He aha ʻo Alemtuzumab: Nā hoʻohana, ka nui, nā hopena ʻaoʻao a me nā mea hou aku

He lāʻau lapaʻau ʻo Alemtuzumab i hāʻawi ʻia ma o ka IV e kōkua ana i ka mālama ʻana i kekahi mau ʻano maʻi koko a me ka sclerosis lehulehu. Hana ia ma ka ʻimi ʻana i nā cell immune kikoʻī e hoʻopilikia ai i kēia mau maʻi, e hāʻawi ana i kāu ʻōnaehana pale i kahi hoʻonohonoho hou i mālama pono ʻia.

No kēia lāʻau lapaʻau i kahi papa i kapa ʻia he monoclonal antibodies, he mau protein i hana ʻia i ka lab i hoʻolālā ʻia e ʻimi a hoʻopili i nā pahuhopu kikoʻī i loko o kou kino. E noʻonoʻo iā ia he mea hana pololei loa e hoʻohana ai kāu hui lapaʻau i ka wā i hana ʻole ai nā lāʻau lapaʻau ʻē aʻe e like me ka mea i manaʻo ʻia.

No ke aha e hoʻohana ʻia ai ʻo Alemtuzumab?

Hoʻomaʻamaʻa ʻo Alemtuzumab i nā maʻi nui ʻelua: chronic lymphocytic leukemia (CLL) a me nā ʻano relapsing o ka sclerosis lehulehu (MS). E ʻōlelo kāu kauka i kēia lāʻau lapaʻau ke pono ʻoe i kahi ala i manaʻo nui ʻia e mālama i kou maʻi.

No ka chronic lymphocytic leukemia, kōkua ʻo alemtuzumab i ka wā i pane ʻole ai kēia maʻi koko i nā lāʻau chemotherapy ʻē aʻe. Hoʻopili pono ia i nā cell B-cancerous e hoʻonui wikiwiki loa i kou koko a me nā lymph nodes.

I ka sclerosis lehulehu, hana ʻo alemtuzumab i nā mea like ʻole ma ka ʻimi ʻana i nā cell immune e hoʻouka hewa i kāu ʻōnaehana nerve. Kōkua kēia i ka hōʻemi ʻana i ke alapine a me ke koʻikoʻi o nā relapses MS, e hāʻawi ana i kou kino i ka manawa e hoʻōla a hoʻopaʻa.

Pehea e hana ai ʻo Alemtuzumab?

Ua manaʻo ʻia ʻo Alemtuzumab he lāʻau lapaʻau ikaika e hana ana ma ka hoʻopili ʻana i kahi protein i kapa ʻia ʻo CD52 i loaʻa ma kekahi mau cell immune. Ke hoʻopili ʻia, hōʻailona ia i kou kino e luku i kēia mau cell, e kōkua ana i ka hoʻonohonoho hou ʻana i ke ʻano o kāu ʻōnaehana pale.

He mea ikaika a piha kēia hana. ʻAʻole hoʻopau wale ka lāʻau lapaʻau i kāu ʻōnaehana pale no ka manawa - hoʻopau maoli ia i nā ʻano cell immune kikoʻī. A laila kūkulu hou kou kino i kēia mau cell i ka manawa, pinepine me ke kaulike maikaʻi a me ka liʻiliʻi o ka hana ʻino.

Hiki i ke kaʻina hana kūkulu hou ke lawe i nā mahina a i ʻole nā makahiki, ʻo ia ke kumu e pono ai ka nānā pono ʻana iā alemtuzumab. E nānā pono kāu hui lapaʻau i ka wā e ola hou ai kou ʻōnaehana pale a hoʻoponopono hou iā ia iho.

Pehea e lawe ai au iā Alemtuzumab?

E loaʻa iā ʻoe ka alemtuzumab ma o ka IV infusion ma kahi haukapila a i ʻole kahi keʻena loea, ʻaʻole loa ma ka home. Hāʻawi mau ʻia ka lāʻau lapaʻau e nā poʻe loea mālama ola i aʻo ʻia e hiki ke nānā pono iā ʻoe i ka wā a ma hope o ka mālama ʻana.

Ma mua o kēlā me kēia infusion, e loaʻa iā ʻoe nā lāʻau lapaʻau ma mua e kōkua i ka pale ʻana i nā hopena. Hoʻopili pinepine kēia i nā antihistamines, acetaminophen, a i kekahi manawa corticosteroids. E hoʻomaka kāu hui mālama ola i kēia mau mea ma kahi o 30 mau minuke ma mua o ka hoʻomaka ʻana o kāu alemtuzumab infusion.

ʻO ka infusion ponoʻī e lawe ma kahi o 4 mau hola no kāu mahele mua, me nā mahele ma hope e lawe ana i ka manawa liʻiliʻi. E nānā ʻia ʻoe i ke kaʻina hana, me ka nānā mau ʻia ʻana o kāu mau hōʻailona ola a me nā limahana lapaʻau e kokoke ana e pane koke i nā hopohopo.

Pono ka hapa nui o nā kānaka e noho no ka nānā ʻana no kekahi mau hola ma hope o ka pau ʻana o ka infusion. Hāʻawi kēia i kāu hui lapaʻau e hōʻoia e maikaʻi ana ʻoe a ʻaʻole i loaʻa nā hopena lohi ma mua o kou hele ʻana i ka home.

Pehea ka lōʻihi e lawe ai au iā Alemtuzumab?

Aia ke ʻano o ka mālama ʻana no alemtuzumab i kou kūlana kikoʻī a me ka maikaʻi o kāu pane ʻana. No ka sclerosis lehulehu, e loaʻa iā ʻoe nā papa hana lapaʻau ʻelua i hoʻokaʻawale ʻia ma kahi o hoʻokahi makahiki.

Aia i loko o kēlā me kēia papa hana lapaʻau nā infusions i kēlā me kēia lā no kekahi mau lā e pili ana. No MS, ʻo ia hoʻi, 5 mau lā o ka mālama ʻana i ka papa mua, a laila 3 mau lā o ka mālama ʻana i ka papa ʻelua i hoʻokahi makahiki ma hope.

No ka leukemia lymphocytic maʻi, ʻokoʻa paha ka papa hana a pili i ke ʻano o ka pane ʻana o kāu maʻi maʻi. E hoʻoholo kāu oncologist i ka lōʻihi pololei e pili ana i kāu helu koko, pehea ʻoe e ʻae nei i ka mālama ʻana, a inā e hoʻomaikaʻi ana ka leukemia.

Pono paha kekahi poʻe i nā papa hou aʻe ma mua o ka papa maʻamau, akā hana ʻia kēia hoʻoholo me ka mālama nui ʻia e kāu hui lapaʻau e pili ana i kāu pane pilikino a me nā hopena ʻaoʻao āu e ʻike ai.

He aha nā hopena ʻaoʻao o Alemtuzumab?

Hiki i ka Alemtuzumab ke hana i nā hopena ʻaoʻao like ʻole, mai nā hopena maʻalahi i ka wā o ka hoʻokomo ʻana i nā pilikia koʻikoʻi e ulu ana i ka manawa. ʻO ka hoʻomaopopo ʻana i kēia mau mea e kōkua iā ʻoe e ʻike i ka mea e nānā ai a i ka manawa e hoʻopili ai i kāu hui mālama ola.

ʻO nā hopena ʻaoʻao maʻamau e hana ʻia i ka wā a i ʻole ma hope koke o kāu hoʻokomo ʻana a maʻamau ka hiki ke mālama ʻia me nā lāʻau lapaʻau mua a me ka nānā pono ʻana:

• Nā hopena hoʻokomo e like me ke kuni, nā anu, a me ka nausea
• ʻO ka ʻili a i ʻole nā hives
• ʻO ke poʻo a me ka luhi
• Ke koko haʻahaʻa a i ʻole ka puʻuwai wikiwiki
• ʻO ka hanu ʻana a i ʻole ka paʻa o ka umauma

Hoʻomaikaʻi maʻamau kēia mau hopena e pili ana i ka hoʻokomo ʻana me ka manawa a me ka mālama kākoʻo. Ua mākaukau kāu hui lapaʻau e mālama iā lākou inā loaʻa lākou.

Hiki ke ulu nā hopena ʻaoʻao koʻikoʻi i nā pule a i nā mahina ma hope o ka mālama ʻana, no ka mea, pili nui ka alemtuzumab i kāu ʻōnaehana pale. Pono kēia mau mea i ka nānā mau ʻana a me ka nānā koke ʻana:

• Nā maʻi koʻikoʻi ma muli o ka nāwaliwali o ka pale ʻana
• Nā pilikia thyroid autoimmune
• Nā maʻi koko mai nā helu platelet haʻahaʻa
• Nā pilikia kīkī mai nā hopena autoimmune
• Nā mea ʻinoʻino o ka puʻuwai

Eia kekahi, aia kekahi mau hopena ʻaoʻao kakaʻikahi akā koʻikoʻi loa e nānā pono ai kāu hui lapaʻau. Aia kēia mau mea i nā kūlana autoimmune koʻikoʻi e pili ana i kou koko, nā kīkī, a i ʻole nā ʻōkana ʻē aʻe, a me kekahi mau ʻano maʻi maʻi e hiki ke ulu ma muli o ka hoʻopaʻa ʻana o ka ʻōnaehana pale.

E hāʻawi kāu hui mālama ola i nā papa hana nānā kikoʻī a e aʻo iā ʻoe i nā hōʻailona e nānā ai ma ka home. He ʻāpana koʻikoʻi kēia o ka mālama ʻana iā alemtuzumab.

ʻO wai ka mea pono ʻole e lawe iā Alemtuzumab?

ʻAʻole kūpono ʻo Alemtuzumab no nā mea a pau, a e loiloi pono kāu kauka inā kūpono ia no ʻoe. ʻO kekahi mau maʻi a me nā kūlana e hoʻoweliweli loa ai kēia lāʻau lapaʻau e hoʻohana palekana.

ʻAʻole pono ʻoe e loaʻa iā alemtuzumab inā loaʻa iā ʻoe nā maʻi maʻi, me ka HIV, hepatitis B a i ʻole C, a i ʻole tuberculosis. ʻO ka hopena o ka lāʻau lapaʻau i kāu ʻōnaehana pale e hiki ke hoʻonui i kēia mau maʻi a hiki ke hoʻoweliweli i ke ola.

ʻAʻole kūpono paha ka poʻe me kekahi mau maʻi autoimmune ma waho o MS no alemtuzumab. E loiloi kāu kauka inā ʻoi aku ka maikaʻi ma mua o nā pilikia inā loaʻa iā ʻoe nā maʻi e like me ka maʻi thyroid autoimmune koʻikoʻi a i ʻole nā maʻi ʻōnaehana pale ʻē aʻe.

He mea nui nō hoʻi ka hāpai ʻana a me ka hānai ʻana i ka waiū. Hiki i ka Alemtuzumab ke hōʻeha i ka pēpē e ulu ana, no laila pono ʻoe i ka contraception hilinaʻi i ka wā o ka mālama ʻana a no kekahi mau mahina ma hope. Inā ʻoe e hoʻolālā nei e hāpai, e kūkākūkā pono i ka manawa me kāu hui mālama ola.

E noʻonoʻo pū kāu kauka i kou olakino holoʻokoʻa, nā lāʻau lapaʻau ʻē aʻe āu e lawe nei, a me kekahi mōʻaukala o nā hopena lāʻau koʻikoʻi ma mua o ka ʻōlelo ʻana i ka mālama ʻana iā alemtuzumab.

Nā inoa inoa inoa ʻo Alemtuzumab

Loaʻa ʻo Alemtuzumab ma lalo o nā inoa inoa ʻo Lemtrada a me Campath, ʻoiai ʻokoʻa ka loaʻa ʻana ma ka ʻāina a me ka hōʻailona lapaʻau kikoʻī. Hoʻohana nui ʻia ʻo Lemtrada no ka mālama ʻana i ka sclerosis lehulehu, ʻoiai ua hoʻohana pinepine ʻia ʻo Campath no ka leukemia.

Ma kekahi mau wahi, ʻaʻole hiki ke loaʻa hou ʻo Campath, akā hiki ke loaʻa ʻo alemtuzumab ma o nā formulations ʻē aʻe. E hōʻoia kāu hui mālama ola e loaʻa iā ʻoe ka mana kūpono no kou kūlana kikoʻī.

ʻOiai ʻo ka inoa inoa, like nā mea hana a me nā hopena. E mālama kāu hui lapaʻau i nā kikoʻī a pau e pili ana i ka formulation kikoʻī āu e loaʻa ai.

Nā koho ʻē aʻe ʻo Alemtuzumab

He nui nā koho ʻē aʻe no ka sclerosis lehulehu a me ka leukemia lymphocytic maʻi, akā e koho kāu kauka ma muli o kou kūlana kūikawā a me ke ʻano o ka hana ʻana o nā lāʻau lapaʻau ʻē aʻe iā ʻoe.

No ka sclerosis lehulehu, nā koho ʻē aʻe e komo pū ana me nā lāʻau lapaʻau e hoʻololi ana i ka maʻi e like me natalizumab, rituximab, a i ʻole nā lāʻau lapaʻau waha hou e like me fingolimod a i ʻole dimethyl fumarate. He mau pōmaikaʻi a me nā pilikia like ʻole ko kēlā me kēia mea e kūkākūkā ai kāu neurologist me ʻoe.

I ka leukemia lymphocytic maʻi, hiki i nā koho ʻē aʻe ke komo pū me nā antibodies monoclonal ʻē aʻe e like me rituximab, nā hui chemotherapy, a i ʻole nā lāʻau lapaʻau i manaʻo ʻia e like me ibrutinib a i ʻole venetoclax. E noʻonoʻo kāu oncologist i nā mea e like me kou olakino holoʻokoʻa, nā genetics o kāu leukemia, a me nā lāʻau lapaʻau i hala.

Aia ka koho o ka ʻokoʻa i kou mau kūlana pilikino, me ke ʻano o ka ikaika o kou maʻi, kou makahiki a me ke olakino holoʻokoʻa, a me nā lāʻau lapaʻau āu i hoʻāʻo ai.

Ua ʻoi aku ka maikaʻi o Alemtuzumab ma mua o nā lāʻau lapaʻau MS ʻē aʻe?

ʻOi aku ka maikaʻi o Alemtuzumab ma mua o nā lāʻau lapaʻau MS ʻē aʻe i ka hōʻemi ʻana i nā relapses a me ka hoʻolohi ʻana i ka holomua o ke kino kīnā, akā lawe pū kekahi i nā pilikia koʻikoʻi. ʻO kēia ka mea e waiwai nui ai no ka poʻe me ka MS ikaika ʻaʻole i pane maikaʻi i nā lāʻau lapaʻau ʻē aʻe.

I ka hoʻohālikelike ʻana me nā interferons a i ʻole glatiramer acetate, hāʻawi ʻo alemtuzumab i nā hopena ikaika a lōʻihi. Nui ka poʻe e ʻike i ka hōʻemi nui ʻana i ka hana MS no nā makahiki ma hope o ka lāʻau lapaʻau, hiki ke hoʻololi i ke ola no ka poʻe me ka maʻi ikaika.

Eia naʻe, hele mai ka hoʻonui ʻia ʻana o ka pono me nā koi nānā nui a me nā hopena ʻaoʻao koʻikoʻi. E kōkua kāu neurologist iā ʻoe e noʻonoʻo inā pono nā pōmaikaʻi i nā pilikia i kou kūlana.

Ke hilinaʻi pinepine nei ka hoʻoholo ʻana i nā mea e like me ka hana ʻana o kāu MS, pehea ka maikaʻi o kāu pane ʻana i nā lāʻau lapaʻau ʻē aʻe, kou makahiki, a me kou ʻae ʻana i ka pilikia e kūʻē i ka pono.

Nā Nīnau i Nīnau Pinepine ʻia e pili ana iā Alemtuzumab

He Palekana anei ʻo Alemtuzumab no ka poʻe me nā pilikia o ka naʻau?

Pono ʻo Alemtuzumab i ka loiloi akahele inā he pilikia kou naʻau, no ka mea, hiki iā ia ke hoʻopilikia i kou puʻuwai a me ke koko i ka wā o ka hoʻokomo ʻana. E hana pū ana kāu cardiologist a me ka hui e hāʻawi ana iā ʻoe i ka alemtuzumab e hoʻoholo inā palekana ia iā ʻoe.

Inā loaʻa iā ʻoe ka alemtuzumab me nā maʻi o ka naʻau, pono ʻoe i ka nānā ʻana i ka wā o ka hoʻokomo ʻana a me ka nānā ʻana i ka puʻuwai ma hope. Nui ka poʻe me nā maʻi o ka naʻau paʻa e hiki ke loaʻa i kēia lāʻau lapaʻau me ka palekana me nā hana kūpono.

He aha kaʻu e hana ai inā ua hala au i kahi mahele alemtuzumab i hoʻonohonoho ʻia?

E hoʻokaʻaʻike koke i kāu hui mālama ola inā ua hala ʻoe i kahi hoʻokomo alemtuzumab i hoʻonohonoho ʻia. No ka mea, hāʻawi ʻia kēia lāʻau lapaʻau i nā papa manawa i hoʻonohonoho pono ʻia, hiki i ka hala ʻana i nā mahele ke hoʻopilikia i ka maikaʻi o kāu lāʻau lapaʻau.

E hoʻonohonoho hou kāu hui lapaʻau i kāu mahele i ka hiki wawe a hiki ke hoʻololi iki i kāu papa hana lapaʻau. Mai ho'āʻo e

Ke hoʻomau nei ka nānā ʻana no ka liʻiliʻi loa o 4 mau makahiki ma hope o kāu alemtuzumab hope loa, a pono paha kekahi mau mea e mālama ʻia i ke ola a pau. He mea nui kēia nānā ʻana no ka mea hiki ke ulu nā hopena ʻaoʻao koʻikoʻi i nā mahina a i ʻole nā makahiki ma hope o ka mālama ʻana.

E hāʻawi kāu hui mālama ola i kahi papa hana nānā kikoʻī e pili ana i nā hoʻokolohua koko maʻamau, nā loiloi hana thyroid, a me nā loiloi ʻē aʻe. He mea nui ka hahai ʻana i kēia papa hana me ka ʻoiaʻiʻo no ka hopu ʻana i nā pilikia i ka wā mua ke hiki ke mālama ʻia.

Hiki iaʻu ke loaʻa nā lāʻau lapaʻau i ka wā e lawe ana i ka Alemtuzumab?

ʻAʻole palekana nā lāʻau lapaʻau ola i ka wā e ola hou ana kāu ʻōnaehana pale mai ka alemtuzumab, maʻamau no ka liʻiliʻi o 6 mau mahina ma hope o ka mālama ʻana. Eia naʻe, hiki iā ʻoe ke loaʻa kekahi mau lāʻau lapaʻau i hoʻopau ʻia me ka ʻae ʻia o kāu kauka.

E hāʻawi kāu hui mālama ola i ke alakaʻi kikoʻī e pili ana i nā lāʻau lapaʻau palekana a me ka manawa. He mea nui e kūkākūkā i nā pono lāʻau lapaʻau, me nā lāʻau lapaʻau huakaʻi, ma mua o kāu mau immunizations i hoʻolālā ʻia.