i ka maʻi.

Ma mua o kāu ʻōpala, e hoʻopōpō kāu kauka i kou maka me nā kulu anesthetic e hōʻemi i ka ʻoluʻolu ʻole. E hoʻomaʻemaʻe nō hoʻi lākou i ka wahi a puni kou maka a hiki ke hoʻohana i nā kulu antibiotic e hōʻemi i ka pilikia o ka maʻi. He mau kekona wale nō ka ʻōpala maoli, akā ʻo ka manawa holoʻokoʻa e mau ana he 15-30 mau minuke.

ʻAʻole pono ʻoe e hoʻokē ʻai a pale i ka meaʻai ma mua o kāu lapaʻau. Eia naʻe, pono ʻoe e hoʻonohonoho i kekahi e hoʻokele iā ʻoe i ka home, no ka mea, e pōpō paha kou ʻike ma hope o ka ʻōpala. E hāʻawi kāu kauka i nā ʻōlelo kikoʻī e pili ana i nā kulu maka e hoʻohana ma hope o ka lapaʻau.

He mea nui e mālama i kāu mau manawa e hahai ai, ʻoiai inā e paʻa ana kou ʻike. Ke kōkua nei ka nānā mau ʻana i kāu kauka e nānā i kāu holomua a hoʻoponopono i kāu papa hana lapaʻau inā pono.

Pehea ka lōʻihi e lawe ai au i ka Aflibercept?

Pono ka hapa nui o nā kānaka i nā ʻōpala aflibercept no nā mahina a i nā makahiki, a pono paha kekahi i ka lapaʻau mau loa. Aia ka lōʻihi i kāu kūlana kikoʻī, pehea ka maikaʻi o kou pane ʻana i ka lapaʻau, a inā paha e holomua ana kāu maʻi kumu.

I ka wā mua, e loaʻa paha iā ʻoe nā ʻōpala i kēlā me kēia 4-8 pule no nā mahina mua. Ke kōkua nei kēia pae hoʻouka i ka hoʻokumu ʻana i nā hopena o ka lāʻau lapaʻau i kou maka. Ke paʻa kāu kūlana, hiki i kāu kauka ke hoʻolōʻihi i ka manawa ma waena o nā ʻōpala i kēlā me kēia 8-12 pule.

E nānā kāu kauka maka i kāu holomua ma o nā hoʻokolohua maka maʻamau a me nā hoʻokolohua kiʻi. Inā paʻa kou ʻike a nānā ke olakino o kou retina, hiki iā lākou ke hoʻokaʻawale i nā lapaʻau. Eia naʻe, ʻo ka hoʻōki ʻana i ka lapaʻau holoʻokoʻa e alakaʻi pinepine i ka holomua o ka maʻi a me ka nalowale o ka ʻike.

Loaʻa i kekahi poʻe ka remission lōʻihi kahi e hiki ai ke hoʻomaha palekana i nā lapaʻau. Pono kekahi i nā ʻōpala mau a mau e mālama i ko lākou ʻike. E hoʻopilikino ʻia kāu hoʻolālā lapaʻau i kāu kūlana a hiki ke loli i ka manawa.

He aha nā hopena ʻaoʻao o Aflibercept?

E like me nā lāʻau lapaʻau a pau, hiki i ka aflibercept ke hana i nā hopena ʻaoʻao, akā ua ʻae ka hapa nui o nā kānaka iā ia. ʻO ka hoʻomaopopo ʻana i ka mea e manaʻo ai hiki ke kōkua iā ʻoe e mākaukau a ʻike i ka manawa e hoʻokaʻaʻike aku ai i kāu kauka.

ʻO nā hopena ʻaoʻao maʻamau i ʻike ʻia e nā kānaka he nui, ʻo ia ka hōʻoluʻolu maka manawā, ka ʻulaʻula, a me ka manaʻo e loaʻa ana kekahi mea i kou maka. Hoʻoponopono maʻamau kēia mau mea i loko o hoʻokahi a ʻelua paha lā ma hope o ka injection.

Eia nā hopena ʻaoʻao i hōʻike pinepine ʻia:

• ʻEha maka a i ʻole ka hōʻoluʻolu (maʻamau ka maʻalahi a me ka manawā)
• Piʻi ke kaomi maka
• Nā kiko liʻiliʻi a i ʻole nā mea lana i kou ʻike
• Hemorrhage conjunctival (kiko ʻulaʻula liʻiliʻi ma ke keʻokeʻo o kou maka)
• Maka maloʻo
• ʻEha poʻo
• Ihu kahe a i ʻole ihu paʻa

Hiki ke mālama ʻia kēia mau hopena maʻamau a ʻaʻole pono e hoʻōki i ka lapaʻau. Hiki i kāu kauka ke hāʻawi i nā hoʻolālā e hōʻemi i ka hōʻoluʻolu a kōkua iā ʻoe e hoʻokaʻawale ma waena o nā hopena ʻaoʻao i manaʻo ʻia a me nā hōʻailona e pili ana.

Pono nā hopena ʻaoʻao koʻikoʻi akā ʻaʻole maʻamau i ka mālama olakino koke. Pākuʻi ʻia kēia mau mea i ka ʻeha maka nui, nā loli ʻike koke, nā hōʻailona o ka maʻi, a i ʻole nā ʻeha poʻo mau me nā pilikia ʻike.

ʻO nā pilikia kakaʻikahi akā koʻikoʻi, ʻo ia:

• Endophthalmitis (maʻi maka koʻikoʻi)
• Retinal detachment
• Retinal pigment epithelial tear
• Piʻi ka pilikia o ka hahau ʻana a i ʻole ka puʻuwai (kakaʻikahi loa)
• Nā hopena maʻi maʻi koʻikoʻi

ʻOiai ʻaʻole maʻamau kēia mau hopena ʻaoʻao koʻikoʻi, e hana ana i ka liʻiliʻi ma mua o 1% o nā maʻi, he mea nui e ʻimi i ka mālama olakino koke inā ʻoe e ʻike i ka ʻeha maka nui, ka nalowale ʻana o ka ʻike koke, a i ʻole nā hōʻailona o ka maʻi e like me ka hoʻokuʻu ʻana a i ʻole ke kuni.

ʻO wai ka mea pono ʻole e lawe iā Aflibercept?

ʻAʻole kūpono ʻo Aflibercept no nā mea a pau, a e loiloi pono kāu kauka inā palekana ia iā ʻoe. ʻO ka mea nui e noʻonoʻo ai inā loaʻa iā ʻoe kahi maʻi maʻi i loko a i ʻole a puni kou maka, no ka mea, hiki i ka injection ke hoʻonui i ka maʻi.

ʻAʻole pono ʻoe e loaʻa ka aflibercept inā he maʻi ʻoe i ka lāʻau lapaʻau a i ʻole kekahi o kāna mau mea. ʻO nā hōʻailona o nā hopena maʻi e komo pū ana me ka ʻeha nui o ka maka, ka pehu ʻana, ka pilikia o ka hanu ʻana, a i ʻole ka ʻōpala ākea. E haʻi i kāu kauka e pili ana i nā hopena maʻi i nā lāʻau lapaʻau.

Pono kekahi mau maʻi olakino i ka mālama kūikawā i ka wā e noʻonoʻo ai i ka mālama ʻana i ka aflibercept. E loiloi kāu kauka i nā pōmaikaʻi e kūʻē i nā pilikia hiki ke loaʻa inā loaʻa iā ʻoe kekahi o kēia mau maʻi:

• ʻO ka hahau hou ʻana a i ʻole ka puʻuwai (i loko o 3 mahina)
• Ke koko kiʻekiʻe ʻole i ka mana
• Nā maʻi koko e hana ana
• Hāpai a i ʻole nā hoʻolālā e hāpai
• Ka hānai ʻana i ka umauma
• Maʻi kīkī a i ʻole ke ake nui

Inā hāpai ʻoe a i ʻole e hoʻolālā ana e hāpai, e kūkākūkā i kēia me kāu kauka i kēia manawa. Hiki i ka Aflibercept ke hōʻino i nā pēpē e ulu ana, a ua ʻōlelo ʻia ka pale ʻana i ka hāpai ʻana i ka wā o ka mālama ʻana a no ka liʻiliʻi o 3 mau mahina ma hope o kāu injection hope loa.

E noʻonoʻono nō hoʻi kāu kauka i kou kūlana olakino holoʻokoʻa, nā lāʻau lapaʻau ʻē aʻe āu e lawe nei, a me kou hiki ke hele i nā manawa maʻamau i ka wā e hoʻoholo ai inā kūpono ka aflibercept iā ʻoe.

Nā inoa inoa ʻo Aflibercept

Loaʻa ka Aflibercept ma lalo o ka inoa inoa Eylea ma ka hapa nui o nā ʻāina, me ʻAmelika Hui Pū ʻIa. ʻO kēia ka mea i kauoha pinepine ʻia no nā injections maka a loaʻa iā 2 mg o ka aflibercept no ka 0.05 mL injection.

I kēia mau lā, ua loaʻa kahi formulation kiʻekiʻe i kapa ʻia ʻo Eylea HD (8 mg no 0.07 mL) ma kekahi mau wahi. Hiki i kēia mana ikaika ke hoʻemi i nā injections i kekahi mau maʻi, e hōʻemi ana i ka ukana lapaʻau me ka mālama ʻana i ka pono.

E hoʻoholo kāu kauka i ka formulation a me ka papa hana dosing e hana maikaʻi loa no kou kūlana kikoʻī. Loaʻa nā mana ʻelua i ka mea hana like akā ʻokoʻa i ka ʻike a me ke alapine injection.

Nā koho ʻē aʻe ʻo Aflibercept

He nui nā lāʻau lapaʻau anti-VEGF ʻē aʻe i loaʻa inā ʻaʻole kūpono ka aflibercept iā ʻoe a i ʻole ʻaʻole e hāʻawi i nā hopena kūpono. ʻO nā koho maʻamau e komo pū ana me ranibizumab (Lucentis) a me bevacizumab (Avastin).

Hana like ʻo Ranibizumab me aflibercept akā pono paha i nā injections pinepine. Pane maikaʻi kekahi poʻe i kekahi lāʻau lapaʻau ma mua o kekahi, no laila e ʻōlelo paha kāu kauka e hoʻololi inā ʻaʻole e hana maikaʻi ana kāu lapaʻau i kēia manawa.

Hoʻohana pinepine ʻia ʻo Bevacizumab ma waho o ka lepili no nā maʻi maka a ʻoi aku ka liʻiliʻi o ke kumukūʻai ma mua o nā koho ʻē aʻe. Eia naʻe, ʻaʻole i ʻae ʻia no nā injections maka, ʻoiai he nui nā kauka e hoʻohana palekana a maikaʻi.

No kekahi mau maʻi, hiki ke noʻonoʻo ʻia nā koho lapaʻau ʻē aʻe, me ka laser therapy, photodynamic therapy, a i ʻole steroid injections. E kōkua kāu kauka maka iā ʻoe e hoʻomaopopo i nā koho a pau i loaʻa a koho i ke ala maikaʻi loa no kou kūlana.

Ua ʻoi aku ka maikaʻi o Aflibercept ma mua o Ranibizumab?

He mau lapaʻau maikaʻi loa ʻo Aflibercept a me ranibizumab, a ʻaʻole ʻoi aku kekahi ma mua o kekahi. ʻO ke koho maikaʻi loa e hilinaʻi ana i kou kūlana kikoʻī, nā kumu ola, a me ke ʻano o kou pane ʻana i ka lapaʻau.

Loaʻa paha iā Aflibercept kahi pōmaikaʻi liʻiliʻi e pili ana i ke alapine o ka injection, no ka mea, hiki pinepine i nā lapaʻau i kēlā me kēia 8 pule ma hope o ka pae hoʻomaka. Pono ʻo Ranibizumab i nā injections i kēlā me kēia mahina i ka wā mua, ʻoiai hiki i kekahi poʻe maʻi ke hoʻolōʻihi i kēlā me kēia 6-8 pule.

Hōʻike nā haʻawina lapaʻau e hāʻawi nā lāʻau lapaʻau ʻelua i nā hopena ʻike like no ka hapa nui o nā kānaka. Manaʻo kekahi noiʻi e ʻoi aku ka maikaʻi o ka aflibercept no kekahi mau ʻano maʻi maka diabetic, ʻoiai ua hoʻohana ʻia ʻo ranibizumab no ka lōʻihi a loaʻa nā ʻikepili palekana nui.

E noʻonoʻo kāu kauka i nā mea e like me kāu pane ʻana i ka lāʻau lapaʻau, ka maʻalahi o ka papa hana lāʻau, ka uhi ʻinikua, a me nā hopena ʻaoʻao āu e ʻike ai i ka wā e hoʻoholo ai i ka lāʻau lapaʻau kūpono loa iā ʻoe. Hiki paha i kekahi poʻe ke hoʻololi ma waena o nā lāʻau lapaʻau inā lilo kā lākou lapaʻau mua i mea liʻiliʻi i ka manawa.

Nā Nīnau i Nīnau pinepine ʻia e pili ana iā Aflibercept

Q1. Palekana ʻo Aflibercept no ka poʻe me ka maʻi diabetes?

ʻAe, palekana ʻo aflibercept no ka poʻe me ka maʻi diabetes a hoʻohana pinepine ʻia e mālama i nā pilikia o ka maka diabetic. ʻO ka ʻoiaʻiʻo, ua ʻae ʻia no ka edema macular diabetic a me ka retinopathy diabetic.

Eia naʻe, hiki i ka poʻe me ka maʻi diabetes ke loaʻa nā mea hou aʻe, e like me ka mālama ʻana i ke kō koko a me ke olakino cardiovascular. E nānā pono kāu kauka iā ʻoe a hiki ke hoʻopili me kāu hui mālama diabetes e hōʻoia i ka paʻa ʻana o kou olakino holoʻokoʻa i ka wā o ka mālama ʻana.

Q2. He aha kaʻu e hana ai inā hoʻohana hewa au i ka nui o Aflibercept?

No ka mea, hāʻawi wale ʻia ʻo aflibercept e nā poʻe loea lapaʻau i nā hoʻonohonoho lapaʻau i mālama ʻia, ʻaʻole hiki ke loaʻa ka overdose. Ana pololei ʻia ka lāʻau lapaʻau a lawelawe ʻia e nā mea mālama ola i hoʻomaʻamaʻa ʻia.

Inā ʻike ʻoe i nā hōʻailona maʻamau ma hope o ka injection, e like me ka ʻeha nui, nā loli ʻike koke, a i ʻole nā ​​hōʻailona o ka maʻi, e kelepona koke i kāu kauka maka. Hiki iā lākou ke loiloi inā pili kāu mau hōʻailona i ka injection a i ʻole e koi i ka mālama hou.

Q3. He aha kaʻu e hana ai inā hala au i kahi mahele o Aflibercept?

Inā hala ʻoe i kahi manawa i hoʻonohonoho ʻia, e hoʻonohonoho hou i ka hiki wawe. ʻO ka hoʻopaneʻe ʻana i ka mālama ʻana hiki ke ʻae i kou kūlana e ʻino a hiki ke alakaʻi i ka nalowale o ka ʻike.

Mai kali a hiki i kāu manawa i hoʻonohonoho ʻia e hiki mai ana inā ua hala ʻoe i hoʻokahi. E kelepona i ke keʻena o kāu kauka e hoʻonohonoho i ka injection i hala, a e kōkua lākou iā ʻoe e hoʻi i ke ala me kāu papa hana lapaʻau.

Q4. I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana iā Aflibercept?

Mai hooki i ka lapaʻau ʻana me ka aflibercept me ka ʻole e kūkākūkā mua me kāu kauka maka. ʻO ka hooki ʻana i ka wā mua e alakaʻi pinepine i ka holomua o ka maʻi a me ka nalowale o ka ʻike, ʻoiai inā maikaʻi kou mau maka.

Na kāu kauka e hoʻoholo i ka wā e palekana ai e hōʻemi i ke alapine o ka lapaʻau a i ʻole e hooki i nā injections e pili ana i kāu mau hoʻokolohua maka, nā hopena kiʻi, a me ke kūpaʻa maʻi holoʻokoʻa. Hiki i kekahi poʻe ke hiki ke lawe i nā wā hoʻomaha lapaʻau, ʻoiai nā mea ʻē aʻe e pono i ka mālama mau.

Q5. Hiki iaʻu ke kalaiwa ma hope o ka loaʻa ʻana o Aflibercept?

ʻAʻole pono ʻoe e kalaiwa koke ma hope o ka loaʻa ʻana o ka aflibercept, no ka mea, hiki ke ʻike ʻia kou ʻike no ka manawa pōkole mai nā kulu anesthetic a me ka injection ponoʻī. E hoʻolālā e loaʻa i kekahi e kalaiwa iā ʻoe i ka home ma hope o kāu manawa.

Hiki i ka hapa nui o nā kānaka ke hoʻomau i nā hana maʻamau, me ke kalaiwa ʻana, i loko o 24 mau hola o kā lākou injection. Eia naʻe, e kali a hiki i ka hoʻi ʻana o kou ʻike i kona pae kumu ma mua o ka noho ʻana ma hope o ka huila. Inā ʻike ʻoe i nā loli ʻike mau, e hoʻokaʻaʻike i kāu kauka ma mua o ka hoʻomau ʻana i ke kalaiwa.