He aha ʻo Albiglutide: Nā Hoʻohana, Nā Kumu, Nā ʻaoʻao ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau ʻo Albiglutide e kōkua ana i ka mālama ʻana i ka maʻi diabetes type 2 ma ka mālama ʻana i nā pae kōpaʻa koko. No ka papa o nā lāʻau i kapa ʻia ʻo GLP-1 receptor agonists kēia lāʻau lapaʻau injectable, e hana ana ma ka hoʻohālike ʻana i kahi hormone maoli i loko o kou kino e kōkua ana i ka hoʻoponopono ʻana i ka glucose.

ʻOiai ua loaʻa ʻo albiglutide ma lalo o ka inoa inoa ʻo Tanzeum, he mea nui e ʻike ua hoʻōki ka mea hana i kēia lāʻau lapaʻau i ka makahiki 2018. Eia naʻe, ʻo ka hoʻomaopopo ʻana i ke ʻano o kāna hana hiki ke kōkua iā ʻoe e loaʻa nā kamaʻilio i ʻike ʻia me kāu mea mālama ola e pili ana i nā koho lapaʻau like.

He aha ʻo Albiglutide?

He mana synthetic ʻo Albiglutide o kahi hormone i kapa ʻia ʻo GLP-1 e hana maoli ai kou kino i loko o kou ʻōpū. Ua hoʻolālā ʻia kēia lāʻau lapaʻau e lōʻihi i loko o kāu ʻōnaehana ma mua o ka hormone maoli, e koi ana i hoʻokahi wale nō pahu i kēlā me kēia pule.

Ua hana ka lāʻau ma ka hoʻopili ʻana i nā mea hoʻokipa kikoʻī i loko o kou kino e mālama ana i ke ʻano o ka hoʻokuʻu ʻana o kou pancreas i ka insulin a me ke ʻano o ka hana ʻana o kou ate i ka glucose. E noʻonoʻo iā ia he ʻōnaehana hoʻomanaʻo mālie i kōkua i kou kino e mālama i ke kōpaʻa koko maikaʻi aʻe i ka pule.

Mai ka wā i loaʻa hou ʻole ai ʻo albiglutide, e ʻōlelo paha kāu kauka i nā lāʻau lapaʻau ʻē aʻe i ka papa like e hana like ana, e like me semaglutide a i ʻole liraglutide.

No ke aha i hoʻohana ʻia ai ʻo Albiglutide?

Ua ʻae ʻia ʻo Albiglutide e mālama i nā mākua me ka maʻi diabetes type 2 ma ke ʻano he ʻāpana o kahi hoʻolālā lapaʻau piha. ʻAʻole i manaʻo ʻia he lāʻau lapaʻau kū hoʻokahi akā he mea hana i ka mālama ʻana i kēia maʻi maʻi.

Hoʻomaʻamaʻa nā kauka i kēia lāʻau lapaʻau i ka wā ʻaʻole lawa ka ʻai a me ka hoʻoikaika kino wale nō e mālama i nā pae kōpaʻa koko. Hoʻohana pinepine ʻia ia me nā lāʻau lapaʻau diabetes ʻē aʻe e like me metformin e hāʻawi i ka mana glucose maikaʻi.

Ua kōkua nui ka lāʻau lapaʻau i ka poʻe i hakakā me nā piʻi kō kō koko pinepine ma hope o nā meaʻai. Ua hāʻawi pū kekahi i ka maʻalahi o ka hoʻohana ʻana i hoʻokahi manawa i ka pule, kahi i ʻike ai ka nui o nā maʻi he maʻalahi ke mālama ma mua o nā lāʻau lapaʻau i kēlā me kēia lā.

Pehea e hana ai ʻo Albiglutide?

Hana ʻo Albiglutide ma ka hoʻāla ʻana i nā mea hoʻokipa GLP-1 ma kou kino a pau, e hoʻoulu ana i nā pane kōkua no ka mālama ʻana i ke kō kō koko. Ua manaʻo ʻia kēia lāʻau lapaʻau he ikaika ma waena o ka papa GLP-1, e hāʻawi ana i ka mālama glucose maikaʻi me kahi ʻaoʻao hopena maʻalahi ma mua o kekahi mau koho ʻē aʻe.

Ke ʻai ʻoe, hōʻailona ka lāʻau lapaʻau i kou pancreas e hoʻokuʻu i ka insulin, akā inā kiʻekiʻe kou kō kō koko. Kōkua kēia pane akamai i ka pale ʻana i nā hāʻule weliweli i ke kō kō koko e hiki ke hana me nā lāʻau lapaʻau maʻi diabetes ʻē aʻe.

Hoʻolohi pū ka lāʻau i ka wikiwiki o ka neʻe ʻana o ka meaʻai ma kou ʻōpū, kahi e kōkua ai i ka pale ʻana i nā piʻi wikiwiki i ke kō kō koko ma hope o nā meaʻai. Eia kekahi, hoʻouna ia i nā hōʻailona i kou ate e hōʻemi i ka hana glucose ke pono ʻole ʻoe i ke kō hou i loko o kou kahe koko.

Ua hana kēia ala multi-pronged i ka albiglutide i ka hoʻohaʻahaʻa ʻana i nā pae HbA1c, ʻo ia ka hōʻailona nui a nā kauka e hoʻohana ai e loiloi i ka mālama ʻana i ke kō kō koko no ka wā lōʻihi ma luna o 2-3 mau mahina.

Pehea e lawe ai au i ka Albiglutide?

No ka mea ʻaʻole i loaʻa hou ka albiglutide, no nā kumu hoʻonaʻauao kēia ʻike e kōkua iā ʻoe e hoʻomaopopo i ke ʻano o ka hana ʻana o nā lāʻau lapaʻau GLP-1. Ua lawelawe ʻia ʻo Albiglutide ma ke ʻano he injection subcutaneous hoʻokahi manawa i ka pule, ʻo ia hoʻi e hoʻokomo ʻoe ma lalo o ka ʻili.

Ua hele mai ka lāʻau lapaʻau ma ke ʻano he pauka e pono e hui pū ʻia me kahi wai kūikawā ma mua o ka injection. E hoʻokomo maʻamau ʻoe i loko o kou ʻūhā, lima luna, a i ʻole ka ʻōpū, e hoʻololi ana i nā wahi injection i kēlā me kēia pule e pale ai i ka huhū o ka ʻili.

ʻAʻole like me kekahi mau lāʻau lapaʻau, hiki ke lawe ʻia ʻo albiglutide me ka ʻai ʻana a i ʻole me ka ʻole o ka ʻai ʻana, e hāʻawi ana iā ʻoe i ka maʻalahi i kāu papa hana lāʻau. Ua ʻike ka hapa nui o nā kānaka he mea kōkua ke koho ʻana i ka lā like i kēlā me kēia pule no kā lākou injection e mālama i ka kūlike.

Ua hāʻawi ʻia ka injection me ka hoʻohana ʻana i kahi mea hana peni i hoʻopiha mua ʻia, e maʻalahi ai ke hāʻawi ʻia ma ka home ke aʻo ʻoe i ke ʻano kūpono mai kāu mea mālama ola.

Pehea ka lōʻihi e lawe ai au i ka Albiglutide?

Ua hoʻolālā ʻia ʻo Albiglutide ma ke ʻano he lapaʻau lōʻihi no ka maʻi diabetes type 2, e like me nā lāʻau lapaʻau ʻē aʻe i loko o kāna papa. No ka mea he maʻi maʻi ka maʻi diabetes, ua lawe ka hapa nui o ka poʻe i hoʻohana i kēia lāʻau lapaʻau no ka manawa pau ʻole ma ke ʻano he ʻāpana o kā lākou hoʻolālā hoʻokele e hana nei.

E loiloi maʻamau kāu kauka i kāu pane ʻana i ka lāʻau lapaʻau ma hope o 3-6 mau mahina, e nānā ana i kāu pae HbA1c a me ka maikaʻi o kou hoʻomanawanui ʻana i nā hopena ʻaoʻao. Inā hana maikaʻi ka lāʻau lapaʻau a ʻaʻole ʻoe i ʻike i nā pilikia nui, e hoʻomau paha ʻoe i ka lawe ʻana.

Pono paha kekahi poʻe e hooki i ka lāʻau lapaʻau inā loaʻa iā lākou nā hopena ʻaoʻao mau a i ʻole inā ua loli nui kā lākou hana kīkī. Ua hoʻololi paha kekahi poʻe i nā lāʻau lapaʻau like ʻole i ka wā e holomua ai kā lākou maʻi diabetes a i ʻole i ka wā i loli ai ko lākou olakino.

Ua hana mau ʻia ka hoʻoholo e hoʻomau a hoʻōki paha i ka hui pū ʻana me kāu mea mālama ola, me ka noʻonoʻo ʻana i kou olakino holoʻokoʻa, nā lāʻau lapaʻau ʻē aʻe, a me nā makemake pilikino.

He aha nā hopena ʻaoʻao o Albiglutide?

E like me nā lāʻau lapaʻau a pau, hiki i ka albiglutide ke hana i nā hopena ʻaoʻao, ʻoiai ʻaʻole i ʻike nā kānaka a pau iā lākou. ʻO ka hoʻomaopopo ʻana i kēia mau hopena hiki ke kōkua iā ʻoe e ʻike i ka mea maʻamau a i ka manawa e hoʻopili ai i kāu mea mālama ola.

ʻO nā hopena ʻaoʻao maʻamau he maʻalahi a ua hoʻomaikaʻi pinepine ʻia i ka wā i hoʻoponopono ai kou kino i ka lāʻau lapaʻau i nā pule mua:

• Ka manaʻo ʻino a me ka ʻoluʻolu ʻole o ka ʻōpū
• Ka maʻi palahē a i ʻole nā noho palupalu
• Ka luaʻi ʻana, ʻoi loa i nā pule mua
• Ka emi ʻana o ka ʻai
• Nā hopena ma ke kahua o ka pahu, e like me ka ʻulaʻula a i ʻole ka pehu ʻoluʻolu
• Nā poʻo
• Ka luhi a i ʻole ka manaʻo luhi

Ua lilo pinepine kēia mau hopena maʻamau i mea hiki ke mālama ʻia i ka wā i hoʻopili ai kou kino i ka lāʻau lapaʻau, a ua ʻike ka nui o nā kānaka e hiki iā lākou ke hōʻemi i ka manaʻo ʻino ma ka hoʻomaka ʻana me nā meaʻai liʻiliʻi.

ʻO nā hopena ʻoi aku ka koʻikoʻi akā ʻaʻole maʻamau i koi i ka mālama olakino koke a ua komo pū:

• Ka ʻeha nui o ka ʻōpū e hōʻike ana i ka pancreatitis
• Ka luaʻi mau e pale ana i ka mālama ʻana i nā wai
• Nā hōʻailona o nā pilikia o ka puʻupaʻa e like me nā loli i ka mimi
• Nā hopena maʻi koʻikoʻi me ka pilikia o ka hanu ʻana a i ʻole ka pehu
• Nā hōʻailona o nā maʻi ʻaʻai thyroid, ʻoiai he mea maʻamau loa kēia

ʻOiai ʻaʻole maʻamau kēia mau hopena koʻikoʻi, he mea nui e ʻike i nā hōʻailona ʻōlelo aʻo a e ʻimi i ka mālama olakino wikiwiki inā loaʻa lākou.

ʻO wai ka mea ʻaʻole pono e lawe iā Albiglutide?

ʻAʻole pono kekahi poʻe e hoʻohana i ka albiglutide ma muli o ka piʻi ʻana o nā pilikia. E nānā pono kāu kauka i kāu mōʻaukala olakino ma mua o ke kau ʻana i kēia lāʻau.

ʻO ka poʻe e pale aku i ka albiglutide me ka poʻe i loaʻa:

• ʻO ka maʻi diabetes type 1, no ka mea, ʻaʻole i hoʻolālā ʻia nā lāʻau GLP-1 no kēia maʻi
• Mōʻaukala pilikino a i ʻole ka ʻohana o ka maʻi ʻaʻai thyroid medullary
• Multiple Endocrine Neoplasia syndrome type 2
• Ka maʻi puʻupaʻa koʻikoʻi a i ʻole ka hāʻule ʻana o ka puʻupaʻa
• Mōʻaukala o ka maʻi gastrointestinal koʻikoʻi
• Nā hopena maʻi koʻikoʻi i nā lāʻau GLP-1

Pono nō hoʻi nā wāhine hāpai a me nā wāhine e hānai ana i ka waiū i ka noʻonoʻo kūikawā, no ka mea, ʻaʻole lawa ka ʻikepili palekana no kēia mau heluna kanaka.

Eia kekahi, pono e loiloi pono ʻia ka poʻe me ka moʻolelo o ka pancreatitis, no ka mea, hiki i nā lāʻau GLP-1 ke hoʻonui i ka pilikia o ka hoʻi hou ʻana o kēia maʻi koʻikoʻi.

Inoa Brand Albiglutide

Ua kūʻai ʻia ʻo Albiglutide ma lalo o ka inoa brand Tanzeum e GlaxoSmithKline. ʻO kēia wale nō ka inoa brand i loaʻa ai ka lāʻau lapaʻau ma ʻAmelika Hui Pū ʻIa.

Ua hoʻōki ʻia ʻo Tanzeum i Iulai 2018, ʻaʻole ma muli o nā hopohopo palekana, akā ma muli o nā kumu kalepa a me ka hoʻokūkū mākeke mai nā lāʻau GLP-1 ʻē aʻe. Ua koho ka mea hana e kālele i nā kumuwaiwai i nā lāʻau ʻē aʻe i kā lākou paipu.

Inā ʻoe e lawe ana iā Tanzeum ma mua, ua hoʻololi paha kāu kauka iā ʻoe i kahi lāʻau lapaʻau like me Trulicity (dulaglutide), Ozempic (semaglutide), a i ʻole Victoza (liraglutide).

Nā Koho ʻē aʻe o Albiglutide

Loaʻa i kēia manawa kekahi mau koho ʻē aʻe i ka albiglutide, no ka papa like o ka GLP-1 receptor agonist. Hana like kēia mau lāʻau lapaʻau akā loaʻa paha nā papa hana ʻokoʻa a i ʻole nā ​​hopena ʻaoʻao.

ʻO nā koho injection i kēlā me kēia pule e komo pū ana:

• Semaglutide (Ozempic) - manaʻo pinepine ʻia he ʻoi aku ka ikaika no ka mālama ʻana i ke kō koko
• Dulaglutide (Trulicity) - hele mai i loko o kahi peni i hoʻopiha mua ʻia
• Exenatide extended-release (Bydureon) - kahi koho i hoʻokahi manawa i ka pule

ʻO nā koho injection i kēlā me kēia lā e komo pū ana:

• Liraglutide (Victoza) - ua hoʻokumu maikaʻi ʻia me ka noiʻi nui
• Exenatide (Byetta) - lawe pinepine ʻia ʻelua i ka lā
• Lixisenatide (Adlyxin) - hoʻokahi manawa i ka lā me nā pōmaikaʻi manawa ʻai kūʻokoʻa

E kōkua kāu kauka iā ʻoe e koho i ke koho maikaʻi loa e pili ana i kāu mau pono kikoʻī, ka uhi ʻinikua, a me ka maikaʻi o kou ʻae ʻana iā albiglutide ma mua.

Ua ʻoi aku ka maikaʻi o Albiglutide ma mua o Semaglutide?

Ke hoʻohālikelike ʻana iā albiglutide me semaglutide, pono e nānā i ka pono, nā hopena ʻaoʻao, a me nā mea e pono ai. Hana nā lāʻau lapaʻau ʻelua ma ke ʻano like akā he mau ʻokoʻa nui.

Hōʻike maʻamau ʻo Semaglutide (Ozempic) i nā hopena hoʻohaʻahaʻa i ke kō koko i nā haʻawina lapaʻau, e loaʻa pinepine ana i nā hoʻemi nui i nā pae HbA1c. Hoʻomaikaʻi pū ia i ka lilo ʻana o ke kaumaha, he mea maikaʻi ia no ka poʻe he nui me ka maʻi diabetes type 2.

Eia naʻe, ua hana maʻamau ʻo albiglutide i nā hopena ʻaoʻao gastrointestinal liʻiliʻi e like me ka nausea a me ka luaʻi ʻana, e maʻalahi ai no kekahi poʻe e ʻae. ʻO ke koho ma waena o lākou e pili pinepine ana i ka hoʻohālikelike ʻana i ka pono me ka ʻae ʻia.

Mai ka wā i loaʻa hou ʻole ai ʻo albiglutide, he mea hoʻonaʻauao nui kēia hoʻohālikelike. Inā ʻoe e noʻonoʻo ana i nā lāʻau lapaʻau GLP-1, hiki i kāu kauka ke kōkua iā ʻoe e hoʻomaopopo i nā koho i kēia manawa a me ko lākou mau pono a me nā hemahema.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Albiglutide

He Palekana ʻo Albiglutide no ka poʻe me ka maʻi puʻuwai?

Ua manaʻo ʻia ʻo Albiglutide he palekana no ka poʻe me ka maʻi puʻuwai a ua hāʻawi paha i kekahi mau pōmaikaʻi cardiovascular. Ua hōʻike nā haʻawina lapaʻau e hiki i nā lāʻau lapaʻau GLP-1 e like me albiglutide ke kōkua i ka hōʻemi ʻana i ka pilikia o ka puʻuwai a me nā hahau i ka poʻe me ka maʻi diabetes type 2.

Eia naʻe, pono mau ka poʻe me ka maʻi puʻuwai i ka mālama pilikino, a e noʻonoʻo kāu kauka i kāu kiʻi olakino piha ma mua o ka ʻōlelo ʻana i kekahi lāʻau lapaʻau diabetes. Ua like nā pōmaikaʻi cardiovascular i ʻike ʻia me albiglutide me nā mea i ʻike ʻia me nā lāʻau lapaʻau GLP-1 ʻē aʻe i loaʻa i kēia lā.

He aha kaʻu e hana ai inā ua hoʻohana hewa au i ka nui o Albiglutide?

Inā ua lawe hewa kekahi i ka nui o albiglutide, pono lākou e hoʻokaʻaʻike i kā lākou mea mālama ola a i ʻole ka mana hoʻomalu lāʻau make. Hiki i ka overdose ke alakaʻi i ka nausea koʻikoʻi, ka luaʻi ʻana, a me nā hāʻule pōʻino i ke kō koko.

ʻO ka hana nui loa, ʻo ia ke nānā i nā hōʻailona e like me ka luaʻi mau, ka ʻeha nui o ka ʻōpū, a i ʻole nā hōʻailona o ke kōpaʻa koko haʻahaʻa e like me ka haʻalulu, ka hou, a i ʻole ka huikau. No ka mea, ʻaʻole i loaʻa hou ka albiglutide, ʻaʻole paha e hiki kēia hanana me nā kauoha hou.

He aha kaʻu e hana ai inā ua hala wau i kahi mahele o Albiglutide?

Inā ua hala ʻoe i kahi mahele o ka albiglutide i kēlā me kēia pule, ʻo ka ʻōlelo maʻamau, e lawe koke ʻoe i ka wā āu i hoʻomanaʻo ai, inā ʻo ka mahele i hoʻonohonoho ʻia e hiki mai ana ma kahi o ʻekolu lā ma hope. Inā e hiki mai ana kāu mahele e hiki mai ana i loko o ʻekolu lā, e lele ʻoe i ka mahele i hala a e hoʻomau me kāu papa manawa maʻamau.

ʻAʻole pono ʻoe e lawe i ʻelua mahele i loko o ʻekolu lā o kekahi i kekahi, no ka mea, hiki i kēia ke hoʻonui i ka pilikia o nā hopena ʻaoʻao. ʻO ke ʻano lōʻihi o ka lāʻau lapaʻau, ʻo ia hoʻi, ʻaʻole paha e hana nā pilikia koʻikoʻi me ka mālama ʻana i ke kōpaʻa koko i ka wā e hala ai kekahi mahele.

I ka manawa hea e hiki ai iaʻu ke hooki i ka lawe ʻana i ka Albiglutide?

Ua hana mau ʻia ka hoʻoholo e hooki i ka albiglutide ma ke kūkākūkā ʻana me kāu mea mālama ola, ʻaʻole loa ma kāu iho. No ka mea, he maʻi maʻi mau ka maʻi diabetes type 2, ʻo ka hooki ʻana i nā lāʻau lapaʻau diabetes me ka nānā ʻole ʻana o ke kauka, hiki ke alakaʻi i ka piʻi ʻana o ke kōpaʻa koko.

Hiki i kāu kauka ke ʻōlelo e hooki inā ua loaʻa iā ʻoe nā hopena ʻaoʻao koʻikoʻi, inā ua emi nui kāu hana ʻana o ka puʻupaʻa, a i ʻole inā ua loaʻa iā ʻoe nā maʻi olakino ʻē aʻe i hana ʻole i ka lāʻau lapaʻau. Hiki i kekahi poʻe ke hooki inā ua loaʻa iā lākou ka mālama ʻana i ke kōpaʻa koko maikaʻi loa ma o nā loli nui o ke ola, akā e koi kēia i ka nānā pono.

Hiki i ka Albiglutide ke hoʻoulu i ka pohō kaumaha?

ʻAe, ua hoʻoulu pinepine ka albiglutide i ka pohō kaumaha ma ke ʻano he hopena ʻaoʻao, i manaʻo ʻia he mea maikaʻi no ka poʻe me ka maʻi diabetes type 2. Ua hana maʻamau kēia pohō kaumaha no ka mea ua lohi ka lāʻau lapaʻau i ka hakahaka o ka ʻōpū a hoʻemi i ka ʻai.

ʻO ka hapa nui o nā kānaka i lilo ke kaumaha me ka albiglutide i lilo ma waena o 2-7 paona i loko o kekahi mau mahina. ʻOiai ʻaʻole i nui ka lilo ʻana o ke kaumaha e like me ka mea i ʻike ʻia me kekahi mau lāʻau GLP-1 ʻē aʻe, he mea nui nō ia no nā maʻi he nui. Ua lohi a paʻa ka lilo ʻana o ke kaumaha i ka wā i hoʻomau ʻia ai ka lāʻau.