He aha ʻo Alectinib: Nā hoʻohana, ka nui o ka lāʻau, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau maʻi maʻi i manaʻo ʻia ʻo Alectinib e kōkua i ka mālama ʻana i kahi ʻano maʻi maʻi maʻi maʻi māmā i kapa ʻia ʻo ALK-positive non-small cell lung cancer. Hana kēia lāʻau lapaʻau ma ka pale ʻana i kekahi mau protein e kōkua i nā pūnaewele maʻi maʻi e ulu a laha, e hāʻawi ana i kou kino i kahi manawa maikaʻi e hakakā i ka maʻi.

Inā ua kauoha ʻia ʻo alectinib iā ʻoe a i ʻole kekahi āu e mālama ai, nui paha kāu mau nīnau e pili ana i ke ʻano o kāna hana a me ka mea e manaʻo ai. E hele kākou i nā mea a pau e pono ai ʻoe e ʻike e pili ana i kēia lāʻau lapaʻau ma nā huaʻōlelo maʻemaʻe a pololei.

He aha ʻo Alectinib?

He lāʻau lapaʻau kauoha ʻo Alectinib e pili ana i kahi hui o nā lāʻau i kapa ʻia ʻo tyrosine kinase inhibitors. E noʻonoʻo iā ia he lāʻau lapaʻau i manaʻo ʻia e hele pololei i nā pūnaewele maʻi maʻi me kahi loli genetic.

Ua hoʻolālā ʻia kēia lāʻau lapaʻau no ka poʻe nona ka maʻi maʻi māmā i kahi hoʻololi genetic i kapa ʻia ʻo ALK rearrangement. E hoʻāʻo kāu kauka i kāu mau pūnaewele maʻi maʻi e ʻike inā loaʻa iā lākou kēia loli ma mua o ke kau ʻana i ka alectinib.

Hele mai ka lāʻau lapaʻau i ke ʻano capsule a lawe ʻia e ka waha, e maʻalahi ai ma mua o nā lāʻau lapaʻau e koi ai i nā kipa i ka haukapila no nā infusions.

No ke aha i hoʻohana ʻia ai ʻo Alectinib?

Ua ʻae ʻia ʻo Alectinib e mālama i ka ALK-positive non-small cell lung cancer. ʻO kēia ʻano maʻi maʻi māmā e hana ana ma kahi o 3-5% o nā maʻi maʻi māmā a pau, a ʻoi aku ka maʻamau i nā poʻe ʻōpio a me nā mea puhi ʻole.

Hiki i kāu kauka ke kauoha i ka alectinib ma ke ʻano he lāʻau lapaʻau mua inā ua ʻike ʻia ʻoe me kēia ʻano maʻi maʻi. Hiki nō hoʻi ke hoʻohana ʻia inā ʻaʻole i hana maikaʻi nā mea pale ALK ʻē aʻe iā ʻoe a i ʻole ua pau ka hana.

He mea pono loa ka lāʻau lapaʻau i ka wā i laha ai ka maʻi maʻi i nā ʻāpana ʻē aʻe o kou kino, me ka lolo. Hōʻike nā haʻawina hiki iā ia ke kōkua i ka hōʻemi ʻana i nā ʻōpū a hoʻolohi i ka ulu ʻana o ka maʻi maʻi.

Pehea e hana ai ʻo Alectinib?

Hana ʻo Alectinib ma ka pale ʻana i kahi protein i kapa ʻia ʻo ALK e kōkua ana i nā pūnaewele maʻi ʻaʻai e ulu a hoʻonui. Ke hana nui kēia protein ma muli o nā loli genetic, hoʻouna ia i nā hōʻailona e wikiwiki ai nā pūnaewele maʻi ʻaʻai.

Ma ka pale ʻana i kēia mau hōʻailona, ​​hoʻokomo maoli ʻo alectinib i nā kaʻa ma ka ulu ʻana o ka maʻi ʻaʻai. Hāʻawi kēia i kāu ʻōnaehana pale a me nā lāʻau lapaʻau ʻē aʻe i kahi manawa maikaʻi e hana kūʻē i ka maʻi ʻaʻai.

Ua manaʻo ʻia kēia lāʻau lapaʻau he lāʻau lapaʻau ikaika a maikaʻi no ka maʻi maʻi maʻi maʻi maʻi maʻi ALK-positive. Nui ka poʻe e ʻike i ka emi ʻana o kā lākou mau ʻōpū i loko o nā mahina mua o ka lāʻau lapaʻau.

Pehea e lawe ai au i ka Alectinib?

E lawe i ka alectinib e like me ke kauoha a kāu kauka, ʻelua manawa i ka lā me ka meaʻai. ʻO ka lawe ʻana me ka ʻai e kōkua i kou kino e komo maikaʻi i ka lāʻau lapaʻau a hiki ke hōʻemi i ka pilikia o ka ʻōpū.

Hiki iā ʻoe ke lawe i ka alectinib me kekahi ʻano meaʻai, akā ʻo ka loaʻa ʻana me ka ʻai e loaʻa ana kekahi momona e kōkua i ka absorption. Mai hopohopo e pili ana i ka manawa me nā meaʻai kikoʻī - e hōʻoia wale ʻaʻole ʻoe e lawe ana ma ka ʻōpū ʻole.

E ale i nā capsules holoʻokoʻa me ka wai. Mai wehe, ʻoki, a nau paha iā lākou, no ka mea, hiki i kēia ke hoʻopilikia i ka hana ʻana o ka lāʻau lapaʻau. Inā he pilikia kāu i ka ale ʻana i nā capsules, e kamaʻilio me kāu kauka e pili ana i nā koho ʻē aʻe.

E ho'āʻo e lawe i kāu mau lāʻau i nā manawa like i kēlā me kēia lā e mālama i nā pae paʻa o ka lāʻau lapaʻau i loko o kou kino. Hiki i ka hoʻonohonoho ʻana i nā mea hoʻomanaʻo kelepona ke kōkua iā ʻoe e hoʻomanaʻo.

Pehea ka lōʻihi e lawe ai au i ka Alectinib?

E hoʻomau ʻoe i ka lawe ʻana i ka alectinib i ka wā e kōkua ana i ka mālama ʻana i kāu maʻi ʻaʻai a hiki ke mālama ʻia nā hopena ʻaoʻao. Hiki i kēia ke mau mahina a i ʻole nā ​​makahiki - ʻokoʻa ke kūlana o kēlā me kēia kanaka.

E nānā kāu kauka i kāu holomua me nā scans maʻamau a me nā hoʻokolohua koko e ʻike i ka maikaʻi o ka hana ʻana o ka lāʻau lapaʻau. E ʻimi lākou i nā hōʻailona e emi ana a paʻa paha nā ʻōpū.

Inā hoʻomaka hou ka maʻi 'aʻai e ulu a i ʻole e loaʻa iā ʻoe nā hopena ʻaoʻao koʻikoʻi, hiki i kāu kauka ke hoʻoponopono i kāu mahele lāʻau a i ʻole e hoʻololi iā ʻoe i kahi lapaʻau ʻē aʻe. He ʻāpana maʻamau kēia o ka mālama ʻana i ka maʻi 'aʻai, ʻaʻole he hemahema o ka lāʻau.

He aha nā hopena ʻaoʻao o Alectinib?

E like me nā lāʻau lapaʻau a pau, hiki i ka alectinib ke hoʻoulu i nā hopena ʻaoʻao, ʻoiai ʻaʻole e loaʻa iā lākou a pau. Hiki ke mālama ʻia ka hapa nui o nā hopena ʻaoʻao, a e kōkua kāu hui mālama ola iā ʻoe e hana me nā mea e loaʻa ana.

Eia nā hopena ʻaoʻao maʻamau e hiki iā ʻoe ke ʻike, ma ke ʻano mai ka mea pinepine a hiki i ka mea liʻiliʻi:

• Luhi a me ka manaʻo luhi ma mua o ka maʻamau
• ʻEha ʻiʻo a me nā ʻeha
• Pehu i kou mau lima, wāwae, a i ʻole ka maka
• Paʻa
• Ua
• Nausea
• ʻEha a i ʻole ka huhū o ka ʻili
• Nā loli i ka ʻike

ʻO ka hapa nui o kēia mau hopena ʻaoʻao he maʻalahi a i ka waena a pinepine e hoʻomaikaʻi i ka wā e hoʻoponopono ai kou kino i ka lāʻau. Hiki i kāu kauka ke hōʻike i nā ala e mālama pono ai iā lākou.

ʻO kekahi mau hopena ʻaoʻao liʻiliʻi akā ʻoi aku ka koʻikoʻi e koi i ka lāʻau lapaʻau koke. Pākuʻi ʻia kēia i ka pilikia o ka hanu ʻana, ka ʻeha ʻiʻo nui, nā loli nui i ka ʻike, a i ʻole nā ​​hōʻailona o nā pilikia o ke ake e like me ka melemele o kou ʻili a i ʻole nā ​​maka.

I nā manawa kakaʻikahi, hiki i ka alectinib ke hoʻoulu i ka mumū o ka māmā a i ʻole ka pōʻino nui o ke ake. E nānā pono kāu kauka iā ʻoe me nā hoʻokolohua koko maʻamau e hopu i nā pilikia i ka wā mua.

ʻO wai ka mea pono ʻole e lawe iā Alectinib?

ʻAʻole kūpono ʻo Alectinib no nā mea a pau. ʻAʻole pono ʻoe e lawe i kēia lāʻau inā ua loaʻa iā ʻoe kahi hopena maʻi koʻikoʻi iā ia i ka wā ma mua a i ʻole inā ʻaʻole i loaʻa i kāu maʻi 'aʻai ka loli genetic ALK.

E haʻi i kāu kauka e pili ana i kāu mau maʻi olakino a pau ma mua o ka hoʻomaka ʻana i ka alectinib. He mea nui kēia inā loaʻa iā ʻoe nā pilikia o ke ake, ka maʻi māmā, a i ʻole nā ​​pilikia ʻike, no ka mea, hiki i ka lāʻau lapaʻau ke hoʻonui i kēia mau maʻi.

Inā hāpai ʻoe, e hoʻolālā ana e hāpai, a i ʻole e hānai ana i ka waiū, e kūkākūkā i kēia me kāu kauka. Hiki i ka Alectinib ke hōʻeha i kahi pēpē i hānau ʻole ʻia, no laila he mea nui ka mālama ʻana i ka hānau ʻana i ka wā e mālama ʻia ai.

E nānā pū kāu kauka i kāu mau lāʻau lapaʻau a pau e nānā i nā pilina. Hiki i kekahi mau lāʻau lapaʻau ke hoʻopilikia i ka hana ʻana o ka alectinib a i ʻole e hoʻonui i kou pilikia o nā hopena ʻaoʻao.

Nā inoa inoa Alectinib

Kūʻai ʻia ʻo Alectinib ma lalo o ka inoa inoa ʻo Alecensa ma ka hapa nui o nā ʻāina, me ʻAmelika Hui Pū ʻIa. ʻO kēia ka inoa maʻamau āu e ʻike ai ma kāu ʻōmole kauoha.

Hana ʻia ka lāʻau lapaʻau e Roche/Genentech, a hiki iā ʻoe ke ʻike i ko lākou inoa ma ka ʻeke me ka inoa inoa Alecensa.

ʻAʻole i loaʻa nā mana generic o ka alectinib, no laila ka hapa nui o nā kānaka e loaʻa i ka mana inoa inoa. Loaʻa paha i kāu ʻinikua nā koi kikoʻī no ka uhi ʻana i kēia lāʻau lapaʻau.

Nā koho ʻē aʻe o Alectinib

Inā ʻaʻole kūpono ka alectinib iā ʻoe a i ʻole e pau ka hana ʻana, hiki i kekahi mau lāʻau lapaʻau i manaʻo ʻia ke mālama i ka maʻi maʻi maʻi maʻi ALK-positive. Hiki i kāu kauka ke noʻonoʻo i ka crizotinib, ceritinib, a i ʻole brigatinib ma ke ʻano he koho ʻē aʻe.

Hana iki kēlā me kēia o kēia mau lāʻau lapaʻau a loaʻa iā lākou iho nā hopena ʻaoʻao. E koho kāu kauka i ke koho maikaʻi loa e pili ana i kāu kūlana kikoʻī, me nā lāʻau lapaʻau āu i hoʻāʻo ai ma mua.

I kekahi mau hihia, hiki i kāu kauka ke ʻōlelo aku i ka chemotherapy kuʻuna a i ʻole immunotherapy ma kahi o ka lāʻau lapaʻau i manaʻo ʻia a i ʻole me ia. Aia ke koho i nā mea he nui, me ke ʻano o ka pane ʻana o kāu maʻi maʻi i nā lāʻau lapaʻau ma mua.

ʻOi aku ka maikaʻi o Alectinib ma mua o Crizotinib?

Hōʻike nā haʻawina lapaʻau e ʻoi aku ka maikaʻi o ka alectinib ma mua o ka crizotinib, ʻoiai no ka pale ʻana i ka maʻi maʻi mai ka laha ʻana i ka lolo. Hoʻomaʻamaʻa pū ʻo Alectinib i nā hopena ʻaoʻao koʻikoʻi ma mua o ka crizotinib.

Nui nā kauka i kēia manawa e makemake ana i ka alectinib ma ke ʻano he lapaʻau mua no ka maʻi maʻi maʻi maʻi maʻi ALK-positive i hōʻike ʻia. Eia naʻe, ua kūpono nā lāʻau lapaʻau ʻelua, a e koho kāu kauka ma muli o kou kūlana pilikino.

Aia ka lāʻau lapaʻau

E hooki wale i ka lawe ʻana i ka alectinib ke haʻi mai kāu kauka iā ʻoe. ʻOiai inā maikaʻi kou manaʻo, e hana ana paha ka lāʻau lapaʻau e kāohi i kāu maʻi kanesa.

Na kāu kauka e hoʻoholo i ka manawa e hooki ai ma muli o ke ʻano o ka pane ʻana o kāu maʻi kanesa, nā hopena ʻaoʻao āu e ʻike nei, a me kou olakino holoʻokoʻa. E hoʻohana lākou i nā scans a me nā hoʻokolohua koko e hana i kēia hoʻoholo.

Hiki iaʻu ke inu i ka waiʻona i ka wā e lawe ana i ka Alectinib?

He maikaʻi ka nui o ka waiʻona i ka wā e lawe ana i ka alectinib, akā ʻoi aku ka maikaʻi e kūkākūkā mua me kāu kauka. Hiki i ka waiʻona ke hoʻonui i nā hopena ʻaoʻao e like me ka luhi a i ʻole ka nausea.

Inā inu ʻoe, e pili i nā mea maʻalahi a e nānā i ke ʻano o ka pane ʻana o kou kino. ʻIke kekahi poʻe i ka hopena o ka waiʻona iā lākou i ka wā e mālama ʻia ai ka maʻi kanesa.